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P53966 (KTR5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable mannosyltransferase KTR5

EC=2.4.1.-
Gene names
Name:KTR5
Ordered Locus Names:YNL029C
ORF Names:N2755
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length522 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Possible glycosyltransferase.

Catalytic activity

Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.

Subcellular location

Membrane; Single-pass type II membrane protein Probable.

Miscellaneous

Present with 450 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the glycosyltransferase 15 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 522522Probable mannosyltransferase KTR5
PRO_0000208246

Regions

Topological domain1 – 1616Cytoplasmic Potential
Transmembrane17 – 3721Helical; Signal-anchor for type II membrane protein; Potential
Topological domain38 – 522485Lumenal Potential
Region38 – 8245Stem region By similarity
Region83 – 522440Catalytic By similarity

Sites

Active site3631Nucleophile Potential

Amino acid modifications

Glycosylation861N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P53966 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 3F9D75D3F09D4110

FASTA52261,728
        10         20         30         40         50         60 
MLLIRRTINA FLGCIHCNLT ATCILIAFVI TMYVVLVSEP ASVDGTMGNF LPFSKMDLAT 

        70         80         90        100        110        120 
KRDRPFYSNC VNTQDYLLNP SYIKQNASFV MLTRNGELED VIKTINSIEE HFNQWFHYPY 

       130        140        150        160        170        180 
VFLNDQPFEE DFKAKVRDVT VGALVEFGTI DEISWNFPSD VKDTFEFYNA IEDQGDRSIL 

       190        200        210        220        230        240 
YGNLESYHKM CRFYSGLFYK HPLVQKYEWY WRLEPDVEFF CDITYDPFLE MLRTNKKYGF 

       250        260        270        280        290        300 
TIIIPELYWT VPNLFRHTKS FISQKGVTLG SLWKLFTKDY DIFESDDPEL RDWINYDFQA 

       310        320        330        340        350        360 
KAKISEKIAI EQLLKKGDDF QQINDDKEGI MNLIHKARSR KHIVEDKFFN EEYNLCHFWS 

       370        380        390        400        410        420 
NFEIARLSVF DNDIYNSFFQ YLEKSGGFWK ERWGDAPVHS IGLSLTLDLD DVHYFRDIGY 

       430        440        450        460        470        480 
RHSTIQHCPH NAMGNEEFSY LASDSKFKRK NAAYDEGREF GCGCRCRCPK KKREIEDSMG 

       490        500        510        520 
FCVNIWVNLL NQQRGHERHV EALNGNEMEE HIREDYLRQF GN 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Completion of the Saccharomyces cerevisiae genome sequence allows identification of KTR5, KTR6 and KTR7 and definition of the nine-membered KRE2/MNT1 mannosyltransferase gene family in this organism."
Lussier M., Sdicu A.-M., Winnett E., Vo D.H., Sheraton J., Duesterhoeft A., Storms R.K., Bussey H.
Yeast 13:267-274(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z71305 Genomic DNA. Translation: CAA95891.1.
BK006947 Genomic DNA. Translation: DAA10516.1.
PIRS62941.
RefSeqNP_014369.3. NM_001182868.3.

3D structure databases

ProteinModelPortalP53966.
SMRP53966. Positions 73-497.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35798. 13 interactions.
DIPDIP-6646N.
IntActP53966. 2 interactions.
MINTMINT-614539.
STRING4932.YNL029C.

Protein family/group databases

CAZyGT15. Glycosyltransferase Family 15.

Proteomic databases

PaxDbP53966.
PeptideAtlasP53966.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYNL029C; YNL029C; YNL029C.
GeneID855703.
KEGGsce:YNL029C.

Organism-specific databases

CYGDYNL029c.
SGDS000004974. KTR5.

Phylogenomic databases

eggNOGCOG5020.
GeneTreeENSGT00390000000831.
HOGENOMHOG000160667.
KOK03854.
OMAFWKERWG.
OrthoDBEOG779P83.

Enzyme and pathway databases

BioCycYEAST:G3O-33066-MONOMER.

Gene expression databases

GenevestigatorP53966.

Family and domain databases

InterProIPR002685. Glyco_trans_15.
[Graphical view]
PfamPF01793. Glyco_transf_15. 1 hit.
[Graphical view]
PIRSFPIRSF018153. Glyco_trans_15. 1 hit.
ProtoNetSearch...

Other

NextBio980037.

Entry information

Entry nameKTR5_YEAST
AccessionPrimary (citable) accession number: P53966
Secondary accession number(s): D6W1F0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families