Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

RNA polymerase II transcriptional coactivator SUB1

Gene

SUB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the release of TFIIB from the transcription complex during transcription initiation. Binds to TFIIB and specifically inhibits the formation of the TBP-TFIIB-promoter complexes.

Miscellaneous

Present with 7820 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • chromatin binding Source: SGD
  • DNA binding Source: UniProtKB-KW
  • transcription coactivator activity Source: SGD

GO - Biological processi

  • double-strand break repair via nonhomologous end joining Source: SGD
  • hyperosmotic response Source: SGD
  • negative regulation of ascospore formation Source: SGD
  • positive regulation of transcription by RNA polymerase II Source: SGD
  • positive regulation of transcription by RNA polymerase III Source: SGD
  • positive regulation of transcription elongation from RNA polymerase II promoter Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter by pheromones Source: SGD
  • positive regulation of transcription initiation from RNA polymerase II promoter Source: GO_Central
  • regulation of transcription from RNA polymerase II promoter in response to stress Source: SGD
  • RNA polymerase III transcriptional preinitiation complex assembly Source: SGD
  • termination of RNA polymerase II transcription Source: SGD

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-32744-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcriptional coactivator SUB1
Gene namesi
Name:SUB1
Synonyms:TSP1
Ordered Locus Names:YMR039C
ORF Names:YM9532.04C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR039C
SGDiS000004642 SUB1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002159511 – 292RNA polymerase II transcriptional coactivator SUB1Add BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei119PhosphoserineCombined sources1
Modified residuei268PhosphoserineCombined sources1
Modified residuei269PhosphoserineCombined sources1
Modified residuei289PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP54000
PaxDbiP54000
PRIDEiP54000

PTM databases

iPTMnetiP54000

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RNA15P252992EBI-18492,EBI-15640

Protein-protein interaction databases

BioGridi35211, 409 interactors
DIPiDIP-4696N
IntActiP54000, 4 interactors
MINTiP54000
STRINGi4932.YMR039C

Structurei

3D structure databases

ProteinModelPortaliP54000
SMRiP54000
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000008802
HOGENOMiHOG000000752
InParanoidiP54000
OMAiIANLVDH
OrthoDBiEOG092C5QFZ

Family and domain databases

Gene3Di2.30.31.10, 1 hit
InterProiView protein in InterPro
IPR003173 PC4
IPR009044 ssDNA-bd_transcriptional_reg
PfamiView protein in Pfam
PF02229 PC4, 1 hit
SUPFAMiSSF54447 SSF54447, 1 hit

Sequencei

Sequence statusi: Complete.

P54000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYYNRYRNK RRSDNGGGNL SNSNNNNGGM PSGLSASDAI FDLGKNKRVT
60 70 80 90 100
VRQFRNINLI DIREYYLDSS TGEMKPGKKG ISLTEDLYDE LLKHRLNIDE
110 120 130 140 150
ALRRLGSKRP KTKMVRLLSD DEYEDDNNND STNNDKDKNG KDKNSPKKRR
160 170 180 190 200
EDKSKASNES HDLEPRSKKK KPAPPTLLPH EENIQNAERE ANATLIIPGQ
210 220 230 240 250
AGRKQQEERK QKEKEEAEEA KAKAVAEQEK EAKAKEKIAE PEPEPVPTLQ
260 270 280 290
AKKEDIVSNI NESKDANSSD EEFAQSLEAE MNKAEDDISE EE
Length:292
Mass (Da):33,102
Last modified:October 1, 1996 - v1
Checksum:i1E278C3EF2D569C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48502 Genomic DNA Translation: CAA88405.1
BK006946 Genomic DNA Translation: DAA09938.1
PIRiS52888
RefSeqiNP_013753.1, NM_001182536.1

Genome annotation databases

EnsemblFungiiYMR039C; YMR039C; YMR039C
GeneIDi855055
KEGGisce:YMR039C

Similar proteinsi

Entry informationi

Entry nameiSUB1_YEAST
AccessioniPrimary (citable) accession number: P54000
Secondary accession number(s): D6VZL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health