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Protein

Tyrosine-protein phosphatase SIW14

Gene

SIW14

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in actin filament organization and endocytosis.1 Publication

Miscellaneous

Present with 4070 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei214Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • protein tyrosine phosphatase activity Source: SGD

GO - Biological processi

  • actin filament organization Source: SGD
  • endocytosis Source: SGD
  • protein dephosphorylation Source: SGD

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciYEAST:G3O-33069-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase SIW14 (EC:3.1.3.48)
Gene namesi
Name:SIW14
Ordered Locus Names:YNL032W
ORF Names:N2746
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL032W.
SGDiS000004977. SIW14.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000949221 – 281Tyrosine-protein phosphatase SIW14Add BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei94PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53965.
PRIDEiP53965.

PTM databases

iPTMnetiP53965.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35795. 433 interactors.
DIPiDIP-1990N.
IntActiP53965. 22 interactors.
MINTiMINT-384829.
STRINGi4932.YNL032W.

Structurei

3D structure databases

ProteinModelPortaliP53965.
SMRiP53965.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00530000066535.
HOGENOMiHOG000188365.
InParanoidiP53965.
KOiK18045.
OMAiNKEVIPP.
OrthoDBiEOG092C4JKC.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR020428. Tyr_Pase_SIW14-lik_euk.
IPR004861. Tyr_Pase_SIW14-like.
PfamiView protein in Pfam
PF03162. Y_phosphatase2. 1 hit.
PRINTSiPR01911. PFDSPHPHTASE.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiView protein in PROSITE
PS00383. TYR_PHOSPHATASE_1. 1 hit.

Sequencei

Sequence statusi: Complete.

P53965-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLYQAKNDE GSDPKSSSKI DDLIENEAEI IRLIKEDGKL LIDNGDGRDI
60 70 80 90 100
HNIIQEDKLL SVEFNEVLKR FHGEEKSDIP RKEFDEDEDD GYDSNEHHQK
110 120 130 140 150
TIEVMNTLNH VINKEVIPPE NFSHVVGEIY RSSFPRQENF SFLHERLKLK
160 170 180 190 200
SILVLIPEEY PQENLNFLKL TGIKLYQVGM SGNKEPFVNI PSHLLTKALE
210 220 230 240 250
IVLNPANQPI LIHCNRGKHR TGCLIGCIRK LQNWSLTMIF DEYRRFAFPK
260 270 280
ARALDQQFIE MYDDDEIKRI ASKNNWLPLQ W
Length:281
Mass (Da):32,755
Last modified:October 1, 1996 - v1
Checksum:i88BD8AFC620B4570
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71308 Genomic DNA. Translation: CAA95895.1.
BK006947 Genomic DNA. Translation: DAA10513.1.
PIRiS62954.
RefSeqiNP_014366.3. NM_001182871.3.

Genome annotation databases

EnsemblFungiiYNL032W; YNL032W; YNL032W.
GeneIDi855699.
KEGGisce:YNL032W.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSIW14_YEAST
AccessioniPrimary (citable) accession number: P53965
Secondary accession number(s): D6W1E7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 5, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names