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P53966

- KTR5_YEAST

UniProt

P53966 - KTR5_YEAST

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Protein
Probable mannosyltransferase KTR5
Gene
KTR5, YNL029C, N2755
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Possible glycosyltransferase.

Catalytic activityi

Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei363 – 3631Nucleophile Reviewed prediction

GO - Molecular functioni

  1. mannosyltransferase activity Source: SGD

GO - Biological processi

  1. mannosylation Source: SGD
  2. protein glycosylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciYEAST:G3O-33066-MONOMER.

Protein family/group databases

CAZyiGT15. Glycosyltransferase Family 15.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mannosyltransferase KTR5 (EC:2.4.1.-)
Gene namesi
Name:KTR5
Ordered Locus Names:YNL029C
ORF Names:N2755
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL029c.
SGDiS000004974. KTR5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei17 – 3721Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini38 – 522485Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: SGD
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 522522Probable mannosyltransferase KTR5
PRO_0000208246Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi86 – 861N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP53966.
PaxDbiP53966.
PeptideAtlasiP53966.

Expressioni

Gene expression databases

GenevestigatoriP53966.

Interactioni

Protein-protein interaction databases

BioGridi35798. 13 interactions.
DIPiDIP-6646N.
IntActiP53966. 2 interactions.
MINTiMINT-614539.
STRINGi4932.YNL029C.

Structurei

3D structure databases

ProteinModelPortaliP53966.
SMRiP53966. Positions 73-429.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni38 – 8245Stem region By similarity
Add
BLAST
Regioni83 – 522440Catalytic By similarity
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5020.
GeneTreeiENSGT00390000000831.
HOGENOMiHOG000160667.
KOiK03854.
OMAiFWKERWG.
OrthoDBiEOG779P83.

Family and domain databases

Gene3Di3.90.550.10. 2 hits.
InterProiIPR002685. Glyco_trans_15.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01793. Glyco_transf_15. 1 hit.
[Graphical view]
PIRSFiPIRSF018153. Glyco_trans_15. 1 hit.
SUPFAMiSSF53448. SSF53448. 3 hits.

Sequencei

Sequence statusi: Complete.

P53966-1 [UniParc]FASTAAdd to Basket

« Hide

MLLIRRTINA FLGCIHCNLT ATCILIAFVI TMYVVLVSEP ASVDGTMGNF    50
LPFSKMDLAT KRDRPFYSNC VNTQDYLLNP SYIKQNASFV MLTRNGELED 100
VIKTINSIEE HFNQWFHYPY VFLNDQPFEE DFKAKVRDVT VGALVEFGTI 150
DEISWNFPSD VKDTFEFYNA IEDQGDRSIL YGNLESYHKM CRFYSGLFYK 200
HPLVQKYEWY WRLEPDVEFF CDITYDPFLE MLRTNKKYGF TIIIPELYWT 250
VPNLFRHTKS FISQKGVTLG SLWKLFTKDY DIFESDDPEL RDWINYDFQA 300
KAKISEKIAI EQLLKKGDDF QQINDDKEGI MNLIHKARSR KHIVEDKFFN 350
EEYNLCHFWS NFEIARLSVF DNDIYNSFFQ YLEKSGGFWK ERWGDAPVHS 400
IGLSLTLDLD DVHYFRDIGY RHSTIQHCPH NAMGNEEFSY LASDSKFKRK 450
NAAYDEGREF GCGCRCRCPK KKREIEDSMG FCVNIWVNLL NQQRGHERHV 500
EALNGNEMEE HIREDYLRQF GN 522
Length:522
Mass (Da):61,728
Last modified:October 1, 1996 - v1
Checksum:i3F9D75D3F09D4110
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71305 Genomic DNA. Translation: CAA95891.1.
BK006947 Genomic DNA. Translation: DAA10516.1.
PIRiS62941.
RefSeqiNP_014369.3. NM_001182868.3.

Genome annotation databases

EnsemblFungiiYNL029C; YNL029C; YNL029C.
GeneIDi855703.
KEGGisce:YNL029C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71305 Genomic DNA. Translation: CAA95891.1 .
BK006947 Genomic DNA. Translation: DAA10516.1 .
PIRi S62941.
RefSeqi NP_014369.3. NM_001182868.3.

3D structure databases

ProteinModelPortali P53966.
SMRi P53966. Positions 73-429.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35798. 13 interactions.
DIPi DIP-6646N.
IntActi P53966. 2 interactions.
MINTi MINT-614539.
STRINGi 4932.YNL029C.

Protein family/group databases

CAZyi GT15. Glycosyltransferase Family 15.

Proteomic databases

MaxQBi P53966.
PaxDbi P53966.
PeptideAtlasi P53966.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL029C ; YNL029C ; YNL029C .
GeneIDi 855703.
KEGGi sce:YNL029C.

Organism-specific databases

CYGDi YNL029c.
SGDi S000004974. KTR5.

Phylogenomic databases

eggNOGi COG5020.
GeneTreei ENSGT00390000000831.
HOGENOMi HOG000160667.
KOi K03854.
OMAi FWKERWG.
OrthoDBi EOG779P83.

Enzyme and pathway databases

BioCyci YEAST:G3O-33066-MONOMER.

Miscellaneous databases

NextBioi 980037.

Gene expression databases

Genevestigatori P53966.

Family and domain databases

Gene3Di 3.90.550.10. 2 hits.
InterProi IPR002685. Glyco_trans_15.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF01793. Glyco_transf_15. 1 hit.
[Graphical view ]
PIRSFi PIRSF018153. Glyco_trans_15. 1 hit.
SUPFAMi SSF53448. SSF53448. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Completion of the Saccharomyces cerevisiae genome sequence allows identification of KTR5, KTR6 and KTR7 and definition of the nine-membered KRE2/MNT1 mannosyltransferase gene family in this organism."
    Lussier M., Sdicu A.-M., Winnett E., Vo D.H., Sheraton J., Duesterhoeft A., Storms R.K., Bussey H.
    Yeast 13:267-274(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKTR5_YEAST
AccessioniPrimary (citable) accession number: P53966
Secondary accession number(s): D6W1F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 450 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

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