Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P53990

- IST1_HUMAN

UniProt

P53990 - IST1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

IST1 homolog

Gene

IST1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.2 Publications

GO - Molecular functioni

  1. MIT domain binding Source: UniProtKB
  2. protein complex binding Source: UniProtKB
  3. protein domain specific binding Source: UniProtKB

GO - Biological processi

  1. abscission Source: UniProtKB
  2. cell division Source: UniProtKB
  3. cytokinesis Source: UniProtKB
  4. establishment of protein localization Source: UniProt
  5. positive regulation of collateral sprouting Source: Ensembl
  6. positive regulation of proteolysis Source: UniProtKB
  7. protein localization Source: UniProtKB
  8. viral capsid secondary envelopment Source: UniProtKB
  9. viral release from host cell Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
IST1 homolog
Short name:
hIST1
Alternative name(s):
Putative MAPK-activating protein PM28
Gene namesi
Name:IST1
Synonyms:KIAA0174
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:28977. IST1.

Subcellular locationi

Cytoplasmic vesicle 2 Publications
Note: Localizes to the midbody of dividing cells.

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytoplasmic vesicle Source: UniProtKB-KW
  3. cytosol Source: UniProtKB
  4. endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB
  5. extracellular vesicular exosome Source: UniProtKB
  6. Flemming body Source: UniProtKB
  7. midbody Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi323 – 3231L → D: Diminishes interaction with VPS4A. 1 Publication
Mutagenesisi323 – 3231L → D: Greatly diminishes interaction with VPS4A; when associated with A-353. 1 Publication
Mutagenesisi326 – 3261L → D: Diminishes interaction with VPS4A. 1 Publication
Mutagenesisi326 – 3261L → D: Greatly diminishes interaction with VPS4A and abolishes interaction with VTA1; when associated with A-353. 1 Publication
Mutagenesisi326 – 3261L → D: Greatly diminishes interaction with VPS4A; when associated with A-360. 1 Publication
Mutagenesisi353 – 3531L → A: Diminishes interaction with VPS4A. 1 Publication
Mutagenesisi353 – 3531L → A: Greatly diminishes interaction with VPS4A and abolishes interaction with VTA1; when associated with D-326. 1 Publication
Mutagenesisi353 – 3531L → A: Greatly diminishes interaction with VPS4A; when associated with D-323. 1 Publication
Mutagenesisi360 – 3612LK → AA: Abolishes interaction with VTA1, MITD1 and USP8; diminishes interaction with VPS4A. 1 Publication
Mutagenesisi360 – 3601L → A: Diminishes interaction with VPS4A. 1 Publication
Mutagenesisi360 – 3601L → A: Greatly diminishes interaction with VPS4A; when associated with D-326. 1 Publication

Organism-specific databases

PharmGKBiPA142671633.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364IST1 homologPRO_0000050727Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei43 – 431Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53990.
PaxDbiP53990.
PRIDEiP53990.

PTM databases

PhosphoSiteiP53990.

Miscellaneous databases

PMAP-CutDBP53990.

Expressioni

Gene expression databases

BgeeiP53990.
CleanExiHS_KIAA0174.
ExpressionAtlasiP53990. baseline and differential.
GenevestigatoriP53990.

Organism-specific databases

HPAiHPA041802.
HPA054532.

Interactioni

Subunit structurei

Interacts with CHMP1A, CHMP1B, VPS4A and VTA1. Interacts with SPAST, STAMBP, and USP8. May interact with VPS37B. May associate with the ESCRT-I complex. Interacts with MITD1, in competition with VSP4.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ATXN1P542532EBI-945994,EBI-930964
CAPN7Q9Y6W36EBI-945994,EBI-1765641

Protein-protein interaction databases

BioGridi115141. 19 interactions.
DIPiDIP-42546N.
IntActiP53990. 6 interactions.
MINTiMINT-1461091.
STRINGi9606.ENSP00000330408.

Structurei

Secondary structure

1
364
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 4538Combined sources
Helixi49 – 8133Combined sources
Helixi83 – 875Combined sources
Helixi94 – 963Combined sources
Helixi97 – 11014Combined sources
Turni111 – 1133Combined sources
Helixi115 – 12814Combined sources
Helixi130 – 1378Combined sources
Turni138 – 1414Combined sources
Helixi146 – 1516Combined sources
Helixi159 – 17315Combined sources
Helixi181 – 1855Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FRRX-ray1.80A1-189[»]
3FRSX-ray2.61A5-189[»]
ProteinModelPortaliP53990.
SMRiP53990. Positions 2-187.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP53990.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 168168Interaction with CHMP1A and CHMP1BAdd
BLAST
Regioni64 – 279216Interaction with VPS37BAdd
BLAST
Regioni190 – 364175Interaction with VTA1Add
BLAST
Regioni348 – 36417Interaction with VPS4A, VTA1, MITD1 STAMBP and USP8Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi321 – 33212Type-2 MIT-interacting motifAdd
BLAST
Motifi351 – 36111MIT-interacting motifAdd
BLAST

Sequence similaritiesi

Belongs to the IST1 family.Curated

Phylogenomic databases

eggNOGiNOG273475.
GeneTreeiENSGT00390000007453.
HOGENOMiHOG000205346.
InParanoidiP53990.
OMAiPTYESID.
PhylomeDBiP53990.
TreeFamiTF314258.

Family and domain databases

InterProiIPR005061. DUF292_euk.
[Graphical view]
PfamiPF03398. Ist1. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P53990-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLGSGFKAER LRVNLRLVIN RLKLLEKKKT ELAQKARKEI ADYLAAGKDE
60 70 80 90 100
RARIRVEHII REDYLVEAME ILELYCDLLL ARFGLIQSMK ELDSGLAESV
110 120 130 140 150
STLIWAAPRL QSEVAELKIV ADQLCAKYSK EYGKLCRTNQ IGTVNDRLMH
160 170 180 190 200
KLSVEAPPKI LVERYLIEIA KNYNVPYEPD SVVMAEAPPG VETDLIDVGF
210 220 230 240 250
TDDVKKGGPG RGGSGGFTAP VGGPDGTVPM PMPMPMPSAN TPFSYPLPKG
260 270 280 290 300
PSDFNGLPMG TYQAFPNIHP PQIPATPPSY ESVDDINADK NISSAQIVGP
310 320 330 340 350
GPKPEASAKL PSRPADNYDN FVLPELPSVP DTLPTASAGA STSASEDIDF
360
DDLSRRFEEL KKKT
Length:364
Mass (Da):39,751
Last modified:October 1, 1996 - v1
Checksum:i0DD3C186A52A4380
GO
Isoform 2 (identifier: P53990-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     228-228: V → VPM
     252-282: Missing.

Note: No experimental confirmation available.

Show »
Length:335
Mass (Da):36,622
Checksum:i7D0714269380E835
GO
Isoform 5 (identifier: P53990-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVFKLKTKEEQHSM
     237-237: P → PMP

Show »
Length:379
Mass (Da):41,566
Checksum:i37E0FEF4BB93C054
GO
Isoform 4 (identifier: P53990-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     228-228: V → VPM

Show »
Length:366
Mass (Da):39,979
Checksum:iE25DE7D7A5693AF8
GO
Isoform 3 (identifier: P53990-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     228-228: V → VPM
     283-364: VDDINADKNI...RRFEELKKKT → MTLMLIRISL...LMIFPGGLKS

Note: No experimental confirmation available.

Show »
Length:360
Mass (Da):39,928
Checksum:i5D0DDB4113DAA2BC
GO
Isoform 6 (identifier: P53990-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-148: Missing.
     228-228: V → VPM

Note: No experimental confirmation available. Gene prediction based on EST data.

Show »
Length:218
Mass (Da):23,089
Checksum:iB0405956455B9777
GO

Sequence cautioni

The sequence BAA11491.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 148148Missing in isoform 6. CuratedVSP_055118Add
BLAST
Alternative sequencei1 – 11M → MVFKLKTKEEQHSM in isoform 5. 1 PublicationVSP_047075
Alternative sequencei228 – 2281V → VPM in isoform 2, isoform 3, isoform 4 and isoform 6. 2 PublicationsVSP_017118
Alternative sequencei237 – 2371P → PMP in isoform 5. 1 PublicationVSP_047076
Alternative sequencei252 – 28231Missing in isoform 2. 1 PublicationVSP_017119Add
BLAST
Alternative sequencei283 – 36482VDDIN…LKKKT → MTLMLIRISLLHRLLVLDPS QKPLQSFLPDLQITMTTLSY QSCHLCQTHYQLHLLVPAPQ HLKTLTLMIFPGGLKS in isoform 3. 1 PublicationVSP_017120Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB097052 mRNA. Translation: BAC77405.1.
D79996 mRNA. Translation: BAA11491.2. Different initiation.
AK057258 mRNA. Translation: BAG51894.1.
AK293022 mRNA. Translation: BAF85711.1.
AK293040 mRNA. Translation: BAF85729.1.
AC009127 Genomic DNA. No translation available.
AC010653 Genomic DNA. No translation available.
BC000116 mRNA. Translation: AAH00116.1.
BC000430 mRNA. Translation: AAH00430.1.
BC004359 mRNA. Translation: AAH04359.1.
BC103745 mRNA. Translation: AAI03746.1.
CCDSiCCDS10905.1. [P53990-3]
CCDS59271.1. [P53990-5]
CCDS59272.1. [P53990-4]
CCDS59273.1. [P53990-2]
CCDS59274.1. [P53990-6]
RefSeqiNP_001257904.1. NM_001270975.1. [P53990-4]
NP_001257905.1. NM_001270976.1. [P53990-5]
NP_001257906.1. NM_001270977.1. [P53990-2]
NP_001257907.1. NM_001270978.1. [P53990-6]
NP_055576.2. NM_014761.3. [P53990-3]
UniGeneiHs.232194.

Genome annotation databases

EnsembliENST00000329908; ENSP00000330408; ENSG00000182149. [P53990-3]
ENST00000378798; ENSP00000368075; ENSG00000182149. [P53990-2]
ENST00000378799; ENSP00000368076; ENSG00000182149. [P53990-4]
ENST00000535424; ENSP00000438399; ENSG00000182149. [P53990-5]
ENST00000538850; ENSP00000463711; ENSG00000182149. [P53990-6]
ENST00000541571; ENSP00000455860; ENSG00000182149. [P53990-4]
ENST00000544564; ENSP00000457844; ENSG00000182149. [P53990-4]
ENST00000606369; ENSP00000475853; ENSG00000182149. [P53990-6]
GeneIDi9798.
KEGGihsa:9798.
UCSCiuc002fbk.2. human. [P53990-3]
uc002fbl.2. human. [P53990-2]
uc002fbm.2. human. [P53990-4]
uc010cgh.2. human.

Polymorphism databases

DMDMi1723119.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB097052 mRNA. Translation: BAC77405.1 .
D79996 mRNA. Translation: BAA11491.2 . Different initiation.
AK057258 mRNA. Translation: BAG51894.1 .
AK293022 mRNA. Translation: BAF85711.1 .
AK293040 mRNA. Translation: BAF85729.1 .
AC009127 Genomic DNA. No translation available.
AC010653 Genomic DNA. No translation available.
BC000116 mRNA. Translation: AAH00116.1 .
BC000430 mRNA. Translation: AAH00430.1 .
BC004359 mRNA. Translation: AAH04359.1 .
BC103745 mRNA. Translation: AAI03746.1 .
CCDSi CCDS10905.1. [P53990-3 ]
CCDS59271.1. [P53990-5 ]
CCDS59272.1. [P53990-4 ]
CCDS59273.1. [P53990-2 ]
CCDS59274.1. [P53990-6 ]
RefSeqi NP_001257904.1. NM_001270975.1. [P53990-4 ]
NP_001257905.1. NM_001270976.1. [P53990-5 ]
NP_001257906.1. NM_001270977.1. [P53990-2 ]
NP_001257907.1. NM_001270978.1. [P53990-6 ]
NP_055576.2. NM_014761.3. [P53990-3 ]
UniGenei Hs.232194.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3FRR X-ray 1.80 A 1-189 [» ]
3FRS X-ray 2.61 A 5-189 [» ]
ProteinModelPortali P53990.
SMRi P53990. Positions 2-187.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115141. 19 interactions.
DIPi DIP-42546N.
IntActi P53990. 6 interactions.
MINTi MINT-1461091.
STRINGi 9606.ENSP00000330408.

PTM databases

PhosphoSitei P53990.

Polymorphism databases

DMDMi 1723119.

Proteomic databases

MaxQBi P53990.
PaxDbi P53990.
PRIDEi P53990.

Protocols and materials databases

DNASUi 9798.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329908 ; ENSP00000330408 ; ENSG00000182149 . [P53990-3 ]
ENST00000378798 ; ENSP00000368075 ; ENSG00000182149 . [P53990-2 ]
ENST00000378799 ; ENSP00000368076 ; ENSG00000182149 . [P53990-4 ]
ENST00000535424 ; ENSP00000438399 ; ENSG00000182149 . [P53990-5 ]
ENST00000538850 ; ENSP00000463711 ; ENSG00000182149 . [P53990-6 ]
ENST00000541571 ; ENSP00000455860 ; ENSG00000182149 . [P53990-4 ]
ENST00000544564 ; ENSP00000457844 ; ENSG00000182149 . [P53990-4 ]
ENST00000606369 ; ENSP00000475853 ; ENSG00000182149 . [P53990-6 ]
GeneIDi 9798.
KEGGi hsa:9798.
UCSCi uc002fbk.2. human. [P53990-3 ]
uc002fbl.2. human. [P53990-2 ]
uc002fbm.2. human. [P53990-4 ]
uc010cgh.2. human.

Organism-specific databases

CTDi 9798.
GeneCardsi GC16P071881.
HGNCi HGNC:28977. IST1.
HPAi HPA041802.
HPA054532.
neXtProti NX_P53990.
PharmGKBi PA142671633.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG273475.
GeneTreei ENSGT00390000007453.
HOGENOMi HOG000205346.
InParanoidi P53990.
OMAi PTYESID.
PhylomeDBi P53990.
TreeFami TF314258.

Miscellaneous databases

ChiTaRSi IST1. human.
EvolutionaryTracei P53990.
GenomeRNAii 9798.
NextBioi 35464749.
PMAP-CutDB P53990.
PROi P53990.

Gene expression databases

Bgeei P53990.
CleanExi HS_KIAA0174.
ExpressionAtlasi P53990. baseline and differential.
Genevestigatori P53990.

Family and domain databases

InterProi IPR005061. DUF292_euk.
[Graphical view ]
Pfami PF03398. Ist1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N.
    DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  2. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
    Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
    Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung fibroblast.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5).
    Tissue: Testis and Uterus.
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
    Tissue: Eye and Lung.
  6. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-43, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: FUNCTION IN CYTOKINESIS, SUBCELLULAR LOCATION, INTERACTION WITH CHMP1A; CHMP1B; VPS4A; VTA1; MITD1; STAMBP; SPAST AND USP8, MUTAGENESIS OF 360-LEU-LYS-361.
  8. "Biochemical analyses of human IST1 and its function in cytokinesis."
    Bajorek M., Morita E., Skalicky J.J., Morham S.G., Babst M., Sundquist W.I.
    Mol. Biol. Cell 20:1360-1373(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CYTOKINESIS, SUBCELLULAR LOCATION, INTERACTION WITH VPS37B; VTA1; CHMP1A; CHMP1B; VPS4A AND VPS4B, INTERACTION WITH THE ESCRT-1 COMPLEX, MUTAGENESIS OF LEU-323; LEU-326; LEU-353 AND LEU-360.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "MITD1 is recruited to midbodies by ESCRT-III and participates in cytokinesis."
    Lee S., Chang J., Renvoise B., Tipirneni A., Yang S., Blackstone C.
    Mol. Biol. Cell 23:4347-4361(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MITD1.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiIST1_HUMAN
AccessioniPrimary (citable) accession number: P53990
Secondary accession number(s): A8KAH5
, J3QLU7, Q3SYM4, Q9BQ81, Q9BWN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3