50S ribosomal protein L1P - Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

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P54050 (RL1_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 78. History...

Clusters with 100%, 90%, 50% identity |

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
50S ribosomal protein L1P

Gene names

Name:	rpl1p
Ordered Locus Names:	MJ0510

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probably involved in E site tRNA release By similarity. Binds directly to 23S rRNA. HAMAP MF_01318_A Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA By similarity. HAMAP MF_01318_A
Subunit structure	Part of the 50S ribosomal subunit.
Sequence similarities	Belongs to the ribosomal protein L1P family.
Sequence caution	The sequence AAB98500.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Translation regulation
Ligand	RNA-binding rRNA-binding tRNA-binding
Molecular function	Repressor Ribonucleoprotein Ribosomal protein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of translation Inferred from electronic annotation. Source: UniProtKB-KW translation Inferred from electronic annotation. Source: InterPro
Cellular component	large ribosomal subunit Inferred from electronic annotation. Source: InterPro
Molecular function	rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Inferred from electronic annotation. Source: InterPro tRNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 219

219

50S ribosomal protein L1P HAMAP MF_01318_A

PRO_0000125798

Secondary structure

219

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P54050 [UniParc].

Last modified June 1, 2001. Version 2.
Checksum: BEFF3E31B693F9EA
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FASTA

219

24,793

        10         20         30         40         50         60 
MDREALLQAV KEARELAKPR NFTQSFEFIA TLKEIDMRKP ENRIKTEVVL PHGRGKEAKI 

        70         80         90        100        110        120 
AVIGTGDLAK QAEELGLTVI RKEEIEELGK NKRKLRKIAK AHDFFIAQAD LMPLIGRYMG 

       130        140        150        160        170        180 
VILGPRGKMP KPVPANANIK PLVERLKKTV VINTRDKPYF QVLVGNEKMT DEQIVDNIEA 

       190        200        210 
VLNVVAKKYE KGLYHIKDAY VKLTMGPAVK VKKEKAKKK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
[2]	"Interaction of ribosomal L1 proteins from mesophilic and thermophilic Archaea and Bacteria with specific L1-binding sites on 23S rRNA and mRNA." Koehrer C., Mayer C., Neumair O., Groebner P., Piendl W. Eur. J. Biochem. 256:97-105(1998) [PubMed: 9746351] [Abstract] Cited for: BINDING TO ENDOGENOUS 23S RRNA, BINDING TO METHANOCOCCUS VANNIELII L1 MRNA.
[3]	"Archaeal ribosomal protein L1: the structure provides new insights into RNA binding of the L1 protein family." Nevskaya N., Tischenko S., Fedorov R., Al-Karadaghi S., Liljas A., Kraft A., Piendl W., Garber M.B., Nikonov S. Structure 8:363-371(2000) [PubMed: 10801481] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
[4]	"Structure of ribosomal protein L1 from Methanococcus thermolithotrophicus. Functionally important structural invariants on the L1 surface." Nevskaya N., Tishchenko S., Paveliev M., Smolinskaya Y., Fedorov R., Piendl W., Nakamura Y., Toyoda T., Garber M.B., Nikonov S. Acta Crystallogr. D 58:1023-1029(2002) [PubMed: 12037305] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
[5]	"Ribosomal protein L1 recognizes the same specific structural motif in its target sites on the autoregulatory mRNA and 23S rRNA." Nevskaya N., Tishchenko S., Gabdoulkhakov A., Nikonova E., Nikonov O., Nikulin A., Platonova O., Garber M.B., Nikonov S., Piendl W. Nucleic Acids Res. 33:478-485(2005) [PubMed: 15659579] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) IN COMPLEX WITH AN ENDOGENOUS L1 MRNA FRAGMENT.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L77117 Genomic DNA. Translation: AAB98500.1. Different initiation.

PIR

F64363.

RefSeq

NP_247486.1. NC_000909.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1CJS	X-ray	2.30	A	1-219	[»]
1I2A	X-ray	1.85	A	1-219	[»]
1U63	X-ray	3.40	A/C	1-219	[»]

ProteinModelPortal

P54050.

SMR

P54050. Positions 1-214.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

1451372.

GenomeReviews

Gene locus MJ0510 in contig L77117_GR.

KEGG

mja:MJ_0510.

NMPDR

fig|243232.1.peg.523.

TIGR

MJ0510.

Phylogenomic databases

HOGENOM

HBG297400.

OMA

LPHGRGK.

ProtClustDB

PRK04203.

Enzyme and pathway databases

BioCyc

MJAN243232:MJ_0510-MONOMER.

Family and domain databases

HAMAP

MF_01318_A. Ribosomal_L1_A.
[Tree]

InterPro

IPR002143. Ribosomal_L1.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR023669. Ribosomal_L1_arc.
IPR023673. Ribosomal_L1_CS.
IPR023674. Ribosomal_L1_SF.
[Graphical view]

Gene3D

G3DSA:3.30.190.20. Ribosomal_L1_2-a/b-sand. 2 hits.
G3DSA:3.40.50.790. Ribosomal_L1_3-a/b-sand. 1 hit.

K02863.

Pfam

PF00687. Ribosomal_L1. 1 hit.
[Graphical view]

PIRSF

PIRSF002155. Ribosomal_L1. 1 hit.

SUPFAM

SSF56808. Ribosomal_L1. 1 hit.

PROSITE

PS01199. RIBOSOMAL_L1. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

RL1_METJA

Accession

Primary (citable) accession number: P54050

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	June 1, 2001
Last modified:	November 16, 2011
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program