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P53971

- FAP1_YEAST

UniProt

P53971 - FAP1_YEAST

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Protein
FKBP12-associated protein 1
Gene
FAP1, YNL023C, N2812
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in transcription regulation By similarity.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri68 – 11851RING-type; degenerate
Add
BLAST
Zinc fingeri159 – 17719NF-X1-type 1
Add
BLAST
Zinc fingeri216 – 23520NF-X1-type 2
Add
BLAST
Zinc fingeri362 – 38221NF-X1-type 3
Add
BLAST
Zinc fingeri468 – 48720NF-X1-type 4
Add
BLAST
Zinc fingeri586 – 60621NF-X1-type 5
Add
BLAST

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: SGD
  3. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-33061-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
FKBP12-associated protein 1
Gene namesi
Name:FAP1
Ordered Locus Names:YNL023C
ORF Names:N2812
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL023c.
SGDiS000004968. FAP1.

Subcellular locationi

Cytoplasm. Nucleus
Note: Translocates to the nucleus in response to rapamycin.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 965965FKBP12-associated protein 1
PRO_0000056343Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei951 – 9511Phosphothreonine1 Publication
Modified residuei958 – 9581Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53971.
PaxDbiP53971.
PeptideAtlasiP53971.

Expressioni

Gene expression databases

GenevestigatoriP53971.

Interactioni

Subunit structurei

Interacts with FPR1.1 Publication

Protein-protein interaction databases

BioGridi35803. 30 interactions.
DIPiDIP-967N.
IntActiP53971. 14 interactions.
MINTiMINT-388122.
STRINGi4932.YNL023C.

Structurei

3D structure databases

ProteinModelPortaliP53971.
SMRiP53971. Positions 66-122.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini733 – 79664R3H
Add
BLAST

Sequence similaritiesi

Belongs to the NFX1 family.
Contains 1 R3H domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00400000022083.
HOGENOMiHOG000112499.
OMAiRSRVWSC.
OrthoDBiEOG7T4MTT.

Family and domain databases

Gene3Di3.30.1370.50. 1 hit.
InterProiIPR001374. R3H_ss-bd.
IPR000967. Znf_NFX1.
IPR001841. Znf_RING.
[Graphical view]
PfamiPF01424. R3H. 1 hit.
PF01422. zf-NF-X1. 2 hits.
[Graphical view]
SMARTiSM00393. R3H. 1 hit.
SM00184. RING. 1 hit.
SM00438. ZnF_NFX. 7 hits.
[Graphical view]
SUPFAMiSSF82708. SSF82708. 1 hit.
PROSITEiPS51061. R3H. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53971-1 [UniParc]FASTAAdd to Basket

« Hide

MTEHESLGLE QNQDGGDTYR HHNLSDGCIS SVEDANEQPS SYEEESDDDM    50
QYYERAIQEI SSGDSYVCMI CTVEMDYTCQ MFACKRCYRV FDYGCIREWA 100
LKSTEKTVDR IWKCPNCYYV SKRVPVKNRP TCWCGKVVNP DPNPLDPNSC 150
GQTCNASTCM HGCSKICHLG PHPECTRMVE IMCHCGKHSK SIFCYQSKVM 200
KKNFNCQEVC GLPLSCSIHT CKKKCHPGLC GPCPEMIISK DSPKKQIKCY 250
CGNHTRANIK CSETKFPKSG KSSKDENGNR WIGVFACADN RVVDYSCRKH 300
SFIESCISPP TINGEKACPF LPSSLKTCPC GRTALEELTK PRKHCDDPIP 350
TCDSRCGKPL KCGKHSCPFT CHDKACMEPC LQIDSVKCAC EQSTFSVPCG 400
FQGRPRCNIK CESLMSCRRH RCTDRCCSGR PSAIRRKKNL FRTQDLLDES 450
LVEAKHICLK PCNLTLSCGI HKCQRKCHPG KCPPCLESDS NDLVCPCGNT 500
VVPAPVRCGT KLPTCNHPCI KVVRGESTCG HKPMPHTCHS LDVSCPPCTE 550
TVFKPCKCGK KTKVRTVCFQ TDVSCGIKCG IPLSYCYHTC QKTCHLPGNC 600
QKVCKQTCGQ KRLNCNHECP KPCHGKTECP DLPCATLVKI YCKCGRIKKS 650
VTCGAKSDRV SVTESSVLDC NEECEALKRL KELKEAFGIK EETNNFTSNE 700
LDALKKLVSV ATTFEELQLP FTEAALSVYS KQERWCSQIE AILNKLMDDK 750
TRSSLHFKPM RPPQRHFIRE LAKAYGLYSE SQDREPMRSV FIKKEDNGAS 800
NKPVLSLAEA YPLYESFKQL QKERKAQEFQ ARTTAKLINF EVQDTEPKVE 850
VAKKNGFLVQ NLVAGNTAED LRRFFEPHLK HTLVVNPQYL ILDDGKTALV 900
YPENYETASV NTERDMELLV GHFDFMAKEA FLADSISLCS TEEELERRLD 950
TPVIQEDSPV MDNNT 965
Length:965
Mass (Da):108,495
Last modified:October 1, 1996 - v1
Checksum:i121C57BB07C6FA9D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71299 Genomic DNA. Translation: CAA95885.1.
BK006947 Genomic DNA. Translation: DAA10522.1.
PIRiS62935.
RefSeqiNP_014375.1. NM_001182862.1.

Genome annotation databases

EnsemblFungiiYNL023C; YNL023C; YNL023C.
GeneIDi855708.
KEGGisce:YNL023C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71299 Genomic DNA. Translation: CAA95885.1 .
BK006947 Genomic DNA. Translation: DAA10522.1 .
PIRi S62935.
RefSeqi NP_014375.1. NM_001182862.1.

3D structure databases

ProteinModelPortali P53971.
SMRi P53971. Positions 66-122.
ModBasei Search...

Protein-protein interaction databases

BioGridi 35803. 30 interactions.
DIPi DIP-967N.
IntActi P53971. 14 interactions.
MINTi MINT-388122.
STRINGi 4932.YNL023C.

Proteomic databases

MaxQBi P53971.
PaxDbi P53971.
PeptideAtlasi P53971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL023C ; YNL023C ; YNL023C .
GeneIDi 855708.
KEGGi sce:YNL023C.

Organism-specific databases

CYGDi YNL023c.
SGDi S000004968. FAP1.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00400000022083.
HOGENOMi HOG000112499.
OMAi RSRVWSC.
OrthoDBi EOG7T4MTT.

Enzyme and pathway databases

BioCyci YEAST:G3O-33061-MONOMER.

Miscellaneous databases

NextBioi 980052.
PROi P53971.

Gene expression databases

Genevestigatori P53971.

Family and domain databases

Gene3Di 3.30.1370.50. 1 hit.
InterProi IPR001374. R3H_ss-bd.
IPR000967. Znf_NFX1.
IPR001841. Znf_RING.
[Graphical view ]
Pfami PF01424. R3H. 1 hit.
PF01422. zf-NF-X1. 2 hits.
[Graphical view ]
SMARTi SM00393. R3H. 1 hit.
SM00184. RING. 1 hit.
SM00438. ZnF_NFX. 7 hits.
[Graphical view ]
SUPFAMi SSF82708. SSF82708. 1 hit.
PROSITEi PS51061. R3H. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  4. "FAP1, a homologue of human transcription factor NF-X1, competes with rapamycin for binding to FKBP12 in yeast."
    Kunz J., Loeschmann A., Deuter-Reinhard M., Hall M.N.
    Mol. Microbiol. 37:1480-1493(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH FPR1, SUBCELLULAR LOCATION.
  5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-958, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-951, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFAP1_YEAST
AccessioniPrimary (citable) accession number: P53971
Secondary accession number(s): D6W1F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 589 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

Similar proteinsi