Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras-related protein Rab-2A

Gene

Rab2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for protein transport from the endoplasmic reticulum to the Golgi complex.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 219GTPBy similarity
Nucleotide bindingi61 – 655GTPBy similarity
Nucleotide bindingi119 – 1224GTPBy similarity
Nucleotide bindingi149 – 1513GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-162658. Golgi Cisternae Pericentriolar Stack Reorganization.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-2A
Gene namesi
Name:Rab2a
Synonyms:Rab2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1928750. Rab2a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 212211Ras-related protein Rab-2APRO_0000121067Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Lipidationi211 – 2111S-geranylgeranyl cysteineBy similarity
Lipidationi212 – 2121S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Prenylation

Proteomic databases

EPDiP53994.
PaxDbiP53994.
PeptideAtlasiP53994.
PRIDEiP53994.
TopDownProteomicsiP53994.

PTM databases

iPTMnetiP53994.
PhosphoSiteiP53994.
SwissPalmiP53994.

Expressioni

Gene expression databases

BgeeiP53994.
CleanExiMM_RAB2A.
ExpressionAtlasiP53994. baseline and differential.
GenevisibleiP53994. MM.

Interactioni

Subunit structurei

Interacts with PRKCI.By similarity

Protein-protein interaction databases

BioGridi208489. 2 interactions.
IntActiP53994. 8 interactions.
MINTiMINT-1865962.
STRINGi10090.ENSMUSP00000057664.

Structurei

3D structure databases

ProteinModelPortaliP53994.
SMRiP53994. Positions 2-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 1918Required for interaction with PRKCIBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi35 – 439Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0098. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP53994.
KOiK07877.
OMAiRRDTFTH.
OrthoDBiEOG7QK0CV.
PhylomeDBiP53994.
TreeFamiTF300032.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53994-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMITI
60 70 80 90 100
DGKQIKLQIW DTAGQESFRS ITRSYYRGAA GALLVYDITR RDTFNHLTTW
110 120 130 140 150
LEDARQHSNS NMVIMLIGNK SDLESRREVK KEEGEAFARE HGLIFMETSA
160 170 180 190 200
KTASNVEEAF INTAKEIYEK IQEGVFDINN EANGIKIGPQ HAATNASHGS
210
NQGGQQAGGG CC
Length:212
Mass (Da):23,548
Last modified:October 1, 1996 - v1
Checksum:i58231E3F9EF007A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95403 mRNA. Translation: CAA64684.1.
AK079071 mRNA. Translation: BAC37524.1.
AK135421 mRNA. Translation: BAE22525.1.
AK146179 mRNA. Translation: BAE26957.1.
AK150030 mRNA. Translation: BAE29254.1.
AK159607 mRNA. Translation: BAE35226.1.
AK160333 mRNA. Translation: BAE35742.1.
AK163320 mRNA. Translation: BAE37298.1.
CCDSiCCDS17955.1.
RefSeqiNP_067493.1. NM_021518.3.
UniGeneiMm.397471.

Genome annotation databases

EnsembliENSMUST00000060232; ENSMUSP00000057664; ENSMUSG00000047187.
GeneIDi59021.
KEGGimmu:59021.
UCSCiuc008rxw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95403 mRNA. Translation: CAA64684.1.
AK079071 mRNA. Translation: BAC37524.1.
AK135421 mRNA. Translation: BAE22525.1.
AK146179 mRNA. Translation: BAE26957.1.
AK150030 mRNA. Translation: BAE29254.1.
AK159607 mRNA. Translation: BAE35226.1.
AK160333 mRNA. Translation: BAE35742.1.
AK163320 mRNA. Translation: BAE37298.1.
CCDSiCCDS17955.1.
RefSeqiNP_067493.1. NM_021518.3.
UniGeneiMm.397471.

3D structure databases

ProteinModelPortaliP53994.
SMRiP53994. Positions 2-170.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208489. 2 interactions.
IntActiP53994. 8 interactions.
MINTiMINT-1865962.
STRINGi10090.ENSMUSP00000057664.

PTM databases

iPTMnetiP53994.
PhosphoSiteiP53994.
SwissPalmiP53994.

Proteomic databases

EPDiP53994.
PaxDbiP53994.
PeptideAtlasiP53994.
PRIDEiP53994.
TopDownProteomicsiP53994.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060232; ENSMUSP00000057664; ENSMUSG00000047187.
GeneIDi59021.
KEGGimmu:59021.
UCSCiuc008rxw.1. mouse.

Organism-specific databases

CTDi5862.
MGIiMGI:1928750. Rab2a.

Phylogenomic databases

eggNOGiKOG0098. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP53994.
KOiK07877.
OMAiRRDTFTH.
OrthoDBiEOG7QK0CV.
PhylomeDBiP53994.
TreeFamiTF300032.

Enzyme and pathway databases

ReactomeiR-MMU-162658. Golgi Cisternae Pericentriolar Stack Reorganization.

Miscellaneous databases

ChiTaRSiRab2a. mouse.
PROiP53994.
SOURCEiSearch...

Gene expression databases

BgeeiP53994.
CleanExiMM_RAB2A.
ExpressionAtlasiP53994. baseline and differential.
GenevisibleiP53994. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Laufer W.
    Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NIH Swiss.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: BALB/cJ and C57BL/6J.
    Tissue: Bone marrow, Diencephalon, Egg and Muellerian duct.
  3. Lubec G., Klug S.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 31-46, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hippocampus.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiRAB2A_MOUSE
AccessioniPrimary (citable) accession number: P53994
Secondary accession number(s): Q3UK45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 6, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.