Reviewed,
UniProtKB/Swiss-Prot P53966 (KTR5_YEAST)
Last modified
June 16, 2009.
Version 70.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Probable mannosyltransferase KTR5 EC=2.4.1.131 | ||||||
| Gene names |
| ||||||
| Organism | Saccharomyces cerevisiae (Baker's yeast) [Complete proteome] | ||||||
| Taxonomic identifier | 4932 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 522 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Possible glycosyltransferase. |
| Catalytic activity | Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage. |
| Subcellular location | Membrane; Single-pass type II membrane protein Probable. |
| Miscellaneous | Present with 450 molecules/cell in log phase SD medium. Ref.3 |
| Sequence similarities | Belongs to the glycosyltransferase 15 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Signal-anchor Transmembrane |
| Molecular function | Glycosyltransferase Transferase |
| PTM | Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cell wall organization Ref.2 Inferred from mutant phenotype. Source: SGD protein amino acid glycosylationInferred from electronic annotation. Source: InterPro |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | glycolipid 2-alpha-mannosyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 522 | 522 | Probable mannosyltransferase KTR5 | PRO_0000208246 | |||||
Regions | |||||||||
| Topological domain | 1 – 16 | 16 | Cytoplasmic Potential | ||||||
| Transmembrane | 17 – 37 | 21 | Signal-anchor for type II membrane protein Potential | ||||||
| Topological domain | 38 – 522 | 485 | Lumenal Potential | ||||||
| Region | 38 – 82 | 45 | Stem region By similarity | ||||||
| Region | 83 – 522 | 440 | Catalytic By similarity | ||||||
Sites | |||||||||
| Active site | 363 | 1 | Nucleophile Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 86 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. Hani J.Nature 387:93-98(1997) [PubMed: 9169873] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c. |
| [2] | "Completion of the Saccharomyces cerevisiae genome sequence allows identification of KTR5, KTR6 and KTR7 and definition of the nine-membered KRE2/MNT1 mannosyltransferase gene family in this organism." Lussier M., Sdicu A.-M., Winnett E., Vo D.H., Sheraton J., Duesterhoeft A., Storms R.K., Bussey H. Yeast 13:267-274(1997) [PubMed: 9090056] [Abstract] Cited for: CHARACTERIZATION. |
| [3] | "Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| Z71305 Genomic DNA. Translation: CAA95891.1. | |
| PIR | S62941. |
| RefSeq | NP_014369.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:6646N. |
Protein family/group databases | |
| CAZy | GT15. Glycosyltransferase Family 15. |
Proteomic databases | |
| PeptideAtlas | P53966. |
Genome annotation databases | |
| Ensembl | YNL029C. Saccharomyces cerevisiae. [Contig view] |
| GeneID | 855703. |
| GenomeReviews | Gene locus YNL029C in contig Y13139_GR. |
| KEGG | sce:YNL029C. |
| NMPDR | fig|4932.3.peg.5446. |
Organism-specific databases | |
| CYGD | YNL029c. |
| SGD | S000004974. KTR5. |
| Yeast-GFP | Search... |
Phylogenomic databases | |
| HOGENOM | P53966. |
| OMA | P53966. MERHFNQ. |
Enzyme and pathway databases | |
| BRENDA | 2.4.1.131. 250. |
Gene expression databases | |
| ArrayExpress | P53966. |
| GermOnline | YNL029C. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR002685. Glyco_trans_15. [Graphical view] |
| Pfam | PF01793. Glyco_transf_15. 1 hit. [Graphical view] |
| PIRSF | PIRSF018153. Glyco_trans_15. 1 hit. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 980037. |
Entry information
| Entry name | KTR5_YEAST | ||||||||
| Accession | Primary (citable) accession number: P53966 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome XIV Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names |

Clusters with


