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Protein

Dual specificity protein phosphatase VP2

Gene

VP2

Organism
Chicken anemia virus (isolate Japan 82-2) (CAV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a scaffold protein in virion assembly. May also play a role in intracellular signaling during viral replication (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase VP2 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:VP2
OrganismiChicken anemia virus (isolate Japan 82-2) (CAV)
Taxonomic identifieri73476 [NCBI]
Taxonomic lineageiVirusesssDNA virusesCircoviridaeGyrovirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]
ProteomesiUP000008443: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Dual specificity protein phosphatase VP2PRO_0000223003Add
BLAST

Expressioni

Inductioni

VP1 and VP2 are detected 12 hours post infection, while VP3 only after 24 hours.

Keywords - Developmental stagei

Early protein

Family & Domainsi

Sequence similaritiesi

Belongs to the gyrovirus protein VP2 family.Curated

Family and domain databases

InterProiIPR004118. HEV_TT_virus_Orf2/Gyrovir_Vp2.
[Graphical view]
PfamiPF02957. TT_ORF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54093-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHGNGGQPAA GGSESALSRE GQPGPSGAAQ GQVISNERSP RRYSTRTING
60 70 80 90 100
VQATNKFTAV GNPSLQRDPD WYRWNYNHSI AVWLRECSRS HAKICNCGQF
110 120 130 140 150
RKHWFQECAG LEDRSTQASL EEAILRPLRV QGKRAKRKLD YHYSQPTPNR
160 170 180 190 200
KKVYKTVRWK DELADREADF TPSEEDGGTT SSDFDEDINF DIGGDSGIVD
210
ELLGRPFTTP APVRIV
Length:216
Mass (Da):24,139
Last modified:October 1, 1996 - v1
Checksum:iE23169F592BDDE52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31965 Genomic DNA. Translation: BAA06732.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31965 Genomic DNA. Translation: BAA06732.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR004118. HEV_TT_virus_Orf2/Gyrovir_Vp2.
[Graphical view]
PfamiPF02957. TT_ORF2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiVP2_CAV82
AccessioniPrimary (citable) accession number: P54093
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.