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P54066

- RL7A_METJA

UniProt

P54066 - RL7A_METJA

Protein

50S ribosomal protein L7Ae

Gene

rpl7ae

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. ribonuclease P activity Source: UniProtKB-HAMAP
    3. rRNA binding Source: UniProtKB-KW
    4. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. ribosome biogenesis Source: InterPro
    2. translation Source: UniProtKB-HAMAP
    3. tRNA 5'-leader removal Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    50S ribosomal protein L7AeUniRule annotation
    Alternative name(s):
    Ribosomal protein L8eUniRule annotation
    Gene namesi
    Name:rpl7aeUniRule annotation
    Ordered Locus Names:MJ1203
    OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
    Taxonomic identifieri243232 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
    ProteomesiUP000000805: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. ribosome Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11711750S ribosomal protein L7AePRO_0000136793Add
    BLAST

    Interactioni

    Subunit structurei

    Part of the 50S ribosomal subunit. Probably part of the RNase P complex.UniRule annotation

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MJ0694Q581054EBI-2944269,EBI-2944259

    Protein-protein interaction databases

    IntActiP54066. 2 interactions.
    STRINGi243232.MJ1203.

    Structurei

    Secondary structure

    1
    117
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi11 – 2212
    Beta strandi25 – 306
    Helixi31 – 399
    Beta strandi44 – 507
    Helixi55 – 573
    Turni58 – 603
    Helixi61 – 677
    Beta strandi72 – 765
    Helixi78 – 847
    Beta strandi92 – 987
    Helixi102 – 11514

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1RA4X-ray1.86A1-117[»]
    1SDSX-ray1.80A/B/C1-117[»]
    1XBIX-ray1.45A1-117[»]
    3PAFX-ray1.70A/B1-117[»]
    ProteinModelPortaliP54066.
    SMRiP54066. Positions 1-117.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP54066.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L7Ae family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1358.
    KOiK02936.
    OMAiWIQASQP.
    PhylomeDBiP54066.

    Family and domain databases

    Gene3Di3.30.1330.30. 1 hit.
    HAMAPiMF_00326. Ribosomal_L7Ae_Arch.
    InterProiIPR029064. L30e-like.
    IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
    IPR018492. Ribosomal_L7Ae/L8/Nhp2.
    IPR022481. Ribosomal_L7Ae_arc.
    IPR004037. Ribosomal_L7Ae_CS.
    IPR000948. Ribosomal_L7Ae_prok.
    [Graphical view]
    PfamiPF01248. Ribosomal_L7Ae. 1 hit.
    [Graphical view]
    PRINTSiPR00881. L7ARS6FAMILY.
    PR00884. RIBOSOMALHS6.
    SUPFAMiSSF55315. SSF55315. 1 hit.
    TIGRFAMsiTIGR03677. rpl7ae. 1 hit.
    PROSITEiPS01082. RIBOSOMAL_L7AE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P54066-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVYVKFKVP EEIQKELLDA VAKAQKIKKG ANEVTKAVER GIAKLVIIAE    50
    DVKPEEVVAH LPYLCEEKGI PYAYVASKQD LGKAAGLEVA ASSVAIINEG 100
    DAEELKVLIE KVNVLKQ 117
    Length:117
    Mass (Da):12,686
    Last modified:July 15, 1998 - v2
    Checksum:i7CAB706F09371BA6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB99207.1.
    RefSeqiNP_248198.1. NC_000909.1.

    Genome annotation databases

    EnsemblBacteriaiAAB99207; AAB99207; MJ_1203.
    GeneIDi1452098.
    KEGGimja:MJ_1203.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB99207.1 .
    RefSeqi NP_248198.1. NC_000909.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1RA4 X-ray 1.86 A 1-117 [» ]
    1SDS X-ray 1.80 A/B/C 1-117 [» ]
    1XBI X-ray 1.45 A 1-117 [» ]
    3PAF X-ray 1.70 A/B 1-117 [» ]
    ProteinModelPortali P54066.
    SMRi P54066. Positions 1-117.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P54066. 2 interactions.
    STRINGi 243232.MJ1203.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB99207 ; AAB99207 ; MJ_1203 .
    GeneIDi 1452098.
    KEGGi mja:MJ_1203.

    Phylogenomic databases

    eggNOGi COG1358.
    KOi K02936.
    OMAi WIQASQP.
    PhylomeDBi P54066.

    Miscellaneous databases

    EvolutionaryTracei P54066.

    Family and domain databases

    Gene3Di 3.30.1330.30. 1 hit.
    HAMAPi MF_00326. Ribosomal_L7Ae_Arch.
    InterProi IPR029064. L30e-like.
    IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
    IPR018492. Ribosomal_L7Ae/L8/Nhp2.
    IPR022481. Ribosomal_L7Ae_arc.
    IPR004037. Ribosomal_L7Ae_CS.
    IPR000948. Ribosomal_L7Ae_prok.
    [Graphical view ]
    Pfami PF01248. Ribosomal_L7Ae. 1 hit.
    [Graphical view ]
    PRINTSi PR00881. L7ARS6FAMILY.
    PR00884. RIBOSOMALHS6.
    SUPFAMi SSF55315. SSF55315. 1 hit.
    TIGRFAMsi TIGR03677. rpl7ae. 1 hit.
    PROSITEi PS01082. RIBOSOMAL_L7AE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
    2. "Structure of protein L7Ae bound to a K-turn derived from an archaeal box H/ACA sRNA at 1.8 A resolution."
      Hamma T., Ferre-D'Amare A.R.
      Structure 12:893-903(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS), RNA-BINDING.
    3. "The crystal structure of the Methanocaldococcus jannaschii multifunctional L7Ae RNA-binding protein reveals an induced-fit interaction with the box C/D RNAs."
      Suryadi J., Tran E.J., Maxwell E.S., Brown B.A. II
      Biochemistry 44:9657-9672(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS).

    Entry informationi

    Entry nameiRL7A_METJA
    AccessioniPrimary (citable) accession number: P54066
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Methanococcus jannaschii
      Methanococcus jannaschii: entries and gene names
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. Ribosomal proteins
      Ribosomal proteins families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3