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P54003

- SUR7_YEAST

UniProt

P54003 - SUR7_YEAST

Protein

Protein SUR7

Gene

SUR7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Involved in sporulation and affects the sphingolipid composition of the plasma membrane. Probably involved in endocytosis.1 Publication

    GO - Biological processi

    1. ascospore formation Source: SGD
    2. endocytosis Source: SGD

    Keywords - Biological processi

    Endocytosis, Sporulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32649-MONOMER.

    Protein family/group databases

    TCDBi1.A.81.3.1. the low affinity ca(2+) channel (lacc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein SUR7
    Gene namesi
    Name:SUR7
    Ordered Locus Names:YML052W
    ORF Names:YM9958.11
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYML052w.
    SGDiS000004516. SUR7.

    Subcellular locationi

    Cell membrane 5 Publications; Multi-pass membrane protein 5 Publications
    Note: Localizes at eisosomes, structures which colocalize with sites of protein and lipid endocytosis.

    GO - Cellular componenti

    1. cell cortex Source: SGD
    2. integral component of membrane Source: SGD
    3. membrane raft Source: SGD
    4. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 302302Protein SUR7PRO_0000072317Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Modified residuei293 – 2931Phosphoserine1 Publication
    Modified residuei301 – 3011Phosphoserine3 Publications

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP54003.
    PaxDbiP54003.
    PeptideAtlasiP54003.

    Expressioni

    Gene expression databases

    GenevestigatoriP54003.

    Interactioni

    Protein-protein interaction databases

    BioGridi35116. 59 interactions.
    IntActiP54003. 3 interactions.
    MINTiMINT-2779769.
    STRINGi4932.YML052W.

    Structurei

    3D structure databases

    ProteinModelPortaliP54003.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010CytoplasmicSequence Analysis
    Topological domaini32 – 11483ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini136 – 14510CytoplasmicSequence Analysis
    Topological domaini167 – 18923ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini211 – 30292CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei115 – 13521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei146 – 16621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei190 – 21021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SUR7 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46868.
    GeneTreeiENSGT00390000000875.
    HOGENOMiHOG000248312.
    OMAiCIVEFIL.
    OrthoDBiEOG7GN30D.

    Family and domain databases

    InterProiIPR009571. SUR7/PalI.
    [Graphical view]
    PfamiPF06687. SUR7. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P54003-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKVWNIVLR LVVLLFLAGN TLLLILMIIS GATDHYPVNR FYWVQGNTTG    50
    IPNAGDETRW TFWGACLQDK DGSDTCTSNL APAYPISPVD NFNTHINVPH 100
    QFISKRDAFY YLTRFSFCFF WIALAFVGVS FILYVLTWCS KMLSEMVLIL 150
    MSFGFVFNTA AVVLQTAASA MAKNAFHDDH RSAQLGASMM GMAWASVFLC 200
    IVEFILLVFW SVRARLASTY SIDNSRYRTS SRWNPFHREK EQATDPILTA 250
    TGPEDMQQSA SIVGPSSNAN PVTATAATEN QPKGINFFTI RKSHERPDDV 300
    SV 302
    Length:302
    Mass (Da):33,830
    Last modified:October 1, 1996 - v1
    Checksum:i14625FD6A48F515A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46729 Genomic DNA. Translation: CAA86724.1.
    AY557986 Genomic DNA. Translation: AAS56312.1.
    BK006946 Genomic DNA. Translation: DAA09847.1.
    PIRiS49809.
    RefSeqiNP_013660.1. NM_001182410.1.

    Genome annotation databases

    EnsemblFungiiYML052W; YML052W; YML052W.
    GeneIDi854953.
    KEGGisce:YML052W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46729 Genomic DNA. Translation: CAA86724.1 .
    AY557986 Genomic DNA. Translation: AAS56312.1 .
    BK006946 Genomic DNA. Translation: DAA09847.1 .
    PIRi S49809.
    RefSeqi NP_013660.1. NM_001182410.1.

    3D structure databases

    ProteinModelPortali P54003.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35116. 59 interactions.
    IntActi P54003. 3 interactions.
    MINTi MINT-2779769.
    STRINGi 4932.YML052W.

    Protein family/group databases

    TCDBi 1.A.81.3.1. the low affinity ca(2+) channel (lacc) family.

    Proteomic databases

    MaxQBi P54003.
    PaxDbi P54003.
    PeptideAtlasi P54003.

    Protocols and materials databases

    DNASUi 854953.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YML052W ; YML052W ; YML052W .
    GeneIDi 854953.
    KEGGi sce:YML052W.

    Organism-specific databases

    CYGDi YML052w.
    SGDi S000004516. SUR7.

    Phylogenomic databases

    eggNOGi NOG46868.
    GeneTreei ENSGT00390000000875.
    HOGENOMi HOG000248312.
    OMAi CIVEFIL.
    OrthoDBi EOG7GN30D.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32649-MONOMER.

    Miscellaneous databases

    NextBioi 978024.

    Gene expression databases

    Genevestigatori P54003.

    Family and domain databases

    InterProi IPR009571. SUR7/PalI.
    [Graphical view ]
    Pfami PF06687. SUR7. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "Cloning of the multicopy suppressor gene SUR7: evidence for a functional relationship between the yeast actin-binding protein Rvs167 and a putative membranous protein."
      Sivadon P., Peypouquet M.-F., Doignon F., Aigle M., Crouzet M.
      Yeast 13:747-761(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    5. "The Sur7p family defines novel cortical domains in Saccharomyces cerevisiae, affects sphingolipid metabolism, and is involved in sporulation."
      Young M.E., Karpova T.S., Bruegger B., Moschenross D.M., Wang G.K., Schneiter R., Wieland F.T., Cooper J.A.
      Mol. Cell. Biol. 22:927-934(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    6. "Subproteomics: identification of plasma membrane proteins from the yeast Saccharomyces cerevisiae."
      Navarre C., Degand H., Bennett K.L., Crawford J.S., Moertz E., Boutry M.
      Proteomics 2:1706-1714(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    9. "Distribution of Can1p into stable domains reflects lateral protein segregation within the plasma membrane of living S. cerevisiae cells."
      Malinska K., Malinsky J., Opekarova M., Tanner W.
      J. Cell Sci. 117:6031-6041(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    10. Cited for: SUBCELLULAR LOCATION.
    11. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    12. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    13. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
      Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
      Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293 AND SER-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSUR7_YEAST
    AccessioniPrimary (citable) accession number: P54003
    Secondary accession number(s): D6VZC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 17000 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3