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Protein

Mitochondrial N(5)-glutamine methyltransferase MTQ1

Gene

MTQ1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Methylates MRF1 on 'Gln-287' using S-adenosyl L-methionine as methyl donor.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei141S-adenosyl-L-methionineBy similarity1
Binding sitei188S-adenosyl-L-methionineBy similarity1

GO - Molecular functioni

GO - Biological processi

  • translational readthrough Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciYEAST:G3O-33093-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial N(5)-glutamine methyltransferase MTQ1 (EC:2.1.1.-)
Gene namesi
Name:MTQ1
Ordered Locus Names:YNL063W
ORF Names:N2420, YNL2420W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL063W.
SGDiS000005007. MTQ1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002034481 – 314Mitochondrial N(5)-glutamine methyltransferase MTQ1Add BLAST314

Proteomic databases

MaxQBiP53944.
PRIDEiP53944.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MRF1P307752EBI-28737,EBI-14964

Protein-protein interaction databases

BioGridi35760. 10 interactors.
DIPiDIP-6545N.
IntActiP53944. 3 interactors.
MINTiMINT-677281.

Structurei

3D structure databases

ProteinModelPortaliP53944.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni118 – 122S-adenosyl-L-methionine bindingBy similarity5
Regioni188 – 191Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000014125.
HOGENOMiHOG000248841.
InParanoidiP53944.
OMAiWETEEWA.
OrthoDBiEOG092C359M.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR004556. Modification_methylase_HemK.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00536. hemK_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

P53944-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRISTSLIR KASRIRPGLH LLLPECRTLE QAKLEYKWLT EELPPDKSIR
60 70 80 90 100
WACLQRYKHV PLQYILRSQP FGALDIVCKP GVLIPRWETE EWVMAIIRAL
110 120 130 140 150
NNSMLSRHTI PLHICDTFTG TGCIALALSH GIANCTFTAI DVSTRAIKLV
160 170 180 190 200
KENMLKNKVS GGKLVQHNIL SSKASDEYPS HIDILTGNPP YIRKRDFNRD
210 220 230 240 250
VKTSVKLFEP RLALVGELEC YINLVNYWLP KTDSFFYEIG DVEQFNYVER
260 270 280 290 300
RIKEDSYLSR IWSIGLKYDS NGKARVVYGF KATPKGRILH QIFASFGTIR
310
HLATALSGHK ANCN
Length:314
Mass (Da):35,871
Last modified:October 1, 1996 - v1
Checksum:i2281F44B511EAA65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12141 Genomic DNA. Translation: AAA99648.1.
Z71339 Genomic DNA. Translation: CAA95936.1.
AY692585 Genomic DNA. Translation: AAT92604.1.
BK006947 Genomic DNA. Translation: DAA10483.1.
PIRiS58715.
RefSeqiNP_014336.1. NM_001182901.1.

Genome annotation databases

EnsemblFungiiYNL063W; YNL063W; YNL063W.
GeneIDi855662.
KEGGisce:YNL063W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12141 Genomic DNA. Translation: AAA99648.1.
Z71339 Genomic DNA. Translation: CAA95936.1.
AY692585 Genomic DNA. Translation: AAT92604.1.
BK006947 Genomic DNA. Translation: DAA10483.1.
PIRiS58715.
RefSeqiNP_014336.1. NM_001182901.1.

3D structure databases

ProteinModelPortaliP53944.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35760. 10 interactors.
DIPiDIP-6545N.
IntActiP53944. 3 interactors.
MINTiMINT-677281.

Proteomic databases

MaxQBiP53944.
PRIDEiP53944.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL063W; YNL063W; YNL063W.
GeneIDi855662.
KEGGisce:YNL063W.

Organism-specific databases

EuPathDBiFungiDB:YNL063W.
SGDiS000005007. MTQ1.

Phylogenomic databases

GeneTreeiENSGT00390000014125.
HOGENOMiHOG000248841.
InParanoidiP53944.
OMAiWETEEWA.
OrthoDBiEOG092C359M.

Enzyme and pathway databases

BioCyciYEAST:G3O-33093-MONOMER.

Miscellaneous databases

PROiP53944.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR004556. Modification_methylase_HemK.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00536. hemK_fam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMTQ1_YEAST
AccessioniPrimary (citable) accession number: P53944
Secondary accession number(s): D6W1B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 13200 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.