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Protein

Tyrosine-protein phosphatase SIW14

Gene

SIW14

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in actin filament organization and endocytosis.1 Publication

Miscellaneous

Present with 4070 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei214Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • protein tyrosine phosphatase activity Source: SGD

GO - Biological processi

  • actin filament organization Source: SGD
  • endocytosis Source: SGD
  • protein dephosphorylation Source: SGD

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciMetaCyc:G3O-33069-MONOMER
YEAST:G3O-33069-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase SIW14 (EC:3.1.3.48)
Gene namesi
Name:SIW14
Ordered Locus Names:YNL032W
ORF Names:N2746
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL032W
SGDiS000004977 SIW14

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000949221 – 281Tyrosine-protein phosphatase SIW14Add BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei94PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53965
PaxDbiP53965
PRIDEiP53965

PTM databases

iPTMnetiP53965

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35795, 449 interactors
DIPiDIP-1990N
IntActiP53965, 30 interactors
MINTiP53965
STRINGi4932.YNL032W

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6BYFX-ray2.35A/B/C/D/E/F/G/H/I116-281[»]
ProteinModelPortaliP53965
SMRiP53965
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00530000066535
HOGENOMiHOG000188365
InParanoidiP53965
KOiK18045
OMAiNKEVIPP
OrthoDBiEOG092C4JKC

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020428 PFA-DSPs
IPR029021 Prot-tyrosine_phosphatase-like
IPR004861 Siw14-like
IPR016130 Tyr_Pase_AS
PfamiView protein in Pfam
PF03162 Y_phosphatase2, 1 hit
PRINTSiPR01911 PFDSPHPHTASE
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

P53965-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLYQAKNDE GSDPKSSSKI DDLIENEAEI IRLIKEDGKL LIDNGDGRDI
60 70 80 90 100
HNIIQEDKLL SVEFNEVLKR FHGEEKSDIP RKEFDEDEDD GYDSNEHHQK
110 120 130 140 150
TIEVMNTLNH VINKEVIPPE NFSHVVGEIY RSSFPRQENF SFLHERLKLK
160 170 180 190 200
SILVLIPEEY PQENLNFLKL TGIKLYQVGM SGNKEPFVNI PSHLLTKALE
210 220 230 240 250
IVLNPANQPI LIHCNRGKHR TGCLIGCIRK LQNWSLTMIF DEYRRFAFPK
260 270 280
ARALDQQFIE MYDDDEIKRI ASKNNWLPLQ W
Length:281
Mass (Da):32,755
Last modified:October 1, 1996 - v1
Checksum:i88BD8AFC620B4570
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71308 Genomic DNA Translation: CAA95895.1
BK006947 Genomic DNA Translation: DAA10513.1
PIRiS62954
RefSeqiNP_014366.3, NM_001182871.3

Genome annotation databases

EnsemblFungiiYNL032W; YNL032W; YNL032W
GeneIDi855699
KEGGisce:YNL032W

Similar proteinsi

Entry informationi

Entry nameiSIW14_YEAST
AccessioniPrimary (citable) accession number: P53965
Secondary accession number(s): D6W1E7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

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