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Protein

Ras-related protein Rab-2A

Gene

Rab2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for protein transport from the endoplasmic reticulum to the Golgi complex.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 21GTPBy similarity9
Nucleotide bindingi61 – 65GTPBy similarity5
Nucleotide bindingi119 – 122GTPBy similarity4
Nucleotide bindingi149 – 151GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-162658. Golgi Cisternae Pericentriolar Stack Reorganization.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-2A
Gene namesi
Name:Rab2a
Synonyms:Rab2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1928750. Rab2a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001210672 – 212Ras-related protein Rab-2AAdd BLAST211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Lipidationi211S-geranylgeranyl cysteineBy similarity1
Lipidationi212S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Prenylation

Proteomic databases

EPDiP53994.
PaxDbiP53994.
PeptideAtlasiP53994.
PRIDEiP53994.
TopDownProteomicsiP53994.

PTM databases

iPTMnetiP53994.
PhosphoSitePlusiP53994.
SwissPalmiP53994.

Expressioni

Gene expression databases

BgeeiENSMUSG00000047187.
CleanExiMM_RAB2A.
ExpressionAtlasiP53994. baseline and differential.
GenevisibleiP53994. MM.

Interactioni

Subunit structurei

Interacts with PRKCI.By similarity

Protein-protein interaction databases

BioGridi208489. 2 interactors.
IntActiP53994. 8 interactors.
MINTiMINT-1865962.
STRINGi10090.ENSMUSP00000057664.

Structurei

3D structure databases

ProteinModelPortaliP53994.
SMRiP53994.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 19Required for interaction with PRKCIBy similarityAdd BLAST18

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 43Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0098. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP53994.
KOiK07877.
OMAiCAFVKCF.
OrthoDBiEOG091G0QOB.
PhylomeDBiP53994.
TreeFamiTF300032.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53994-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMITI
60 70 80 90 100
DGKQIKLQIW DTAGQESFRS ITRSYYRGAA GALLVYDITR RDTFNHLTTW
110 120 130 140 150
LEDARQHSNS NMVIMLIGNK SDLESRREVK KEEGEAFARE HGLIFMETSA
160 170 180 190 200
KTASNVEEAF INTAKEIYEK IQEGVFDINN EANGIKIGPQ HAATNASHGS
210
NQGGQQAGGG CC
Length:212
Mass (Da):23,548
Last modified:October 1, 1996 - v1
Checksum:i58231E3F9EF007A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95403 mRNA. Translation: CAA64684.1.
AK079071 mRNA. Translation: BAC37524.1.
AK135421 mRNA. Translation: BAE22525.1.
AK146179 mRNA. Translation: BAE26957.1.
AK150030 mRNA. Translation: BAE29254.1.
AK159607 mRNA. Translation: BAE35226.1.
AK160333 mRNA. Translation: BAE35742.1.
AK163320 mRNA. Translation: BAE37298.1.
CCDSiCCDS17955.1.
RefSeqiNP_067493.1. NM_021518.3.
UniGeneiMm.397471.

Genome annotation databases

EnsembliENSMUST00000060232; ENSMUSP00000057664; ENSMUSG00000047187.
GeneDBiSmp_071630.1:pep.
GeneIDi59021.
KEGGimmu:59021.
UCSCiuc008rxw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95403 mRNA. Translation: CAA64684.1.
AK079071 mRNA. Translation: BAC37524.1.
AK135421 mRNA. Translation: BAE22525.1.
AK146179 mRNA. Translation: BAE26957.1.
AK150030 mRNA. Translation: BAE29254.1.
AK159607 mRNA. Translation: BAE35226.1.
AK160333 mRNA. Translation: BAE35742.1.
AK163320 mRNA. Translation: BAE37298.1.
CCDSiCCDS17955.1.
RefSeqiNP_067493.1. NM_021518.3.
UniGeneiMm.397471.

3D structure databases

ProteinModelPortaliP53994.
SMRiP53994.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208489. 2 interactors.
IntActiP53994. 8 interactors.
MINTiMINT-1865962.
STRINGi10090.ENSMUSP00000057664.

PTM databases

iPTMnetiP53994.
PhosphoSitePlusiP53994.
SwissPalmiP53994.

Proteomic databases

EPDiP53994.
PaxDbiP53994.
PeptideAtlasiP53994.
PRIDEiP53994.
TopDownProteomicsiP53994.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060232; ENSMUSP00000057664; ENSMUSG00000047187.
GeneDBiSmp_071630.1:pep.
GeneIDi59021.
KEGGimmu:59021.
UCSCiuc008rxw.1. mouse.

Organism-specific databases

CTDi5862.
MGIiMGI:1928750. Rab2a.

Phylogenomic databases

eggNOGiKOG0098. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP53994.
KOiK07877.
OMAiCAFVKCF.
OrthoDBiEOG091G0QOB.
PhylomeDBiP53994.
TreeFamiTF300032.

Enzyme and pathway databases

ReactomeiR-MMU-162658. Golgi Cisternae Pericentriolar Stack Reorganization.

Miscellaneous databases

ChiTaRSiRab2a. mouse.
PROiP53994.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047187.
CleanExiMM_RAB2A.
ExpressionAtlasiP53994. baseline and differential.
GenevisibleiP53994. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB2A_MOUSE
AccessioniPrimary (citable) accession number: P53994
Secondary accession number(s): Q3UK45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.