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P53959

- COG6_YEAST

UniProt

P53959 - COG6_YEAST

Protein

Conserved oligomeric Golgi complex subunit 6

Gene

COG6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. CVT pathway Source: SGD
    2. intra-Golgi vesicle-mediated transport Source: SGD

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33077-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Conserved oligomeric Golgi complex subunit 6
    Short name:
    COG complex subunit 6
    Alternative name(s):
    Complexed with DOR1 protein 2
    Component of oligomeric Golgi complex 6
    Protein SEC37
    Gene namesi
    Name:COG6
    Synonyms:COD2, SEC37, TFI2
    Ordered Locus Names:YNL041C
    ORF Names:N2675
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNL041c.
    SGDiS000004986. COG6.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. Golgi transport complex Source: SGD

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 839839Conserved oligomeric Golgi complex subunit 6PRO_0000213517Add
    BLAST

    Proteomic databases

    MaxQBiP53959.
    PaxDbiP53959.

    Expressioni

    Gene expression databases

    GenevestigatoriP53959.

    Interactioni

    Subunit structurei

    Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    COG1P530795EBI-4829,EBI-4835
    COG2P532713EBI-4829,EBI-16614
    COG3P400943EBI-4829,EBI-16605
    COG5P539512EBI-4829,EBI-4841
    COG7P531953EBI-4829,EBI-4847
    COG8Q046325EBI-4829,EBI-6035

    Protein-protein interaction databases

    BioGridi35783. 294 interactions.
    DIPiDIP-4373N.
    IntActiP53959. 21 interactions.
    MINTiMINT-485603.
    STRINGi4932.YNL041C.

    Structurei

    3D structure databases

    ProteinModelPortaliP53959.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the COG6 family.Curated

    Phylogenomic databases

    eggNOGiNOG291168.
    GeneTreeiENSGT00390000013518.
    HOGENOMiHOG000111882.
    OMAiEWIIEFY.
    OrthoDBiEOG7FBRS5.

    Family and domain databases

    InterProiIPR010490. COG6.
    [Graphical view]
    PANTHERiPTHR21506. PTHR21506. 1 hit.
    PfamiPF06419. COG6. 1 hit.
    [Graphical view]
    SMARTiSM01087. COG6. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53959-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFVVDYQTY AMADTATPEL PEPEPRLNLT SDAQSQPTGK LDLQFKLPDL    50
    QRYSNNNATL PVDNDGAGSK DLHKKMTHYA MSSIDKIQLS NPSKQLGQNS 100
    QDEKLSQQES QNFTNYEPKN LDLSKLVSPS SGSNKNTTNL VLSNKLSKIL 150
    NNYTLINYQA TVQLRKSLKV LEENKERLSL DEQKLMNPEY VGTLARRALR 200
    TDLESQLLKE HITVLEEFKP IIRRIKRLSS SVEKIQRTSE KLLSNETNEV 250
    PTNNVVLQEI DQYRLKAEQL KLKKKILLSI RDRFTLNQVE DDVITNGTID 300
    NIFFEVVKKV INIKDESSFL LTLPNLNAGN ALIMGVNEIL EKTNKKIFNY 350
    LIDFLYSFES SSNLLNDHGT TEQESLNIFR KSLVFLSSDL ELFNELLKRV 400
    TTLRSKSILD EFLSQFDMNS TTSKPIILSA HDPIRYIGDV LASVHSIIAN 450
    EADFVKSLFD FQDEDLKDTP ISILQQNKTF LKGIDNKLLN DIIQSLSNSC 500
    RIRIEQIVRF EENPIINFEI VRLLKLYRVM FERKGIQDDS SIINNLKSLE 550
    DISKNRIIGY YEDYMKQTVM AETKNSSDDL LPPEWLSEYM NKLVELFEIY 600
    EKTHAAEDEE SEDNKLLSSK NLQTIVEQPI KDVLLKQLQT SFPLAKKNEK 650
    EKASLLTIEI NCFDLIKSRL QPFEGLFAQD DDSRKITIWV CDKLKEYTKQ 700
    MLTLQIKFLF ENTGLDLYSN LVNMIFPVDS VKDELDYDMY LALRDNSLME 750
    LDMVRKNVHD KLNYYLPQAL TDVQGNLLFK LTSPMIADEI CDECFKKLSL 800
    FYNIFRKLLI HLYPNKKDQV FEILNFSTDE FDMLIGIDH 839
    Length:839
    Mass (Da):96,976
    Last modified:October 1, 1996 - v1
    Checksum:i6484A40F999AD787
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71317 Genomic DNA. Translation: CAA95908.1.
    BK006947 Genomic DNA. Translation: DAA10504.1.
    PIRiS62963.
    RefSeqiNP_014357.1. NM_001182880.1.

    Genome annotation databases

    EnsemblFungiiYNL041C; YNL041C; YNL041C.
    GeneIDi855687.
    KEGGisce:YNL041C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71317 Genomic DNA. Translation: CAA95908.1 .
    BK006947 Genomic DNA. Translation: DAA10504.1 .
    PIRi S62963.
    RefSeqi NP_014357.1. NM_001182880.1.

    3D structure databases

    ProteinModelPortali P53959.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35783. 294 interactions.
    DIPi DIP-4373N.
    IntActi P53959. 21 interactions.
    MINTi MINT-485603.
    STRINGi 4932.YNL041C.

    Proteomic databases

    MaxQBi P53959.
    PaxDbi P53959.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNL041C ; YNL041C ; YNL041C .
    GeneIDi 855687.
    KEGGi sce:YNL041C.

    Organism-specific databases

    CYGDi YNL041c.
    SGDi S000004986. COG6.

    Phylogenomic databases

    eggNOGi NOG291168.
    GeneTreei ENSGT00390000013518.
    HOGENOMi HOG000111882.
    OMAi EWIIEFY.
    OrthoDBi EOG7FBRS5.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33077-MONOMER.

    Miscellaneous databases

    NextBioi 979995.
    PROi P53959.

    Gene expression databases

    Genevestigatori P53959.

    Family and domain databases

    InterProi IPR010490. COG6.
    [Graphical view ]
    PANTHERi PTHR21506. PTHR21506. 1 hit.
    Pfami PF06419. COG6. 1 hit.
    [Graphical view ]
    SMARTi SM01087. COG6. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic."
      Whyte J.R., Munro S.
      Dev. Cell 1:527-537(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
    4. "The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins."
      Suvorova E.S., Duden R., Lupashin V.V.
      J. Cell Biol. 157:631-643(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE COG COMPLEX, FUNCTION OF THE COG COMPLEX.
    5. "Identification of sec36p, sec37p, and sec38p: components of yeast complex that contains sec34p and sec35p."
      Ram R.J., Li B., Kaiser C.A.
      Mol. Biol. Cell 13:1484-1500(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE COG COMPLEX.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "The binary interacting network of the conserved oligomeric Golgi tethering complex."
      Loh E., Hong W.
      J. Biol. Chem. 279:24640-24648(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: COMPOSITION OF THE COG COMPLEX, INTERACTION WITH COG3 AND COG4.

    Entry informationi

    Entry nameiCOG6_YEAST
    AccessioniPrimary (citable) accession number: P53959
    Secondary accession number(s): D6W1D8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1720 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3