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P54099

- DPOG1_MOUSE

UniProt

P54099 - DPOG1_MOUSE

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Protein

DNA polymerase subunit gamma-1

Gene

Polg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Cofactori

Magnesium.By similarity

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. DNA binding Source: UniProtKB-KW
  3. DNA-directed DNA polymerase activity Source: MGI
  4. exonuclease activity Source: MGI

GO - Biological processi

  1. aging Source: MGI
  2. mitochondrial DNA replication Source: MGI
  3. nucleic acid phosphodiester bond hydrolysis Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding, Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase subunit gamma-1 (EC:2.7.7.7)
Alternative name(s):
Mitochondrial DNA polymerase catalytic subunit
PolG-alpha
Gene namesi
Name:Polg
Synonyms:Polg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1196389. Polg.

Subcellular locationi

GO - Cellular componenti

  1. gamma DNA polymerase complex Source: InterPro
  2. mitochondrial inner membrane Source: MGI
  3. mitochondrial nucleoid Source: UniProtKB
  4. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Mitochondrion nucleoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12391239DNA polymerase subunit gamma-1PRO_0000101271Add
BLAST

Proteomic databases

MaxQBiP54099.
PRIDEiP54099.

PTM databases

PhosphoSiteiP54099.

Expressioni

Gene expression databases

CleanExiMM_POLG.
GenevestigatoriP54099.

Interactioni

Subunit structurei

Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.

Binary interactionsi

WithEntry#Exp.IntActNotes
Sod2P096712EBI-863636,EBI-1635071
Tp53P023402EBI-863636,EBI-474016

Protein-protein interaction databases

IntActiP54099. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP54099.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi517 – 5204Poly-Glu

Sequence similaritiesi

Belongs to the DNA polymerase type-A family.Curated

Phylogenomic databases

eggNOGiCOG0749.
HOGENOMiHOG000176668.
HOVERGENiHBG051400.
InParanoidiP54099.
PhylomeDBiP54099.

Family and domain databases

InterProiIPR019760. DNA-dir_DNA_pol_A_CS.
IPR002297. DNA-dir_DNA_pol_A_mt.
IPR016265. DNA-dir_DNA_pol_A_mt_sub.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10267. PTHR10267. 1 hit.
PfamiPF00476. DNA_pol_A. 1 hit.
[Graphical view]
PIRSFiPIRSF000797. DNA_pol_mt. 1 hit.
PRINTSiPR00867. DNAPOLG.
SMARTiSM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 2 hits.
PROSITEiPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54099 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRLLWKKVA GAKVASGPVP ATARWVASSV LDPVPSDGRP PSQMPSSENG
60 70 80 90 100
QLRLNPLLIQ MLSRGLHEQI FGCGGEMPDE AAVQRSVEHL QKHGLWGQPA
110 120 130 140 150
TPLPDVELRL PRLFGGNLDQ HFRLLAQKQS LPYLEAAASL LEAQLPPEPK
160 170 180 190 200
SWAWAEGWTR YGPEGEAEPV AIPEERALVF DVEVCLAEGT CPTLAVAISP
210 220 230 240 250
SAWYSWCSRR LVEERYSWTS QLSPADLIPL GGSTSASSST KQDGQEQLVV
260 270 280 290 300
GHNVSFDRAH IREQYLIQDS RMRFLDTMSM HMAISGLSSF QRSLWMGAKQ
310 320 330 340 350
GKHKNPAAHK ARAEVPEESQ WSSESSSWDW MDISSANNLA DVHNLYVGGP
360 370 380 390 400
PLEKEPRELF VKGSMRDIRE NFQDLMQYCA RDVWATFEVF QQQLPLFLER
410 420 430 440 450
CPHPVTLAGM LEMGVSYLPV NQNWERYLTE AQNTYEELQR EMKKSLMDLA
460 470 480 490 500
NDACQLLSGE RYKEDPWLWD LEWDLQEFKQ KKAKKVKKPA SASKLPIEGA
510 520 530 540 550
GPFGDPMDQE DPGPPSEEEE LQRSVTAHNR LQQLRSTTDL LPKRPQHLPG
560 570 580 590 600
HPGWYRQLCP RLDDPAWAPG PSLLSLQMRV TPKLMALTWD GFPLHYSDSH
610 620 630 640 650
GWGYLVPGRR DNLTEPPVSP TVESAAVTCP YRAIESLYRK HCLEQGKQQL
660 670 680 690 700
EPQEVDLAEE FLLTDNSAMW QTVEELGCLD VEAEAKMENS GLSQPLVLPA
710 720 730 740 750
ACAPKSSQPT YHHGNGPYND VNIPGCWFFK LPHKDGNNYN VGSPFAKDFL
760 770 780 790 800
PKMEDGTLQA GPGGASGPRA LEINKMISFW RNAHKRISSQ MVVWLPRSAL
810 820 830 840 850
PRVVTRHPAF DEEGHYGAIL PQVVTAGTIT RRAVEPTWLT ASNARPDRVG
860 870 880 890 900
SELKAMVQAP PGYVLVGADV DSQELWIAAV LGDAHFAGMH GCTAFGWMTL
910 920 930 940 950
QGRKSRGTDL HSKTAATVGI SREHAKIFNY GRIYGAGQSF AERLLMQFNH
960 970 980 990 1000
RLTRQEAAEK AQQMYAVTKG LRRYRLSADG EWLVKQLNLP VDRTEDGWVS
1010 1020 1030 1040 1050
LQDLRMIRRE ASRKSRWKKW EVAAERAWTG GTESEMFNKL ESIAMSDTPR
1060 1070 1080 1090 1100
TPVLGCCISR ALEPSVVQGE FITSRVNWVV QSSAVDYLHL MLVAMKWLFE
1110 1120 1130 1140 1150
EFAIDGRFCI SIHDEVRYLV REEDRYRAAL ALQITNLLTR CMFAYKLGLN
1160 1170 1180 1190 1200
DLPQSVAFFS AVDIDQCLRK EVTMDCKTPS NPTGMERRYG IPQGEALDIY
1210 1220 1230
QIIELTKGSL EKRKPAWTLA LSGGSVFAPV ELHWSGAGS
Length:1,239
Mass (Da):138,899
Last modified:November 2, 2001 - v2
Checksum:i77E514FA0FB679FE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 242AR → EG in AAA98977. 1 PublicationCurated
Sequence conflicti27 – 271A → S in AAA98977. 1 PublicationCurated
Sequence conflicti32 – 321D → A in AAA98977. 1 PublicationCurated
Sequence conflicti159 – 1591T → N in AAA98977. 1 PublicationCurated
Sequence conflicti228 – 2281I → T in AAA98977. 1 PublicationCurated
Sequence conflicti303 – 3086HKNPAA → QQDPAV in AAA98977. 1 PublicationCurated
Sequence conflicti324 – 3241E → D in AAA98977. 1 PublicationCurated
Sequence conflicti327 – 3271Missing in AAA98977. 1 PublicationCurated
Sequence conflicti441 – 45414EMKKS…ANDAC → DDEEVVVVWLMMPG in AAA98977. 1 PublicationCuratedAdd
BLAST
Sequence conflicti557 – 5571Q → K in AAA98977. 1 PublicationCurated
Sequence conflicti666 – 6661N → S in AAA98977. 1 PublicationCurated
Sequence conflicti861 – 8611P → T in AAA98977. 1 PublicationCurated
Sequence conflicti886 – 8861F → L in AAA98977. 1 PublicationCurated
Sequence conflicti919 – 9213GIS → RIH in AAA98977. 1 PublicationCurated
Sequence conflicti1024 – 10241A → S in AAA98977. 1 PublicationCurated
Sequence conflicti1233 – 12331H → Y in AAA98977. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U53584 mRNA. Translation: AAA98977.1.
AF268975
, AF268970, AF268971, AF268972, AF268973, AF268974 Genomic DNA. Translation: AAF82772.1.
UniGeneiMm.3616.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U53584 mRNA. Translation: AAA98977.1 .
AF268975
, AF268970 , AF268971 , AF268972 , AF268973 , AF268974 Genomic DNA. Translation: AAF82772.1 .
UniGenei Mm.3616.

3D structure databases

ProteinModelPortali P54099.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P54099. 2 interactions.

PTM databases

PhosphoSitei P54099.

Proteomic databases

MaxQBi P54099.
PRIDEi P54099.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1196389. Polg.

Phylogenomic databases

eggNOGi COG0749.
HOGENOMi HOG000176668.
HOVERGENi HBG051400.
InParanoidi P54099.
PhylomeDBi P54099.

Miscellaneous databases

PROi P54099.
SOURCEi Search...

Gene expression databases

CleanExi MM_POLG.
Genevestigatori P54099.

Family and domain databases

InterProi IPR019760. DNA-dir_DNA_pol_A_CS.
IPR002297. DNA-dir_DNA_pol_A_mt.
IPR016265. DNA-dir_DNA_pol_A_mt_sub.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view ]
PANTHERi PTHR10267. PTHR10267. 1 hit.
Pfami PF00476. DNA_pol_A. 1 hit.
[Graphical view ]
PIRSFi PIRSF000797. DNA_pol_mt. 1 hit.
PRINTSi PR00867. DNAPOLG.
SMARTi SM00482. POLAc. 1 hit.
[Graphical view ]
SUPFAMi SSF53098. SSF53098. 2 hits.
PROSITEi PS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Chang S.W., Colvin S., Sarkos P., Denniger G., Zassenhaus H.P.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Muscle.
  2. "Genomic structure of murine mitochondrial DNA polymerase-gamma."
    Mott J.L., Denniger G., Zullo S.J., Zassenhaus H.P.
    DNA Cell Biol. 19:601-605(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.

Entry informationi

Entry nameiDPOG1_MOUSE
AccessioniPrimary (citable) accession number: P54099
Secondary accession number(s): Q9JI28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 2, 2001
Last modified: October 29, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3