P54002 (YTH3_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative glycosyltransferase C14A4.3
EC=2.4.-.-

Gene names

ORF Names:

C14A4.3

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	603 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase 22 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	GPI anchor biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intrinsic to endoplasmic reticulum membrane Inferred from electronic annotation. Source: InterPro
Molecular function	transferase activity, transferring glycosyl groups Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 603	603	Putative glycosyltransferase C14A4.3		PRO_0000215791
Regions
	Transmembrane	109 – 129	21	Helical; Potential
	Transmembrane	131 – 151	21	Helical; Potential
	Transmembrane	167 – 187	21	Helical; Potential
	Transmembrane	196 – 216	21	Helical; Potential
	Transmembrane	246 – 266	21	Helical; Potential
	Transmembrane	311 – 331	21	Helical; Potential
	Transmembrane	344 – 364	21	Helical; Potential
	Transmembrane	371 – 391	21	Helical; Potential
	Transmembrane	398 – 418	21	Helical; Potential
Amino acid modifications
	Glycosylation	443	1	N-linked (GlcNAc...) Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P54002 [UniParc]. Last modified April 11, 2003. Version 2. Checksum: 6AFDD9F995CEC0C5	FASTA	603	68,912
	10 20 30 40 50 60 MVTHRRKGGS GPPQKPPPRI VDRSSFDADK KKIKVEKLYH KANNPDNDWP FSFGSVFKML 70 80 90 100 110 120 LSIRISGAIW GIINDCDEVY NYWEPLHLFL YGEGFQTWEY SPVYAIRSYF YIYLHYIPAS 130 140 150 160 170 180 LFANLFGDTK IVVFTLIRLT IGLFCLLGEY YAFDAICKKI NIATGRFFIL FSIFSSGMFL 190 200 210 220 230 240 ASTAFVPSSF CMAITFYILG AYLNENWTAG IFCVAFSTMV GWPFSAVLGL PIVADMLLLK 250 260 270 280 290 300 GLRIRFILTS LVIGLCIGGV QVITDSHYFG KTVLAPLNIF LYNVVSGPGP SLYGEEPLSF 310 320 330 340 350 360 YIKNLFNNWN IVIFAAPFGF PLSLAYFTKV WMSQDRNVAL YQRFAPIILL AVTTAAWLLI 370 380 390 400 410 420 FGSQAHKEER FLFPIYPFIA FFAALALDAT NRLCLKKLGM DNILSILFIL CFAILSASRT 430 440 450 460 470 480 YSIHNNYGSH VEIYRSLNAE LTNRTNFKNF HDPIRVCVGK EWHRFPSSFF IPQTVSDGKK 490 500 510 520 530 540 VEMRFIQSEF RGLLPKPFLK SDKLVEVTRH IPTEMNNLNQ EEISRYVDLD SCDYVVDVDM 550 560 570 580 590 600 PQSDREPDFR KMEDNWKPVD SLPFIDVSKS TGFHGLLRAF YVPFLSAKHN VMTTCTLYRK SNL

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins." Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T. Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed: 17761667] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-443, MASS SPECTROMETRY. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z49909 Genomic DNA. Translation: CAA90107.2.
PIR	T19245.
RefSeq	NP_496282.2. NM_063881.3.
UniGene	Cel.32864.
3D structure databases
ProteinModelPortal	P54002.
ModBase	Search...
Protein-protein interaction databases
STRING	P54002.
Protein family/group databases
CAZy	GT22. Glycosyltransferase Family 22.
Proteomic databases
PRIDE	P54002.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	C14A4.3; C14A4.3; C14A4.3.
GeneID	174633.
KEGG	cel:C14A4.3.
NMPDR	fig|6239.3.peg.7257.
UCSC	C14A4.3. c. elegans.
Organism-specific databases
CTD	174633.
WormBase	C14A4.3; CE32796; WBGene00007556.
Phylogenomic databases
eggNOG	meNOG04156.
GeneTree	EMGT00050000010282.
HOGENOM	HBG736291.
InParanoid	P54002.
OMA	FHRIATD.
PhylomeDB	P54002.
Gene expression databases
ArrayExpress	P54002.
Family and domain databases
InterPro	IPR005599. GPI_mannosylTrfase. [Graphical view]
KO	K03846.
PANTHER	PTHR22760. Alg9_trans. 1 hit.
Pfam	PF03901. Glyco_transf_22. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	884838.

Entry information

Entry name

YTH3_CAEEL

Accession

Primary (citable) accession number: P54002

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	April 11, 2003
Last modified:	November 16, 2011
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project