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P54099

- DPOG1_MOUSE

UniProt

P54099 - DPOG1_MOUSE

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Protein
DNA polymerase subunit gamma-1
Gene
Polg, Polg1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA By similarity.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Cofactori

Magnesium By similarity.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. DNA-directed DNA polymerase activity Source: MGI
  3. chromatin binding Source: UniProtKB
  4. exonuclease activity Source: MGI
  5. protein binding Source: IntAct

GO - Biological processi

  1. aging Source: MGI
  2. mitochondrial DNA replication Source: MGI
  3. nucleic acid phosphodiester bond hydrolysis Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding, Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase subunit gamma-1 (EC:2.7.7.7)
Alternative name(s):
Mitochondrial DNA polymerase catalytic subunit
PolG-alpha
Gene namesi
Name:Polg
Synonyms:Polg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1196389. Polg.

Subcellular locationi

GO - Cellular componenti

  1. gamma DNA polymerase complex Source: InterPro
  2. mitochondrial inner membrane Source: MGI
  3. mitochondrial nucleoid Source: UniProtKB
  4. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Mitochondrion nucleoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12391239DNA polymerase subunit gamma-1
PRO_0000101271Add
BLAST

Proteomic databases

PRIDEiP54099.

PTM databases

PhosphoSiteiP54099.

Expressioni

Gene expression databases

CleanExiMM_POLG.
GenevestigatoriP54099.

Interactioni

Subunit structurei

Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.

Binary interactionsi

WithEntry#Exp.IntActNotes
Sod2P096712EBI-863636,EBI-1635071
Tp53P023402EBI-863636,EBI-474016

Protein-protein interaction databases

IntActiP54099. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP54099.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi517 – 5204Poly-Glu

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0749.
HOGENOMiHOG000176668.
HOVERGENiHBG051400.
InParanoidiP54099.
PhylomeDBiP54099.

Family and domain databases

InterProiIPR019760. DNA-dir_DNA_pol_A_CS.
IPR002297. DNA-dir_DNA_pol_A_mt.
IPR016265. DNA-dir_DNA_pol_A_mt_sub.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10267. PTHR10267. 1 hit.
PfamiPF00476. DNA_pol_A. 1 hit.
[Graphical view]
PIRSFiPIRSF000797. DNA_pol_mt. 1 hit.
PRINTSiPR00867. DNAPOLG.
SMARTiSM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 2 hits.
PROSITEiPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54099-1 [UniParc]FASTAAdd to Basket

« Hide

MSRLLWKKVA GAKVASGPVP ATARWVASSV LDPVPSDGRP PSQMPSSENG     50
QLRLNPLLIQ MLSRGLHEQI FGCGGEMPDE AAVQRSVEHL QKHGLWGQPA 100
TPLPDVELRL PRLFGGNLDQ HFRLLAQKQS LPYLEAAASL LEAQLPPEPK 150
SWAWAEGWTR YGPEGEAEPV AIPEERALVF DVEVCLAEGT CPTLAVAISP 200
SAWYSWCSRR LVEERYSWTS QLSPADLIPL GGSTSASSST KQDGQEQLVV 250
GHNVSFDRAH IREQYLIQDS RMRFLDTMSM HMAISGLSSF QRSLWMGAKQ 300
GKHKNPAAHK ARAEVPEESQ WSSESSSWDW MDISSANNLA DVHNLYVGGP 350
PLEKEPRELF VKGSMRDIRE NFQDLMQYCA RDVWATFEVF QQQLPLFLER 400
CPHPVTLAGM LEMGVSYLPV NQNWERYLTE AQNTYEELQR EMKKSLMDLA 450
NDACQLLSGE RYKEDPWLWD LEWDLQEFKQ KKAKKVKKPA SASKLPIEGA 500
GPFGDPMDQE DPGPPSEEEE LQRSVTAHNR LQQLRSTTDL LPKRPQHLPG 550
HPGWYRQLCP RLDDPAWAPG PSLLSLQMRV TPKLMALTWD GFPLHYSDSH 600
GWGYLVPGRR DNLTEPPVSP TVESAAVTCP YRAIESLYRK HCLEQGKQQL 650
EPQEVDLAEE FLLTDNSAMW QTVEELGCLD VEAEAKMENS GLSQPLVLPA 700
ACAPKSSQPT YHHGNGPYND VNIPGCWFFK LPHKDGNNYN VGSPFAKDFL 750
PKMEDGTLQA GPGGASGPRA LEINKMISFW RNAHKRISSQ MVVWLPRSAL 800
PRVVTRHPAF DEEGHYGAIL PQVVTAGTIT RRAVEPTWLT ASNARPDRVG 850
SELKAMVQAP PGYVLVGADV DSQELWIAAV LGDAHFAGMH GCTAFGWMTL 900
QGRKSRGTDL HSKTAATVGI SREHAKIFNY GRIYGAGQSF AERLLMQFNH 950
RLTRQEAAEK AQQMYAVTKG LRRYRLSADG EWLVKQLNLP VDRTEDGWVS 1000
LQDLRMIRRE ASRKSRWKKW EVAAERAWTG GTESEMFNKL ESIAMSDTPR 1050
TPVLGCCISR ALEPSVVQGE FITSRVNWVV QSSAVDYLHL MLVAMKWLFE 1100
EFAIDGRFCI SIHDEVRYLV REEDRYRAAL ALQITNLLTR CMFAYKLGLN 1150
DLPQSVAFFS AVDIDQCLRK EVTMDCKTPS NPTGMERRYG IPQGEALDIY 1200
QIIELTKGSL EKRKPAWTLA LSGGSVFAPV ELHWSGAGS 1239
Length:1,239
Mass (Da):138,899
Last modified:November 2, 2001 - v2
Checksum:i77E514FA0FB679FE
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 242AR → EG in AAA98977. 1 Publication
Sequence conflicti27 – 271A → S in AAA98977. 1 Publication
Sequence conflicti32 – 321D → A in AAA98977. 1 Publication
Sequence conflicti159 – 1591T → N in AAA98977. 1 Publication
Sequence conflicti228 – 2281I → T in AAA98977. 1 Publication
Sequence conflicti303 – 3086HKNPAA → QQDPAV in AAA98977. 1 Publication
Sequence conflicti324 – 3241E → D in AAA98977. 1 Publication
Sequence conflicti327 – 3271Missing in AAA98977. 1 Publication
Sequence conflicti441 – 45414EMKKS…ANDAC → DDEEVVVVWLMMPG in AAA98977. 1 Publication
Add
BLAST
Sequence conflicti557 – 5571Q → K in AAA98977. 1 Publication
Sequence conflicti666 – 6661N → S in AAA98977. 1 Publication
Sequence conflicti861 – 8611P → T in AAA98977. 1 Publication
Sequence conflicti886 – 8861F → L in AAA98977. 1 Publication
Sequence conflicti919 – 9213GIS → RIH in AAA98977. 1 Publication
Sequence conflicti1024 – 10241A → S in AAA98977. 1 Publication
Sequence conflicti1233 – 12331H → Y in AAA98977. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U53584 mRNA. Translation: AAA98977.1.
AF268975
, AF268970, AF268971, AF268972, AF268973, AF268974 Genomic DNA. Translation: AAF82772.1.
UniGeneiMm.3616.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U53584 mRNA. Translation: AAA98977.1 .
AF268975
, AF268970 , AF268971 , AF268972 , AF268973 , AF268974 Genomic DNA. Translation: AAF82772.1 .
UniGenei Mm.3616.

3D structure databases

ProteinModelPortali P54099.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P54099. 2 interactions.

PTM databases

PhosphoSitei P54099.

Proteomic databases

PRIDEi P54099.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1196389. Polg.

Phylogenomic databases

eggNOGi COG0749.
HOGENOMi HOG000176668.
HOVERGENi HBG051400.
InParanoidi P54099.
PhylomeDBi P54099.

Miscellaneous databases

PROi P54099.
SOURCEi Search...

Gene expression databases

CleanExi MM_POLG.
Genevestigatori P54099.

Family and domain databases

InterProi IPR019760. DNA-dir_DNA_pol_A_CS.
IPR002297. DNA-dir_DNA_pol_A_mt.
IPR016265. DNA-dir_DNA_pol_A_mt_sub.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view ]
PANTHERi PTHR10267. PTHR10267. 1 hit.
Pfami PF00476. DNA_pol_A. 1 hit.
[Graphical view ]
PIRSFi PIRSF000797. DNA_pol_mt. 1 hit.
PRINTSi PR00867. DNAPOLG.
SMARTi SM00482. POLAc. 1 hit.
[Graphical view ]
SUPFAMi SSF53098. SSF53098. 2 hits.
PROSITEi PS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Chang S.W., Colvin S., Sarkos P., Denniger G., Zassenhaus H.P.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Muscle.
  2. "Genomic structure of murine mitochondrial DNA polymerase-gamma."
    Mott J.L., Denniger G., Zullo S.J., Zassenhaus H.P.
    DNA Cell Biol. 19:601-605(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.

Entry informationi

Entry nameiDPOG1_MOUSE
AccessioniPrimary (citable) accession number: P54099
Secondary accession number(s): Q9JI28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 2, 2001
Last modified: June 11, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi