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P53944

- MTQ1_YEAST

UniProt

P53944 - MTQ1_YEAST

Protein

Mitochondrial N(5)-glutamine methyltransferase MTQ1

Gene

MTQ1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Methylates MRF1 on 'Gln-287' using S-adenosyl L-methionine as methyl donor.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei141 – 1411S-adenosyl-L-methionineBy similarity
    Binding sitei188 – 1881S-adenosyl-L-methionineBy similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein methyltransferase activity Source: InterPro
    3. S-adenosylmethionine-dependent methyltransferase activity Source: SGD

    GO - Biological processi

    1. translational readthrough Source: SGD

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33093-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial N(5)-glutamine methyltransferase MTQ1 (EC:2.1.1.-)
    Gene namesi
    Name:MTQ1
    Ordered Locus Names:YNL063W
    ORF Names:N2420, YNL2420W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNL063w.
    SGDiS000005007. MTQ1.

    Subcellular locationi

    Mitochondrion 2 Publications

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Mitochondrial N(5)-glutamine methyltransferase MTQ1PRO_0000203448Add
    BLAST

    Proteomic databases

    MaxQBiP53944.
    PaxDbiP53944.

    Expressioni

    Gene expression databases

    GenevestigatoriP53944.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MRF1P307752EBI-28737,EBI-14964

    Protein-protein interaction databases

    BioGridi35760. 10 interactions.
    DIPiDIP-6545N.
    IntActiP53944. 3 interactions.
    MINTiMINT-677281.
    STRINGi4932.YNL063W.

    Structurei

    3D structure databases

    ProteinModelPortaliP53944.
    SMRiP53944. Positions 55-275.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni118 – 1225S-adenosyl-L-methionine bindingBy similarity
    Regioni188 – 1914Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2890.
    GeneTreeiENSGT00390000014125.
    HOGENOMiHOG000248841.
    OMAiWETEEWA.
    OrthoDBiEOG712V67.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR004556. Modification_methylase_HemK.
    IPR029063. SAM-dependent_MTases-like.
    IPR007848. Small_mtfrase_dom.
    [Graphical view]
    PfamiPF05175. MTS. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00536. hemK_fam. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P53944-1 [UniParc]FASTAAdd to Basket

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    MPRISTSLIR KASRIRPGLH LLLPECRTLE QAKLEYKWLT EELPPDKSIR    50
    WACLQRYKHV PLQYILRSQP FGALDIVCKP GVLIPRWETE EWVMAIIRAL 100
    NNSMLSRHTI PLHICDTFTG TGCIALALSH GIANCTFTAI DVSTRAIKLV 150
    KENMLKNKVS GGKLVQHNIL SSKASDEYPS HIDILTGNPP YIRKRDFNRD 200
    VKTSVKLFEP RLALVGELEC YINLVNYWLP KTDSFFYEIG DVEQFNYVER 250
    RIKEDSYLSR IWSIGLKYDS NGKARVVYGF KATPKGRILH QIFASFGTIR 300
    HLATALSGHK ANCN 314
    Length:314
    Mass (Da):35,871
    Last modified:October 1, 1996 - v1
    Checksum:i2281F44B511EAA65
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12141 Genomic DNA. Translation: AAA99648.1.
    Z71339 Genomic DNA. Translation: CAA95936.1.
    AY692585 Genomic DNA. Translation: AAT92604.1.
    BK006947 Genomic DNA. Translation: DAA10483.1.
    PIRiS58715.
    RefSeqiNP_014336.1. NM_001182901.1.

    Genome annotation databases

    EnsemblFungiiYNL063W; YNL063W; YNL063W.
    GeneIDi855662.
    KEGGisce:YNL063W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12141 Genomic DNA. Translation: AAA99648.1 .
    Z71339 Genomic DNA. Translation: CAA95936.1 .
    AY692585 Genomic DNA. Translation: AAT92604.1 .
    BK006947 Genomic DNA. Translation: DAA10483.1 .
    PIRi S58715.
    RefSeqi NP_014336.1. NM_001182901.1.

    3D structure databases

    ProteinModelPortali P53944.
    SMRi P53944. Positions 55-275.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35760. 10 interactions.
    DIPi DIP-6545N.
    IntActi P53944. 3 interactions.
    MINTi MINT-677281.
    STRINGi 4932.YNL063W.

    Proteomic databases

    MaxQBi P53944.
    PaxDbi P53944.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNL063W ; YNL063W ; YNL063W .
    GeneIDi 855662.
    KEGGi sce:YNL063W.

    Organism-specific databases

    CYGDi YNL063w.
    SGDi S000005007. MTQ1.

    Phylogenomic databases

    eggNOGi COG2890.
    GeneTreei ENSGT00390000014125.
    HOGENOMi HOG000248841.
    OMAi WETEEWA.
    OrthoDBi EOG712V67.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33093-MONOMER.

    Miscellaneous databases

    NextBioi 979929.

    Gene expression databases

    Genevestigatori P53944.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR004556. Modification_methylase_HemK.
    IPR029063. SAM-dependent_MTases-like.
    IPR007848. Small_mtfrase_dom.
    [Graphical view ]
    Pfami PF05175. MTS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00536. hemK_fam. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of a 44 420 bp fragment located on the left arm of chromosome XIV from Saccharomyces cerevisiae."
      Bergez P., Doignon F., Crouzet M.
      Yeast 11:967-974(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: S288c / FY1676.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "The yeast translation release factors Mrf1p and Sup45p (eRF1) are methylated, respectively, by the methyltransferases Mtq1p and Mtq2p."
      Polevoda B., Span L., Sherman F.
      J. Biol. Chem. 281:2562-2571(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiMTQ1_YEAST
    AccessioniPrimary (citable) accession number: P53944
    Secondary accession number(s): D6W1B7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 13200 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3