Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein-lysine N-methyltransferase EFM6

Gene

EFM6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha (TEF1 and TEF2) at 'Lys-390'.1 Publication

Miscellaneous

Present with 1760 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51S-adenosyl-L-methionine; via amide nitrogenUniRule annotationBy similarity1
Binding sitei115S-adenosyl-L-methionineUniRule annotationBy similarity1
Binding sitei143S-adenosyl-L-methionine; via amide nitrogenUniRule annotationBy similarity1
Binding sitei169S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotationBy similarity1

GO - Molecular functioni

  • S-adenosylmethionine-dependent methyltransferase activity Source: SGD

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciYEAST:G3O-33062-MONOMER
ReactomeiR-SCE-8876725 Protein methylation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-lysine N-methyltransferase EFM6UniRule annotation1 Publication (EC:2.1.1.-UniRule annotation1 Publication)
Alternative name(s):
Elongation factor methyltransferase 61 PublicationUniRule annotation
Gene namesi
Name:EFM61 PublicationUniRule annotation
Ordered Locus Names:YNL024CImported
ORF Names:N2809
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL024C
SGDiS000004969 EFM6

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002034601 – 246Protein-lysine N-methyltransferase EFM6Add BLAST246

Proteomic databases

PaxDbiP53970
PRIDEiP53970

Interactioni

Protein-protein interaction databases

BioGridi35802, 55 interactors
DIPiDIP-4380N
IntActiP53970, 8 interactors
MINTiP53970
STRINGi4932.YNL024C

Structurei

3D structure databases

ProteinModelPortaliP53970
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni87 – 89S-adenosyl-L-methionine bindingUniRule annotationBy similarity3

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.UniRule annotationCurated

Phylogenomic databases

GeneTreeiENSGT00550000074572
HOGENOMiHOG000187553
InParanoidiP53970
KOiK21804
OMAiEDIHILY
OrthoDBiEOG092C4PYS

Family and domain databases

HAMAPiMF_03198 Methyltr_EFM6, 1 hit
InterProiView protein in InterPro
IPR033684 EFM6
IPR019410 Methyltransf_16
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF10294 Methyltransf_16, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit

Sequencei

Sequence statusi: Complete.

P53970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESIFGGFGD LVVPRPKEHL GQTDLSFGGK LLPALKICED GGESGCGGKV
60 70 80 90 100
WIAGELLCEY ILEKSVDHLL SKTVNGTKQF KKVLELGSGT GLVGLCVGLL
110 120 130 140 150
EKNTFHDGTK VYVTDIDKLI PLLKRNIELD EVQYEVLARE LWWGEPLSAD
160 170 180 190 200
FSPQEGAMQA NNVDLVLAAD CVYLEEAFPL LEKTLLDLTH CINPPVILMA
210 220 230 240
YKKRRKADKH FFNKIKRNFD VLEITDFSKF EHYLKERTHL FQLIRK
Length:246
Mass (Da):27,738
Last modified:October 1, 1996 - v1
Checksum:iEBE1601027A37410
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71300 Genomic DNA Translation: CAA95886.1
BK006947 Genomic DNA Translation: DAA10521.1
PIRiS62936
RefSeqiNP_014374.1, NM_001182863.1

Genome annotation databases

EnsemblFungiiYNL024C; YNL024C; YNL024C
GeneIDi855707
KEGGisce:YNL024C

Similar proteinsi

Entry informationi

Entry nameiEFM6_YEAST
AccessioniPrimary (citable) accession number: P53970
Secondary accession number(s): D6W1F5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health