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Protein

Actin-related protein 5

Gene

ARP5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex.

GO - Biological processi

  • chromatin remodeling Source: SGD
  • DNA duplex unwinding Source: GOC
  • DNA repair Source: InterPro
  • nucleosome mobilization Source: SGD
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-33090-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 5
Alternative name(s):
Actin-like protein ARP5
Gene namesi
Name:ARP5
Ordered Locus Names:YNL059C
ORF Names:N2430, YNL2430C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL059C.
SGDiS000005004. ARP5.

Subcellular locationi

GO - Cellular componenti

  • Ino80 complex Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 755755Actin-related protein 5PRO_0000089104Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71PhosphoserineCombined sources
Modified residuei24 – 241PhosphothreonineCombined sources
Modified residuei383 – 3831PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53946.
PeptideAtlasiP53946.
PRIDEiP53946.

PTM databases

iPTMnetiP53946.

Interactioni

Subunit structurei

Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80.1 Publication

Protein-protein interaction databases

BioGridi35763. 33 interactions.
IntActiP53946. 26 interactions.
MINTiMINT-2731416.

Structurei

3D structure databases

ProteinModelPortaliP53946.
SMRiP53946. Positions 38-262, 617-742.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

GeneTreeiENSGT00720000108866.
HOGENOMiHOG000171615.
InParanoidiP53946.
KOiK11672.
OMAiMGFEGQD.
OrthoDBiEOG7HMS8K.

Family and domain databases

InterProiIPR004000. Actin.
IPR027664. Arp5.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 2 hits.
PTHR11937:SF16. PTHR11937:SF16. 2 hits.
PfamiPF00022. Actin. 2 hits.
[Graphical view]
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53946-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRDASLTP LKAVVIDDPP LRQTPEPFDE QSAYNPQSPI AIDFGSSKLR
60 70 80 90 100
AGFVNHATPT HIFPNALTKF RDRKLNKNFT FVGNDTLLDQ AVRSQSRSPF
110 120 130 140 150
DGPFVTNWNL TEEILDYTFH HLGVVPDNGI PNPILLTERL ATVQSQRTNW
160 170 180 190 200
YQILFETYNV PGVTFGIDSL FSFYNYNPSG NKTGLVISCG HEDTNVIPVV
210 220 230 240 250
DGAGILTDAK RINWGGHQAV DYLNDLMALK YPYFPTKMSY LQYETMYKDY
260 270 280 290 300
CYVSRNYDED IEKILTLENL DTNDVVVEAP FTEVLQPQKT EEELRIQAEK
310 320 330 340 350
RKETGKRLQE QARLKRMEKL VQKQEEFEYF SKVRDQLIDE PKKKVLSVLQ
360 370 380 390 400
NAGFDDERDF KKYLHSLEQS LKKAQMVEAE DDSHLDEMNE DKTAQKFDLL
410 420 430 440 450
DIADEDLNED QIKEKRKQRF LKASQDARQK AKEEKERVAK EEEEKKLKEQ
460 470 480 490 500
QWRETDLNGW IKDKRLKLNK LIKRRKEKLK LRDEMKDRKS QVSQNRMKNL
510 520 530 540 550
ASLAEDNVKQ GAKRNRHQAT IDNDPNDTFG ANDEDWLIYT DITQNPEAFE
560 570 580 590 600
EALEYEYKDI VELERLLLEH DPNFTEEDTL EAQYDWRNSI LHLFLRGPRP
610 620 630 640 650
HDSENIHEQH QMHLNVERIR VPEVIFQPTM GGQDQAGICE LSETILLKKF
660 670 680 690 700
GSQPGKLSQT SIDMVNNVLI TGGNAKVPGL KERIVKEFTG FLPTGTNITV
710 720 730 740 750
NMSSDPSLDA WKGMAALARN EEQYRKTVIS KKEYEEYGPE YIKEHKLGNT

KYFED
Length:755
Mass (Da):87,560
Last modified:October 1, 1996 - v1
Checksum:iD8748B9096B32B53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12141 Genomic DNA. Translation: AAA99652.1.
Z71335 Genomic DNA. Translation: CAA95933.1.
BK006947 Genomic DNA. Translation: DAA10486.1.
PIRiS58718.
RefSeqiNP_014339.1. NM_001182898.1.

Genome annotation databases

EnsemblFungiiYNL059C; YNL059C; YNL059C.
GeneIDi855665.
KEGGisce:YNL059C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12141 Genomic DNA. Translation: AAA99652.1.
Z71335 Genomic DNA. Translation: CAA95933.1.
BK006947 Genomic DNA. Translation: DAA10486.1.
PIRiS58718.
RefSeqiNP_014339.1. NM_001182898.1.

3D structure databases

ProteinModelPortaliP53946.
SMRiP53946. Positions 38-262, 617-742.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35763. 33 interactions.
IntActiP53946. 26 interactions.
MINTiMINT-2731416.

PTM databases

iPTMnetiP53946.

Proteomic databases

MaxQBiP53946.
PeptideAtlasiP53946.
PRIDEiP53946.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL059C; YNL059C; YNL059C.
GeneIDi855665.
KEGGisce:YNL059C.

Organism-specific databases

EuPathDBiFungiDB:YNL059C.
SGDiS000005004. ARP5.

Phylogenomic databases

GeneTreeiENSGT00720000108866.
HOGENOMiHOG000171615.
InParanoidiP53946.
KOiK11672.
OMAiMGFEGQD.
OrthoDBiEOG7HMS8K.

Enzyme and pathway databases

BioCyciYEAST:G3O-33090-MONOMER.

Miscellaneous databases

NextBioi979938.
PROiP53946.

Family and domain databases

InterProiIPR004000. Actin.
IPR027664. Arp5.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 2 hits.
PTHR11937:SF16. PTHR11937:SF16. 2 hits.
PfamiPF00022. Actin. 2 hits.
[Graphical view]
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of a 44 420 bp fragment located on the left arm of chromosome XIV from Saccharomyces cerevisiae."
    Bergez P., Doignon F., Crouzet M.
    Yeast 11:967-974(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S288c / FY1676.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Who's who among the Saccharomyces cerevisiae actin-related proteins? A classification and nomenclature proposal for a large family."
    Poch O., Winsor B.
    Yeast 13:1053-1058(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE NAME.
  5. "Involvement of actin-related proteins in ATP-dependent chromatin remodeling."
    Shen X., Ranallo R., Choi E., Wu C.
    Mol. Cell 12:147-155(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE INO80 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-24, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7 AND SER-383, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiARP5_YEAST
AccessioniPrimary (citable) accession number: P53946
Secondary accession number(s): D6W1C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 11, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2170 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.