Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P54099 (DPOG1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA polymerase subunit gamma-1

EC=2.7.7.7
Alternative name(s):
Mitochondrial DNA polymerase catalytic subunit
PolG-alpha
Gene names
Name:Polg
Synonyms:Polg1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1239 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA By similarity.

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Cofactor

Magnesium By similarity.

Subunit structure

Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.

Subcellular location

Mitochondrion. Mitochondrion matrixmitochondrion nucleoid By similarity.

Sequence similarities

Belongs to the DNA polymerase type-A family.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12391239DNA polymerase subunit gamma-1
PRO_0000101271

Regions

Compositional bias517 – 5204Poly-Glu

Experimental info

Sequence conflict23 – 242AR → EG in AAA98977. Ref.1
Sequence conflict271A → S in AAA98977. Ref.1
Sequence conflict321D → A in AAA98977. Ref.1
Sequence conflict1591T → N in AAA98977. Ref.1
Sequence conflict2281I → T in AAA98977. Ref.1
Sequence conflict303 – 3086HKNPAA → QQDPAV in AAA98977. Ref.1
Sequence conflict3241E → D in AAA98977. Ref.1
Sequence conflict3271Missing in AAA98977. Ref.1
Sequence conflict441 – 45414EMKKS…ANDAC → DDEEVVVVWLMMPG in AAA98977. Ref.1
Sequence conflict5571Q → K in AAA98977. Ref.1
Sequence conflict6661N → S in AAA98977. Ref.1
Sequence conflict8611P → T in AAA98977. Ref.1
Sequence conflict8861F → L in AAA98977. Ref.1
Sequence conflict919 – 9213GIS → RIH in AAA98977. Ref.1
Sequence conflict10241A → S in AAA98977. Ref.1
Sequence conflict12331H → Y in AAA98977. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P54099 [UniParc].

Last modified November 2, 2001. Version 2.
Checksum: 77E514FA0FB679FE

FASTA1,239138,899
        10         20         30         40         50         60 
MSRLLWKKVA GAKVASGPVP ATARWVASSV LDPVPSDGRP PSQMPSSENG QLRLNPLLIQ 

        70         80         90        100        110        120 
MLSRGLHEQI FGCGGEMPDE AAVQRSVEHL QKHGLWGQPA TPLPDVELRL PRLFGGNLDQ 

       130        140        150        160        170        180 
HFRLLAQKQS LPYLEAAASL LEAQLPPEPK SWAWAEGWTR YGPEGEAEPV AIPEERALVF 

       190        200        210        220        230        240 
DVEVCLAEGT CPTLAVAISP SAWYSWCSRR LVEERYSWTS QLSPADLIPL GGSTSASSST 

       250        260        270        280        290        300 
KQDGQEQLVV GHNVSFDRAH IREQYLIQDS RMRFLDTMSM HMAISGLSSF QRSLWMGAKQ 

       310        320        330        340        350        360 
GKHKNPAAHK ARAEVPEESQ WSSESSSWDW MDISSANNLA DVHNLYVGGP PLEKEPRELF 

       370        380        390        400        410        420 
VKGSMRDIRE NFQDLMQYCA RDVWATFEVF QQQLPLFLER CPHPVTLAGM LEMGVSYLPV 

       430        440        450        460        470        480 
NQNWERYLTE AQNTYEELQR EMKKSLMDLA NDACQLLSGE RYKEDPWLWD LEWDLQEFKQ 

       490        500        510        520        530        540 
KKAKKVKKPA SASKLPIEGA GPFGDPMDQE DPGPPSEEEE LQRSVTAHNR LQQLRSTTDL 

       550        560        570        580        590        600 
LPKRPQHLPG HPGWYRQLCP RLDDPAWAPG PSLLSLQMRV TPKLMALTWD GFPLHYSDSH 

       610        620        630        640        650        660 
GWGYLVPGRR DNLTEPPVSP TVESAAVTCP YRAIESLYRK HCLEQGKQQL EPQEVDLAEE 

       670        680        690        700        710        720 
FLLTDNSAMW QTVEELGCLD VEAEAKMENS GLSQPLVLPA ACAPKSSQPT YHHGNGPYND 

       730        740        750        760        770        780 
VNIPGCWFFK LPHKDGNNYN VGSPFAKDFL PKMEDGTLQA GPGGASGPRA LEINKMISFW 

       790        800        810        820        830        840 
RNAHKRISSQ MVVWLPRSAL PRVVTRHPAF DEEGHYGAIL PQVVTAGTIT RRAVEPTWLT 

       850        860        870        880        890        900 
ASNARPDRVG SELKAMVQAP PGYVLVGADV DSQELWIAAV LGDAHFAGMH GCTAFGWMTL 

       910        920        930        940        950        960 
QGRKSRGTDL HSKTAATVGI SREHAKIFNY GRIYGAGQSF AERLLMQFNH RLTRQEAAEK 

       970        980        990       1000       1010       1020 
AQQMYAVTKG LRRYRLSADG EWLVKQLNLP VDRTEDGWVS LQDLRMIRRE ASRKSRWKKW 

      1030       1040       1050       1060       1070       1080 
EVAAERAWTG GTESEMFNKL ESIAMSDTPR TPVLGCCISR ALEPSVVQGE FITSRVNWVV 

      1090       1100       1110       1120       1130       1140 
QSSAVDYLHL MLVAMKWLFE EFAIDGRFCI SIHDEVRYLV REEDRYRAAL ALQITNLLTR 

      1150       1160       1170       1180       1190       1200 
CMFAYKLGLN DLPQSVAFFS AVDIDQCLRK EVTMDCKTPS NPTGMERRYG IPQGEALDIY 

      1210       1220       1230 
QIIELTKGSL EKRKPAWTLA LSGGSVFAPV ELHWSGAGS 

« Hide

References

[1]Chang S.W., Colvin S., Sarkos P., Denniger G., Zassenhaus H.P.
Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Muscle.
[2]"Genomic structure of murine mitochondrial DNA polymerase-gamma."
Mott J.L., Denniger G., Zullo S.J., Zassenhaus H.P.
DNA Cell Biol. 19:601-605(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U53584 mRNA. Translation: AAA98977.1.
AF268975 expand/collapse EMBL AC list , AF268970, AF268971, AF268972, AF268973, AF268974 Genomic DNA. Translation: AAF82772.1.
UniGeneMm.3616.

3D structure databases

ProteinModelPortalP54099.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP54099. 2 interactions.

PTM databases

PhosphoSiteP54099.

Proteomic databases

PRIDEP54099.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1196389. Polg.

Phylogenomic databases

eggNOGCOG0749.
HOGENOMHOG000176668.
HOVERGENHBG051400.
InParanoidP54099.
PhylomeDBP54099.

Gene expression databases

CleanExMM_POLG.
GenevestigatorP54099.

Family and domain databases

InterProIPR019760. DNA-dir_DNA_pol_A_CS.
IPR002297. DNA-dir_DNA_pol_A_mt.
IPR016265. DNA-dir_DNA_pol_A_mt_sub.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERPTHR10267. PTHR10267. 1 hit.
PfamPF00476. DNA_pol_A. 1 hit.
[Graphical view]
PIRSFPIRSF000797. DNA_pol_mt. 1 hit.
PRINTSPR00867. DNAPOLG.
SMARTSM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMSSF53098. SSF53098. 2 hits.
PROSITEPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP54099.
SOURCESearch...

Entry information

Entry nameDPOG1_MOUSE
AccessionPrimary (citable) accession number: P54099
Secondary accession number(s): Q9JI28
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 2, 2001
Last modified: April 16, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot