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P53959

- COG6_YEAST

UniProt

P53959 - COG6_YEAST

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Protein

Conserved oligomeric Golgi complex subunit 6

Gene
COG6, COD2, SEC37, TFI2, YNL041C, N2675
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.2 Publications

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. CVT pathway Source: SGD
  2. intra-Golgi vesicle-mediated transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33077-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 6
Short name:
COG complex subunit 6
Alternative name(s):
Complexed with DOR1 protein 2
Component of oligomeric Golgi complex 6
Protein SEC37
Gene namesi
Name:COG6
Synonyms:COD2, SEC37, TFI2
Ordered Locus Names:YNL041C
ORF Names:N2675
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL041c.
SGDiS000004986. COG6.

Subcellular locationi

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. Golgi transport complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 839839Conserved oligomeric Golgi complex subunit 6PRO_0000213517Add
BLAST

Proteomic databases

MaxQBiP53959.
PaxDbiP53959.

Expressioni

Gene expression databases

GenevestigatoriP53959.

Interactioni

Subunit structurei

Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
COG1P530795EBI-4829,EBI-4835
COG2P532713EBI-4829,EBI-16614
COG3P400943EBI-4829,EBI-16605
COG5P539512EBI-4829,EBI-4841
COG7P531953EBI-4829,EBI-4847
COG8Q046325EBI-4829,EBI-6035

Protein-protein interaction databases

BioGridi35783. 294 interactions.
DIPiDIP-4373N.
IntActiP53959. 21 interactions.
MINTiMINT-485603.
STRINGi4932.YNL041C.

Structurei

3D structure databases

ProteinModelPortaliP53959.

Family & Domainsi

Sequence similaritiesi

Belongs to the COG6 family.

Phylogenomic databases

eggNOGiNOG291168.
GeneTreeiENSGT00390000013518.
HOGENOMiHOG000111882.
OMAiEWIIEFY.
OrthoDBiEOG7FBRS5.

Family and domain databases

InterProiIPR010490. COG6.
[Graphical view]
PANTHERiPTHR21506. PTHR21506. 1 hit.
PfamiPF06419. COG6. 1 hit.
[Graphical view]
SMARTiSM01087. COG6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53959-1 [UniParc]FASTAAdd to Basket

« Hide

MDFVVDYQTY AMADTATPEL PEPEPRLNLT SDAQSQPTGK LDLQFKLPDL    50
QRYSNNNATL PVDNDGAGSK DLHKKMTHYA MSSIDKIQLS NPSKQLGQNS 100
QDEKLSQQES QNFTNYEPKN LDLSKLVSPS SGSNKNTTNL VLSNKLSKIL 150
NNYTLINYQA TVQLRKSLKV LEENKERLSL DEQKLMNPEY VGTLARRALR 200
TDLESQLLKE HITVLEEFKP IIRRIKRLSS SVEKIQRTSE KLLSNETNEV 250
PTNNVVLQEI DQYRLKAEQL KLKKKILLSI RDRFTLNQVE DDVITNGTID 300
NIFFEVVKKV INIKDESSFL LTLPNLNAGN ALIMGVNEIL EKTNKKIFNY 350
LIDFLYSFES SSNLLNDHGT TEQESLNIFR KSLVFLSSDL ELFNELLKRV 400
TTLRSKSILD EFLSQFDMNS TTSKPIILSA HDPIRYIGDV LASVHSIIAN 450
EADFVKSLFD FQDEDLKDTP ISILQQNKTF LKGIDNKLLN DIIQSLSNSC 500
RIRIEQIVRF EENPIINFEI VRLLKLYRVM FERKGIQDDS SIINNLKSLE 550
DISKNRIIGY YEDYMKQTVM AETKNSSDDL LPPEWLSEYM NKLVELFEIY 600
EKTHAAEDEE SEDNKLLSSK NLQTIVEQPI KDVLLKQLQT SFPLAKKNEK 650
EKASLLTIEI NCFDLIKSRL QPFEGLFAQD DDSRKITIWV CDKLKEYTKQ 700
MLTLQIKFLF ENTGLDLYSN LVNMIFPVDS VKDELDYDMY LALRDNSLME 750
LDMVRKNVHD KLNYYLPQAL TDVQGNLLFK LTSPMIADEI CDECFKKLSL 800
FYNIFRKLLI HLYPNKKDQV FEILNFSTDE FDMLIGIDH 839
Length:839
Mass (Da):96,976
Last modified:October 1, 1996 - v1
Checksum:i6484A40F999AD787
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71317 Genomic DNA. Translation: CAA95908.1.
BK006947 Genomic DNA. Translation: DAA10504.1.
PIRiS62963.
RefSeqiNP_014357.1. NM_001182880.1.

Genome annotation databases

EnsemblFungiiYNL041C; YNL041C; YNL041C.
GeneIDi855687.
KEGGisce:YNL041C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71317 Genomic DNA. Translation: CAA95908.1 .
BK006947 Genomic DNA. Translation: DAA10504.1 .
PIRi S62963.
RefSeqi NP_014357.1. NM_001182880.1.

3D structure databases

ProteinModelPortali P53959.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35783. 294 interactions.
DIPi DIP-4373N.
IntActi P53959. 21 interactions.
MINTi MINT-485603.
STRINGi 4932.YNL041C.

Proteomic databases

MaxQBi P53959.
PaxDbi P53959.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL041C ; YNL041C ; YNL041C .
GeneIDi 855687.
KEGGi sce:YNL041C.

Organism-specific databases

CYGDi YNL041c.
SGDi S000004986. COG6.

Phylogenomic databases

eggNOGi NOG291168.
GeneTreei ENSGT00390000013518.
HOGENOMi HOG000111882.
OMAi EWIIEFY.
OrthoDBi EOG7FBRS5.

Enzyme and pathway databases

BioCyci YEAST:G3O-33077-MONOMER.

Miscellaneous databases

NextBioi 979995.
PROi P53959.

Gene expression databases

Genevestigatori P53959.

Family and domain databases

InterProi IPR010490. COG6.
[Graphical view ]
PANTHERi PTHR21506. PTHR21506. 1 hit.
Pfami PF06419. COG6. 1 hit.
[Graphical view ]
SMARTi SM01087. COG6. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic."
    Whyte J.R., Munro S.
    Dev. Cell 1:527-537(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
  4. "The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins."
    Suvorova E.S., Duden R., Lupashin V.V.
    J. Cell Biol. 157:631-643(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE COG COMPLEX, FUNCTION OF THE COG COMPLEX.
  5. "Identification of sec36p, sec37p, and sec38p: components of yeast complex that contains sec34p and sec35p."
    Ram R.J., Li B., Kaiser C.A.
    Mol. Biol. Cell 13:1484-1500(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE COG COMPLEX.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "The binary interacting network of the conserved oligomeric Golgi tethering complex."
    Loh E., Hong W.
    J. Biol. Chem. 279:24640-24648(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPOSITION OF THE COG COMPLEX, INTERACTION WITH COG3 AND COG4.

Entry informationi

Entry nameiCOG6_YEAST
AccessioniPrimary (citable) accession number: P53959
Secondary accession number(s): D6W1D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1720 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

Similar proteinsi