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P54099

- DPOG1_MOUSE

UniProt

P54099 - DPOG1_MOUSE

Protein

DNA polymerase subunit gamma-1

Gene

Polg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (02 Nov 2001)
      Previous versions | rss
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    Functioni

    Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA By similarity.By similarity

    Catalytic activityi

    Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB
    2. DNA binding Source: UniProtKB-KW
    3. DNA-directed DNA polymerase activity Source: MGI
    4. exonuclease activity Source: MGI
    5. protein binding Source: IntAct

    GO - Biological processi

    1. aging Source: MGI
    2. mitochondrial DNA replication Source: MGI
    3. nucleic acid phosphodiester bond hydrolysis Source: GOC

    Keywords - Molecular functioni

    DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    DNA-binding, Magnesium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA polymerase subunit gamma-1 (EC:2.7.7.7)
    Alternative name(s):
    Mitochondrial DNA polymerase catalytic subunit
    PolG-alpha
    Gene namesi
    Name:Polg
    Synonyms:Polg1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1196389. Polg.

    Subcellular locationi

    GO - Cellular componenti

    1. gamma DNA polymerase complex Source: InterPro
    2. mitochondrial inner membrane Source: MGI
    3. mitochondrial nucleoid Source: UniProtKB
    4. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion, Mitochondrion nucleoid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12391239DNA polymerase subunit gamma-1PRO_0000101271Add
    BLAST

    Proteomic databases

    PRIDEiP54099.

    PTM databases

    PhosphoSiteiP54099.

    Expressioni

    Gene expression databases

    CleanExiMM_POLG.
    GenevestigatoriP54099.

    Interactioni

    Subunit structurei

    Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Sod2P096712EBI-863636,EBI-1635071
    Tp53P023402EBI-863636,EBI-474016

    Protein-protein interaction databases

    IntActiP54099. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP54099.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi517 – 5204Poly-Glu

    Sequence similaritiesi

    Belongs to the DNA polymerase type-A family.Curated

    Phylogenomic databases

    eggNOGiCOG0749.
    HOGENOMiHOG000176668.
    HOVERGENiHBG051400.
    InParanoidiP54099.
    PhylomeDBiP54099.

    Family and domain databases

    InterProiIPR019760. DNA-dir_DNA_pol_A_CS.
    IPR002297. DNA-dir_DNA_pol_A_mt.
    IPR016265. DNA-dir_DNA_pol_A_mt_sub.
    IPR001098. DNA-dir_DNA_pol_A_palm_dom.
    IPR012337. RNaseH-like_dom.
    [Graphical view]
    PANTHERiPTHR10267. PTHR10267. 1 hit.
    PfamiPF00476. DNA_pol_A. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000797. DNA_pol_mt. 1 hit.
    PRINTSiPR00867. DNAPOLG.
    SMARTiSM00482. POLAc. 1 hit.
    [Graphical view]
    SUPFAMiSSF53098. SSF53098. 2 hits.
    PROSITEiPS00447. DNA_POLYMERASE_A. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P54099-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRLLWKKVA GAKVASGPVP ATARWVASSV LDPVPSDGRP PSQMPSSENG     50
    QLRLNPLLIQ MLSRGLHEQI FGCGGEMPDE AAVQRSVEHL QKHGLWGQPA 100
    TPLPDVELRL PRLFGGNLDQ HFRLLAQKQS LPYLEAAASL LEAQLPPEPK 150
    SWAWAEGWTR YGPEGEAEPV AIPEERALVF DVEVCLAEGT CPTLAVAISP 200
    SAWYSWCSRR LVEERYSWTS QLSPADLIPL GGSTSASSST KQDGQEQLVV 250
    GHNVSFDRAH IREQYLIQDS RMRFLDTMSM HMAISGLSSF QRSLWMGAKQ 300
    GKHKNPAAHK ARAEVPEESQ WSSESSSWDW MDISSANNLA DVHNLYVGGP 350
    PLEKEPRELF VKGSMRDIRE NFQDLMQYCA RDVWATFEVF QQQLPLFLER 400
    CPHPVTLAGM LEMGVSYLPV NQNWERYLTE AQNTYEELQR EMKKSLMDLA 450
    NDACQLLSGE RYKEDPWLWD LEWDLQEFKQ KKAKKVKKPA SASKLPIEGA 500
    GPFGDPMDQE DPGPPSEEEE LQRSVTAHNR LQQLRSTTDL LPKRPQHLPG 550
    HPGWYRQLCP RLDDPAWAPG PSLLSLQMRV TPKLMALTWD GFPLHYSDSH 600
    GWGYLVPGRR DNLTEPPVSP TVESAAVTCP YRAIESLYRK HCLEQGKQQL 650
    EPQEVDLAEE FLLTDNSAMW QTVEELGCLD VEAEAKMENS GLSQPLVLPA 700
    ACAPKSSQPT YHHGNGPYND VNIPGCWFFK LPHKDGNNYN VGSPFAKDFL 750
    PKMEDGTLQA GPGGASGPRA LEINKMISFW RNAHKRISSQ MVVWLPRSAL 800
    PRVVTRHPAF DEEGHYGAIL PQVVTAGTIT RRAVEPTWLT ASNARPDRVG 850
    SELKAMVQAP PGYVLVGADV DSQELWIAAV LGDAHFAGMH GCTAFGWMTL 900
    QGRKSRGTDL HSKTAATVGI SREHAKIFNY GRIYGAGQSF AERLLMQFNH 950
    RLTRQEAAEK AQQMYAVTKG LRRYRLSADG EWLVKQLNLP VDRTEDGWVS 1000
    LQDLRMIRRE ASRKSRWKKW EVAAERAWTG GTESEMFNKL ESIAMSDTPR 1050
    TPVLGCCISR ALEPSVVQGE FITSRVNWVV QSSAVDYLHL MLVAMKWLFE 1100
    EFAIDGRFCI SIHDEVRYLV REEDRYRAAL ALQITNLLTR CMFAYKLGLN 1150
    DLPQSVAFFS AVDIDQCLRK EVTMDCKTPS NPTGMERRYG IPQGEALDIY 1200
    QIIELTKGSL EKRKPAWTLA LSGGSVFAPV ELHWSGAGS 1239
    Length:1,239
    Mass (Da):138,899
    Last modified:November 2, 2001 - v2
    Checksum:i77E514FA0FB679FE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti23 – 242AR → EG in AAA98977. 1 PublicationCurated
    Sequence conflicti27 – 271A → S in AAA98977. 1 PublicationCurated
    Sequence conflicti32 – 321D → A in AAA98977. 1 PublicationCurated
    Sequence conflicti159 – 1591T → N in AAA98977. 1 PublicationCurated
    Sequence conflicti228 – 2281I → T in AAA98977. 1 PublicationCurated
    Sequence conflicti303 – 3086HKNPAA → QQDPAV in AAA98977. 1 PublicationCurated
    Sequence conflicti324 – 3241E → D in AAA98977. 1 PublicationCurated
    Sequence conflicti327 – 3271Missing in AAA98977. 1 PublicationCurated
    Sequence conflicti441 – 45414EMKKS…ANDAC → DDEEVVVVWLMMPG in AAA98977. 1 PublicationCuratedAdd
    BLAST
    Sequence conflicti557 – 5571Q → K in AAA98977. 1 PublicationCurated
    Sequence conflicti666 – 6661N → S in AAA98977. 1 PublicationCurated
    Sequence conflicti861 – 8611P → T in AAA98977. 1 PublicationCurated
    Sequence conflicti886 – 8861F → L in AAA98977. 1 PublicationCurated
    Sequence conflicti919 – 9213GIS → RIH in AAA98977. 1 PublicationCurated
    Sequence conflicti1024 – 10241A → S in AAA98977. 1 PublicationCurated
    Sequence conflicti1233 – 12331H → Y in AAA98977. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U53584 mRNA. Translation: AAA98977.1.
    AF268975
    , AF268970, AF268971, AF268972, AF268973, AF268974 Genomic DNA. Translation: AAF82772.1.
    UniGeneiMm.3616.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U53584 mRNA. Translation: AAA98977.1 .
    AF268975
    , AF268970 , AF268971 , AF268972 , AF268973 , AF268974 Genomic DNA. Translation: AAF82772.1 .
    UniGenei Mm.3616.

    3D structure databases

    ProteinModelPortali P54099.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P54099. 2 interactions.

    PTM databases

    PhosphoSitei P54099.

    Proteomic databases

    PRIDEi P54099.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1196389. Polg.

    Phylogenomic databases

    eggNOGi COG0749.
    HOGENOMi HOG000176668.
    HOVERGENi HBG051400.
    InParanoidi P54099.
    PhylomeDBi P54099.

    Miscellaneous databases

    PROi P54099.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_POLG.
    Genevestigatori P54099.

    Family and domain databases

    InterProi IPR019760. DNA-dir_DNA_pol_A_CS.
    IPR002297. DNA-dir_DNA_pol_A_mt.
    IPR016265. DNA-dir_DNA_pol_A_mt_sub.
    IPR001098. DNA-dir_DNA_pol_A_palm_dom.
    IPR012337. RNaseH-like_dom.
    [Graphical view ]
    PANTHERi PTHR10267. PTHR10267. 1 hit.
    Pfami PF00476. DNA_pol_A. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000797. DNA_pol_mt. 1 hit.
    PRINTSi PR00867. DNAPOLG.
    SMARTi SM00482. POLAc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53098. SSF53098. 2 hits.
    PROSITEi PS00447. DNA_POLYMERASE_A. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Chang S.W., Colvin S., Sarkos P., Denniger G., Zassenhaus H.P.
      Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Muscle.
    2. "Genomic structure of murine mitochondrial DNA polymerase-gamma."
      Mott J.L., Denniger G., Zullo S.J., Zassenhaus H.P.
      DNA Cell Biol. 19:601-605(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.

    Entry informationi

    Entry nameiDPOG1_MOUSE
    AccessioniPrimary (citable) accession number: P54099
    Secondary accession number(s): Q9JI28
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 2, 2001
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3