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P53971

- FAP1_YEAST

UniProt

P53971 - FAP1_YEAST

Protein

FKBP12-associated protein 1

Gene

FAP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    May play a role in transcription regulation.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri68 – 11851RING-type; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri159 – 17719NF-X1-type 1Add
    BLAST
    Zinc fingeri216 – 23520NF-X1-type 2Add
    BLAST
    Zinc fingeri362 – 38221NF-X1-type 3Add
    BLAST
    Zinc fingeri468 – 48720NF-X1-type 4Add
    BLAST
    Zinc fingeri586 – 60621NF-X1-type 5Add
    BLAST

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: SGD
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33061-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FKBP12-associated protein 1
    Gene namesi
    Name:FAP1
    Ordered Locus Names:YNL023C
    ORF Names:N2812
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNL023c.
    SGDiS000004968. FAP1.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication
    Note: Translocates to the nucleus in response to rapamycin.

    GO - Cellular componenti

    1. cytoplasm Source: SGD
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 965965FKBP12-associated protein 1PRO_0000056343Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei951 – 9511Phosphothreonine1 Publication
    Modified residuei958 – 9581Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP53971.
    PaxDbiP53971.
    PeptideAtlasiP53971.

    Expressioni

    Gene expression databases

    GenevestigatoriP53971.

    Interactioni

    Subunit structurei

    Interacts with FPR1.1 Publication

    Protein-protein interaction databases

    BioGridi35803. 30 interactions.
    DIPiDIP-967N.
    IntActiP53971. 14 interactions.
    MINTiMINT-388122.
    STRINGi4932.YNL023C.

    Structurei

    3D structure databases

    ProteinModelPortaliP53971.
    SMRiP53971. Positions 66-122.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini733 – 79664R3HPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NFX1 family.Curated
    Contains 5 NF-X1-type zinc fingers.Curated
    Contains 1 R3H domain.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri68 – 11851RING-type; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri159 – 17719NF-X1-type 1Add
    BLAST
    Zinc fingeri216 – 23520NF-X1-type 2Add
    BLAST
    Zinc fingeri362 – 38221NF-X1-type 3Add
    BLAST
    Zinc fingeri468 – 48720NF-X1-type 4Add
    BLAST
    Zinc fingeri586 – 60621NF-X1-type 5Add
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00400000022083.
    HOGENOMiHOG000112499.
    OMAiRSRVWSC.
    OrthoDBiEOG7T4MTT.

    Family and domain databases

    Gene3Di3.30.1370.50. 1 hit.
    InterProiIPR001374. R3H_ss-bd.
    IPR000967. Znf_NFX1.
    IPR001841. Znf_RING.
    [Graphical view]
    PfamiPF01424. R3H. 1 hit.
    PF01422. zf-NF-X1. 2 hits.
    [Graphical view]
    SMARTiSM00393. R3H. 1 hit.
    SM00184. RING. 1 hit.
    SM00438. ZnF_NFX. 7 hits.
    [Graphical view]
    SUPFAMiSSF82708. SSF82708. 1 hit.
    PROSITEiPS51061. R3H. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53971-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEHESLGLE QNQDGGDTYR HHNLSDGCIS SVEDANEQPS SYEEESDDDM    50
    QYYERAIQEI SSGDSYVCMI CTVEMDYTCQ MFACKRCYRV FDYGCIREWA 100
    LKSTEKTVDR IWKCPNCYYV SKRVPVKNRP TCWCGKVVNP DPNPLDPNSC 150
    GQTCNASTCM HGCSKICHLG PHPECTRMVE IMCHCGKHSK SIFCYQSKVM 200
    KKNFNCQEVC GLPLSCSIHT CKKKCHPGLC GPCPEMIISK DSPKKQIKCY 250
    CGNHTRANIK CSETKFPKSG KSSKDENGNR WIGVFACADN RVVDYSCRKH 300
    SFIESCISPP TINGEKACPF LPSSLKTCPC GRTALEELTK PRKHCDDPIP 350
    TCDSRCGKPL KCGKHSCPFT CHDKACMEPC LQIDSVKCAC EQSTFSVPCG 400
    FQGRPRCNIK CESLMSCRRH RCTDRCCSGR PSAIRRKKNL FRTQDLLDES 450
    LVEAKHICLK PCNLTLSCGI HKCQRKCHPG KCPPCLESDS NDLVCPCGNT 500
    VVPAPVRCGT KLPTCNHPCI KVVRGESTCG HKPMPHTCHS LDVSCPPCTE 550
    TVFKPCKCGK KTKVRTVCFQ TDVSCGIKCG IPLSYCYHTC QKTCHLPGNC 600
    QKVCKQTCGQ KRLNCNHECP KPCHGKTECP DLPCATLVKI YCKCGRIKKS 650
    VTCGAKSDRV SVTESSVLDC NEECEALKRL KELKEAFGIK EETNNFTSNE 700
    LDALKKLVSV ATTFEELQLP FTEAALSVYS KQERWCSQIE AILNKLMDDK 750
    TRSSLHFKPM RPPQRHFIRE LAKAYGLYSE SQDREPMRSV FIKKEDNGAS 800
    NKPVLSLAEA YPLYESFKQL QKERKAQEFQ ARTTAKLINF EVQDTEPKVE 850
    VAKKNGFLVQ NLVAGNTAED LRRFFEPHLK HTLVVNPQYL ILDDGKTALV 900
    YPENYETASV NTERDMELLV GHFDFMAKEA FLADSISLCS TEEELERRLD 950
    TPVIQEDSPV MDNNT 965
    Length:965
    Mass (Da):108,495
    Last modified:October 1, 1996 - v1
    Checksum:i121C57BB07C6FA9D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71299 Genomic DNA. Translation: CAA95885.1.
    BK006947 Genomic DNA. Translation: DAA10522.1.
    PIRiS62935.
    RefSeqiNP_014375.1. NM_001182862.1.

    Genome annotation databases

    EnsemblFungiiYNL023C; YNL023C; YNL023C.
    GeneIDi855708.
    KEGGisce:YNL023C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71299 Genomic DNA. Translation: CAA95885.1 .
    BK006947 Genomic DNA. Translation: DAA10522.1 .
    PIRi S62935.
    RefSeqi NP_014375.1. NM_001182862.1.

    3D structure databases

    ProteinModelPortali P53971.
    SMRi P53971. Positions 66-122.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35803. 30 interactions.
    DIPi DIP-967N.
    IntActi P53971. 14 interactions.
    MINTi MINT-388122.
    STRINGi 4932.YNL023C.

    Proteomic databases

    MaxQBi P53971.
    PaxDbi P53971.
    PeptideAtlasi P53971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNL023C ; YNL023C ; YNL023C .
    GeneIDi 855708.
    KEGGi sce:YNL023C.

    Organism-specific databases

    CYGDi YNL023c.
    SGDi S000004968. FAP1.

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00400000022083.
    HOGENOMi HOG000112499.
    OMAi RSRVWSC.
    OrthoDBi EOG7T4MTT.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33061-MONOMER.

    Miscellaneous databases

    NextBioi 980052.
    PROi P53971.

    Gene expression databases

    Genevestigatori P53971.

    Family and domain databases

    Gene3Di 3.30.1370.50. 1 hit.
    InterProi IPR001374. R3H_ss-bd.
    IPR000967. Znf_NFX1.
    IPR001841. Znf_RING.
    [Graphical view ]
    Pfami PF01424. R3H. 1 hit.
    PF01422. zf-NF-X1. 2 hits.
    [Graphical view ]
    SMARTi SM00393. R3H. 1 hit.
    SM00184. RING. 1 hit.
    SM00438. ZnF_NFX. 7 hits.
    [Graphical view ]
    SUPFAMi SSF82708. SSF82708. 1 hit.
    PROSITEi PS51061. R3H. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    4. "FAP1, a homologue of human transcription factor NF-X1, competes with rapamycin for binding to FKBP12 in yeast."
      Kunz J., Loeschmann A., Deuter-Reinhard M., Hall M.N.
      Mol. Microbiol. 37:1480-1493(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH FPR1, SUBCELLULAR LOCATION.
    5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-958, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-951, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFAP1_YEAST
    AccessioniPrimary (citable) accession number: P53971
    Secondary accession number(s): D6W1F6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 589 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3