Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P53985

- MOT1_HUMAN

UniProt

P53985 - MOT1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Monocarboxylate transporter 1

Gene

SLC16A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.1 Publication

GO - Molecular functioni

  1. mevalonate transmembrane transporter activity Source: ProtInc
  2. monocarboxylic acid transmembrane transporter activity Source: ProtInc
  3. organic cyclic compound binding Source: Ensembl
  4. secondary active monocarboxylate transmembrane transporter activity Source: InterPro
  5. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. behavioral response to nutrient Source: Ensembl
  2. blood coagulation Source: Reactome
  3. cellular metabolic process Source: Reactome
  4. cellular response to organic cyclic compound Source: Ensembl
  5. centrosome organization Source: UniProtKB
  6. glucose homeostasis Source: Ensembl
  7. leukocyte migration Source: Reactome
  8. lipid metabolic process Source: Ensembl
  9. mevalonate transport Source: ProtInc
  10. monocarboxylic acid transport Source: ProtInc
  11. plasma membrane lactate transport Source: UniProtKB
  12. pyruvate metabolic process Source: Reactome
  13. regulation of insulin secretion Source: Ensembl
  14. response to food Source: Ensembl
  15. small molecule metabolic process Source: Reactome
  16. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000155380-MONOMER.
ReactomeiREACT_12560. Basigin interactions.
REACT_20515. Proton-coupled monocarboxylate transport.
REACT_2071. Pyruvate metabolism.
SABIO-RKP53985.

Protein family/group databases

TCDBi2.A.1.13.1. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 1
Short name:
MCT 1
Alternative name(s):
Solute carrier family 16 member 1
Gene namesi
Name:SLC16A1
Synonyms:MCT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:10922. SLC16A1.

Subcellular locationi

Cell membrane 3 Publications; Multi-pass membrane protein 3 Publications

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProt
  3. integral component of membrane Source: ProtInc
  4. integral component of plasma membrane Source: UniProtKB
  5. membrane Source: UniProtKB
  6. mitochondrion Source: Ensembl
  7. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Symptomatic deficiency in lactate transport (SDLT) [MIM:245340]: Deficiency of lactate transporter may result in an acidic intracellular environment created by muscle activity with consequent degeneration of muscle and release of myoglobin and creatine kinase. This defect might compromise extreme performance in otherwise healthy individuals.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti204 – 2041K → E in SDLT. 1 Publication
VAR_010434
Natural varianti472 – 4721G → R in SDLT. 1 Publication
Corresponds to variant rs72552271 [ dbSNP | Ensembl ].
VAR_010435
Familial hyperinsulinemic hypoglycemia 7 (HHF7) [MIM:610021]: Dominantly inherited hypoglycemic disorder characterized by inappropriate insulin secretion during anaerobic exercise or on pyruvate load.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi245340. phenotype.
610021. phenotype.
Orphaneti165991. Exercise-induced hyperinsulinism.
171690. Metabolic myopathy due to lactate transporter defect.
PharmGKBiPA35813.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Monocarboxylate transporter 1PRO_0000211381Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei210 – 2101PhosphoserineBy similarity
Modified residuei213 – 2131Phosphoserine3 Publications
Modified residuei231 – 2311PhosphothreonineBy similarity
Modified residuei461 – 4611Phosphoserine3 Publications
Modified residuei466 – 4661Phosphothreonine1 Publication
Modified residuei467 – 4671Phosphoserine1 Publication
Modified residuei483 – 4831Phosphoserine3 Publications
Modified residuei498 – 4981Phosphoserine5 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53985.
PaxDbiP53985.
PRIDEiP53985.

PTM databases

PhosphoSiteiP53985.

Miscellaneous databases

PMAP-CutDBP53985.

Expressioni

Tissue specificityi

Detected in heart and in blood lymphocytes and monocytes (at protein level). Widely expressed.1 Publication

Gene expression databases

BgeeiP53985.
CleanExiHS_SLC16A1.
ExpressionAtlasiP53985. baseline and differential.
GenevestigatoriP53985.

Organism-specific databases

HPAiCAB017489.
HPA003324.

Interactioni

Subunit structurei

Interacts with EMB. Interaction with either BSG or EMB is required for expression at the cell membrane (By similarity). Interacts with BSG; this is required for expression at the cell membrane.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AP1S1P619661EBI-1054708,EBI-516199
DEGS1O151211EBI-1054708,EBI-1052713
SERINC3Q135301EBI-1054708,EBI-1045571

Protein-protein interaction databases

BioGridi112454. 11 interactions.
IntActiP53985. 4 interactions.
MINTiMINT-5004345.
STRINGi9606.ENSP00000358640.

Structurei

3D structure databases

ProteinModelPortaliP53985.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini37 – 5923ExtracellularSequence AnalysisAdd
BLAST
Topological domaini81 – 866CytoplasmicSequence Analysis
Topological domaini108 – 1114ExtracellularSequence Analysis
Topological domaini133 – 14311CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini165 – 1662ExtracellularSequence Analysis
Topological domaini188 – 26275CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini284 – 29815ExtracellularSequence AnalysisAdd
BLAST
Topological domaini320 – 3289CytoplasmicSequence Analysis
Topological domaini350 – 3534ExtracellularSequence Analysis
Topological domaini375 – 38915CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini411 – 42212ExtracellularSequence AnalysisAdd
BLAST
Topological domaini444 – 50057CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence AnalysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence AnalysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence AnalysisAdd
BLAST
Transmembranei112 – 13221HelicalSequence AnalysisAdd
BLAST
Transmembranei144 – 16421HelicalSequence AnalysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence AnalysisAdd
BLAST
Transmembranei263 – 28321HelicalSequence AnalysisAdd
BLAST
Transmembranei299 – 31921HelicalSequence AnalysisAdd
BLAST
Transmembranei329 – 34921HelicalSequence AnalysisAdd
BLAST
Transmembranei354 – 37421HelicalSequence AnalysisAdd
BLAST
Transmembranei390 – 41021HelicalSequence AnalysisAdd
BLAST
Transmembranei423 – 44321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG314865.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiP53985.
KOiK08179.
OMAiQYFFAIS.
OrthoDBiEOG7W9RTN.
PhylomeDBiP53985.
TreeFamiTF313792.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004743. Monocarb_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P53985) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPAVGGPVG YTPPDGGWGW AVVIGAFISI GFSYAFPKSI TVFFKEIEGI
60 70 80 90 100
FHATTSEVSW ISSIMLAVMY GGGPISSILV NKYGSRIVMI VGGCLSGCGL
110 120 130 140 150
IAASFCNTVQ QLYVCIGVIG GLGLAFNLNP ALTMIGKYFY KRRPLANGLA
160 170 180 190 200
MAGSPVFLCT LAPLNQVFFG IFGWRGSFLI LGGLLLNCCV AGALMRPIGP
210 220 230 240 250
KPTKAGKDKS KASLEKAGKS GVKKDLHDAN TDLIGRHPKQ EKRSVFQTIN
260 270 280 290 300
QFLDLTLFTH RGFLLYLSGN VIMFFGLFAP LVFLSSYGKS QHYSSEKSAF
310 320 330 340 350
LLSILAFVDM VARPSMGLVA NTKPIRPRIQ YFFAASVVAN GVCHMLAPLS
360 370 380 390 400
TTYVGFCVYA GFFGFAFGWL SSVLFETLMD LVGPQRFSSA VGLVTIVECC
410 420 430 440 450
PVLLGPPLLG RLNDMYGDYK YTYWACGVVL IISGIYLFIG MGINYRLLAK
460 470 480 490 500
EQKANEQKKE SKEEETSIDV AGKPNEVTKA AESPDQKDTD GGPKEEESPV
Length:500
Mass (Da):53,944
Last modified:November 30, 2010 - v3
Checksum:i3F5B048CB962ECC8
GO
Isoform 2 (identifier: P53985-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     411-500: RLNDMYGDYK...GGPKEEESPV → IVYLPTNVGLLQNKHVRWEC

Note: No experimental confirmation available.

Show »
Length:430
Mass (Da):46,234
Checksum:i28C6B55692E6C4BE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti480 – 4801A → T in AAC41707. (PubMed:7835905)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851S → G.
Corresponds to variant rs11551867 [ dbSNP | Ensembl ].
VAR_054804
Natural varianti204 – 2041K → E in SDLT. 1 Publication
VAR_010434
Natural varianti472 – 4721G → R in SDLT. 1 Publication
Corresponds to variant rs72552271 [ dbSNP | Ensembl ].
VAR_010435
Natural varianti490 – 4901D → E.9 Publications
Corresponds to variant rs1049434 [ dbSNP | Ensembl ].
VAR_010436

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei411 – 50090RLNDM…EESPV → IVYLPTNVGLLQNKHVRWEC in isoform 2. 1 PublicationVSP_056191Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L31801 mRNA. Translation: AAC41707.1.
AJ438945 Genomic DNA. Translation: CAD27707.1.
AL162079 mRNA. Translation: CAB82412.1.
AL158844 Genomic DNA. Translation: CAI21872.1.
CH471122 Genomic DNA. Translation: EAW56552.1.
BC026317 mRNA. Translation: AAH26317.1.
BC045664 mRNA. Translation: AAH45664.1.
CCDSiCCDS858.1. [P53985-1]
PIRiA55568.
RefSeqiNP_001159968.1. NM_001166496.1.
NP_003042.3. NM_003051.3.
UniGeneiHs.75231.

Genome annotation databases

EnsembliENST00000369626; ENSP00000358640; ENSG00000155380. [P53985-1]
ENST00000538576; ENSP00000441065; ENSG00000155380. [P53985-1]
GeneIDi6566.
KEGGihsa:6566.
UCSCiuc001ecx.3. human. [P53985-1]

Polymorphism databases

DMDMi313104214.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L31801 mRNA. Translation: AAC41707.1 .
AJ438945 Genomic DNA. Translation: CAD27707.1 .
AL162079 mRNA. Translation: CAB82412.1 .
AL158844 Genomic DNA. Translation: CAI21872.1 .
CH471122 Genomic DNA. Translation: EAW56552.1 .
BC026317 mRNA. Translation: AAH26317.1 .
BC045664 mRNA. Translation: AAH45664.1 .
CCDSi CCDS858.1. [P53985-1 ]
PIRi A55568.
RefSeqi NP_001159968.1. NM_001166496.1.
NP_003042.3. NM_003051.3.
UniGenei Hs.75231.

3D structure databases

ProteinModelPortali P53985.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112454. 11 interactions.
IntActi P53985. 4 interactions.
MINTi MINT-5004345.
STRINGi 9606.ENSP00000358640.

Chemistry

BindingDBi P53985.
ChEMBLi CHEMBL4360.
DrugBanki DB03166. Acetic acid.
DB00345. Aminohippurate.
DB00415. Ampicillin.
DB00529. Foscarnet.
DB01440. Gamma Hydroxybutyric Acid.
DB00563. Methotrexate.
DB00731. Nateglinide.
DB00627. Niacin.
DB04552. Niflumic Acid.
DB00175. Pravastatin.
DB01032. Probenecid.
DB00119. Pyruvic acid.
DB00936. Salicylic acid.
DB00313. Valproic Acid.

Protein family/group databases

TCDBi 2.A.1.13.1. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei P53985.

Polymorphism databases

DMDMi 313104214.

Proteomic databases

MaxQBi P53985.
PaxDbi P53985.
PRIDEi P53985.

Protocols and materials databases

DNASUi 6566.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369626 ; ENSP00000358640 ; ENSG00000155380 . [P53985-1 ]
ENST00000538576 ; ENSP00000441065 ; ENSG00000155380 . [P53985-1 ]
GeneIDi 6566.
KEGGi hsa:6566.
UCSCi uc001ecx.3. human. [P53985-1 ]

Organism-specific databases

CTDi 6566.
GeneCardsi GC01M113454.
H-InvDB HIX0000897.
HGNCi HGNC:10922. SLC16A1.
HPAi CAB017489.
HPA003324.
MIMi 245340. phenotype.
600682. gene.
610021. phenotype.
neXtProti NX_P53985.
Orphaneti 165991. Exercise-induced hyperinsulinism.
171690. Metabolic myopathy due to lactate transporter defect.
PharmGKBi PA35813.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG314865.
GeneTreei ENSGT00760000118926.
HOGENOMi HOG000280688.
HOVERGENi HBG006384.
InParanoidi P53985.
KOi K08179.
OMAi QYFFAIS.
OrthoDBi EOG7W9RTN.
PhylomeDBi P53985.
TreeFami TF313792.

Enzyme and pathway databases

BioCyci MetaCyc:ENSG00000155380-MONOMER.
Reactomei REACT_12560. Basigin interactions.
REACT_20515. Proton-coupled monocarboxylate transport.
REACT_2071. Pyruvate metabolism.
SABIO-RK P53985.

Miscellaneous databases

ChiTaRSi SLC16A1. human.
GenomeRNAii 6566.
NextBioi 25547.
PMAP-CutDB P53985.
PROi P53985.
SOURCEi Search...

Gene expression databases

Bgeei P53985.
CleanExi HS_SLC16A1.
ExpressionAtlasi P53985. baseline and differential.
Genevestigatori P53985.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004743. Monocarb_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 2 hits.
TIGRFAMsi TIGR00892. 2A0113. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12."
    Garcia C.K., Li X., Luna J., Francke U.
    Genomics 23:500-503(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLU-490.
    Tissue: Heart.
  2. "The human monocarboxylate transporter, MCT1: genomic organization and promoter analysis."
    Cuff M.A., Shirazi-Beechey S.P.
    Biochem. Biophys. Res. Commun. 292:1048-1056(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Colon.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLU-490.
    Tissue: Melanoma.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Testis.
  7. "Presence and localization of three lactic acid transporters (MCT1, -2, and -4) in separated human granulocytes, lymphocytes, and monocytes."
    Merezhinskaya N., Ogunwuyi S.A., Mullick F.G., Fishbein W.N.
    J. Histochem. Cytochem. 52:1483-1493(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213 AND SER-498, VARIANT [LARGE SCALE ANALYSIS] GLU-490, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity."
    Manoharan C., Wilson M.C., Sessions R.B., Halestrap A.P.
    Mol. Membr. Biol. 23:486-498(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BSG, SUBCELLULAR LOCATION.
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-461 AND SER-498, VARIANT [LARGE SCALE ANALYSIS] GLU-490, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-461; SER-467; SER-483 AND SER-498, VARIANT [LARGE SCALE ANALYSIS] GLU-490, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-461, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213; SER-483 AND SER-498, VARIANT [LARGE SCALE ANALYSIS] GLU-490, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213; THR-466; SER-483 AND SER-498, VARIANT [LARGE SCALE ANALYSIS] GLU-490, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "The monocarboxylate transporter family--role and regulation."
    Halestrap A.P., Wilson M.C.
    IUBMB Life 64:109-119(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  17. "Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico."
    The SIGMA Type 2 Diabetes Consortium
    Nature 506:97-101(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  18. "Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport."
    Merezhinskaya N., Fishbein W.N., Davis J.I., Foellmer J.W.
    Muscle Nerve 23:90-97(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS SDLT GLU-204 AND ARG-472, VARIANT GLU-490.
  19. "Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells."
    Otonkoski T., Jiao H., Kaminen-Ahola N., Tapia-Paez I., Ullah M.S., Parton L.E., Schuit F., Quintens R., Sipilae I., Mayatepek E., Meissner T., Halestrap A.P., Rutter G.A., Kere J.
    Am. J. Hum. Genet. 81:467-474(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN HHF7, FUNCTION.
  20. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-490, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMOT1_HUMAN
AccessioniPrimary (citable) accession number: P53985
Secondary accession number(s): Q49A45, Q5T8R6, Q9NSJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Overexpression in pancreatic beta-cells triggers insulin secretion in response to pyruvate, causing hyperinsulemia and hypoglycemia during strenuous exercise.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3