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Protein

Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI15

Gene

GPI15

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.1 Publication

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • GPI anchor biosynthetic process Source: SGD

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processGPI-anchor biosynthesis

Enzyme and pathway databases

BioCyciYEAST:G3O-33074-MONOMER
UniPathwayiUPA00196

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI15 (EC:2.4.1.198)
Short name:
GPI-GlcNAc transferase complex subunit GPI5
Short name:
GPI-GnT subunit GPI5
Alternative name(s):
PIGH homolog
Gene namesi
Name:GPI15
Ordered Locus Names:YNL038W
ORF Names:N2687
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL038W
SGDiS000004983 GPI15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000875561 – 229Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI15Add BLAST229

Proteomic databases

MaxQBiP53961
PaxDbiP53961
PRIDEiP53961

Interactioni

Subunit structurei

Component of the phosphatidylinositol N-acetylglucosaminyltransferase (GPI-GlcNAc transferase) complex composed of at least GPI1, GPI2, GPI3, GPI15, GPI19 and ERI1.1 Publication

Protein-protein interaction databases

BioGridi35786, 268 interactors
DIPiDIP-6356N
IntActiP53961, 1 interactor
STRINGi4932.YNL038W

Structurei

3D structure databases

ProteinModelPortaliP53961
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGH family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP53961
KOiK03858
OMAiVINEGFC
OrthoDBiEOG092C5XP3

Family and domain databases

InterProiView protein in InterPro
IPR019328 GPI-GlcNAc_Trfase_PIG-H_dom
PfamiView protein in Pfam
PF10181 PIG-H, 1 hit

Sequencei

Sequence statusi: Complete.

P53961-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISKEYEFGK TSILNRKKYT LVIDEDKNGN FIRFTVLPVS NRKFKKVKQN
60 70 80 90 100
GRVEINMGIQ YHQIVLILLL NILFYVICLR SRFLEHINRT FEVTIARSFQ
110 120 130 140 150
ILIIMGLFAL GTIILVRGPS VETVTIFKES GLQLSRVKGM VIFPQQWNRK
160 170 180 190 200
FFEQVEFISN ERIIDVVINE GFCRGFRVIF YLAAIVRKSS TLKLLFPSNL
210 220
PSIDDQRLIY NISRKYLSKQ EKPLSRPKD
Length:229
Mass (Da):26,817
Last modified:December 20, 2005 - v2
Checksum:iE89CB192B65FBF06
GO

Sequence cautioni

The sequence AAT93131 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA95905 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10K → E in AAT93131 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71314 Genomic DNA Translation: CAA95905.1 Sequence problems.
AY693112 Genomic DNA Translation: AAT93131.1 Sequence problems.
BK006947 Genomic DNA Translation: DAA10507.1
PIRiS62960
RefSeqiNP_014360.2, NM_001182877.1

Genome annotation databases

EnsemblFungiiYNL038W; YNL038W; YNL038W
GeneIDi855690
KEGGisce:YNL038W

Similar proteinsi

Entry informationi

Entry nameiGPI15_YEAST
AccessioniPrimary (citable) accession number: P53961
Secondary accession number(s): D6W1E1, Q6B1G8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

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