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P54072 (YL152_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uncharacterized transporter YLR152C
Gene names
Ordered Locus Names:YLR152C
ORF Names:L9634.9
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length576 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the auxin efflux carrier (TC 2.A.69) family. [View classification]

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processtransmembrane transport

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 576576Uncharacterized transporter YLR152C
PRO_0000123806

Regions

Topological domain1 – 88Cytoplasmic Potential
Transmembrane9 – 2921Helical; Potential
Topological domain30 – 4516Extracellular Potential
Transmembrane46 – 6621Helical; Potential
Topological domain67 – 715Cytoplasmic Potential
Transmembrane72 – 9221Helical; Potential
Topological domain93 – 10311Extracellular Potential
Transmembrane104 – 12421Helical; Potential
Topological domain125 – 14117Cytoplasmic Potential
Transmembrane142 – 16221Helical; Potential
Topological domain163 – 400238Extracellular Potential
Transmembrane401 – 42121Helical; Potential
Topological domain422 – 43716Cytoplasmic Potential
Transmembrane438 – 45821Helical; Potential
Topological domain459 – 47618Extracellular Potential
Transmembrane477 – 49721Helical; Potential
Topological domain498 – 51215Cytoplasmic Potential
Transmembrane513 – 53321Helical; Potential
Topological domain534 – 54512Extracellular Potential
Transmembrane546 – 56621Helical; Potential
Topological domain567 – 57610Cytoplasmic Potential

Amino acid modifications

Modified residue1811Phosphothreonine Ref.4
Modified residue2731Phosphoserine Ref.4

Sequences

Sequence LengthMass (Da)Tools
P54072 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 12319CA4985EC784

FASTA57664,032
        10         20         30         40         50         60 
MSLSLGAAIY IALKPIFKIY TIMLVGYLVA KFDIVSMENA KGISNMVVNA ILPCLTFNKI 

        70         80         90        100        110        120 
VSNISWRDIK EIGVIILSAF ILFVLGATGA LFTTFATTVP KKFFWGLIFA GFFPNISDLP 

       130        140        150        160        170        180 
IAYIQSMGNG SIFTAEEADK GVAYSCIFLF IQSFLMMNFG MWRVVGLDFR DTKEPDSENI 

       190        200        210        220        230        240 
TPSVSPAIDD RKLTEITKLP NITRPTNAYQ SEDARSNSDL SCNSITTNEM TPQAFYEGFT 

       250        260        270        280        290        300 
GYIKPYKESN GASHKFESDL PHAEIYRVSS TYSSPGALEF SRIDGSSLSY SRISKNSDGR 

       310        320        330        340        350        360 
SYRRKRKADM NELISKYSAA EKIRQGELDL SRPLSLTEEV GSRNASIGNV HTGYTDESSI 

       370        380        390        400        410        420 
EEENCTNMAT DGRGSLSFFI ERHNLKWLQY FIINCLRPAS LGAILGIICA LIPWVKACFV 

       430        440        450        460        470        480 
TTYVHVHKAP DGEPVLNFLM DFTEYIGNAC VPLGLLLLGG TLARLEIKSL PPGFIKSALL 

       490        500        510        520        530        540 
MTCFRLIVIP IIGVLWVNKL YSIDWLDTGI GKFDMILTWS MPSATAQVYF TAFYTPACGD 

       550        560        570 
HIQMNCLSVL FVMQYAILFI TVAFVVTYTL KVDLKV

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. expand/collapse author list , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
Nature 387:87-90(1997) [PubMed: 9169871] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[4]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-181 AND SER-273, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z73324 Genomic DNA. Translation: CAA97724.1.
U53879 Genomic DNA. Translation: AAB82386.1.
BK006945 Genomic DNA. Translation: DAA09463.1.
PIRS65001.
RefSeqNP_013253.1. NM_001182039.1.

3D structure databases

ProteinModelPortalP54072.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-6543N.
IntActP54072. 1 interaction.
MINTMINT-700506.
STRINGP54072.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYLR152C; YLR152C; YLR152C.
GeneID850845.
KEGGsce:YLR152C.
NMPDRfig|4932.3.peg.4247.

Organism-specific databases

CYGDYLR152c.
SGDS000004142. YLR152C.

Phylogenomic databases

eggNOGfuNOG04129.
GeneTreeEFGT00050000008593.
HOGENOMHBG396136.
OMATEYIGNA.
OrthoDBEOG4PK5HM.

Gene expression databases

ArrayExpressP54072.
GenevestigatorP54072.
GermOnlineYLR152C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR004776. Auxin_eff.
[Graphical view]
KOK07088.
PfamPF03547. Mem_trans. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio967135.

Entry information

Entry nameYL152_YEAST
AccessionPrimary (citable) accession number: P54072
Secondary accession number(s): D6VYE7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 14, 2011
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

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