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Protein

Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI15

Gene

GPI15

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.1 Publication

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • GPI anchor biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

BioCyciYEAST:G3O-33074-MONOMER.
UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI15 (EC:2.4.1.198)
Alternative name(s):
PIGH homolog
Gene namesi
Name:GPI15
Ordered Locus Names:YNL038W
ORF Names:N2687
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL038W.
SGDiS000004983. GPI15.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000875561 – 229Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI15Add BLAST229

Proteomic databases

MaxQBiP53961.
PRIDEiP53961.

Interactioni

Subunit structurei

Component of a complex with GPI1, GPI2, GPI3, GPI15 and ERI1.Curated

Protein-protein interaction databases

BioGridi35786. 19 interactors.
DIPiDIP-6356N.
MINTiMINT-701877.

Structurei

3D structure databases

ProteinModelPortaliP53961.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGH family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP53961.
KOiK03858.
OMAiMISKEYE.
OrthoDBiEOG092C5XP3.

Family and domain databases

InterProiIPR019328. GPI-GlcNAc_Trfase_PIG-H_dom.
[Graphical view]
PfamiPF10181. PIG-H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53961-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISKEYEFGK TSILNRKKYT LVIDEDKNGN FIRFTVLPVS NRKFKKVKQN
60 70 80 90 100
GRVEINMGIQ YHQIVLILLL NILFYVICLR SRFLEHINRT FEVTIARSFQ
110 120 130 140 150
ILIIMGLFAL GTIILVRGPS VETVTIFKES GLQLSRVKGM VIFPQQWNRK
160 170 180 190 200
FFEQVEFISN ERIIDVVINE GFCRGFRVIF YLAAIVRKSS TLKLLFPSNL
210 220
PSIDDQRLIY NISRKYLSKQ EKPLSRPKD
Length:229
Mass (Da):26,817
Last modified:December 20, 2005 - v2
Checksum:iE89CB192B65FBF06
GO

Sequence cautioni

The sequence AAT93131 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA95905 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10K → E in AAT93131 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71314 Genomic DNA. Translation: CAA95905.1. Sequence problems.
AY693112 Genomic DNA. Translation: AAT93131.1. Sequence problems.
BK006947 Genomic DNA. Translation: DAA10507.1.
PIRiS62960.
RefSeqiNP_014360.2. NM_001182877.1.

Genome annotation databases

EnsemblFungiiYNL038W; YNL038W; YNL038W.
GeneIDi855690.
KEGGisce:YNL038W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71314 Genomic DNA. Translation: CAA95905.1. Sequence problems.
AY693112 Genomic DNA. Translation: AAT93131.1. Sequence problems.
BK006947 Genomic DNA. Translation: DAA10507.1.
PIRiS62960.
RefSeqiNP_014360.2. NM_001182877.1.

3D structure databases

ProteinModelPortaliP53961.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35786. 19 interactors.
DIPiDIP-6356N.
MINTiMINT-701877.

Proteomic databases

MaxQBiP53961.
PRIDEiP53961.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL038W; YNL038W; YNL038W.
GeneIDi855690.
KEGGisce:YNL038W.

Organism-specific databases

EuPathDBiFungiDB:YNL038W.
SGDiS000004983. GPI15.

Phylogenomic databases

InParanoidiP53961.
KOiK03858.
OMAiMISKEYE.
OrthoDBiEOG092C5XP3.

Enzyme and pathway databases

UniPathwayiUPA00196.
BioCyciYEAST:G3O-33074-MONOMER.

Miscellaneous databases

PROiP53961.

Family and domain databases

InterProiIPR019328. GPI-GlcNAc_Trfase_PIG-H_dom.
[Graphical view]
PfamiPF10181. PIG-H. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPI15_YEAST
AccessioniPrimary (citable) accession number: P53961
Secondary accession number(s): D6W1E1, Q6B1G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 20, 2005
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.