Reviewed, UniProtKB/Swiss-Prot P53997 (SET_DROME)

Names and origin

Protein names

Recommended name:
    Protein SET

Gene names

Name:	Set
ORF Names:	CG4299

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Interacts specifically with B-type cyclins.
Sequence similarities	Belongs to the nucleosome assembly protein (NAP) family.

Ontologies

Keywords
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleosome assembly Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: InterPro
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CG42360	Q9W135	1	EBI-136687,EBI-86909

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Protein SET		PRO_0000185665
Regions
	Compositional bias	230 – 269	40	Asp/Glu-rich (highly acidic)
Amino acid modifications
	Modified residue	30	1	Phosphoserine Ref.7
	Modified residue	148	1	Phosphoserine Ref.7
	Modified residue	152	1	Phosphoserine Ref.7
Experimental info
	Sequence conflict	15	1	Missing in AAA74264. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P53997-1 [UniParc]. Last modified October 18, 2001. Version 2. Checksum: 05F88CB85933BB09	FASTA	269	30,995
	10 20 30 40 50 60 MSSVPKRAKL DGAPADGNTS AAAGNNEEES EALEQIDACQ NEIDALNEKA SEEILKVEQK 70 80 90 100 110 120 YNKLRKPCYE KRSELVKRIP NFWVTSFINH PQVSGILDEE EEECLHALNK LEVEEFEDIK 130 140 150 160 170 180 SGYRINFHFD ENPYFENKVL TKEFHLNSAA ASENGDWPAS TSTPIKWKEG KNLLKLLLTK 190 200 210 220 230 240 PYGNKKKRNS EYKTFFDWFS DNTDPVNDEI AELIKDDLWP NPLQYYLVPD IEVEPEDEED 250 260 NEDNDEEAFD DEDGEDGEGE EEEEDEDDK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Members of the NAP/SET family of proteins interact specifically with B-type cyclins." Kellogg D.R., Kikuchi A., Fujii-Nakata T., Turck C.W., Murray A.W. J. Cell Biol. 130:661-673(1995) [PubMed: 7622566] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Widespread adaptive evolution of Drosophila genes with sex-biased expression." Proeschel M., Zhang Z., Parsch J. Genetics 174:893-900(2006) [PubMed: 16951084] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ZBMEL131, ZBMEL157, ZBMEL186, ZBMEL191, ZBMEL229, ZBMEL377, ZBMEL398, ZBMEL82, ZBMEL84 and ZBMEL95.
[3]	"The influence of demography and weak selection on the McDonald-Kreitman test: an empirical study in Drosophila." Parsch J., Zhang Z., Baines J.F. Mol. Biol. Evol. 26:691-698(2009) [PubMed: 19126864] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: MEL01, MEL11, MEL12, MEL13, MEL14, MEL15, MEL16, MEL17, MEL18, MEL19 and MEL20.
[4]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[5]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[6]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
[7]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30; SER-148 AND SER-152, MASS SPECTROMETRY. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U30470 mRNA. Translation: AAA74264.1. AM294381 Genomic DNA. Translation: CAL26311.1. AM294382 Genomic DNA. Translation: CAL26312.1. AM294383 Genomic DNA. Translation: CAL26313.1. AM294384 Genomic DNA. Translation: CAL26314.1. AM294385 Genomic DNA. Translation: CAL26315.1. AM294386 Genomic DNA. Translation: CAL26316.1. AM294387 Genomic DNA. Translation: CAL26317.1. AM294388 Genomic DNA. Translation: CAL26318.1. AM294389 Genomic DNA. Translation: CAL26319.1. AM294390 Genomic DNA. Translation: CAL26320.1. FM245455 Genomic DNA. Translation: CAR93381.1. FM245456 Genomic DNA. Translation: CAR93382.1. FM245457 Genomic DNA. Translation: CAR93383.1. FM245458 Genomic DNA. Translation: CAR93384.1. FM245459 Genomic DNA. Translation: CAR93385.1. FM245460 Genomic DNA. Translation: CAR93386.1. FM245461 Genomic DNA. Translation: CAR93387.1. FM245462 Genomic DNA. Translation: CAR93388.1. FM245463 Genomic DNA. Translation: CAR93389.1. FM245464 Genomic DNA. Translation: CAR93390.1. FM245465 Genomic DNA. Translation: CAR93391.1. AE014297 Genomic DNA. Translation: AAF55155.1. AY118922 mRNA. Translation: AAM50782.1.
RefSeq	NP_650438.2.
UniGene	Dm.7187
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:19697N.
IntAct	P53997. 4 interactions.
Proteomic databases
PRIDE	P53997.
Genome annotation databases
Ensembl	FBgn0014879. Drosophila melanogaster. [Contig view]
GeneID	41844.
KEGG	dme:Dmel_CG4299.
Organism-specific databases
FlyBase	FBgn0014879. Set.
Phylogenomic databases
HOGENOM	P53997.
OMA	P53997. WFTDHAD.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-011716-MON.
Gene expression databases
ArrayExpress	P53997.
GermOnline	CG4299. Drosophila melanogaster.
Family and domain databases
InterPro	IPR002164. NAP_family. [Graphical view]
PANTHER	PTHR11875. NAP_family. 1 hit.
Pfam	PF00956. NAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	825857.

Entry information

Entry name

SET_DROME

Accession

Primary (citable) accession number: P53997
Secondary accession number(s): Q540W9, Q9VFA5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 18, 2001
Last modified:	July 7, 2009
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project