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P53944

- MTQ1_YEAST

UniProt

P53944 - MTQ1_YEAST

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Protein

Mitochondrial N(5)-glutamine methyltransferase MTQ1

Gene

MTQ1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Methylates MRF1 on 'Gln-287' using S-adenosyl L-methionine as methyl donor.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei141 – 1411S-adenosyl-L-methionineBy similarity
Binding sitei188 – 1881S-adenosyl-L-methionineBy similarity

GO - Molecular functioni

  1. protein methyltransferase activity Source: InterPro
  2. S-adenosylmethionine-dependent methyltransferase activity Source: SGD

GO - Biological processi

  1. translational readthrough Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciYEAST:G3O-33093-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial N(5)-glutamine methyltransferase MTQ1 (EC:2.1.1.-)
Gene namesi
Name:MTQ1
Ordered Locus Names:YNL063W
ORF Names:N2420, YNL2420W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL063w.
SGDiS000005007. MTQ1.

Subcellular locationi

Mitochondrion 2 Publications

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Mitochondrial N(5)-glutamine methyltransferase MTQ1PRO_0000203448Add
BLAST

Proteomic databases

MaxQBiP53944.
PaxDbiP53944.

Expressioni

Gene expression databases

GenevestigatoriP53944.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MRF1P307752EBI-28737,EBI-14964

Protein-protein interaction databases

BioGridi35760. 10 interactions.
DIPiDIP-6545N.
IntActiP53944. 3 interactions.
MINTiMINT-677281.
STRINGi4932.YNL063W.

Structurei

3D structure databases

ProteinModelPortaliP53944.
SMRiP53944. Positions 55-275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni118 – 1225S-adenosyl-L-methionine bindingBy similarity
Regioni188 – 1914Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2890.
GeneTreeiENSGT00390000014125.
HOGENOMiHOG000248841.
InParanoidiP53944.
OMAiWETEEWA.
OrthoDBiEOG712V67.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR004556. Modification_methylase_HemK.
IPR029063. SAM-dependent_MTases-like.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00536. hemK_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

P53944-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRISTSLIR KASRIRPGLH LLLPECRTLE QAKLEYKWLT EELPPDKSIR
60 70 80 90 100
WACLQRYKHV PLQYILRSQP FGALDIVCKP GVLIPRWETE EWVMAIIRAL
110 120 130 140 150
NNSMLSRHTI PLHICDTFTG TGCIALALSH GIANCTFTAI DVSTRAIKLV
160 170 180 190 200
KENMLKNKVS GGKLVQHNIL SSKASDEYPS HIDILTGNPP YIRKRDFNRD
210 220 230 240 250
VKTSVKLFEP RLALVGELEC YINLVNYWLP KTDSFFYEIG DVEQFNYVER
260 270 280 290 300
RIKEDSYLSR IWSIGLKYDS NGKARVVYGF KATPKGRILH QIFASFGTIR
310
HLATALSGHK ANCN
Length:314
Mass (Da):35,871
Last modified:October 1, 1996 - v1
Checksum:i2281F44B511EAA65
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12141 Genomic DNA. Translation: AAA99648.1.
Z71339 Genomic DNA. Translation: CAA95936.1.
AY692585 Genomic DNA. Translation: AAT92604.1.
BK006947 Genomic DNA. Translation: DAA10483.1.
PIRiS58715.
RefSeqiNP_014336.1. NM_001182901.1.

Genome annotation databases

EnsemblFungiiYNL063W; YNL063W; YNL063W.
GeneIDi855662.
KEGGisce:YNL063W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12141 Genomic DNA. Translation: AAA99648.1 .
Z71339 Genomic DNA. Translation: CAA95936.1 .
AY692585 Genomic DNA. Translation: AAT92604.1 .
BK006947 Genomic DNA. Translation: DAA10483.1 .
PIRi S58715.
RefSeqi NP_014336.1. NM_001182901.1.

3D structure databases

ProteinModelPortali P53944.
SMRi P53944. Positions 55-275.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35760. 10 interactions.
DIPi DIP-6545N.
IntActi P53944. 3 interactions.
MINTi MINT-677281.
STRINGi 4932.YNL063W.

Proteomic databases

MaxQBi P53944.
PaxDbi P53944.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL063W ; YNL063W ; YNL063W .
GeneIDi 855662.
KEGGi sce:YNL063W.

Organism-specific databases

CYGDi YNL063w.
SGDi S000005007. MTQ1.

Phylogenomic databases

eggNOGi COG2890.
GeneTreei ENSGT00390000014125.
HOGENOMi HOG000248841.
InParanoidi P53944.
OMAi WETEEWA.
OrthoDBi EOG712V67.

Enzyme and pathway databases

BioCyci YEAST:G3O-33093-MONOMER.

Miscellaneous databases

NextBioi 979929.

Gene expression databases

Genevestigatori P53944.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR004556. Modification_methylase_HemK.
IPR029063. SAM-dependent_MTases-like.
IPR007848. Small_mtfrase_dom.
[Graphical view ]
Pfami PF05175. MTS. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00536. hemK_fam. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of a 44 420 bp fragment located on the left arm of chromosome XIV from Saccharomyces cerevisiae."
    Bergez P., Doignon F., Crouzet M.
    Yeast 11:967-974(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S288c / FY1676.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "The yeast translation release factors Mrf1p and Sup45p (eRF1) are methylated, respectively, by the methyltransferases Mtq1p and Mtq2p."
    Polevoda B., Span L., Sherman F.
    J. Biol. Chem. 281:2562-2571(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiMTQ1_YEAST
AccessioniPrimary (citable) accession number: P53944
Secondary accession number(s): D6W1B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 13200 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3