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Protein

Sec-independent protein translocase protein TatC

Gene

tatC

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sec-independent protein translocase protein TatCUniRule annotation
Gene namesi
Name:tatCUniRule annotation
Synonyms:mttB
Ordered Locus Names:ML1332
ORF Names:B2126_C1_183, MLCB2533.28, u2126a
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1332.

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei38 – 5821HelicalUniRule annotationAdd
BLAST
Transmembranei109 – 12921HelicalUniRule annotationAdd
BLAST
Transmembranei142 – 16221HelicalUniRule annotationAdd
BLAST
Transmembranei190 – 21021HelicalUniRule annotationAdd
BLAST
Transmembranei229 – 24921HelicalUniRule annotationAdd
BLAST
Transmembranei250 – 27021HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Sec-independent protein translocase protein TatCPRO_0000098089Add
BLAST

Interactioni

Subunit structurei

The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML1332.

Family & Domainsi

Sequence similaritiesi

Belongs to the TatC family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DCX. Bacteria.
COG0805. LUCA.
HOGENOMiHOG000245380.
OrthoDBiPOG091H02DA.

Family and domain databases

HAMAPiMF_00902. TatC. 1 hit.
InterProiIPR019820. Sec-indep_translocase_CS.
IPR002033. TatC.
[Graphical view]
PANTHERiPTHR30371:SF0. PTHR30371:SF0. 1 hit.
PfamiPF00902. TatC. 1 hit.
[Graphical view]
PRINTSiPR01840. TATCFAMILY.
TIGRFAMsiTIGR00945. tatC. 1 hit.
PROSITEiPS01218. TATC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54078-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRACDLLKRI KQHYRRSRTN PDATMSLIDH LTELRTRLLI SLAAIVVTTI
60 70 80 90 100
FGFIWYSHSI FGLESLGEWL RRPYCSLPQS ARADISPDGQ CRLLATAPFD
110 120 130 140 150
QFMLRIKVGM AAGIVLASPV WFYQLWAFIT PGLYTKERRF TVAFVVPAAV
160 170 180 190 200
LFAGGTVLAY LVLSKALGFL LIVGSGVQVT ALSGDRYFGF LLNLLVVFGV
210 220 230 240 250
SFEFPLLIVM LNIAGLLTYQ RLKSWRRGLI FAMFVFAAVF TPGSDPFSMT
260 270 280 290 300
ALGAALTVLL ELAIQLVRLH DKRRVKHEAL IADDEASVIE PPSSIPERSY
310
TATRSHDDVT
Length:310
Mass (Da):34,536
Last modified:December 1, 2000 - v2
Checksum:i74362D5AD9C3E96F
GO

Sequence cautioni

The sequence AAA17191 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAC31713 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00017 Genomic DNA. Translation: AAA17191.1. Different initiation.
AL035310 Genomic DNA. Translation: CAA22942.1.
AL583921 Genomic DNA. Translation: CAC31713.1. Different initiation.
PIRiF87075.
S72851.
RefSeqiWP_010908277.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31713; CAC31713; CAC31713.
PATRICi18055028. VBIMycLep78757_2452.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00017 Genomic DNA. Translation: AAA17191.1. Different initiation.
AL035310 Genomic DNA. Translation: CAA22942.1.
AL583921 Genomic DNA. Translation: CAC31713.1. Different initiation.
PIRiF87075.
S72851.
RefSeqiWP_010908277.1. NC_002677.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1332.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31713; CAC31713; CAC31713.
PATRICi18055028. VBIMycLep78757_2452.

Organism-specific databases

LepromaiML1332.

Phylogenomic databases

eggNOGiENOG4105DCX. Bacteria.
COG0805. LUCA.
HOGENOMiHOG000245380.
OrthoDBiPOG091H02DA.

Family and domain databases

HAMAPiMF_00902. TatC. 1 hit.
InterProiIPR019820. Sec-indep_translocase_CS.
IPR002033. TatC.
[Graphical view]
PANTHERiPTHR30371:SF0. PTHR30371:SF0. 1 hit.
PfamiPF00902. TatC. 1 hit.
[Graphical view]
PRINTSiPR01840. TATCFAMILY.
TIGRFAMsiTIGR00945. tatC. 1 hit.
PROSITEiPS01218. TATC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTATC_MYCLE
AccessioniPrimary (citable) accession number: P54078
Secondary accession number(s): Q9CC36, Q9S373
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 1, 2000
Last modified: September 7, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.