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Protein

Protein transport protein Sec24C

Gene

SEC24C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296).4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi425ZincCombined sources1
Metal bindingi428ZincCombined sources1
Metal bindingi447ZincCombined sources1
Metal bindingi450ZincCombined sources1

GO - Molecular functioni

  • SNARE binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-1655829. Regulation of cholesterol biosynthesis by SREBP (SREBF).
R-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-5694530. Cargo concentration in the ER.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec24CCurated
Alternative name(s):
SEC24-related protein C
Gene namesi
Name:SEC24CImported
Synonyms:KIAA0079Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000176986.15.
HGNCiHGNC:10705. SEC24C.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi895 – 897LIL → AAA: Loss of packaging into COPII-coated vesicles of the IxM motif-containing cargos GOSR2 and STX5. 1 Publication3

Organism-specific databases

DisGeNETi9632.
MalaCardsiSEC24C.
OpenTargetsiENSG00000176986.
PharmGKBiPA35628.

Polymorphism and mutation databases

BioMutaiSEC24C.
DMDMi257051070.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002051561 – 1094Protein transport protein Sec24CAdd BLAST1094

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei214PhosphothreonineCombined sources1
Modified residuei328PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP53992.
MaxQBiP53992.
PaxDbiP53992.
PeptideAtlasiP53992.
PRIDEiP53992.

PTM databases

iPTMnetiP53992.
PhosphoSitePlusiP53992.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000176986.
CleanExiHS_SEC24C.
ExpressionAtlasiP53992. baseline and differential.
GenevisibleiP53992. HS.

Organism-specific databases

HPAiHPA040196.
HPA040213.

Interactioni

Subunit structurei

COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1 (PubMed:10214955, PubMed:10075675, PubMed:17499046). Interacts with TMED2 and TMED10 (PubMed:20427317). Interacts with GOSR2 (via IxM motif) and STX5 (via IxM motif); recruits GOSR2 and STX5 into COPII-coated vesicles (PubMed:18843296).5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • SNARE binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114991. 68 interactors.
DIPiDIP-30981N.
IntActiP53992. 36 interactors.
MINTiMINT-4998997.
STRINGi9606.ENSP00000321845.

Structurei

Secondary structure

11094
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi331 – 340Combined sources10
Beta strandi343 – 346Combined sources4
Beta strandi362 – 364Combined sources3
Beta strandi366 – 368Combined sources3
Turni371 – 373Combined sources3
Beta strandi374 – 384Combined sources11
Helixi385 – 391Combined sources7
Beta strandi395 – 399Combined sources5
Beta strandi413 – 415Combined sources3
Helixi418 – 420Combined sources3
Turni426 – 428Combined sources3
Beta strandi437 – 439Combined sources3
Helixi440 – 442Combined sources3
Beta strandi444 – 446Combined sources3
Turni448 – 450Combined sources3
Beta strandi453 – 455Combined sources3
Turni458 – 461Combined sources4
Helixi462 – 466Combined sources5
Beta strandi467 – 469Combined sources3
Helixi477 – 480Combined sources4
Beta strandi482 – 487Combined sources6
Helixi490 – 492Combined sources3
Helixi494 – 496Combined sources3
Beta strandi503 – 509Combined sources7
Helixi512 – 516Combined sources5
Helixi519 – 530Combined sources12
Helixi531 – 533Combined sources3
Beta strandi546 – 560Combined sources15
Beta strandi569 – 573Combined sources5
Turni576 – 578Combined sources3
Beta strandi587 – 589Combined sources3
Turni591 – 594Combined sources4
Helixi595 – 609Combined sources15
Helixi620 – 632Combined sources13
Beta strandi637 – 643Combined sources7
Beta strandi649 – 651Combined sources3
Helixi661 – 663Combined sources3
Helixi669 – 672Combined sources4
Helixi679 – 689Combined sources11
Beta strandi692 – 698Combined sources7
Helixi706 – 709Combined sources4
Helixi711 – 715Combined sources5
Beta strandi720 – 722Combined sources3
Helixi728 – 744Combined sources17
Beta strandi747 – 757Combined sources11
Beta strandi761 – 769Combined sources9
Beta strandi773 – 776Combined sources4
Beta strandi778 – 784Combined sources7
Beta strandi789 – 797Combined sources9
Turni801 – 803Combined sources3
Beta strandi805 – 814Combined sources10
Beta strandi820 – 834Combined sources15
Helixi835 – 840Combined sources6
Helixi844 – 858Combined sources15
Turni859 – 861Combined sources3
Helixi864 – 885Combined sources22
Helixi899 – 901Combined sources3
Helixi904 – 912Combined sources9
Turni915 – 917Combined sources3
Helixi925 – 937Combined sources13
Helixi940 – 947Combined sources8
Beta strandi950 – 953Combined sources4
Helixi972 – 974Combined sources3
Beta strandi980 – 984Combined sources5
Beta strandi986 – 993Combined sources8
Helixi999 – 1006Combined sources8
Helixi1011 – 1013Combined sources3
Helixi1027 – 1040Combined sources14
Beta strandi1043 – 1045Combined sources3
Beta strandi1048 – 1056Combined sources9
Helixi1059 – 1063Combined sources5
Turni1072 – 1074Combined sources3
Helixi1078 – 1092Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EH2X-ray2.35A/B/C329-1094[»]
ProteinModelPortaliP53992.
SMRiP53992.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP53992.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati962 – 1034Gelsolin-likeSequence analysisAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni425 – 450Zinc finger-likeAdd BLAST26

Sequence similaritiesi

Belongs to the SEC23/SEC24 family. SEC24 subfamily.Curated

Phylogenomic databases

eggNOGiKOG1985. Eukaryota.
COG5028. LUCA.
GeneTreeiENSGT00590000082962.
HOGENOMiHOG000196365.
HOVERGENiHBG062229.
InParanoidiP53992.
KOiK14007.
OMAiLYCIPNT.
OrthoDBiEOG091G0288.
PhylomeDBiP53992.
TreeFamiTF300464.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
3.40.50.410. 1 hit.
InterProiView protein in InterPro
IPR029006. ADF-H/Gelsolin-like_dom_sf.
IPR007123. Gelsolin-like_dom.
IPR036180. Gelsolin-like_dom_sf.
IPR006900. Sec23/24_helical_dom.
IPR036175. Sec23/24_helical_dom_sf.
IPR006896. Sec23/24_trunk_dom.
IPR012990. Sec23_24_beta_S.
IPR036465. vWFA_dom_sf.
IPR006895. Znf_Sec23_Sec24.
IPR036174. Znf_Sec23_Sec24_sf.
PfamiView protein in Pfam
PF00626. Gelsolin. 1 hit.
PF08033. Sec23_BS. 1 hit.
PF04815. Sec23_helical. 1 hit.
PF04811. Sec23_trunk. 1 hit.
PF04810. zf-Sec23_Sec24. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF81811. SSF81811. 1 hit.
SSF82754. SSF82754. 1 hit.
SSF82919. SSF82919. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P53992-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNVNQSVPPV PPFGQPQPIY PGYHQSSYGG QSGSTAPAIP YGAYNGPVPG
60 70 80 90 100
YQQTPPQGMS RAPPSSGAPP ASTAQAPCGQ AAYGQFGQGD VQNGPSSTVQ
110 120 130 140 150
MQRLPGSQPF GSPLAPVGNQ PPVLQPYGPP PTSAQVATQL SGMQISGAVA
160 170 180 190 200
PAPPSSGLGF GPPTSLASAS GSFPNSGLYG SYPQGQAPPL SQAQGHPGIQ
210 220 230 240 250
TPQRSAPSQA SSFTPPASGG PRLPSMTGPL LPGQSFGGPS VSQPNHVSSP
260 270 280 290 300
PQALPPGTQM TGPLGPLPPM HSPQQPGYQP QQNGSFGPAR GPQSNYGGPY
310 320 330 340 350
PAAPTFGSQP GPPQPLPPKR LDPDAIPSPI QVIEDDRNNR GTEPFVTGVR
360 370 380 390 400
GQVPPLVTTN FLVKDQGNAS PRYIRCTSYN IPCTSDMAKQ AQVPLAAVIK
410 420 430 440 450
PLARLPPEEA SPYVVDHGES GPLRCNRCKA YMCPFMQFIE GGRRFQCCFC
460 470 480 490 500
SCINDVPPQY FQHLDHTGKR VDAYDRPELS LGSYEFLATV DYCKNNKFPS
510 520 530 540 550
PPAFIFMIDV SYNAIRTGLV RLLCEELKSL LDFLPREGGA EESAIRVGFV
560 570 580 590 600
TYNKVLHFYN VKSSLAQPQM MVVSDVADMF VPLLDGFLVN VNESRAVITS
610 620 630 640 650
LLDQIPEMFA DTRETETVFV PVIQAGMEAL KAAECAGKLF LFHTSLPIAE
660 670 680 690 700
APGKLKNRDD RKLINTDKEK TLFQPQTGAY QTLAKECVAQ GCCVDLFLFP
710 720 730 740 750
NQYVDVATLS VVPQLTGGSV YKYASFQVEN DQERFLSDLR RDVQKVVGFD
760 770 780 790 800
AVMRVRTSTG IRAVDFFGAF YMSNTTDVEL AGLDGDKTVT VEFKHDDRLN
810 820 830 840 850
EESGALLQCA LLYTSCAGQR RLRIHNLALN CCTQLADLYR NCETDTLINY
860 870 880 890 900
MAKFAYRGVL NSPVKAVRDT LITQCAQILA CYRKNCASPS SAGQLILPEC
910 920 930 940 950
MKLLPVYLNC VLKSDVLQPG AEVTTDDRAY VRQLVTSMDV TETNVFFYPR
960 970 980 990 1000
LLPLTKSPVE STTEPPAVRA SEERLSNGDI YLLENGLNLF LWVGASVQQG
1010 1020 1030 1040 1050
VVQSLFSVSS FSQITSGLSV LPVLDNPLSK KVRGLIDSLR AQRSRYMKLT
1060 1070 1080 1090
VVKQEDKMEM LFKHFLVEDK SLSGGASYVD FLCHMHKEIR QLLS
Length:1,094
Mass (Da):118,325
Last modified:September 1, 2009 - v3
Checksum:i5E308E4B8E596ECE
GO
Isoform 2 (identifier: P53992-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-752: Missing.

Note: No experimental confirmation available.
Show »
Length:342
Mass (Da):38,181
Checksum:i9FE10EE8578DBE79
GO

Sequence cautioni

The sequence BAA07558 differs from that shown. Reason: Frameshift at position 1041.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_058690109P → S1 PublicationCorresponds to variant dbSNP:rs17851695Ensembl.1
Natural variantiVAR_057174934L → P. Corresponds to variant dbSNP:rs16930872Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565161 – 752Missing in isoform 2. 1 PublicationAdd BLAST752

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38555 mRNA. Translation: BAA07558.2. Sequence problems.
AK303085 mRNA. Translation: BAG64196.1.
AC022400 Genomic DNA. No translation available.
BC018928 mRNA. Translation: AAH18928.1.
CCDSiCCDS7332.1. [P53992-1]
RefSeqiNP_004913.2. NM_004922.3. [P53992-1]
NP_940999.1. NM_198597.2. [P53992-1]
UniGeneiHs.81964.

Genome annotation databases

EnsembliENST00000339365; ENSP00000343405; ENSG00000176986. [P53992-1]
ENST00000345254; ENSP00000321845; ENSG00000176986. [P53992-1]
GeneIDi9632.
KEGGihsa:9632.
UCSCiuc001juw.4. human. [P53992-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSC24C_HUMAN
AccessioniPrimary (citable) accession number: P53992
Secondary accession number(s): B4DZT4, Q8WV25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 1, 2009
Last modified: November 22, 2017
This is version 172 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families