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P54003 (SUR7_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein SUR7
Gene names
Name:SUR7
Ordered Locus Names:YML052W
ORF Names:YM9958.11
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length302 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in sporulation and affects the sphingolipid composition of the plasma membrane. Probably involved in endocytosis. Ref.5

Subcellular location

Cell membrane; Multi-pass membrane protein. Note: Localizes at eisosomes, structures which colocalize with sites of protein and lipid endocytosis. Ref.5 Ref.6 Ref.7 Ref.9 Ref.10

Miscellaneous

Present with 17000 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the SUR7 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 302302Protein SUR7
PRO_0000072317

Regions

Topological domain1 – 1010Cytoplasmic Potential
Transmembrane11 – 3121Helical; Potential
Topological domain32 – 11483Extracellular Potential
Transmembrane115 – 13521Helical; Potential
Topological domain136 – 14510Cytoplasmic Potential
Transmembrane146 – 16621Helical; Potential
Topological domain167 – 18923Extracellular Potential
Transmembrane190 – 21021Helical; Potential
Topological domain211 – 30292Cytoplasmic Potential

Amino acid modifications

Modified residue2931Phosphoserine Ref.14
Modified residue3011Phosphoserine Ref.12 Ref.13 Ref.14
Glycosylation471N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P54003 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 14625FD6A48F515A

FASTA30233,830
        10         20         30         40         50         60 
MVKVWNIVLR LVVLLFLAGN TLLLILMIIS GATDHYPVNR FYWVQGNTTG IPNAGDETRW 

        70         80         90        100        110        120 
TFWGACLQDK DGSDTCTSNL APAYPISPVD NFNTHINVPH QFISKRDAFY YLTRFSFCFF 

       130        140        150        160        170        180 
WIALAFVGVS FILYVLTWCS KMLSEMVLIL MSFGFVFNTA AVVLQTAASA MAKNAFHDDH 

       190        200        210        220        230        240 
RSAQLGASMM GMAWASVFLC IVEFILLVFW SVRARLASTY SIDNSRYRTS SRWNPFHREK 

       250        260        270        280        290        300 
EQATDPILTA TGPEDMQQSA SIVGPSSNAN PVTATAATEN QPKGINFFTI RKSHERPDDV 


SV 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Cloning of the multicopy suppressor gene SUR7: evidence for a functional relationship between the yeast actin-binding protein Rvs167 and a putative membranous protein."
Sivadon P., Peypouquet M.-F., Doignon F., Aigle M., Crouzet M.
Yeast 13:747-761(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[5]"The Sur7p family defines novel cortical domains in Saccharomyces cerevisiae, affects sphingolipid metabolism, and is involved in sporulation."
Young M.E., Karpova T.S., Bruegger B., Moschenross D.M., Wang G.K., Schneiter R., Wieland F.T., Cooper J.A.
Mol. Cell. Biol. 22:927-934(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[6]"Subproteomics: identification of plasma membrane proteins from the yeast Saccharomyces cerevisiae."
Navarre C., Degand H., Bennett K.L., Crawford J.S., Moertz E., Boutry M.
Proteomics 2:1706-1714(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
[7]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[8]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[9]"Distribution of Can1p into stable domains reflects lateral protein segregation within the plasma membrane of living S. cerevisiae cells."
Malinska K., Malinsky J., Opekarova M., Tanner W.
J. Cell Sci. 117:6031-6041(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[10]"Eisosomes mark static sites of endocytosis."
Walther T.C., Brickner J.H., Aguilar P.S., Bernales S., Pantoja C., Walter P.
Nature 439:998-1003(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[11]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[12]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[13]"Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293 AND SER-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z46729 Genomic DNA. Translation: CAA86724.1.
AY557986 Genomic DNA. Translation: AAS56312.1.
BK006946 Genomic DNA. Translation: DAA09847.1.
PIRS49809.
RefSeqNP_013660.1. NM_001182410.1.

3D structure databases

ProteinModelPortalP54003.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35116. 59 interactions.
IntActP54003. 3 interactions.
MINTMINT-2779769.
STRING4932.YML052W.

Protein family/group databases

TCDB1.A.81.3.1. the low affinity ca(2+) channel (lacc) family.

Proteomic databases

PaxDbP54003.
PeptideAtlasP54003.

Protocols and materials databases

DNASU854953.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYML052W; YML052W; YML052W.
GeneID854953.
KEGGsce:YML052W.

Organism-specific databases

CYGDYML052w.
SGDS000004516. SUR7.

Phylogenomic databases

eggNOGNOG46868.
GeneTreeENSGT00390000000875.
HOGENOMHOG000248312.
OMARDAFYYL.
OrthoDBEOG7GN30D.

Enzyme and pathway databases

BioCycYEAST:G3O-32649-MONOMER.

Gene expression databases

GenevestigatorP54003.

Family and domain databases

InterProIPR009571. SUR7/PalI.
[Graphical view]
PfamPF06687. SUR7. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio978024.

Entry information

Entry nameSUR7_YEAST
AccessionPrimary (citable) accession number: P54003
Secondary accession number(s): D6VZC3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families