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P53985

- MOT1_HUMAN

UniProt

P53985 - MOT1_HUMAN

Protein

Monocarboxylate transporter 1

Gene

SLC16A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 3 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.1 Publication

    GO - Molecular functioni

    1. mevalonate transmembrane transporter activity Source: ProtInc
    2. monocarboxylic acid transmembrane transporter activity Source: ProtInc
    3. organic cyclic compound binding Source: Ensembl
    4. secondary active monocarboxylate transmembrane transporter activity Source: InterPro
    5. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. cellular metabolic process Source: Reactome
    3. cellular response to organic cyclic compound Source: Ensembl
    4. centrosome organization Source: UniProtKB
    5. leukocyte migration Source: Reactome
    6. mevalonate transport Source: ProtInc
    7. monocarboxylic acid transport Source: ProtInc
    8. plasma membrane lactate transport Source: UniProtKB
    9. pyruvate metabolic process Source: Reactome
    10. small molecule metabolic process Source: Reactome
    11. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Symport, Transport

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000155380-MONOMER.
    ReactomeiREACT_12560. Basigin interactions.
    REACT_20515. Proton-coupled monocarboxylate transport.
    REACT_2071. Pyruvate metabolism.
    SABIO-RKP53985.

    Protein family/group databases

    TCDBi2.A.1.13.1. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Monocarboxylate transporter 1
    Short name:
    MCT 1
    Alternative name(s):
    Solute carrier family 16 member 1
    Gene namesi
    Name:SLC16A1
    Synonyms:MCT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:10922. SLC16A1.

    Subcellular locationi

    Cell membrane 3 Publications; Multi-pass membrane protein 3 Publications

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of membrane Source: ProtInc
    4. integral component of plasma membrane Source: UniProtKB
    5. membrane Source: UniProtKB
    6. mitochondrion Source: Ensembl
    7. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Symptomatic deficiency in lactate transport (SDLT) [MIM:245340]: Deficiency of lactate transporter may result in an acidic intracellular environment created by muscle activity with consequent degeneration of muscle and release of myoglobin and creatine kinase. This defect might compromise extreme performance in otherwise healthy individuals.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti204 – 2041K → E in SDLT. 1 Publication
    VAR_010434
    Natural varianti472 – 4721G → R in SDLT. 1 Publication
    Corresponds to variant rs72552271 [ dbSNP | Ensembl ].
    VAR_010435
    Familial hyperinsulinemic hypoglycemia 7 (HHF7) [MIM:610021]: Dominantly inherited hypoglycemic disorder characterized by inappropriate insulin secretion during anaerobic exercise or on pyruvate load.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi245340. phenotype.
    610021. phenotype.
    Orphaneti165991. Exercise-induced hyperinsulinism.
    171690. Metabolic myopathy due to lactate transporter defect.
    PharmGKBiPA35813.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Monocarboxylate transporter 1PRO_0000211381Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei210 – 2101PhosphoserineBy similarity
    Modified residuei213 – 2131Phosphoserine3 Publications
    Modified residuei231 – 2311PhosphothreonineBy similarity
    Modified residuei461 – 4611Phosphoserine3 Publications
    Modified residuei466 – 4661Phosphothreonine1 Publication
    Modified residuei467 – 4671Phosphoserine1 Publication
    Modified residuei483 – 4831Phosphoserine3 Publications
    Modified residuei498 – 4981Phosphoserine5 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP53985.
    PaxDbiP53985.
    PRIDEiP53985.

    PTM databases

    PhosphoSiteiP53985.

    Miscellaneous databases

    PMAP-CutDBP53985.

    Expressioni

    Tissue specificityi

    Detected in heart and in blood lymphocytes and monocytes (at protein level). Widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiP53985.
    BgeeiP53985.
    CleanExiHS_SLC16A1.
    GenevestigatoriP53985.

    Organism-specific databases

    HPAiCAB017489.
    HPA003324.

    Interactioni

    Subunit structurei

    Interacts with EMB. Interaction with either BSG or EMB is required for expression at the cell membrane By similarity. Interacts with BSG; this is required for expression at the cell membrane.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AP1S1P619661EBI-1054708,EBI-516199
    DEGS1O151211EBI-1054708,EBI-1052713
    SERINC3Q135301EBI-1054708,EBI-1045571

    Protein-protein interaction databases

    BioGridi112454. 11 interactions.
    IntActiP53985. 4 interactions.
    MINTiMINT-5004345.
    STRINGi9606.ENSP00000358640.

    Structurei

    3D structure databases

    ProteinModelPortaliP53985.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1515CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini37 – 5923ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini81 – 866CytoplasmicSequence Analysis
    Topological domaini108 – 1114ExtracellularSequence Analysis
    Topological domaini133 – 14311CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini165 – 1662ExtracellularSequence Analysis
    Topological domaini188 – 26275CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini284 – 29815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini320 – 3289CytoplasmicSequence Analysis
    Topological domaini350 – 3534ExtracellularSequence Analysis
    Topological domaini375 – 38915CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini411 – 42212ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini444 – 50057CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei112 – 13221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei144 – 16421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei167 – 18721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei299 – 31921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei329 – 34921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei354 – 37421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei390 – 41021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei423 – 44321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG314865.
    HOGENOMiHOG000280688.
    HOVERGENiHBG006384.
    InParanoidiP53985.
    KOiK08179.
    OMAiQYFFAIS.
    OrthoDBiEOG7W9RTN.
    PhylomeDBiP53985.
    TreeFamiTF313792.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004743. Monocarb_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 2 hits.
    TIGRFAMsiTIGR00892. 2A0113. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P53985-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPPAVGGPVG YTPPDGGWGW AVVIGAFISI GFSYAFPKSI TVFFKEIEGI    50
    FHATTSEVSW ISSIMLAVMY GGGPISSILV NKYGSRIVMI VGGCLSGCGL 100
    IAASFCNTVQ QLYVCIGVIG GLGLAFNLNP ALTMIGKYFY KRRPLANGLA 150
    MAGSPVFLCT LAPLNQVFFG IFGWRGSFLI LGGLLLNCCV AGALMRPIGP 200
    KPTKAGKDKS KASLEKAGKS GVKKDLHDAN TDLIGRHPKQ EKRSVFQTIN 250
    QFLDLTLFTH RGFLLYLSGN VIMFFGLFAP LVFLSSYGKS QHYSSEKSAF 300
    LLSILAFVDM VARPSMGLVA NTKPIRPRIQ YFFAASVVAN GVCHMLAPLS 350
    TTYVGFCVYA GFFGFAFGWL SSVLFETLMD LVGPQRFSSA VGLVTIVECC 400
    PVLLGPPLLG RLNDMYGDYK YTYWACGVVL IISGIYLFIG MGINYRLLAK 450
    EQKANEQKKE SKEEETSIDV AGKPNEVTKA AESPDQKDTD GGPKEEESPV 500
    Length:500
    Mass (Da):53,944
    Last modified:November 30, 2010 - v3
    Checksum:i3F5B048CB962ECC8
    GO
    Isoform 2 (identifier: P53985-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         411-500: RLNDMYGDYK...GGPKEEESPV → IVYLPTNVGLLQNKHVRWEC

    Note: No experimental confirmation available.

    Show »
    Length:430
    Mass (Da):46,234
    Checksum:i28C6B55692E6C4BE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti480 – 4801A → T in AAC41707. (PubMed:7835905)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti85 – 851S → G.
    Corresponds to variant rs11551867 [ dbSNP | Ensembl ].
    VAR_054804
    Natural varianti204 – 2041K → E in SDLT. 1 Publication
    VAR_010434
    Natural varianti472 – 4721G → R in SDLT. 1 Publication
    Corresponds to variant rs72552271 [ dbSNP | Ensembl ].
    VAR_010435
    Natural varianti490 – 4901D → E.9 Publications
    Corresponds to variant rs1049434 [ dbSNP | Ensembl ].
    VAR_010436

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei411 – 50090RLNDM…EESPV → IVYLPTNVGLLQNKHVRWEC in isoform 2. 1 PublicationVSP_056191Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L31801 mRNA. Translation: AAC41707.1.
    AJ438945 Genomic DNA. Translation: CAD27707.1.
    AL162079 mRNA. Translation: CAB82412.1.
    AL158844 Genomic DNA. Translation: CAI21872.1.
    CH471122 Genomic DNA. Translation: EAW56552.1.
    BC026317 mRNA. Translation: AAH26317.1.
    BC045664 mRNA. Translation: AAH45664.1.
    CCDSiCCDS858.1.
    PIRiA55568.
    RefSeqiNP_001159968.1. NM_001166496.1.
    NP_003042.3. NM_003051.3.
    UniGeneiHs.75231.

    Genome annotation databases

    EnsembliENST00000369626; ENSP00000358640; ENSG00000155380.
    ENST00000433570; ENSP00000445061; ENSG00000155380.
    ENST00000538576; ENSP00000441065; ENSG00000155380.
    GeneIDi6566.
    KEGGihsa:6566.
    UCSCiuc001ecx.3. human.

    Polymorphism databases

    DMDMi313104214.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L31801 mRNA. Translation: AAC41707.1 .
    AJ438945 Genomic DNA. Translation: CAD27707.1 .
    AL162079 mRNA. Translation: CAB82412.1 .
    AL158844 Genomic DNA. Translation: CAI21872.1 .
    CH471122 Genomic DNA. Translation: EAW56552.1 .
    BC026317 mRNA. Translation: AAH26317.1 .
    BC045664 mRNA. Translation: AAH45664.1 .
    CCDSi CCDS858.1.
    PIRi A55568.
    RefSeqi NP_001159968.1. NM_001166496.1.
    NP_003042.3. NM_003051.3.
    UniGenei Hs.75231.

    3D structure databases

    ProteinModelPortali P53985.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112454. 11 interactions.
    IntActi P53985. 4 interactions.
    MINTi MINT-5004345.
    STRINGi 9606.ENSP00000358640.

    Chemistry

    BindingDBi P53985.
    ChEMBLi CHEMBL4360.
    DrugBanki DB00119. Pyruvic acid.

    Protein family/group databases

    TCDBi 2.A.1.13.1. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei P53985.

    Polymorphism databases

    DMDMi 313104214.

    Proteomic databases

    MaxQBi P53985.
    PaxDbi P53985.
    PRIDEi P53985.

    Protocols and materials databases

    DNASUi 6566.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369626 ; ENSP00000358640 ; ENSG00000155380 .
    ENST00000433570 ; ENSP00000445061 ; ENSG00000155380 .
    ENST00000538576 ; ENSP00000441065 ; ENSG00000155380 .
    GeneIDi 6566.
    KEGGi hsa:6566.
    UCSCi uc001ecx.3. human.

    Organism-specific databases

    CTDi 6566.
    GeneCardsi GC01M113454.
    H-InvDB HIX0000897.
    HGNCi HGNC:10922. SLC16A1.
    HPAi CAB017489.
    HPA003324.
    MIMi 245340. phenotype.
    600682. gene.
    610021. phenotype.
    neXtProti NX_P53985.
    Orphaneti 165991. Exercise-induced hyperinsulinism.
    171690. Metabolic myopathy due to lactate transporter defect.
    PharmGKBi PA35813.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG314865.
    HOGENOMi HOG000280688.
    HOVERGENi HBG006384.
    InParanoidi P53985.
    KOi K08179.
    OMAi QYFFAIS.
    OrthoDBi EOG7W9RTN.
    PhylomeDBi P53985.
    TreeFami TF313792.

    Enzyme and pathway databases

    BioCyci MetaCyc:ENSG00000155380-MONOMER.
    Reactomei REACT_12560. Basigin interactions.
    REACT_20515. Proton-coupled monocarboxylate transport.
    REACT_2071. Pyruvate metabolism.
    SABIO-RK P53985.

    Miscellaneous databases

    ChiTaRSi SLC16A1. human.
    GenomeRNAii 6566.
    NextBioi 25547.
    PMAP-CutDB P53985.
    PROi P53985.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P53985.
    Bgeei P53985.
    CleanExi HS_SLC16A1.
    Genevestigatori P53985.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004743. Monocarb_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 2 hits.
    TIGRFAMsi TIGR00892. 2A0113. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12."
      Garcia C.K., Li X., Luna J., Francke U.
      Genomics 23:500-503(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLU-490.
      Tissue: Heart.
    2. "The human monocarboxylate transporter, MCT1: genomic organization and promoter analysis."
      Cuff M.A., Shirazi-Beechey S.P.
      Biochem. Biophys. Res. Commun. 292:1048-1056(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Colon.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLU-490.
      Tissue: Melanoma.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Testis.
    7. "Presence and localization of three lactic acid transporters (MCT1, -2, and -4) in separated human granulocytes, lymphocytes, and monocytes."
      Merezhinskaya N., Ogunwuyi S.A., Mullick F.G., Fishbein W.N.
      J. Histochem. Cytochem. 52:1483-1493(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213 AND SER-498, VARIANT [LARGE SCALE ANALYSIS] GLU-490, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity."
      Manoharan C., Wilson M.C., Sessions R.B., Halestrap A.P.
      Mol. Membr. Biol. 23:486-498(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BSG, SUBCELLULAR LOCATION.
    10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-461 AND SER-498, VARIANT [LARGE SCALE ANALYSIS] GLU-490, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-461; SER-467; SER-483 AND SER-498, VARIANT [LARGE SCALE ANALYSIS] GLU-490, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-461, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213; SER-483 AND SER-498, VARIANT [LARGE SCALE ANALYSIS] GLU-490, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213; THR-466; SER-483 AND SER-498, VARIANT [LARGE SCALE ANALYSIS] GLU-490, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "The monocarboxylate transporter family--role and regulation."
      Halestrap A.P., Wilson M.C.
      IUBMB Life 64:109-119(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    17. "Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico."
      The SIGMA Type 2 Diabetes Consortium
      Nature 506:97-101(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    18. "Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport."
      Merezhinskaya N., Fishbein W.N., Davis J.I., Foellmer J.W.
      Muscle Nerve 23:90-97(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS SDLT GLU-204 AND ARG-472, VARIANT GLU-490.
    19. "Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells."
      Otonkoski T., Jiao H., Kaminen-Ahola N., Tapia-Paez I., Ullah M.S., Parton L.E., Schuit F., Quintens R., Sipilae I., Mayatepek E., Meissner T., Halestrap A.P., Rutter G.A., Kere J.
      Am. J. Hum. Genet. 81:467-474(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN HHF7, FUNCTION.
    20. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-490, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMOT1_HUMAN
    AccessioniPrimary (citable) accession number: P53985
    Secondary accession number(s): Q49A45, Q5T8R6, Q9NSJ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 145 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Overexpression in pancreatic beta-cells triggers insulin secretion in response to pyruvate, causing hyperinsulemia and hypoglycemia during strenuous exercise.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3