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P53972

- YNC2_YEAST

UniProt

P53972 - YNC2_YEAST

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Protein
Methyltransferase YNL022C
Gene
YNL022C, N2815
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei280 – 2801S-adenosyl-L-methionine By similarity
Binding sitei308 – 3081S-adenosyl-L-methionine By similarity
Binding sitei327 – 3271S-adenosyl-L-methionine By similarity
Active sitei404 – 4041Nucleophile By similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
  2. rRNA (cytosine-C5-)-methyltransferase activity Source: SGD

GO - Biological processi

  1. rRNA base methylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciYEAST:G3O-33060-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase YNL022C (EC:2.1.1.-)
Gene namesi
Ordered Locus Names:YNL022C
ORF Names:N2815
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL022c.
SGDiS000004967. YNL022C.

Subcellular locationi

GO - Cellular componenti

  1. nucleolus Source: SGD
  2. nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Methyltransferase YNL022C
PRO_0000203461Add
BLAST

Proteomic databases

MaxQBiP53972.
PaxDbiP53972.
PeptideAtlasiP53972.

Expressioni

Gene expression databases

GenevestigatoriP53972.

Interactioni

Protein-protein interaction databases

BioGridi35804. 43 interactions.
IntActiP53972. 1 interaction.
MINTiMINT-2491929.
STRINGi4932.YNL022C.

Structurei

3D structure databases

ProteinModelPortaliP53972.
SMRiP53972. Positions 154-489.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni250 – 2567S-adenosyl-L-methionine binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0144.
GeneTreeiENSGT00550000074709.
HOGENOMiHOG000203203.
KOiK15264.
OMAiRCSPGED.
OrthoDBiEOG74R21C.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001678. Fmu/NOL1/Nop2p.
IPR023267. RCMT.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF01189. Nol1_Nop2_Fmu. 1 hit.
[Graphical view]
PRINTSiPR02008. RCMTFAMILY.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51686. SAM_MT_RSMB_NOP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53972-1 [UniParc]FASTAAdd to Basket

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MNFYRDATWV LEDIEKEAAK ERISGSMQTL VLKSCKRYKL KSNPKHIYAV    50
LDSCWKYKPY LEKVMKKAHI LEDIPKKKGK PLFSRLTLLL LCHDLLLSKQ 100
KRIQMGKHPI KDYVLKFKSP LHSEMVKLKL KLKVRELSEL VLSEDISNDL 150
PPVRWIRINP LKCHPNGETE PVLAELRKKF TLKVDKWSEL VPGSIYYDEF 200
IPNLFGIHPS DKITAHELYK HGKIIIQDRA SCFPAHILNP GPSDIVIDSC 250
SAPGNKTTHT ASYIYPEPPK DNNTRIYAFE KDPERAKVLQ KMIKIAGCSP 300
NISVNVGDFT KLATPEKYKD VTCFIVDPSC SGSGIFGRKF FDSFNRRKID 350
DKDDDGGIVP DEQEEFIAKE ELQTRLAKLS SFQFQMVKHA MSFPAAKKIV 400
YSTCSIHAEE NERVVIDLLL DKSVREWGWK VAPKREVIPS WPRRGKVEEF 450
EEVFRDGVTY DPQQLAEGCI RALPKSDGGI GFFAVCFERD 490
Length:490
Mass (Da):56,177
Last modified:October 1, 1996 - v1
Checksum:iBB90FF7944FEA4AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71298 Genomic DNA. Translation: CAA95884.1.
BK006947 Genomic DNA. Translation: DAA10523.1.
PIRiS62934.
RefSeqiNP_014376.3. NM_001182861.3.

Genome annotation databases

EnsemblFungiiYNL022C; YNL022C; YNL022C.
GeneIDi855709.
KEGGisce:YNL022C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71298 Genomic DNA. Translation: CAA95884.1 .
BK006947 Genomic DNA. Translation: DAA10523.1 .
PIRi S62934.
RefSeqi NP_014376.3. NM_001182861.3.

3D structure databases

ProteinModelPortali P53972.
SMRi P53972. Positions 154-489.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35804. 43 interactions.
IntActi P53972. 1 interaction.
MINTi MINT-2491929.
STRINGi 4932.YNL022C.

Proteomic databases

MaxQBi P53972.
PaxDbi P53972.
PeptideAtlasi P53972.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL022C ; YNL022C ; YNL022C .
GeneIDi 855709.
KEGGi sce:YNL022C.

Organism-specific databases

CYGDi YNL022c.
SGDi S000004967. YNL022C.

Phylogenomic databases

eggNOGi COG0144.
GeneTreei ENSGT00550000074709.
HOGENOMi HOG000203203.
KOi K15264.
OMAi RCSPGED.
OrthoDBi EOG74R21C.

Enzyme and pathway databases

BioCyci YEAST:G3O-33060-MONOMER.

Miscellaneous databases

NextBioi 980055.
PROi P53972.

Gene expression databases

Genevestigatori P53972.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR001678. Fmu/NOL1/Nop2p.
IPR023267. RCMT.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF01189. Nol1_Nop2_Fmu. 1 hit.
[Graphical view ]
PRINTSi PR02008. RCMTFAMILY.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51686. SAM_MT_RSMB_NOP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYNC2_YEAST
AccessioniPrimary (citable) accession number: P53972
Secondary accession number(s): D6W1F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 922 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

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