Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P53971

- FAP1_YEAST

UniProt

P53971 - FAP1_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

FKBP12-associated protein 1

Gene

FAP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in transcription regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri68 – 11851RING-type; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri159 – 17719NF-X1-type 1Add
BLAST
Zinc fingeri216 – 23520NF-X1-type 2Add
BLAST
Zinc fingeri362 – 38221NF-X1-type 3Add
BLAST
Zinc fingeri468 – 48720NF-X1-type 4Add
BLAST
Zinc fingeri586 – 60621NF-X1-type 5Add
BLAST

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: SGD
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-33061-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
FKBP12-associated protein 1
Gene namesi
Name:FAP1
Ordered Locus Names:YNL023C
ORF Names:N2812
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL023c.
SGDiS000004968. FAP1.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication
Note: Translocates to the nucleus in response to rapamycin.

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 965965FKBP12-associated protein 1PRO_0000056343Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei951 – 9511Phosphothreonine1 Publication
Modified residuei958 – 9581Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53971.
PaxDbiP53971.
PeptideAtlasiP53971.

Expressioni

Gene expression databases

GenevestigatoriP53971.

Interactioni

Subunit structurei

Interacts with FPR1.1 Publication

Protein-protein interaction databases

BioGridi35803. 31 interactions.
DIPiDIP-967N.
IntActiP53971. 14 interactions.
MINTiMINT-388122.
STRINGi4932.YNL023C.

Structurei

3D structure databases

ProteinModelPortaliP53971.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini733 – 79664R3HPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the NFX1 family.Curated
Contains 5 NF-X1-type zinc fingers.Curated
Contains 1 R3H domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri68 – 11851RING-type; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri159 – 17719NF-X1-type 1Add
BLAST
Zinc fingeri216 – 23520NF-X1-type 2Add
BLAST
Zinc fingeri362 – 38221NF-X1-type 3Add
BLAST
Zinc fingeri468 – 48720NF-X1-type 4Add
BLAST
Zinc fingeri586 – 60621NF-X1-type 5Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00400000022083.
HOGENOMiHOG000112499.
InParanoidiP53971.
KOiK12236.
OMAiRSRVWSC.
OrthoDBiEOG7T4MTT.

Family and domain databases

Gene3Di3.30.1370.50. 1 hit.
InterProiIPR001374. R3H_ss-bd.
IPR000967. Znf_NFX1.
IPR001841. Znf_RING.
[Graphical view]
PfamiPF01424. R3H. 1 hit.
PF01422. zf-NF-X1. 2 hits.
[Graphical view]
SMARTiSM00393. R3H. 1 hit.
SM00184. RING. 1 hit.
SM00438. ZnF_NFX. 7 hits.
[Graphical view]
SUPFAMiSSF82708. SSF82708. 1 hit.
PROSITEiPS51061. R3H. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53971-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEHESLGLE QNQDGGDTYR HHNLSDGCIS SVEDANEQPS SYEEESDDDM
60 70 80 90 100
QYYERAIQEI SSGDSYVCMI CTVEMDYTCQ MFACKRCYRV FDYGCIREWA
110 120 130 140 150
LKSTEKTVDR IWKCPNCYYV SKRVPVKNRP TCWCGKVVNP DPNPLDPNSC
160 170 180 190 200
GQTCNASTCM HGCSKICHLG PHPECTRMVE IMCHCGKHSK SIFCYQSKVM
210 220 230 240 250
KKNFNCQEVC GLPLSCSIHT CKKKCHPGLC GPCPEMIISK DSPKKQIKCY
260 270 280 290 300
CGNHTRANIK CSETKFPKSG KSSKDENGNR WIGVFACADN RVVDYSCRKH
310 320 330 340 350
SFIESCISPP TINGEKACPF LPSSLKTCPC GRTALEELTK PRKHCDDPIP
360 370 380 390 400
TCDSRCGKPL KCGKHSCPFT CHDKACMEPC LQIDSVKCAC EQSTFSVPCG
410 420 430 440 450
FQGRPRCNIK CESLMSCRRH RCTDRCCSGR PSAIRRKKNL FRTQDLLDES
460 470 480 490 500
LVEAKHICLK PCNLTLSCGI HKCQRKCHPG KCPPCLESDS NDLVCPCGNT
510 520 530 540 550
VVPAPVRCGT KLPTCNHPCI KVVRGESTCG HKPMPHTCHS LDVSCPPCTE
560 570 580 590 600
TVFKPCKCGK KTKVRTVCFQ TDVSCGIKCG IPLSYCYHTC QKTCHLPGNC
610 620 630 640 650
QKVCKQTCGQ KRLNCNHECP KPCHGKTECP DLPCATLVKI YCKCGRIKKS
660 670 680 690 700
VTCGAKSDRV SVTESSVLDC NEECEALKRL KELKEAFGIK EETNNFTSNE
710 720 730 740 750
LDALKKLVSV ATTFEELQLP FTEAALSVYS KQERWCSQIE AILNKLMDDK
760 770 780 790 800
TRSSLHFKPM RPPQRHFIRE LAKAYGLYSE SQDREPMRSV FIKKEDNGAS
810 820 830 840 850
NKPVLSLAEA YPLYESFKQL QKERKAQEFQ ARTTAKLINF EVQDTEPKVE
860 870 880 890 900
VAKKNGFLVQ NLVAGNTAED LRRFFEPHLK HTLVVNPQYL ILDDGKTALV
910 920 930 940 950
YPENYETASV NTERDMELLV GHFDFMAKEA FLADSISLCS TEEELERRLD
960
TPVIQEDSPV MDNNT
Length:965
Mass (Da):108,495
Last modified:October 1, 1996 - v1
Checksum:i121C57BB07C6FA9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71299 Genomic DNA. Translation: CAA95885.1.
BK006947 Genomic DNA. Translation: DAA10522.1.
PIRiS62935.
RefSeqiNP_014375.1. NM_001182862.1.

Genome annotation databases

EnsemblFungiiYNL023C; YNL023C; YNL023C.
GeneIDi855708.
KEGGisce:YNL023C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71299 Genomic DNA. Translation: CAA95885.1 .
BK006947 Genomic DNA. Translation: DAA10522.1 .
PIRi S62935.
RefSeqi NP_014375.1. NM_001182862.1.

3D structure databases

ProteinModelPortali P53971.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35803. 31 interactions.
DIPi DIP-967N.
IntActi P53971. 14 interactions.
MINTi MINT-388122.
STRINGi 4932.YNL023C.

Proteomic databases

MaxQBi P53971.
PaxDbi P53971.
PeptideAtlasi P53971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL023C ; YNL023C ; YNL023C .
GeneIDi 855708.
KEGGi sce:YNL023C.

Organism-specific databases

CYGDi YNL023c.
SGDi S000004968. FAP1.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00400000022083.
HOGENOMi HOG000112499.
InParanoidi P53971.
KOi K12236.
OMAi RSRVWSC.
OrthoDBi EOG7T4MTT.

Enzyme and pathway databases

BioCyci YEAST:G3O-33061-MONOMER.

Miscellaneous databases

NextBioi 980052.
PROi P53971.

Gene expression databases

Genevestigatori P53971.

Family and domain databases

Gene3Di 3.30.1370.50. 1 hit.
InterProi IPR001374. R3H_ss-bd.
IPR000967. Znf_NFX1.
IPR001841. Znf_RING.
[Graphical view ]
Pfami PF01424. R3H. 1 hit.
PF01422. zf-NF-X1. 2 hits.
[Graphical view ]
SMARTi SM00393. R3H. 1 hit.
SM00184. RING. 1 hit.
SM00438. ZnF_NFX. 7 hits.
[Graphical view ]
SUPFAMi SSF82708. SSF82708. 1 hit.
PROSITEi PS51061. R3H. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  4. "FAP1, a homologue of human transcription factor NF-X1, competes with rapamycin for binding to FKBP12 in yeast."
    Kunz J., Loeschmann A., Deuter-Reinhard M., Hall M.N.
    Mol. Microbiol. 37:1480-1493(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH FPR1, SUBCELLULAR LOCATION.
  5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-958, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-951, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFAP1_YEAST
AccessioniPrimary (citable) accession number: P53971
Secondary accession number(s): D6W1F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 589 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3