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P53943 (AQR1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable transporter AQR1
Gene names
Name:AQR1
Ordered Locus Names:YNL065W
ORF Names:N2417, YNL2417W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length586 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable transporter that confers resistance to short-chain monocarboxylic acids and quinidine. Ref.7

Subcellular location

Membrane; Multi-pass membrane protein Ref.7.

Sequence similarities

Belongs to the major facilitator superfamily. CAR1 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TAF2P232551EBI-28741,EBI-18862

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 586586Probable transporter AQR1
PRO_0000173443

Regions

Topological domain1 – 9999Extracellular Potential
Transmembrane100 – 12021Helical; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 16021Helical; Potential
Topological domain161 – 1666Extracellular Potential
Transmembrane167 – 18721Helical; Potential
Topological domain1881Cytoplasmic Potential
Transmembrane189 – 20921Helical; Potential
Topological domain210 – 22516Extracellular Potential
Transmembrane226 – 24621Helical; Potential
Topological domain247 – 2559Cytoplasmic Potential
Transmembrane256 – 27621Helical; Potential
Topological domain277 – 33458Extracellular Potential
Transmembrane335 – 35521Helical; Potential
Topological domain356 – 37419Cytoplasmic Potential
Transmembrane375 – 39521Helical; Potential
Topological domain396 – 43338Extracellular Potential
Transmembrane434 – 45421Helical; Potential
Topological domain455 – 4595Cytoplasmic Potential
Transmembrane460 – 48021Helical; Potential
Topological domain481 – 52343Extracellular Potential
Transmembrane524 – 54421Helical; Potential
Topological domain545 – 58642Cytoplasmic Potential

Experimental info

Sequence conflict1741L → P in AAT93141. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P53943 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: EC9AE745F2E2C79D

FASTA58665,296
        10         20         30         40         50         60 
MSRSNSIYTE DIEMYPTHNE QHLTREYTKP DGQTKSEKLN FEGAYINSHG TLSKTTTREI 

        70         80         90        100        110        120 
EGDLDSETSS HSSDDKVDPT QQITAETKAP YTLLSYGQKW GMVAILTMCG FWSSLGSPIY 

       130        140        150        160        170        180 
YPALRQLEKQ FNVDENMVNV TVVVYLLFQG ISPTVSGGLA DCFGRRPIIL AGMLIYVIAS 

       190        200        210        220        230        240 
IGLACAPSYG VIIFLRCIQS IGISPTIAIS SGVVGDFTLK HERGTFVGAT SGFVLLGQCF 

       250        260        270        280        290        300 
GSLIGAVLTA RWDWRAIFWF LTIGCGSCFL IAFLILPETK RTIAGNLSIK PKRFINRAPI 

       310        320        330        340        350        360 
FLLGPVRRRF KYDNPDYETL DPTIPKLDLS SAGKILVLPE IILSLFPSGL LFAMWTLMLS 

       370        380        390        400        410        420 
SISSGLSVAP YNYHLVIIGV CYLPGGIGGL MGSFFTGRII DMYFKRKIKK FEQDKANGLI 

       430        440        450        460        470        480 
PQDAEINMFK VRLVCLLPQN FLAVVAYLLF GWSIDKGWRI ESILITSFVC SYCAMSTLST 

       490        500        510        520        530        540 
STTLLVDLYP TKSSTASSCF NFVRCSLSTI FMGCFAKMKA AMTVGGTFTF LCALVFFFNF 

       550        560        570        580 
LMFIPMKYGM KWREDRLLKQ QRQSWLNTLA VKAKKGTKRD QNDNHN 

« Hide

References

« Hide 'large scale' references
[1]"The sequence of a 44 420 bp fragment located on the left arm of chromosome XIV from Saccharomyces cerevisiae."
Bergez P., Doignon F., Crouzet M.
Yeast 11:967-974(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: S288c / FY1676.
[2]Erratum
Bergez P., Doignon F., Crouzet M.
Yeast 12:297-297(1996) [PubMed] [Europe PMC] [Abstract]
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[6]"Sequencing a cosmid clone of Saccharomyces cerevisiae chromosome XIV reveals 12 new open reading frames (ORFs) and an ancient duplication of six ORFs."
Poehlmann R., Philippsen P.
Yeast 12:391-402(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-335.
Strain: ATCC 96604 / S288c / FY1679.
[7]"AQR1 gene (ORF YNL065w) encodes a plasma membrane transporter of the major facilitator superfamily that confers resistance to short-chain monocarboxylic acids and quinidine in Saccharomyces cerevisiae."
Tenreiro S., Nunes P.A., Viegas C.A., Neves M.S., Teixeira M.C., Cabral M.G., Sa-Correia I.
Biochem. Biophys. Res. Commun. 292:741-748(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[8]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U12141 Genomic DNA. Translation: AAA99646.1.
Z71341 Genomic DNA. Translation: CAA95938.1.
AY693122 Genomic DNA. Translation: AAT93141.1.
X86470 Genomic DNA. Translation: CAA60197.1.
BK006947 Genomic DNA. Translation: DAA10481.1.
PIRS58713.
RefSeqNP_014334.3. NM_001182903.3.

3D structure databases

ProteinModelPortalP53943.
SMRP53943. Positions 115-280.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35758. 17 interactions.
IntActP53943. 2 interactions.
MINTMINT-2735094.
STRING4932.YNL065W.

Protein family/group databases

TCDB2.A.1.2.36. the major facilitator superfamily (mfs).

Proteomic databases

MaxQBP53943.
PaxDbP53943.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYNL065W; YNL065W; YNL065W.
GeneID855660.
KEGGsce:YNL065W.

Organism-specific databases

CYGDYNL065w.
SGDS000005009. AQR1.

Phylogenomic databases

eggNOGCOG0477.
GeneTreeENSGT00620000088227.
HOGENOMHOG000248839.
OMAGATACTN.
OrthoDBEOG75F4PT.

Enzyme and pathway databases

BioCycYEAST:G3O-33095-MONOMER.

Gene expression databases

GenevestigatorP53943.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 2 hits.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio979923.

Entry information

Entry nameAQR1_YEAST
AccessionPrimary (citable) accession number: P53943
Secondary accession number(s): D6W1B5, Q6B1F8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families