Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P53943

- AQR1_YEAST

UniProt

P53943 - AQR1_YEAST

Protein

Probable transporter AQR1

Gene

AQR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probable transporter that confers resistance to short-chain monocarboxylic acids and quinidine.1 Publication

    GO - Molecular functioni

    1. drug transmembrane transporter activity Source: SGD
    2. monocarboxylic acid transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. amino acid export Source: SGD
    2. drug transmembrane transport Source: SGD
    3. monocarboxylic acid transport Source: SGD

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33095-MONOMER.

    Protein family/group databases

    TCDBi2.A.1.2.36. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable transporter AQR1
    Gene namesi
    Name:AQR1
    Ordered Locus Names:YNL065W
    ORF Names:N2417, YNL2417W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNL065w.
    SGDiS000005009. AQR1.

    Subcellular locationi

    Membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 586586Probable transporter AQR1PRO_0000173443Add
    BLAST

    Proteomic databases

    MaxQBiP53943.
    PaxDbiP53943.

    Expressioni

    Gene expression databases

    GenevestigatoriP53943.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TAF2P232551EBI-28741,EBI-18862

    Protein-protein interaction databases

    BioGridi35758. 17 interactions.
    IntActiP53943. 2 interactions.
    MINTiMINT-2735094.
    STRINGi4932.YNL065W.

    Structurei

    3D structure databases

    ProteinModelPortaliP53943.
    SMRiP53943. Positions 115-280.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9999ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 1666ExtracellularSequence Analysis
    Topological domaini188 – 1881CytoplasmicSequence Analysis
    Topological domaini210 – 22516ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini247 – 2559CytoplasmicSequence Analysis
    Topological domaini277 – 33458ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini356 – 37419CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini396 – 43338ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini455 – 4595CytoplasmicSequence Analysis
    Topological domaini481 – 52343ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini545 – 58642CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei100 – 12021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei167 – 18721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei226 – 24621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei256 – 27621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei335 – 35521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei375 – 39521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei434 – 45421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei460 – 48021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei524 – 54421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00620000088227.
    HOGENOMiHOG000248839.
    OMAiGATACTN.
    OrthoDBiEOG75F4PT.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 2 hits.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53943-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRSNSIYTE DIEMYPTHNE QHLTREYTKP DGQTKSEKLN FEGAYINSHG    50
    TLSKTTTREI EGDLDSETSS HSSDDKVDPT QQITAETKAP YTLLSYGQKW 100
    GMVAILTMCG FWSSLGSPIY YPALRQLEKQ FNVDENMVNV TVVVYLLFQG 150
    ISPTVSGGLA DCFGRRPIIL AGMLIYVIAS IGLACAPSYG VIIFLRCIQS 200
    IGISPTIAIS SGVVGDFTLK HERGTFVGAT SGFVLLGQCF GSLIGAVLTA 250
    RWDWRAIFWF LTIGCGSCFL IAFLILPETK RTIAGNLSIK PKRFINRAPI 300
    FLLGPVRRRF KYDNPDYETL DPTIPKLDLS SAGKILVLPE IILSLFPSGL 350
    LFAMWTLMLS SISSGLSVAP YNYHLVIIGV CYLPGGIGGL MGSFFTGRII 400
    DMYFKRKIKK FEQDKANGLI PQDAEINMFK VRLVCLLPQN FLAVVAYLLF 450
    GWSIDKGWRI ESILITSFVC SYCAMSTLST STTLLVDLYP TKSSTASSCF 500
    NFVRCSLSTI FMGCFAKMKA AMTVGGTFTF LCALVFFFNF LMFIPMKYGM 550
    KWREDRLLKQ QRQSWLNTLA VKAKKGTKRD QNDNHN 586
    Length:586
    Mass (Da):65,296
    Last modified:October 1, 1996 - v1
    Checksum:iEC9AE745F2E2C79D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti174 – 1741L → P in AAT93141. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12141 Genomic DNA. Translation: AAA99646.1.
    Z71341 Genomic DNA. Translation: CAA95938.1.
    AY693122 Genomic DNA. Translation: AAT93141.1.
    X86470 Genomic DNA. Translation: CAA60197.1.
    BK006947 Genomic DNA. Translation: DAA10481.1.
    PIRiS58713.
    RefSeqiNP_014334.3. NM_001182903.3.

    Genome annotation databases

    EnsemblFungiiYNL065W; YNL065W; YNL065W.
    GeneIDi855660.
    KEGGisce:YNL065W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12141 Genomic DNA. Translation: AAA99646.1 .
    Z71341 Genomic DNA. Translation: CAA95938.1 .
    AY693122 Genomic DNA. Translation: AAT93141.1 .
    X86470 Genomic DNA. Translation: CAA60197.1 .
    BK006947 Genomic DNA. Translation: DAA10481.1 .
    PIRi S58713.
    RefSeqi NP_014334.3. NM_001182903.3.

    3D structure databases

    ProteinModelPortali P53943.
    SMRi P53943. Positions 115-280.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35758. 17 interactions.
    IntActi P53943. 2 interactions.
    MINTi MINT-2735094.
    STRINGi 4932.YNL065W.

    Protein family/group databases

    TCDBi 2.A.1.2.36. the major facilitator superfamily (mfs).

    Proteomic databases

    MaxQBi P53943.
    PaxDbi P53943.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNL065W ; YNL065W ; YNL065W .
    GeneIDi 855660.
    KEGGi sce:YNL065W.

    Organism-specific databases

    CYGDi YNL065w.
    SGDi S000005009. AQR1.

    Phylogenomic databases

    eggNOGi COG0477.
    GeneTreei ENSGT00620000088227.
    HOGENOMi HOG000248839.
    OMAi GATACTN.
    OrthoDBi EOG75F4PT.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33095-MONOMER.

    Miscellaneous databases

    NextBioi 979923.

    Gene expression databases

    Genevestigatori P53943.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 2 hits.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of a 44 420 bp fragment located on the left arm of chromosome XIV from Saccharomyces cerevisiae."
      Bergez P., Doignon F., Crouzet M.
      Yeast 11:967-974(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: S288c / FY1676.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "Sequencing a cosmid clone of Saccharomyces cerevisiae chromosome XIV reveals 12 new open reading frames (ORFs) and an ancient duplication of six ORFs."
      Poehlmann R., Philippsen P.
      Yeast 12:391-402(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-335.
      Strain: ATCC 96604 / S288c / FY1679.
    6. "AQR1 gene (ORF YNL065w) encodes a plasma membrane transporter of the major facilitator superfamily that confers resistance to short-chain monocarboxylic acids and quinidine in Saccharomyces cerevisiae."
      Tenreiro S., Nunes P.A., Viegas C.A., Neves M.S., Teixeira M.C., Cabral M.G., Sa-Correia I.
      Biochem. Biophys. Res. Commun. 292:741-748(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    7. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiAQR1_YEAST
    AccessioniPrimary (citable) accession number: P53943
    Secondary accession number(s): D6W1B5, Q6B1F8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3