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Protein

Ras-related protein Rab-2A

Gene

Rab2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for protein transport from the endoplasmic reticulum to the Golgi complex.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 21GTPBy similarity9
Nucleotide bindingi61 – 65GTPBy similarity5
Nucleotide bindingi119 – 122GTPBy similarity4
Nucleotide bindingi149 – 151GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

  • Golgi organization Source: MGI
  • intracellular protein transport Source: MGI
  • vesicle-mediated transport Source: UniProtKB-KW

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-162658 Golgi Cisternae Pericentriolar Stack Reorganization
R-MMU-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-2A
Gene namesi
Name:Rab2a
Synonyms:Rab2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1928750 Rab2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001210672 – 212Ras-related protein Rab-2AAdd BLAST211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Lipidationi211S-geranylgeranyl cysteineBy similarity1
Lipidationi212S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Prenylation

Proteomic databases

EPDiP53994
PaxDbiP53994
PeptideAtlasiP53994
PRIDEiP53994
TopDownProteomicsiP53994

PTM databases

iPTMnetiP53994
PhosphoSitePlusiP53994
SwissPalmiP53994

Expressioni

Gene expression databases

BgeeiENSMUSG00000047187
CleanExiMM_RAB2A
ExpressionAtlasiP53994 baseline and differential
GenevisibleiP53994 MM

Interactioni

Subunit structurei

Interacts with PRKCI.By similarity

Protein-protein interaction databases

BioGridi208489, 4 interactors
IntActiP53994, 9 interactors
MINTiP53994
STRINGi10090.ENSMUSP00000057664

Structurei

3D structure databases

ProteinModelPortaliP53994
SMRiP53994
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 19Required for interaction with PRKCIBy similarityAdd BLAST18

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 43Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0098 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118841
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP53994
KOiK07877
OMAiFKDHSQH
OrthoDBiEOG091G0QOB
PhylomeDBiP53994
TreeFamiTF300032

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53994-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMITI
60 70 80 90 100
DGKQIKLQIW DTAGQESFRS ITRSYYRGAA GALLVYDITR RDTFNHLTTW
110 120 130 140 150
LEDARQHSNS NMVIMLIGNK SDLESRREVK KEEGEAFARE HGLIFMETSA
160 170 180 190 200
KTASNVEEAF INTAKEIYEK IQEGVFDINN EANGIKIGPQ HAATNASHGS
210
NQGGQQAGGG CC
Length:212
Mass (Da):23,548
Last modified:October 1, 1996 - v1
Checksum:i58231E3F9EF007A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95403 mRNA Translation: CAA64684.1
AK079071 mRNA Translation: BAC37524.1
AK135421 mRNA Translation: BAE22525.1
AK146179 mRNA Translation: BAE26957.1
AK150030 mRNA Translation: BAE29254.1
AK159607 mRNA Translation: BAE35226.1
AK160333 mRNA Translation: BAE35742.1
AK163320 mRNA Translation: BAE37298.1
CCDSiCCDS17955.1
RefSeqiNP_067493.1, NM_021518.3
UniGeneiMm.397471

Genome annotation databases

EnsembliENSMUST00000060232; ENSMUSP00000057664; ENSMUSG00000047187
GeneDBiSmp_071630.1:pep
GeneIDi59021
KEGGimmu:59021
UCSCiuc008rxw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRAB2A_MOUSE
AccessioniPrimary (citable) accession number: P53994
Secondary accession number(s): Q3UK45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health