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P54003

- SUR7_YEAST

UniProt

P54003 - SUR7_YEAST

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Protein

Protein SUR7

Gene

SUR7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in sporulation and affects the sphingolipid composition of the plasma membrane. Probably involved in endocytosis.1 Publication

GO - Biological processi

  1. ascospore formation Source: SGD
  2. endocytosis Source: SGD
Complete GO annotation...

Keywords - Biological processi

Endocytosis, Sporulation

Enzyme and pathway databases

BioCyciYEAST:G3O-32649-MONOMER.

Protein family/group databases

TCDBi1.H.1.7.1. the claudin tight junction (claudin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SUR7
Gene namesi
Name:SUR7
Ordered Locus Names:YML052W
ORF Names:YM9958.11
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYML052w.
SGDiS000004516. SUR7.

Subcellular locationi

Cell membrane 5 Publications; Multi-pass membrane protein 5 Publications
Note: Localizes at eisosomes, structures which colocalize with sites of protein and lipid endocytosis.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence Analysis
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Topological domaini32 – 11483ExtracellularSequence AnalysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence AnalysisAdd
BLAST
Topological domaini136 – 14510CytoplasmicSequence Analysis
Transmembranei146 – 16621HelicalSequence AnalysisAdd
BLAST
Topological domaini167 – 18923ExtracellularSequence AnalysisAdd
BLAST
Transmembranei190 – 21021HelicalSequence AnalysisAdd
BLAST
Topological domaini211 – 30292CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell cortex Source: SGD
  2. integral component of membrane Source: SGD
  3. membrane raft Source: SGD
  4. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Protein SUR7PRO_0000072317Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
Modified residuei293 – 2931Phosphoserine1 Publication
Modified residuei301 – 3011Phosphoserine3 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP54003.
PaxDbiP54003.
PeptideAtlasiP54003.

Expressioni

Gene expression databases

GenevestigatoriP54003.

Interactioni

Protein-protein interaction databases

BioGridi35116. 59 interactions.
IntActiP54003. 3 interactions.
MINTiMINT-2779769.
STRINGi4932.YML052W.

Structurei

3D structure databases

ProteinModelPortaliP54003.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SUR7 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46868.
GeneTreeiENSGT00390000000875.
HOGENOMiHOG000248312.
InParanoidiP54003.
OMAiCIVEFIL.
OrthoDBiEOG7GN30D.

Family and domain databases

InterProiIPR009571. SUR7/PalI.
[Graphical view]
PfamiPF06687. SUR7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54003-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKVWNIVLR LVVLLFLAGN TLLLILMIIS GATDHYPVNR FYWVQGNTTG
60 70 80 90 100
IPNAGDETRW TFWGACLQDK DGSDTCTSNL APAYPISPVD NFNTHINVPH
110 120 130 140 150
QFISKRDAFY YLTRFSFCFF WIALAFVGVS FILYVLTWCS KMLSEMVLIL
160 170 180 190 200
MSFGFVFNTA AVVLQTAASA MAKNAFHDDH RSAQLGASMM GMAWASVFLC
210 220 230 240 250
IVEFILLVFW SVRARLASTY SIDNSRYRTS SRWNPFHREK EQATDPILTA
260 270 280 290 300
TGPEDMQQSA SIVGPSSNAN PVTATAATEN QPKGINFFTI RKSHERPDDV

SV
Length:302
Mass (Da):33,830
Last modified:October 1, 1996 - v1
Checksum:i14625FD6A48F515A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46729 Genomic DNA. Translation: CAA86724.1.
AY557986 Genomic DNA. Translation: AAS56312.1.
BK006946 Genomic DNA. Translation: DAA09847.1.
PIRiS49809.
RefSeqiNP_013660.1. NM_001182410.1.

Genome annotation databases

EnsemblFungiiYML052W; YML052W; YML052W.
GeneIDi854953.
KEGGisce:YML052W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46729 Genomic DNA. Translation: CAA86724.1 .
AY557986 Genomic DNA. Translation: AAS56312.1 .
BK006946 Genomic DNA. Translation: DAA09847.1 .
PIRi S49809.
RefSeqi NP_013660.1. NM_001182410.1.

3D structure databases

ProteinModelPortali P54003.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35116. 59 interactions.
IntActi P54003. 3 interactions.
MINTi MINT-2779769.
STRINGi 4932.YML052W.

Protein family/group databases

TCDBi 1.H.1.7.1. the claudin tight junction (claudin) family.

Proteomic databases

MaxQBi P54003.
PaxDbi P54003.
PeptideAtlasi P54003.

Protocols and materials databases

DNASUi 854953.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YML052W ; YML052W ; YML052W .
GeneIDi 854953.
KEGGi sce:YML052W.

Organism-specific databases

CYGDi YML052w.
SGDi S000004516. SUR7.

Phylogenomic databases

eggNOGi NOG46868.
GeneTreei ENSGT00390000000875.
HOGENOMi HOG000248312.
InParanoidi P54003.
OMAi CIVEFIL.
OrthoDBi EOG7GN30D.

Enzyme and pathway databases

BioCyci YEAST:G3O-32649-MONOMER.

Miscellaneous databases

NextBioi 978024.

Gene expression databases

Genevestigatori P54003.

Family and domain databases

InterProi IPR009571. SUR7/PalI.
[Graphical view ]
Pfami PF06687. SUR7. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Cloning of the multicopy suppressor gene SUR7: evidence for a functional relationship between the yeast actin-binding protein Rvs167 and a putative membranous protein."
    Sivadon P., Peypouquet M.-F., Doignon F., Aigle M., Crouzet M.
    Yeast 13:747-761(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  5. "The Sur7p family defines novel cortical domains in Saccharomyces cerevisiae, affects sphingolipid metabolism, and is involved in sporulation."
    Young M.E., Karpova T.S., Bruegger B., Moschenross D.M., Wang G.K., Schneiter R., Wieland F.T., Cooper J.A.
    Mol. Cell. Biol. 22:927-934(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. "Subproteomics: identification of plasma membrane proteins from the yeast Saccharomyces cerevisiae."
    Navarre C., Degand H., Bennett K.L., Crawford J.S., Moertz E., Boutry M.
    Proteomics 2:1706-1714(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  9. "Distribution of Can1p into stable domains reflects lateral protein segregation within the plasma membrane of living S. cerevisiae cells."
    Malinska K., Malinsky J., Opekarova M., Tanner W.
    J. Cell Sci. 117:6031-6041(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  10. Cited for: SUBCELLULAR LOCATION.
  11. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  12. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  13. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293 AND SER-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSUR7_YEAST
AccessioniPrimary (citable) accession number: P54003
Secondary accession number(s): D6VZC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 17000 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3