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P53985 (MOT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 143. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Monocarboxylate transporter 1

Short name=MCT 1
Alternative name(s):
Solute carrier family 16 member 1
Gene names
Name:SLC16A1
Synonyms:MCT1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. Ref.19

Subunit structure

Interacts with EMB. Interaction with either BSG or EMB is required for expression at the cell membrane By similarity. Interacts with BSG; this is required for expression at the cell membrane. Ref.9

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.7 Ref.9 Ref.17.

Tissue specificity

Detected in heart and in blood lymphocytes and monocytes (at protein level). Widely expressed. Ref.7

Involvement in disease

Symptomatic deficiency in lactate transport (SDLT) [MIM:245340]: Deficiency of lactate transporter may result in an acidic intracellular environment created by muscle activity with consequent degeneration of muscle and release of myoglobin and creatine kinase. This defect might compromise extreme performance in otherwise healthy individuals.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.18

Familial hyperinsulinemic hypoglycemia 7 (HHF7) [MIM:610021]: Dominantly inherited hypoglycemic disorder characterized by inappropriate insulin secretion during anaerobic exercise or on pyruvate load.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.19

Miscellaneous

Overexpression in pancreatic beta-cells triggers insulin secretion in response to pyruvate, causing hyperinsulemia and hypoglycemia during strenuous exercise.

Sequence similarities

Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. [View classification]

Ontologies

Keywords
   Biological processSymport
Transport
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DiseaseDisease mutation
   DomainTransmembrane
Transmembrane helix
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processblood coagulation

Traceable author statement. Source: Reactome

cellular metabolic process

Traceable author statement. Source: Reactome

cellular response to organic cyclic compound

Inferred from electronic annotation. Source: Ensembl

centrosome organization

Inferred from mutant phenotype PubMed 23816619. Source: UniProtKB

leukocyte migration

Traceable author statement. Source: Reactome

mevalonate transport

Traceable author statement PubMed 1429658. Source: ProtInc

monocarboxylic acid transport

Traceable author statement PubMed 8124722. Source: ProtInc

plasma membrane lactate transport

Inferred from sequence or structural similarity. Source: UniProtKB

pyruvate metabolic process

Traceable author statement. Source: Reactome

small molecule metabolic process

Traceable author statement. Source: Reactome

transmembrane transport

Traceable author statement. Source: Reactome

   Cellular_componentcentrosome

Inferred from direct assay PubMed 23816619. Source: UniProtKB

extracellular vesicular exosome

Inferred from direct assay PubMed 20458337. Source: UniProt

integral component of membrane

Traceable author statement PubMed 1429658. Source: ProtInc

integral component of plasma membrane

Inferred from direct assay Ref.7. Source: UniProtKB

membrane

Traceable author statement PubMed 8124722. Source: ProtInc

mitochondrion

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from direct assay Ref.17. Source: UniProtKB

   Molecular_functionmevalonate transmembrane transporter activity

Traceable author statement PubMed 1429658. Source: ProtInc

monocarboxylic acid transmembrane transporter activity

Traceable author statement PubMed 8124722. Source: ProtInc

organic cyclic compound binding

Inferred from electronic annotation. Source: Ensembl

secondary active monocarboxylate transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

symporter activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Monocarboxylate transporter 1
PRO_0000211381

Regions

Topological domain1 – 1515Cytoplasmic Potential
Transmembrane16 – 3621Helical; Potential
Topological domain37 – 5923Extracellular Potential
Transmembrane60 – 8021Helical; Potential
Topological domain81 – 866Cytoplasmic Potential
Transmembrane87 – 10721Helical; Potential
Topological domain108 – 1114Extracellular Potential
Transmembrane112 – 13221Helical; Potential
Topological domain133 – 14311Cytoplasmic Potential
Transmembrane144 – 16421Helical; Potential
Topological domain165 – 1662Extracellular Potential
Transmembrane167 – 18721Helical; Potential
Topological domain188 – 26275Cytoplasmic Potential
Transmembrane263 – 28321Helical; Potential
Topological domain284 – 29815Extracellular Potential
Transmembrane299 – 31921Helical; Potential
Topological domain320 – 3289Cytoplasmic Potential
Transmembrane329 – 34921Helical; Potential
Topological domain350 – 3534Extracellular Potential
Transmembrane354 – 37421Helical; Potential
Topological domain375 – 38915Cytoplasmic Potential
Transmembrane390 – 41021Helical; Potential
Topological domain411 – 42212Extracellular Potential
Transmembrane423 – 44321Helical; Potential
Topological domain444 – 50057Cytoplasmic Potential

Amino acid modifications

Modified residue2101Phosphoserine By similarity
Modified residue2131Phosphoserine Ref.8 Ref.14 Ref.15
Modified residue2311Phosphothreonine By similarity
Modified residue4611Phosphoserine Ref.10 Ref.11 Ref.13
Modified residue4661Phosphothreonine Ref.15
Modified residue4671Phosphoserine Ref.11
Modified residue4831Phosphoserine Ref.11 Ref.14 Ref.15
Modified residue4981Phosphoserine Ref.8 Ref.10 Ref.11 Ref.14 Ref.15

Natural variations

Natural variant851S → G.
Corresponds to variant rs11551867 [ dbSNP | Ensembl ].
VAR_054804
Natural variant2041K → E in SDLT. Ref.18
VAR_010434
Natural variant4721G → R in SDLT. Ref.18
Corresponds to variant rs72552271 [ dbSNP | Ensembl ].
VAR_010435
Natural variant4901D → E. Ref.1 Ref.3 Ref.8 Ref.10 Ref.11 Ref.14 Ref.15 Ref.18 Ref.20
Corresponds to variant rs1049434 [ dbSNP | Ensembl ].
VAR_010436

Experimental info

Sequence conflict4801A → T in AAC41707. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P53985 [UniParc].

Last modified November 30, 2010. Version 3.
Checksum: 3F5B048CB962ECC8

FASTA50053,944
        10         20         30         40         50         60 
MPPAVGGPVG YTPPDGGWGW AVVIGAFISI GFSYAFPKSI TVFFKEIEGI FHATTSEVSW 

        70         80         90        100        110        120 
ISSIMLAVMY GGGPISSILV NKYGSRIVMI VGGCLSGCGL IAASFCNTVQ QLYVCIGVIG 

       130        140        150        160        170        180 
GLGLAFNLNP ALTMIGKYFY KRRPLANGLA MAGSPVFLCT LAPLNQVFFG IFGWRGSFLI 

       190        200        210        220        230        240 
LGGLLLNCCV AGALMRPIGP KPTKAGKDKS KASLEKAGKS GVKKDLHDAN TDLIGRHPKQ 

       250        260        270        280        290        300 
EKRSVFQTIN QFLDLTLFTH RGFLLYLSGN VIMFFGLFAP LVFLSSYGKS QHYSSEKSAF 

       310        320        330        340        350        360 
LLSILAFVDM VARPSMGLVA NTKPIRPRIQ YFFAASVVAN GVCHMLAPLS TTYVGFCVYA 

       370        380        390        400        410        420 
GFFGFAFGWL SSVLFETLMD LVGPQRFSSA VGLVTIVECC PVLLGPPLLG RLNDMYGDYK 

       430        440        450        460        470        480 
YTYWACGVVL IISGIYLFIG MGINYRLLAK EQKANEQKKE SKEEETSIDV AGKPNEVTKA 

       490        500 
AESPDQKDTD GGPKEEESPV 

« Hide

References

« Hide 'large scale' references
[1]"cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12."
Garcia C.K., Li X., Luna J., Francke U.
Genomics 23:500-503(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-490.
Tissue: Heart.
[2]"The human monocarboxylate transporter, MCT1: genomic organization and promoter analysis."
Cuff M.A., Shirazi-Beechey S.P.
Biochem. Biophys. Res. Commun. 292:1048-1056(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Colon.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-490.
Tissue: Melanoma.
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[7]"Presence and localization of three lactic acid transporters (MCT1, -2, and -4) in separated human granulocytes, lymphocytes, and monocytes."
Merezhinskaya N., Ogunwuyi S.A., Mullick F.G., Fishbein W.N.
J. Histochem. Cytochem. 52:1483-1493(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[8]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213 AND SER-498, VARIANT [LARGE SCALE ANALYSIS] GLU-490, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity."
Manoharan C., Wilson M.C., Sessions R.B., Halestrap A.P.
Mol. Membr. Biol. 23:486-498(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH BSG, SUBCELLULAR LOCATION.
[10]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-461 AND SER-498, VARIANT [LARGE SCALE ANALYSIS] GLU-490, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-461; SER-467; SER-483 AND SER-498, VARIANT [LARGE SCALE ANALYSIS] GLU-490, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-461, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213; SER-483 AND SER-498, VARIANT [LARGE SCALE ANALYSIS] GLU-490, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[15]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213; THR-466; SER-483 AND SER-498, VARIANT [LARGE SCALE ANALYSIS] GLU-490, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[16]"The monocarboxylate transporter family--role and regulation."
Halestrap A.P., Wilson M.C.
IUBMB Life 64:109-119(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[17]"Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico."
The SIGMA Type 2 Diabetes Consortium
Nature 506:97-101(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[18]"Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport."
Merezhinskaya N., Fishbein W.N., Davis J.I., Foellmer J.W.
Muscle Nerve 23:90-97(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS SDLT GLU-204 AND ARG-472, VARIANT GLU-490.
[19]"Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells."
Otonkoski T., Jiao H., Kaminen-Ahola N., Tapia-Paez I., Ullah M.S., Parton L.E., Schuit F., Quintens R., Sipilae I., Mayatepek E., Meissner T., Halestrap A.P., Rutter G.A., Kere J.
Am. J. Hum. Genet. 81:467-474(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN HHF7, FUNCTION.
[20]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-490, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L31801 mRNA. Translation: AAC41707.1.
AJ438945 Genomic DNA. Translation: CAD27707.1.
AL162079 mRNA. Translation: CAB82412.1.
AL158844 Genomic DNA. Translation: CAI21872.1.
CH471122 Genomic DNA. Translation: EAW56552.1.
BC026317 mRNA. Translation: AAH26317.1.
CCDSCCDS858.1.
PIRA55568.
RefSeqNP_001159968.1. NM_001166496.1.
NP_003042.3. NM_003051.3.
UniGeneHs.75231.

3D structure databases

ProteinModelPortalP53985.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112454. 13 interactions.
IntActP53985. 4 interactions.
MINTMINT-5004345.
STRING9606.ENSP00000358640.

Chemistry

BindingDBP53985.
ChEMBLCHEMBL4360.
DrugBankDB00119. Pyruvic acid.

Protein family/group databases

TCDB2.A.1.13.1. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteP53985.

Polymorphism databases

DMDM313104214.

Proteomic databases

MaxQBP53985.
PaxDbP53985.
PRIDEP53985.

Protocols and materials databases

DNASU6566.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000369626; ENSP00000358640; ENSG00000155380.
ENST00000538576; ENSP00000441065; ENSG00000155380.
GeneID6566.
KEGGhsa:6566.
UCSCuc001ecx.3. human.

Organism-specific databases

CTD6566.
GeneCardsGC01M113454.
H-InvDBHIX0000897.
HGNCHGNC:10922. SLC16A1.
HPACAB017489.
HPA003324.
MIM245340. phenotype.
600682. gene.
610021. phenotype.
neXtProtNX_P53985.
Orphanet165991. Exercise-induced hyperinsulinism.
171690. Metabolic myopathy due to lactate transporter defect.
PharmGKBPA35813.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG314865.
HOGENOMHOG000280688.
HOVERGENHBG006384.
InParanoidP53985.
KOK08179.
OMAQYFFAIS.
OrthoDBEOG7W9RTN.
PhylomeDBP53985.
TreeFamTF313792.

Enzyme and pathway databases

BioCycMetaCyc:ENSG00000155380-MONOMER.
ReactomeREACT_111217. Metabolism.
REACT_15518. Transmembrane transport of small molecules.
REACT_20633. Bile salt and organic anion SLC transporters.
REACT_604. Hemostasis.
SABIO-RKP53985.

Gene expression databases

ArrayExpressP53985.
BgeeP53985.
CleanExHS_SLC16A1.
GenevestigatorP53985.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004743. Monocarb_transpt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 2 hits.
TIGRFAMsTIGR00892. 2A0113. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC16A1. human.
GenomeRNAi6566.
NextBio25547.
PMAP-CutDBP53985.
PROP53985.
SOURCESearch...

Entry information

Entry nameMOT1_HUMAN
AccessionPrimary (citable) accession number: P53985
Secondary accession number(s): Q5T8R6, Q9NSJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM