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P53944 (MTQ1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial N(5)-glutamine methyltransferase MTQ1

EC=2.1.1.-
Gene names
Name:MTQ1
Ordered Locus Names:YNL063W
ORF Names:N2420, YNL2420W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Methylates MRF1 on 'Gln-287' using S-adenosyl L-methionine as methyl donor. Ref.8

Subcellular location

Mitochondrion Ref.6 Ref.8.

Miscellaneous

Present with 13200 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the protein N5-glutamine methyltransferase family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MRF1P307752EBI-28737,EBI-14964

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Mitochondrial N(5)-glutamine methyltransferase MTQ1
PRO_0000203448

Regions

Region118 – 1225S-adenosyl-L-methionine binding By similarity
Region188 – 1914Substrate binding By similarity

Sites

Binding site1411S-adenosyl-L-methionine By similarity
Binding site1881S-adenosyl-L-methionine By similarity

Sequences

Sequence LengthMass (Da)Tools
P53944 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 2281F44B511EAA65

FASTA31435,871
        10         20         30         40         50         60 
MPRISTSLIR KASRIRPGLH LLLPECRTLE QAKLEYKWLT EELPPDKSIR WACLQRYKHV 

        70         80         90        100        110        120 
PLQYILRSQP FGALDIVCKP GVLIPRWETE EWVMAIIRAL NNSMLSRHTI PLHICDTFTG 

       130        140        150        160        170        180 
TGCIALALSH GIANCTFTAI DVSTRAIKLV KENMLKNKVS GGKLVQHNIL SSKASDEYPS 

       190        200        210        220        230        240 
HIDILTGNPP YIRKRDFNRD VKTSVKLFEP RLALVGELEC YINLVNYWLP KTDSFFYEIG 

       250        260        270        280        290        300 
DVEQFNYVER RIKEDSYLSR IWSIGLKYDS NGKARVVYGF KATPKGRILH QIFASFGTIR 

       310 
HLATALSGHK ANCN 

« Hide

References

« Hide 'large scale' references
[1]"The sequence of a 44 420 bp fragment located on the left arm of chromosome XIV from Saccharomyces cerevisiae."
Bergez P., Doignon F., Crouzet M.
Yeast 11:967-974(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: S288c / FY1676.
[2]Erratum
Bergez P., Doignon F., Crouzet M.
Yeast 12:297-297(1996) [PubMed] [Europe PMC] [Abstract]
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[6]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]"The yeast translation release factors Mrf1p and Sup45p (eRF1) are methylated, respectively, by the methyltransferases Mtq1p and Mtq2p."
Polevoda B., Span L., Sherman F.
J. Biol. Chem. 281:2562-2571(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U12141 Genomic DNA. Translation: AAA99648.1.
Z71339 Genomic DNA. Translation: CAA95936.1.
AY692585 Genomic DNA. Translation: AAT92604.1.
BK006947 Genomic DNA. Translation: DAA10483.1.
PIRS58715.
RefSeqNP_014336.1. NM_001182901.1.

3D structure databases

ProteinModelPortalP53944.
SMRP53944. Positions 15-283.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35760. 10 interactions.
DIPDIP-6545N.
IntActP53944. 3 interactions.
MINTMINT-677281.
STRING4932.YNL063W.

Proteomic databases

PaxDbP53944.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYNL063W; YNL063W; YNL063W.
GeneID855662.
KEGGsce:YNL063W.

Organism-specific databases

CYGDYNL063w.
SGDS000005007. MTQ1.

Phylogenomic databases

eggNOGCOG2890.
GeneTreeENSGT00390000014125.
HOGENOMHOG000248841.
OMAWETEEWA.
OrthoDBEOG712V67.

Enzyme and pathway databases

BioCycYEAST:G3O-33093-MONOMER.

Gene expression databases

GenevestigatorP53944.

Family and domain databases

InterProIPR004556. Modification_methylase_HemK.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamPF05175. MTS. 1 hit.
[Graphical view]
TIGRFAMsTIGR00536. hemK_fam. 1 hit.
ProtoNetSearch...

Other

NextBio979929.

Entry information

Entry nameMTQ1_YEAST
AccessionPrimary (citable) accession number: P53944
Secondary accession number(s): D6W1B7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families