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P54092 (VP2_CAV26) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity protein phosphatase VP2

EC=3.1.3.16
EC=3.1.3.48
Gene names
Name:VP2
OrganismChicken anemia virus (isolate USA 26p4) (CAV) [Complete proteome]
Taxonomic identifier73477 [NCBI]
Taxonomic lineageVirusesssDNA virusesCircoviridaeGyrovirus
Virus hostGallus gallus (Chicken) [TaxID: 9031]

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May act as a scaffold protein in virion assembly. May also play a role in intracellular signaling during viral replication By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Induction

VP1 and VP2 are detected 12 hours post infection, while VP3 only after 24 hours.

Sequence similarities

Belongs to the gyrovirus protein VP2 family.

Ontologies

Keywords
   Developmental stageEarly protein
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 216216Dual specificity protein phosphatase VP2
PRO_0000223002

Sites

Active site951Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P54092 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: CD4B69EF88BDDC72

FASTA21624,067
        10         20         30         40         50         60 
MHGNGGQPAA GGSESALSRE GQPGPSGAAQ GQVISNERSP RRYSTRTING VQATNKFTAV 

        70         80         90        100        110        120 
GNPSLQRDPD WYRWNYNHSI AVWLRECSRS HAKICNCGQF RKHWFQECAG LEDRSTQASL 

       130        140        150        160        170        180 
EEAILRPLRV QGKRAKRKLD YHYSQPTPNR KKVYKTVRWQ DELADREADF TPSEEDGGTT 

       190        200        210 
SSDFDGDINF DIGGDSGIVD ELLGRPFTTP APVRIV 

« Hide

References

[1]"Molecular cloning and sequence analysis of the genome of chicken anaemia agent."
Claessens J.A.J., Schrier C.C., Mockett A.P.A., Jagt E.H.J.M., Sondermeijer P.J.A.
J. Gen. Virol. 72:2003-2006(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D10068 Genomic DNA. Translation: BAA00959.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR004118. HEV_TT_virus_Orf2/Gyrovir_Vp2.
[Graphical view]
PfamPF02957. TT_ORF2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVP2_CAV26
AccessionPrimary (citable) accession number: P54092
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families