Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P53959 (COG6_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Conserved oligomeric Golgi complex subunit 6

Short name=COG complex subunit 6
Alternative name(s):
Complexed with DOR1 protein 2
Component of oligomeric Golgi complex 6
Protein SEC37
Gene names
Name:COG6
Synonyms:COD2, SEC37, TFI2
Ordered Locus Names:YNL041C
ORF Names:N2675
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length839 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events. Ref.4 Ref.5

Subunit structure

Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8. Ref.3 Ref.4 Ref.5

Subcellular location

Golgi apparatus membrane; Peripheral membrane protein By similarity.

Miscellaneous

Present with 1720 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the COG6 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 839839Conserved oligomeric Golgi complex subunit 6
PRO_0000213517

Sequences

Sequence LengthMass (Da)Tools
P53959 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 6484A40F999AD787

FASTA83996,976
        10         20         30         40         50         60 
MDFVVDYQTY AMADTATPEL PEPEPRLNLT SDAQSQPTGK LDLQFKLPDL QRYSNNNATL 

        70         80         90        100        110        120 
PVDNDGAGSK DLHKKMTHYA MSSIDKIQLS NPSKQLGQNS QDEKLSQQES QNFTNYEPKN 

       130        140        150        160        170        180 
LDLSKLVSPS SGSNKNTTNL VLSNKLSKIL NNYTLINYQA TVQLRKSLKV LEENKERLSL 

       190        200        210        220        230        240 
DEQKLMNPEY VGTLARRALR TDLESQLLKE HITVLEEFKP IIRRIKRLSS SVEKIQRTSE 

       250        260        270        280        290        300 
KLLSNETNEV PTNNVVLQEI DQYRLKAEQL KLKKKILLSI RDRFTLNQVE DDVITNGTID 

       310        320        330        340        350        360 
NIFFEVVKKV INIKDESSFL LTLPNLNAGN ALIMGVNEIL EKTNKKIFNY LIDFLYSFES 

       370        380        390        400        410        420 
SSNLLNDHGT TEQESLNIFR KSLVFLSSDL ELFNELLKRV TTLRSKSILD EFLSQFDMNS 

       430        440        450        460        470        480 
TTSKPIILSA HDPIRYIGDV LASVHSIIAN EADFVKSLFD FQDEDLKDTP ISILQQNKTF 

       490        500        510        520        530        540 
LKGIDNKLLN DIIQSLSNSC RIRIEQIVRF EENPIINFEI VRLLKLYRVM FERKGIQDDS 

       550        560        570        580        590        600 
SIINNLKSLE DISKNRIIGY YEDYMKQTVM AETKNSSDDL LPPEWLSEYM NKLVELFEIY 

       610        620        630        640        650        660 
EKTHAAEDEE SEDNKLLSSK NLQTIVEQPI KDVLLKQLQT SFPLAKKNEK EKASLLTIEI 

       670        680        690        700        710        720 
NCFDLIKSRL QPFEGLFAQD DDSRKITIWV CDKLKEYTKQ MLTLQIKFLF ENTGLDLYSN 

       730        740        750        760        770        780 
LVNMIFPVDS VKDELDYDMY LALRDNSLME LDMVRKNVHD KLNYYLPQAL TDVQGNLLFK 

       790        800        810        820        830 
LTSPMIADEI CDECFKKLSL FYNIFRKLLI HLYPNKKDQV FEILNFSTDE FDMLIGIDH 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic."
Whyte J.R., Munro S.
Dev. Cell 1:527-537(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT.
[4]"The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins."
Suvorova E.S., Duden R., Lupashin V.V.
J. Cell Biol. 157:631-643(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE COG COMPLEX, FUNCTION OF THE COG COMPLEX.
[5]"Identification of sec36p, sec37p, and sec38p: components of yeast complex that contains sec34p and sec35p."
Ram R.J., Li B., Kaiser C.A.
Mol. Biol. Cell 13:1484-1500(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN THE COG COMPLEX.
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"The binary interacting network of the conserved oligomeric Golgi tethering complex."
Loh E., Hong W.
J. Biol. Chem. 279:24640-24648(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: COMPOSITION OF THE COG COMPLEX, INTERACTION WITH COG3 AND COG4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z71317 Genomic DNA. Translation: CAA95908.1.
BK006947 Genomic DNA. Translation: DAA10504.1.
PIRS62963.
RefSeqNP_014357.1. NM_001182880.1.

3D structure databases

ProteinModelPortalP53959.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35783. 294 interactions.
DIPDIP-4373N.
IntActP53959. 21 interactions.
MINTMINT-485603.
STRING4932.YNL041C.

Proteomic databases

PaxDbP53959.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYNL041C; YNL041C; YNL041C.
GeneID855687.
KEGGsce:YNL041C.

Organism-specific databases

CYGDYNL041c.
SGDS000004986. COG6.

Phylogenomic databases

eggNOGNOG291168.
GeneTreeENSGT00390000013518.
HOGENOMHOG000111882.
OMAELDYDMY.
OrthoDBEOG7FBRS5.

Enzyme and pathway databases

BioCycYEAST:G3O-33077-MONOMER.

Gene expression databases

GenevestigatorP53959.

Family and domain databases

InterProIPR010490. COG6.
[Graphical view]
PANTHERPTHR21506. PTHR21506. 1 hit.
PfamPF06419. COG6. 1 hit.
[Graphical view]
SMARTSM01087. COG6. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio979995.
PROP53959.

Entry information

Entry nameCOG6_YEAST
AccessionPrimary (citable) accession number: P53959
Secondary accession number(s): D6W1D8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families