Monocarboxylate transporter 1 - Rattus norvegicus (Rat)

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P53987 (MOT1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 101. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Monocarboxylate transporter 1
Short name=MCT 1

Alternative name(s):
Solute carrier family 16 member 1

Gene names

Name:	Slc16a1
Synonyms:	Mct1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	494 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. [View classification]

Ontologies

Keywords
Biological process	Symport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrion Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	secondary active monocarboxylate transmembrane transporter activity Inferred from electronic annotation. Source: InterPro symporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 494

494

Monocarboxylate transporter 1

PRO_0000211384

Regions

Topological domain

1 – 15

Cytoplasmic Potential

Transmembrane

16 – 36

Helical; Potential

Topological domain

37 – 59

Extracellular Potential

Transmembrane

60 – 80

Helical; Potential

Topological domain

81 – 86

Cytoplasmic Potential

Transmembrane

87 – 107

Helical; Potential

Topological domain

108 – 111

Extracellular Potential

Transmembrane

112 – 132

Helical; Potential

Topological domain

133 – 143

Cytoplasmic Potential

Transmembrane

144 – 164

Helical; Potential

Topological domain

165 – 166

Extracellular Potential

Transmembrane

167 – 187

Helical; Potential

Topological domain

188 – 255

Cytoplasmic Potential

Transmembrane

256 – 276

Helical; Potential

Topological domain

277 – 291

Extracellular Potential

Transmembrane

292 – 312

Helical; Potential

Topological domain

313 – 321

Cytoplasmic Potential

Transmembrane

322 – 342

Helical; Potential

Topological domain

343 – 346

Extracellular Potential

Transmembrane

347 – 367

Helical; Potential

Topological domain

368 – 382

Cytoplasmic Potential

Transmembrane

383 – 403

Helical; Potential

Topological domain

404 – 415

Extracellular Potential

Transmembrane

416 – 436

Helical; Potential

Topological domain

437 – 494

Cytoplasmic Potential

Amino acid modifications

Modified residue

210

Phosphoserine Ref.5

Modified residue

213

Phosphoserine Ref.5

Modified residue

230

Phosphoserine By similarity

Modified residue

459

Phosphothreonine By similarity

Modified residue

460

Phosphoserine By similarity

Modified residue

461

Phosphothreonine By similarity

Modified residue

476

Phosphoserine By similarity

Modified residue

492

Phosphoserine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P53987 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: CF82F8794CDBF057
Show »

FASTA

494

53,238

        10         20         30         40         50         60 
MPPAIGGPVG YTPPDGGWGW AVVVGAFISI GFSYAFPKSI TVFFKEIEII FSATTSEVSW 

        70         80         90        100        110        120 
ISSIMLAVMY AGGPISSILV NKYGSRPVMI AGGCLSGCGL IAASFCNTVQ ELYFCIGVIG 

       130        140        150        160        170        180 
GLGLAFNLNP ALTMIGKYFY KKRPLANGLA MAGSPVFLST LAPLNQAFFG IFGWRGSFLI 

       190        200        210        220        230        240 
LGGLLLNCCV AGSLMRPIGP QQGKVEKLKS KESLQEAGKS DANTDLIGGS PKGEKLSVFQ 

       250        260        270        280        290        300 
TVNKFLDLSL FTHRGFLLYL SGNVVMFFGL FTPLVFLSNY GKSKHFSSEK SAFLLSILAF 

       310        320        330        340        350        360 
VDMVARPSMG LAANTRWIRP RVQYFFAASV VANGVCHLLA PLSTTYVGFC IYAGVFGFAF 

       370        380        390        400        410        420 
GWLSSVLFET LMDLVGPQRF SSAVGLVTIV ECCPVLLGPP LLGRLNDMYG DYKYTYWACG 

       430        440        450        460        470        480 
VILIIAGLYL FIGMGINYRL VAKEQKAEEK KRDGKEDETS TDVDEKPKKT MKETQSPAPL 

       490 
QNSSGDPAEE ESPV

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter." Takanaga H., Tamai I., Inaba S., Sai Y., Higashida H., Yamamoto H., Tsuji A. Biochem. Biophys. Res. Commun. 217:370-377(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Small intestine.
[2]	"cDNA cloning of MCT1, a monocarboxylate transporter from rat skeletal muscle." Jackson V.N., Price N.T., Halestrap A.P. Biochim. Biophys. Acta 1238:193-196(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Skeletal muscle.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[4]	"A monocarboxylate transporter MCT1 is located at the basolateral pole of rat jejunum." Orsenigo M.N., Tosco M., Bazzini C., Laforenza U., Faelli A. Exp. Physiol. 84:1033-1042(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 264-472. Tissue: Jejunal epithelium.
[5]	"Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS." Moser K., White F.M. J. Proteome Res. 5:98-104(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-210 AND SER-213, MASS SPECTROMETRY. Strain: Fischer. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D63834 mRNA. Translation: BAA09894.1. X86216 mRNA. Translation: CAA60116.1. BC078877 mRNA. Translation: AAH78877.1. AJ236865 mRNA. Translation: CAB37948.1.
IPI	IPI00214787.
PIR	JC4399.
RefSeq	NP_036848.1. NM_012716.2.
UniGene	Rn.6085.
3D structure databases
ProteinModelPortal	P53987.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000027234.
PTM databases
PhosphoSite	P53987.
Proteomic databases
PaxDb	P53987.
PRIDE	P53987.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000027234; ENSRNOP00000027234; ENSRNOG00000019996.
GeneID	25027.
KEGG	rno:25027.
UCSC	RGD:3690. rat.
Organism-specific databases
CTD	6566.
RGD	3690. Slc16a1.
Phylogenomic databases
eggNOG	COG0477.
GeneTree	ENSGT00670000097675.
HOGENOM	HOG000280688.
HOVERGEN	HBG006384.
InParanoid	P53987.
KO	K08179.
OMA	QYFFAIS.
OrthoDB	EOG41G341.
Enzyme and pathway databases
SABIO-RK	P53987.
Gene expression databases
Genevestigator	P53987.
GermOnline	ENSRNOG00000019996. Rattus norvegicus.
Family and domain databases
InterPro	IPR011701. MFS. IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR004743. Monocarb_transpt. [Graphical view]
Pfam	PF07690. MFS_1. 1 hit. [Graphical view]
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMs	TIGR00892. 2A0113. 1 hit.
PROSITE	PS50850. MFS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	605163.

Entry information

Entry name

MOT1_RAT

Accession

Primary (citable) accession number: P53987

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents