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Protein

Probable transporter AQR1

Gene

AQR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable transporter that confers resistance to short-chain monocarboxylic acids and quinidine.1 Publication

GO - Molecular functioni

  1. drug transmembrane transporter activity Source: SGD
  2. monocarboxylic acid transmembrane transporter activity Source: SGD

GO - Biological processi

  1. amino acid export Source: SGD
  2. drug transmembrane transport Source: SGD
  3. monocarboxylic acid transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33095-MONOMER.

Protein family/group databases

TCDBi2.A.1.2.36. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Probable transporter AQR1
Gene namesi
Name:AQR1
Ordered Locus Names:YNL065W
ORF Names:N2417, YNL2417W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XIV

Organism-specific databases

CYGDiYNL065w.
SGDiS000005009. AQR1.

Subcellular locationi

Membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9999ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021HelicalSequence AnalysisAdd
BLAST
Topological domaini161 – 1666ExtracellularSequence Analysis
Transmembranei167 – 18721HelicalSequence AnalysisAdd
BLAST
Topological domaini188 – 1881CytoplasmicSequence Analysis
Transmembranei189 – 20921HelicalSequence AnalysisAdd
BLAST
Topological domaini210 – 22516ExtracellularSequence AnalysisAdd
BLAST
Transmembranei226 – 24621HelicalSequence AnalysisAdd
BLAST
Topological domaini247 – 2559CytoplasmicSequence Analysis
Transmembranei256 – 27621HelicalSequence AnalysisAdd
BLAST
Topological domaini277 – 33458ExtracellularSequence AnalysisAdd
BLAST
Transmembranei335 – 35521HelicalSequence AnalysisAdd
BLAST
Topological domaini356 – 37419CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei375 – 39521HelicalSequence AnalysisAdd
BLAST
Topological domaini396 – 43338ExtracellularSequence AnalysisAdd
BLAST
Transmembranei434 – 45421HelicalSequence AnalysisAdd
BLAST
Topological domaini455 – 4595CytoplasmicSequence Analysis
Transmembranei460 – 48021HelicalSequence AnalysisAdd
BLAST
Topological domaini481 – 52343ExtracellularSequence AnalysisAdd
BLAST
Transmembranei524 – 54421HelicalSequence AnalysisAdd
BLAST
Topological domaini545 – 58642CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 586586Probable transporter AQR1PRO_0000173443Add
BLAST

Proteomic databases

MaxQBiP53943.
PaxDbiP53943.

Expressioni

Gene expression databases

GenevestigatoriP53943.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TAF2P232551EBI-28741,EBI-18862

Protein-protein interaction databases

BioGridi35758. 17 interactions.
IntActiP53943. 2 interactions.
MINTiMINT-2735094.
STRINGi4932.YNL065W.

Structurei

3D structure databases

ProteinModelPortaliP53943.
SMRiP53943. Positions 115-280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00620000088227.
HOGENOMiHOG000248839.
InParanoidiP53943.
OMAiMTLNIDI.
OrthoDBiEOG75F4PT.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSNSIYTE DIEMYPTHNE QHLTREYTKP DGQTKSEKLN FEGAYINSHG
60 70 80 90 100
TLSKTTTREI EGDLDSETSS HSSDDKVDPT QQITAETKAP YTLLSYGQKW
110 120 130 140 150
GMVAILTMCG FWSSLGSPIY YPALRQLEKQ FNVDENMVNV TVVVYLLFQG
160 170 180 190 200
ISPTVSGGLA DCFGRRPIIL AGMLIYVIAS IGLACAPSYG VIIFLRCIQS
210 220 230 240 250
IGISPTIAIS SGVVGDFTLK HERGTFVGAT SGFVLLGQCF GSLIGAVLTA
260 270 280 290 300
RWDWRAIFWF LTIGCGSCFL IAFLILPETK RTIAGNLSIK PKRFINRAPI
310 320 330 340 350
FLLGPVRRRF KYDNPDYETL DPTIPKLDLS SAGKILVLPE IILSLFPSGL
360 370 380 390 400
LFAMWTLMLS SISSGLSVAP YNYHLVIIGV CYLPGGIGGL MGSFFTGRII
410 420 430 440 450
DMYFKRKIKK FEQDKANGLI PQDAEINMFK VRLVCLLPQN FLAVVAYLLF
460 470 480 490 500
GWSIDKGWRI ESILITSFVC SYCAMSTLST STTLLVDLYP TKSSTASSCF
510 520 530 540 550
NFVRCSLSTI FMGCFAKMKA AMTVGGTFTF LCALVFFFNF LMFIPMKYGM
560 570 580
KWREDRLLKQ QRQSWLNTLA VKAKKGTKRD QNDNHN
Length:586
Mass (Da):65,296
Last modified:September 30, 1996 - v1
Checksum:iEC9AE745F2E2C79D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti174 – 1741L → P in AAT93141 (PubMed:17322287).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12141 Genomic DNA. Translation: AAA99646.1.
Z71341 Genomic DNA. Translation: CAA95938.1.
AY693122 Genomic DNA. Translation: AAT93141.1.
X86470 Genomic DNA. Translation: CAA60197.1.
BK006947 Genomic DNA. Translation: DAA10481.1.
PIRiS58713.
RefSeqiNP_014334.3. NM_001182903.3.

Genome annotation databases

EnsemblFungiiYNL065W; YNL065W; YNL065W.
GeneIDi855660.
KEGGisce:YNL065W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12141 Genomic DNA. Translation: AAA99646.1.
Z71341 Genomic DNA. Translation: CAA95938.1.
AY693122 Genomic DNA. Translation: AAT93141.1.
X86470 Genomic DNA. Translation: CAA60197.1.
BK006947 Genomic DNA. Translation: DAA10481.1.
PIRiS58713.
RefSeqiNP_014334.3. NM_001182903.3.

3D structure databases

ProteinModelPortaliP53943.
SMRiP53943. Positions 115-280.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35758. 17 interactions.
IntActiP53943. 2 interactions.
MINTiMINT-2735094.
STRINGi4932.YNL065W.

Protein family/group databases

TCDBi2.A.1.2.36. the major facilitator superfamily (mfs).

Proteomic databases

MaxQBiP53943.
PaxDbiP53943.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL065W; YNL065W; YNL065W.
GeneIDi855660.
KEGGisce:YNL065W.

Organism-specific databases

CYGDiYNL065w.
SGDiS000005009. AQR1.

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00620000088227.
HOGENOMiHOG000248839.
InParanoidiP53943.
OMAiMTLNIDI.
OrthoDBiEOG75F4PT.

Enzyme and pathway databases

BioCyciYEAST:G3O-33095-MONOMER.

Miscellaneous databases

NextBioi979923.

Gene expression databases

GenevestigatoriP53943.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of a 44 420 bp fragment located on the left arm of chromosome XIV from Saccharomyces cerevisiae."
    Bergez P., Doignon F., Crouzet M.
    Yeast 11:967-974(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S288c / FY1676.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Sequencing a cosmid clone of Saccharomyces cerevisiae chromosome XIV reveals 12 new open reading frames (ORFs) and an ancient duplication of six ORFs."
    Poehlmann R., Philippsen P.
    Yeast 12:391-402(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-335.
    Strain: ATCC 96604 / S288c / FY1679.
  6. "AQR1 gene (ORF YNL065w) encodes a plasma membrane transporter of the major facilitator superfamily that confers resistance to short-chain monocarboxylic acids and quinidine in Saccharomyces cerevisiae."
    Tenreiro S., Nunes P.A., Viegas C.A., Neves M.S., Teixeira M.C., Cabral M.G., Sa-Correia I.
    Biochem. Biophys. Res. Commun. 292:741-748(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  7. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiAQR1_YEAST
AccessioniPrimary (citable) accession number: P53943
Secondary accession number(s): D6W1B5, Q6B1F8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 30, 1996
Last sequence update: September 30, 1996
Last modified: January 6, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.