##gff-version 3 P54099 UniProtKB Chain 1 1218 . . . ID=PRO_0000101271;Note=DNA polymerase subunit gamma-1 P54099 UniProtKB Region 31 50 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P54099 UniProtKB Region 484 524 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P54099 UniProtKB Region 492 553 . . . Note=Accessory-interacting determinant;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Region 837 843 . . . Note=Trigger loop;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Motif 179 183 . . . Note=Exo I;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Motif 250 258 . . . Note=Exo II;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Motif 378 386 . . . Note=Exo III;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Motif 866 875 . . . Note=Pol A;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Motif 922 937 . . . Note=Pol B;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Motif 1113 1120 . . . Note=Pol C;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Active site 181 181 . . . Note=Exonuclease activity;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 289 289 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 561 561 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 575 575 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 733 733 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 742 742 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 747 747 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 785 785 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 828 828 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 842 842 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 848 848 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 869 869 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 869 869 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 869 869 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 870 870 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 870 870 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 872 872 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 874 874 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 922 922 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 926 926 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 930 930 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 1073 1073 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 1074 1074 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 1114 1114 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 1114 1114 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Binding site 1114 1114 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Site 832 832 . . . Note=Critical for replication fidelity and mismatch recognition;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Site 1081 1081 . . . Note=Critical for replication fidelity and mismatch recognition;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54098 P54099 UniProtKB Mutagenesis 257 257 . . . Note=Results in loss of exonuclease activity associated with impaired mtDNA 5'-end ligation and accumulation of somatic mtDNA mutations. Mice carrying this mutation show premature aging and reduced lifespan. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15164064,ECO:0000269|PubMed:26095671;Dbxref=PMID:15164064,PMID:26095671 P54099 UniProtKB Sequence conflict 23 24 . . . Note=AR->EG;Ontology_term=ECO:0000305;evidence=ECO:0000305 P54099 UniProtKB Sequence conflict 27 27 . . . Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 P54099 UniProtKB Sequence conflict 32 32 . . . Note=D->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 P54099 UniProtKB Sequence conflict 159 159 . . . Note=T->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 P54099 UniProtKB Sequence conflict 228 228 . . . Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 P54099 UniProtKB Sequence conflict 303 308 . . . Note=HKNPAA->QQDPAV;Ontology_term=ECO:0000305;evidence=ECO:0000305 P54099 UniProtKB Sequence conflict 324 324 . . . Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 P54099 UniProtKB Sequence conflict 327 327 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 P54099 UniProtKB Sequence conflict 557 557 . . . Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 P54099 UniProtKB Sequence conflict 666 666 . . . Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 P54099 UniProtKB Sequence conflict 861 861 . . . Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 P54099 UniProtKB Sequence conflict 886 886 . . . Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 P54099 UniProtKB Sequence conflict 919 921 . . . Note=GIS->RIH;Ontology_term=ECO:0000305;evidence=ECO:0000305 P54099 UniProtKB Sequence conflict 1024 1024 . . . Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305