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P53996

- CNBP_MOUSE

UniProt

P53996 - CNBP_MOUSE

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Protein

Cellular nucleic acid-binding protein

Gene
Cnbp, Cnbp1, Znf9
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4 – 2118CCHC-type 1Add
BLAST
Zinc fingeri52 – 6918CCHC-type 2Add
BLAST
Zinc fingeri72 – 9019CCHC-type 3Add
BLAST
Zinc fingeri97 – 11418CCHC-type 4Add
BLAST
Zinc fingeri118 – 13518CCHC-type 5Add
BLAST
Zinc fingeri136 – 15318CCHC-type 6Add
BLAST
Zinc fingeri157 – 17418CCHC-type 7Add
BLAST

GO - Molecular functioni

  1. single-stranded DNA binding Source: Ensembl
  2. single-stranded RNA binding Source: Ensembl
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. positive regulation of cell proliferation Source: MGI
  2. positive regulation of transcription, DNA-templated Source: UniProtKB
  3. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular nucleic acid-binding protein
Short name:
CNBP
Alternative name(s):
Zinc finger protein 9
Gene namesi
Name:Cnbp
Synonyms:Cnbp1, Znf9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:88431. Cnbp.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: MGI
  2. endoplasmic reticulum Source: MGI
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 178177Cellular nucleic acid-binding proteinPRO_0000089966Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei8 – 81N6-acetyllysine1 Publication
Modified residuei25 – 251Omega-N-methylarginine; by PRMT1 By similarity
Modified residuei27 – 271Omega-N-methylarginine; by PRMT1 By similarity

Post-translational modificationi

Arginine methylation by PRMT1 in the Arg/Gly-rich region impedes RNA binding By similarity.

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

MaxQBiP53996.
PaxDbiP53996.
PRIDEiP53996.

PTM databases

PhosphoSiteiP53996.

Expressioni

Tissue specificityi

Present in all tissues examined.

Gene expression databases

ArrayExpressiP53996.
BgeeiP53996.
CleanExiMM_CNBP.
GenevestigatoriP53996.

Interactioni

Protein-protein interaction databases

BioGridi198782. 2 interactions.
IntActiP53996. 3 interactions.
MINTiMINT-4091236.

Structurei

3D structure databases

ProteinModelPortaliP53996.
SMRiP53996. Positions 4-70, 75-113, 136-175.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi22 – 4221Arg/Gly-richAdd
BLAST

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4 – 2118CCHC-type 1Add
BLAST
Zinc fingeri52 – 6918CCHC-type 2Add
BLAST
Zinc fingeri72 – 9019CCHC-type 3Add
BLAST
Zinc fingeri97 – 11418CCHC-type 4Add
BLAST
Zinc fingeri118 – 13518CCHC-type 5Add
BLAST
Zinc fingeri136 – 15318CCHC-type 6Add
BLAST
Zinc fingeri157 – 17418CCHC-type 7Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5082.
HOGENOMiHOG000186262.
HOVERGENiHBG000397.
InParanoidiP53996.
KOiK09250.
OMAiCPNGQGG.
OrthoDBiEOG790G22.
PhylomeDBiP53996.
TreeFamiTF316974.

Family and domain databases

Gene3Di4.10.60.10. 4 hits.
InterProiIPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00098. zf-CCHC. 7 hits.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 7 hits.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 4 hits.
PROSITEiPS50158. ZF_CCHC. 7 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P53996-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSSNECFKCG RSGHWARECP TGGGRGRGMR SRGRGGFTSD RGFQFVSSSL    50
PDICYRCGES GHLAKDCDLQ EDEACYNCGR GGHIAKDCKE PKREREQCCY 100
NCGKPGHLAR DCDHADEQKC YSCGEFGHIQ KDCTKVKCYR CGETGHVAIN 150
CSKTSEVNCY RCGESGHLAR ECTIEATA 178
Length:178
Mass (Da):19,592
Last modified:July 19, 2004 - v2
Checksum:iDF0CDAB9BF3D96BB
GO
Isoform 2 (identifier: P53996-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-42: Missing.
     73-73: Missing.

Show »
Length:170
Mass (Da):18,742
Checksum:i152BEC42881358E8
GO
Isoform 3 (identifier: P53996-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-73: Missing.

Show »
Length:177
Mass (Da):19,463
Checksum:i996F398285F52618
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei36 – 427Missing in isoform 2. VSP_010983
Alternative sequencei73 – 731Missing in isoform 2 and isoform 3. VSP_010984

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21S → R in CAA45345. 1 Publication
Sequence conflicti2 – 21S → R in CAA77896. 1 Publication
Sequence conflicti60 – 601S → P in BAC37269. 1 Publication
Sequence conflicti106 – 1061G → D in CAA77897. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L12693 mRNA. Translation: AAA89198.1.
Z11870 mRNA. Translation: CAA77896.1.
X63866 mRNA. Translation: CAA45345.1.
Z11871 mRNA. Translation: CAA77897.1.
U20326 mRNA. Translation: AAB60490.1.
AY176064 Genomic DNA. Translation: AAO31613.1.
AK075760 mRNA. Translation: BAC35938.1.
AK078427 mRNA. Translation: BAC37269.1.
BC058723 mRNA. Translation: AAH58723.1.
CCDSiCCDS51841.1. [P53996-1]
PIRiI48297.
I48298.
I49259.
RefSeqiNP_001103215.1. NM_001109745.1.
NP_038521.1. NM_013493.3. [P53996-1]
XP_006505542.1. XM_006505479.1. [P53996-3]
UniGeneiMm.290251.

Genome annotation databases

EnsembliENSMUST00000032138; ENSMUSP00000032138; ENSMUSG00000030057. [P53996-1]
ENSMUST00000113619; ENSMUSP00000109249; ENSMUSG00000030057. [P53996-3]
GeneIDi12785.
KEGGimmu:12785.
UCSCiuc009cuc.2. mouse. [P53996-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L12693 mRNA. Translation: AAA89198.1 .
Z11870 mRNA. Translation: CAA77896.1 .
X63866 mRNA. Translation: CAA45345.1 .
Z11871 mRNA. Translation: CAA77897.1 .
U20326 mRNA. Translation: AAB60490.1 .
AY176064 Genomic DNA. Translation: AAO31613.1 .
AK075760 mRNA. Translation: BAC35938.1 .
AK078427 mRNA. Translation: BAC37269.1 .
BC058723 mRNA. Translation: AAH58723.1 .
CCDSi CCDS51841.1. [P53996-1 ]
PIRi I48297.
I48298.
I49259.
RefSeqi NP_001103215.1. NM_001109745.1.
NP_038521.1. NM_013493.3. [P53996-1 ]
XP_006505542.1. XM_006505479.1. [P53996-3 ]
UniGenei Mm.290251.

3D structure databases

ProteinModelPortali P53996.
SMRi P53996. Positions 4-70, 75-113, 136-175.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198782. 2 interactions.
IntActi P53996. 3 interactions.
MINTi MINT-4091236.

PTM databases

PhosphoSitei P53996.

Proteomic databases

MaxQBi P53996.
PaxDbi P53996.
PRIDEi P53996.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032138 ; ENSMUSP00000032138 ; ENSMUSG00000030057 . [P53996-1 ]
ENSMUST00000113619 ; ENSMUSP00000109249 ; ENSMUSG00000030057 . [P53996-3 ]
GeneIDi 12785.
KEGGi mmu:12785.
UCSCi uc009cuc.2. mouse. [P53996-1 ]

Organism-specific databases

CTDi 7555.
MGIi MGI:88431. Cnbp.

Phylogenomic databases

eggNOGi COG5082.
HOGENOMi HOG000186262.
HOVERGENi HBG000397.
InParanoidi P53996.
KOi K09250.
OMAi CPNGQGG.
OrthoDBi EOG790G22.
PhylomeDBi P53996.
TreeFami TF316974.

Miscellaneous databases

ChiTaRSi CNBP. mouse.
NextBioi 282182.
PROi P53996.
SOURCEi Search...

Gene expression databases

ArrayExpressi P53996.
Bgeei P53996.
CleanExi MM_CNBP.
Genevestigatori P53996.

Family and domain databases

Gene3Di 4.10.60.10. 4 hits.
InterProi IPR001878. Znf_CCHC.
[Graphical view ]
Pfami PF00098. zf-CCHC. 7 hits.
[Graphical view ]
SMARTi SM00343. ZnF_C2HC. 7 hits.
[Graphical view ]
SUPFAMi SSF57756. SSF57756. 4 hits.
PROSITEi PS50158. ZF_CCHC. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse cellular nucleic acid binding proteins: a highly conserved family identified by genetic mapping and sequencing."
    Warden C.H., Krisans S.K., Purcell-Huynh D., Leete L.M., Daluiski A., Diep A., Taylor B.A., Lusis A.J.
    Genomics 24:14-19(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
    Strain: C57BL/6J X CBA/J.
    Tissue: Liver.
  2. "Primary structure and developmental regulation of murine CNBP, a zinc finger-containing protein whose general structure is present in evolutionarily diverse eukaryotes."
    Kingsley P.D., Palis J.
    Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
    Strain: C57BL/6.
  3. "Molecular cloning, developmental expression, promoter analysis and functional characterization of the mouse CNBP gene."
    Shimizu K., Chen W., Ashique A.M., Moroi R., Li Y.P.
    Gene 307:51-62(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Strain: C57BL/6J.
    Tissue: Testis.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2 AND LYS-8, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiCNBP_MOUSE
AccessioniPrimary (citable) accession number: P53996
Secondary accession number(s): Q80Y06, Q8BP23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 19, 2004
Last modified: July 9, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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