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Protein

Probable mannosyltransferase KTR5

Gene

KTR5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Possible glycosyltransferase.

Catalytic activityi

Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei363 – 3631NucleophileSequence Analysis

GO - Molecular functioni

  1. mannosyltransferase activity Source: SGD

GO - Biological processi

  1. mannosylation Source: SGD
  2. protein glycosylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciYEAST:G3O-33066-MONOMER.

Protein family/group databases

CAZyiGT15. Glycosyltransferase Family 15.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mannosyltransferase KTR5 (EC:2.4.1.-)
Gene namesi
Name:KTR5
Ordered Locus Names:YNL029C
ORF Names:N2755
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL029c.
SGDiS000004974. KTR5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei17 – 3721Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini38 – 522485LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: SGD
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 522522Probable mannosyltransferase KTR5PRO_0000208246Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP53966.
PaxDbiP53966.
PeptideAtlasiP53966.

Expressioni

Gene expression databases

GenevestigatoriP53966.

Interactioni

Protein-protein interaction databases

BioGridi35798. 14 interactions.
DIPiDIP-6646N.
IntActiP53966. 2 interactions.
MINTiMINT-614539.
STRINGi4932.YNL029C.

Structurei

3D structure databases

ProteinModelPortaliP53966.
SMRiP53966. Positions 73-429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni38 – 8245Stem regionBy similarityAdd
BLAST
Regioni83 – 522440CatalyticBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyltransferase 15 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5020.
GeneTreeiENSGT00390000000831.
HOGENOMiHOG000160667.
InParanoidiP53966.
KOiK03854.
OMAiFWKERWG.
OrthoDBiEOG779P83.

Family and domain databases

Gene3Di3.90.550.10. 2 hits.
InterProiIPR002685. Glyco_trans_15.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01793. Glyco_transf_15. 1 hit.
[Graphical view]
PIRSFiPIRSF018153. Glyco_trans_15. 1 hit.
SUPFAMiSSF53448. SSF53448. 3 hits.

Sequencei

Sequence statusi: Complete.

P53966-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLIRRTINA FLGCIHCNLT ATCILIAFVI TMYVVLVSEP ASVDGTMGNF
60 70 80 90 100
LPFSKMDLAT KRDRPFYSNC VNTQDYLLNP SYIKQNASFV MLTRNGELED
110 120 130 140 150
VIKTINSIEE HFNQWFHYPY VFLNDQPFEE DFKAKVRDVT VGALVEFGTI
160 170 180 190 200
DEISWNFPSD VKDTFEFYNA IEDQGDRSIL YGNLESYHKM CRFYSGLFYK
210 220 230 240 250
HPLVQKYEWY WRLEPDVEFF CDITYDPFLE MLRTNKKYGF TIIIPELYWT
260 270 280 290 300
VPNLFRHTKS FISQKGVTLG SLWKLFTKDY DIFESDDPEL RDWINYDFQA
310 320 330 340 350
KAKISEKIAI EQLLKKGDDF QQINDDKEGI MNLIHKARSR KHIVEDKFFN
360 370 380 390 400
EEYNLCHFWS NFEIARLSVF DNDIYNSFFQ YLEKSGGFWK ERWGDAPVHS
410 420 430 440 450
IGLSLTLDLD DVHYFRDIGY RHSTIQHCPH NAMGNEEFSY LASDSKFKRK
460 470 480 490 500
NAAYDEGREF GCGCRCRCPK KKREIEDSMG FCVNIWVNLL NQQRGHERHV
510 520
EALNGNEMEE HIREDYLRQF GN
Length:522
Mass (Da):61,728
Last modified:October 1, 1996 - v1
Checksum:i3F9D75D3F09D4110
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71305 Genomic DNA. Translation: CAA95891.1.
BK006947 Genomic DNA. Translation: DAA10516.1.
PIRiS62941.
RefSeqiNP_014369.3. NM_001182868.3.

Genome annotation databases

EnsemblFungiiYNL029C; YNL029C; YNL029C.
GeneIDi855703.
KEGGisce:YNL029C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71305 Genomic DNA. Translation: CAA95891.1.
BK006947 Genomic DNA. Translation: DAA10516.1.
PIRiS62941.
RefSeqiNP_014369.3. NM_001182868.3.

3D structure databases

ProteinModelPortaliP53966.
SMRiP53966. Positions 73-429.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35798. 14 interactions.
DIPiDIP-6646N.
IntActiP53966. 2 interactions.
MINTiMINT-614539.
STRINGi4932.YNL029C.

Protein family/group databases

CAZyiGT15. Glycosyltransferase Family 15.

Proteomic databases

MaxQBiP53966.
PaxDbiP53966.
PeptideAtlasiP53966.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL029C; YNL029C; YNL029C.
GeneIDi855703.
KEGGisce:YNL029C.

Organism-specific databases

CYGDiYNL029c.
SGDiS000004974. KTR5.

Phylogenomic databases

eggNOGiCOG5020.
GeneTreeiENSGT00390000000831.
HOGENOMiHOG000160667.
InParanoidiP53966.
KOiK03854.
OMAiFWKERWG.
OrthoDBiEOG779P83.

Enzyme and pathway databases

BioCyciYEAST:G3O-33066-MONOMER.

Miscellaneous databases

NextBioi980037.

Gene expression databases

GenevestigatoriP53966.

Family and domain databases

Gene3Di3.90.550.10. 2 hits.
InterProiIPR002685. Glyco_trans_15.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01793. Glyco_transf_15. 1 hit.
[Graphical view]
PIRSFiPIRSF018153. Glyco_trans_15. 1 hit.
SUPFAMiSSF53448. SSF53448. 3 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Completion of the Saccharomyces cerevisiae genome sequence allows identification of KTR5, KTR6 and KTR7 and definition of the nine-membered KRE2/MNT1 mannosyltransferase gene family in this organism."
    Lussier M., Sdicu A.-M., Winnett E., Vo D.H., Sheraton J., Duesterhoeft A., Storms R.K., Bussey H.
    Yeast 13:267-274(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKTR5_YEAST
AccessioniPrimary (citable) accession number: P53966
Secondary accession number(s): D6W1F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 450 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.