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P53966

- KTR5_YEAST

UniProt

P53966 - KTR5_YEAST

Protein

Probable mannosyltransferase KTR5

Gene

KTR5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Possible glycosyltransferase.

    Catalytic activityi

    Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei363 – 3631NucleophileSequence Analysis

    GO - Molecular functioni

    1. mannosyltransferase activity Source: SGD

    GO - Biological processi

    1. mannosylation Source: SGD
    2. protein glycosylation Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33066-MONOMER.

    Protein family/group databases

    CAZyiGT15. Glycosyltransferase Family 15.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable mannosyltransferase KTR5 (EC:2.4.1.-)
    Gene namesi
    Name:KTR5
    Ordered Locus Names:YNL029C
    ORF Names:N2755
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNL029c.
    SGDiS000004974. KTR5.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: SGD
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 522522Probable mannosyltransferase KTR5PRO_0000208246Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP53966.
    PaxDbiP53966.
    PeptideAtlasiP53966.

    Expressioni

    Gene expression databases

    GenevestigatoriP53966.

    Interactioni

    Protein-protein interaction databases

    BioGridi35798. 13 interactions.
    DIPiDIP-6646N.
    IntActiP53966. 2 interactions.
    MINTiMINT-614539.
    STRINGi4932.YNL029C.

    Structurei

    3D structure databases

    ProteinModelPortaliP53966.
    SMRiP53966. Positions 73-429.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini38 – 522485LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni38 – 8245Stem regionBy similarityAdd
    BLAST
    Regioni83 – 522440CatalyticBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyltransferase 15 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5020.
    GeneTreeiENSGT00390000000831.
    HOGENOMiHOG000160667.
    KOiK03854.
    OMAiFWKERWG.
    OrthoDBiEOG779P83.

    Family and domain databases

    Gene3Di3.90.550.10. 2 hits.
    InterProiIPR002685. Glyco_trans_15.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF01793. Glyco_transf_15. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018153. Glyco_trans_15. 1 hit.
    SUPFAMiSSF53448. SSF53448. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    P53966-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLIRRTINA FLGCIHCNLT ATCILIAFVI TMYVVLVSEP ASVDGTMGNF    50
    LPFSKMDLAT KRDRPFYSNC VNTQDYLLNP SYIKQNASFV MLTRNGELED 100
    VIKTINSIEE HFNQWFHYPY VFLNDQPFEE DFKAKVRDVT VGALVEFGTI 150
    DEISWNFPSD VKDTFEFYNA IEDQGDRSIL YGNLESYHKM CRFYSGLFYK 200
    HPLVQKYEWY WRLEPDVEFF CDITYDPFLE MLRTNKKYGF TIIIPELYWT 250
    VPNLFRHTKS FISQKGVTLG SLWKLFTKDY DIFESDDPEL RDWINYDFQA 300
    KAKISEKIAI EQLLKKGDDF QQINDDKEGI MNLIHKARSR KHIVEDKFFN 350
    EEYNLCHFWS NFEIARLSVF DNDIYNSFFQ YLEKSGGFWK ERWGDAPVHS 400
    IGLSLTLDLD DVHYFRDIGY RHSTIQHCPH NAMGNEEFSY LASDSKFKRK 450
    NAAYDEGREF GCGCRCRCPK KKREIEDSMG FCVNIWVNLL NQQRGHERHV 500
    EALNGNEMEE HIREDYLRQF GN 522
    Length:522
    Mass (Da):61,728
    Last modified:October 1, 1996 - v1
    Checksum:i3F9D75D3F09D4110
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71305 Genomic DNA. Translation: CAA95891.1.
    BK006947 Genomic DNA. Translation: DAA10516.1.
    PIRiS62941.
    RefSeqiNP_014369.3. NM_001182868.3.

    Genome annotation databases

    EnsemblFungiiYNL029C; YNL029C; YNL029C.
    GeneIDi855703.
    KEGGisce:YNL029C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71305 Genomic DNA. Translation: CAA95891.1 .
    BK006947 Genomic DNA. Translation: DAA10516.1 .
    PIRi S62941.
    RefSeqi NP_014369.3. NM_001182868.3.

    3D structure databases

    ProteinModelPortali P53966.
    SMRi P53966. Positions 73-429.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35798. 13 interactions.
    DIPi DIP-6646N.
    IntActi P53966. 2 interactions.
    MINTi MINT-614539.
    STRINGi 4932.YNL029C.

    Protein family/group databases

    CAZyi GT15. Glycosyltransferase Family 15.

    Proteomic databases

    MaxQBi P53966.
    PaxDbi P53966.
    PeptideAtlasi P53966.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNL029C ; YNL029C ; YNL029C .
    GeneIDi 855703.
    KEGGi sce:YNL029C.

    Organism-specific databases

    CYGDi YNL029c.
    SGDi S000004974. KTR5.

    Phylogenomic databases

    eggNOGi COG5020.
    GeneTreei ENSGT00390000000831.
    HOGENOMi HOG000160667.
    KOi K03854.
    OMAi FWKERWG.
    OrthoDBi EOG779P83.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33066-MONOMER.

    Miscellaneous databases

    NextBioi 980037.

    Gene expression databases

    Genevestigatori P53966.

    Family and domain databases

    Gene3Di 3.90.550.10. 2 hits.
    InterProi IPR002685. Glyco_trans_15.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF01793. Glyco_transf_15. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018153. Glyco_trans_15. 1 hit.
    SUPFAMi SSF53448. SSF53448. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Completion of the Saccharomyces cerevisiae genome sequence allows identification of KTR5, KTR6 and KTR7 and definition of the nine-membered KRE2/MNT1 mannosyltransferase gene family in this organism."
      Lussier M., Sdicu A.-M., Winnett E., Vo D.H., Sheraton J., Duesterhoeft A., Storms R.K., Bussey H.
      Yeast 13:267-274(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiKTR5_YEAST
    AccessioniPrimary (citable) accession number: P53966
    Secondary accession number(s): D6W1F0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 450 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3