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P53973

- HDA1_YEAST

UniProt

P53973 - HDA1_YEAST

Protein

Histone deacetylase HDA1

Gene

HDA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei206 – 2061By similarity

    GO - Molecular functioni

    1. chromatin binding Source: SGD
    2. identical protein binding Source: IntAct
    3. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    5. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    6. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
    7. protein binding Source: IntAct

    GO - Biological processi

    1. gene silencing by RNA Source: SGD
    2. gene silencing involved in chronological cell aging Source: SGD
    3. histone deacetylation Source: SGD
    4. negative regulation of chromatin silencing involved in replicative cell aging Source: SGD
    5. negative regulation of transcription by transcription factor localization Source: SGD
    6. negative regulation of transcription from RNA polymerase II promoter Source: SGD
    7. positive regulation of transcription from RNA polymerase II promoter Source: SGD
    8. regulation of chromatin silencing at telomere Source: SGD
    9. regulation of transcription by chromatin organization Source: SGD
    10. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33059-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylase HDA1 (EC:3.5.1.98)
    Gene namesi
    Name:HDA1
    Ordered Locus Names:YNL021W
    ORF Names:N2819
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNL021w.
    SGDiS000004966. HDA1.

    Subcellular locationi

    GO - Cellular componenti

    1. HDA1 complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 706706Histone deacetylase HDA1PRO_0000114738Add
    BLAST

    Proteomic databases

    MaxQBiP53973.
    PaxDbiP53973.
    PeptideAtlasiP53973.

    Expressioni

    Gene expression databases

    GenevestigatoriP53973.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself5EBI-8206,EBI-8206
    HDA2Q066297EBI-8206,EBI-32800
    HDA3Q066237EBI-8206,EBI-38663

    Protein-protein interaction databases

    BioGridi35805. 438 interactions.
    DIPiDIP-1360N.
    IntActiP53973. 17 interactions.
    MINTiMINT-387448.
    STRINGi4932.YNL021W.

    Structurei

    3D structure databases

    ProteinModelPortaliP53973.
    SMRiP53973. Positions 55-439.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni67 – 396330Histone deacetylaseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0123.
    GeneTreeiENSGT00530000062809.
    HOGENOMiHOG000161343.
    KOiK11407.
    OMAiCYDDRMK.
    OrthoDBiEOG75B8GB.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR019154. Arb2_domain.
    IPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    IPR017321. Hist_deAcase_II_yeast.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF09757. Arb2. 1 hit.
    PF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037919. HDAC_II_yeast. 1 hit.
    PRINTSiPR01270. HDASUPER.

    Sequencei

    Sequence statusi: Complete.

    P53973-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSVMVKKEV LENPDHDLKR KLEENKEEEN SLSTTSKSKR QVIVPVCMPK    50
    IHYSPLKTGL CYDVRMRYHA KIFTSYFEYI DPHPEDPRRI YRIYKILAEN 100
    GLINDPTLSG VDDLGDLMLK IPVRAATSEE ILEVHTKEHL EFIESTEKMS 150
    REELLKETEK GDSVYFNNDS YASARLPCGG AIEACKAVVE GRVKNSLAVV 200
    RPPGHHAEPQ AAGGFCLFSN VAVAAKNILK NYPESVRRIM ILDWDIHHGN 250
    GTQKSFYQDD QVLYVSLHRF EMGKYYPGTI QGQYDQTGEG KGEGFNCNIT 300
    WPVGGVGDAE YMWAFEQVVM PMGREFKPDL VIISSGFDAA DGDTIGQCHV 350
    TPSCYGHMTH MLKSLARGNL CVVLEGGYNL DAIARSALSV AKVLIGEPPD 400
    ELPDPLSDPK PEVIEMIDKV IRLQSKYWNC FRRRHANSGC NFNEPINDSI 450
    ISKNFPLQKA IRQQQQHYLS DEFNFVTLPL VSMDLPDNTV LCTPNISESN 500
    TIIIVVHDTS DIWAKRNVIS GTIDLSSSVI IDNSLDFIKW GLDRKYGIID 550
    VNIPLTLFEP DNYSGMITSQ EVLIYLWDNY IKYFPSVAKI AFIGIGDSYS 600
    GIVHLLGHRD TRAVTKTVIN FLGDKQLKPL VPLVDETLSE WYFKNSLIFS 650
    NNSHQCWKEN ESRKPRKKFG RVLRCDTDGL NNIIEERFEE ATDFILDSFE 700
    EWSDEE 706
    Length:706
    Mass (Da):80,070
    Last modified:October 1, 1996 - v1
    Checksum:i4E7069E66D03264D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71297 Genomic DNA. Translation: CAA95883.1.
    BK006947 Genomic DNA. Translation: DAA10524.1.
    PIRiS62933.
    RefSeqiNP_014377.1. NM_001182860.1.

    Genome annotation databases

    EnsemblFungiiYNL021W; YNL021W; YNL021W.
    GeneIDi855710.
    KEGGisce:YNL021W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71297 Genomic DNA. Translation: CAA95883.1 .
    BK006947 Genomic DNA. Translation: DAA10524.1 .
    PIRi S62933.
    RefSeqi NP_014377.1. NM_001182860.1.

    3D structure databases

    ProteinModelPortali P53973.
    SMRi P53973. Positions 55-439.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35805. 438 interactions.
    DIPi DIP-1360N.
    IntActi P53973. 17 interactions.
    MINTi MINT-387448.
    STRINGi 4932.YNL021W.

    Proteomic databases

    MaxQBi P53973.
    PaxDbi P53973.
    PeptideAtlasi P53973.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNL021W ; YNL021W ; YNL021W .
    GeneIDi 855710.
    KEGGi sce:YNL021W.

    Organism-specific databases

    CYGDi YNL021w.
    SGDi S000004966. HDA1.

    Phylogenomic databases

    eggNOGi COG0123.
    GeneTreei ENSGT00530000062809.
    HOGENOMi HOG000161343.
    KOi K11407.
    OMAi CYDDRMK.
    OrthoDBi EOG75B8GB.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33059-MONOMER.

    Miscellaneous databases

    NextBioi 980058.

    Gene expression databases

    Genevestigatori P53973.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR019154. Arb2_domain.
    IPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    IPR017321. Hist_deAcase_II_yeast.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF09757. Arb2. 1 hit.
    PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037919. HDAC_II_yeast. 1 hit.
    PRINTSi PR01270. HDASUPER.
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription."
      Rundlett S.E., Carmen A.A., Kobayashi R., Bavykin S., Turner B.M., Grunstein M.
      Proc. Natl. Acad. Sci. U.S.A. 93:14503-14508(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHDA1_YEAST
    AccessioniPrimary (citable) accession number: P53973
    Secondary accession number(s): D6W1F8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 3050 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3