UniProtKB - P53982 (IDHH_YEAST)
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Protein
Isocitrate dehydrogenase [NADP]
Gene
IDP3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
May function in the production of NADPH for fatty acid and sterol synthesis.
Catalytic activityi
Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 77 | SubstrateBy similarity | 1 | |
Binding sitei | 82 | NADPBy similarity | 1 | |
Binding sitei | 109 | SubstrateBy similarity | 1 | |
Binding sitei | 132 | SubstrateBy similarity | 1 | |
Sitei | 139 | Critical for catalysisBy similarity | 1 | |
Sitei | 212 | Critical for catalysisBy similarity | 1 | |
Metal bindingi | 252 | Magnesium or manganeseBy similarity | 1 | |
Binding sitei | 260 | NADPBy similarity | 1 | |
Metal bindingi | 275 | Magnesium or manganeseBy similarity | 1 | |
Binding sitei | 328 | NADP; via amide nitrogen and carbonyl oxygenBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 75 – 77 | NADPBy similarity | 3 | |
Nucleotide bindingi | 310 – 315 | NADPBy similarity | 6 |
GO - Molecular functioni
- isocitrate dehydrogenase (NADP+) activity Source: SGD
- magnesium ion binding Source: InterPro
- NAD binding Source: InterPro
GO - Biological processi
- fatty acid beta-oxidation Source: SGD
- glyoxylate cycle Source: UniProtKB-KW
- isocitrate metabolic process Source: InterPro
- NADPH regeneration Source: SGD
- tricarboxylic acid cycle Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Glyoxylate bypass, Tricarboxylic acid cycle |
Ligand | Magnesium, Manganese, Metal-binding, NADP |
Enzyme and pathway databases
BioCyci | YEAST:YNL009W-MONOMER |
SABIO-RKi | P53982 |
Names & Taxonomyi
Protein namesi | Recommended name: Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)Short name: IDH Alternative name(s): IDP NADP(+)-specific ICDH Oxalosuccinate decarboxylase |
Gene namesi | Name:IDP3 Ordered Locus Names:YNL009W ORF Names:N2870 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YNL009W |
SGDi | S000004954 IDP3 |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000083588 | 1 – 420 | Isocitrate dehydrogenase [NADP]Add BLAST | 420 |
Proteomic databases
MaxQBi | P53982 |
PaxDbi | P53982 |
PRIDEi | P53982 |
PTM databases
CarbonylDBi | P53982 |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGridi | 3581694 interactors. |
DIPi | DIP-4693N |
IntActi | P53982 32 interactors. |
MINTi | P53982 |
STRINGi | 4932.YNL009W |
Structurei
3D structure databases
ProteinModelPortali | P53982 |
SMRi | P53982 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 94 – 100 | Substrate bindingBy similarity | 7 |
Sequence similaritiesi
Belongs to the isocitrate and isopropylmalate dehydrogenases family.Curated
Phylogenomic databases
GeneTreei | ENSGT00390000012547 |
HOGENOMi | HOG000019858 |
InParanoidi | P53982 |
KOi | K00031 |
OMAi | IQKRWPL |
OrthoDBi | EOG092C2D51 |
Family and domain databases
InterProi | View protein in InterPro IPR019818 IsoCit/isopropylmalate_DH_CS IPR004790 Isocitrate_DH_NADP IPR024084 IsoPropMal-DH-like_dom |
PANTHERi | PTHR11822 PTHR11822, 1 hit |
Pfami | View protein in Pfam PF00180 Iso_dh, 1 hit |
PIRSFi | PIRSF000108 IDH_NADP, 1 hit |
SMARTi | View protein in SMART SM01329 Iso_dh, 1 hit |
TIGRFAMsi | TIGR00127 nadp_idh_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00470 IDH_IMDH, 1 hit |
i Sequence
Sequence statusi: Complete.
P53982-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKIKVVHPI VEMDGDEQTR VIWKLIKEKL ILPYLDVDLK YYDLSIQERD
60 70 80 90 100
RTNDQVTKDS SYATLKYGVA VKCATITPDE ARMKEFNLKE MWKSPNGTIR
110 120 130 140 150
NILGGTVFRE PIIIPKIPRL VPHWEKPIII GRHAFGDQYR ATDIKIKKAG
160 170 180 190 200
KLRLQFSSDD GKENIDLKVY EFPKSGGIAM AMFNTNDSIK GFAKASFELA
210 220 230 240 250
LKRKLPLFFT TKNTILKNYD NQFKQIFDNL FDKEYKEKFQ ALKITYEHRL
260 270 280 290 300
IDDMVAQMLK SKGGFIIAMK NYDGDVQSDI VAQGFGSLGL MTSILITPDG
310 320 330 340 350
KTFESEAAHG TVTRHFRKHQ RGEETSTNSI ASIFAWTRAI IQRGKLDNTD
360 370 380 390 400
DVIKFGNLLE KATLDTVQVG GKMTKDLALM LGKTNRSSYV TTEEFIDEVA
410 420
KRLQNMMLSS NEDKKGMCKL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z71285 Genomic DNA Translation: CAA95869.1 AY693154 Genomic DNA Translation: AAT93173.1 BK006947 Genomic DNA Translation: DAA10534.1 |
PIRi | S62921 |
RefSeqi | NP_014389.3, NM_001182848.3 |
Genome annotation databases
EnsemblFungii | YNL009W; YNL009W; YNL009W |
GeneIDi | 855723 |
KEGGi | sce:YNL009W |
Similar proteinsi
Entry informationi
Entry namei | IDHH_YEAST | |
Accessioni | P53982Primary (citable) accession number: P53982 Secondary accession number(s): D6W1G8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | March 28, 2018 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |