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P53943

- AQR1_YEAST

UniProt

P53943 - AQR1_YEAST

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Protein
Probable transporter AQR1
Gene
AQR1, YNL065W, N2417, YNL2417W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Probable transporter that confers resistance to short-chain monocarboxylic acids and quinidine.1 Publication

GO - Molecular functioni

  1. drug transmembrane transporter activity Source: SGD
  2. monocarboxylic acid transmembrane transporter activity Source: SGD
Complete GO annotation...

GO - Biological processi

  1. amino acid export Source: SGD
  2. drug transmembrane transport Source: SGD
  3. monocarboxylic acid transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33095-MONOMER.

Protein family/group databases

TCDBi2.A.1.2.36. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Probable transporter AQR1
Gene namesi
Name:AQR1
Ordered Locus Names:YNL065W
ORF Names:N2417, YNL2417W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL065w.
SGDiS000005009. AQR1.

Subcellular locationi

Membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9999Extracellular Reviewed prediction
Add
BLAST
Transmembranei100 – 12021Helical; Reviewed prediction
Add
BLAST
Topological domaini121 – 13919Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei140 – 16021Helical; Reviewed prediction
Add
BLAST
Topological domaini161 – 1666Extracellular Reviewed prediction
Transmembranei167 – 18721Helical; Reviewed prediction
Add
BLAST
Topological domaini188 – 1881Cytoplasmic Reviewed prediction
Transmembranei189 – 20921Helical; Reviewed prediction
Add
BLAST
Topological domaini210 – 22516Extracellular Reviewed prediction
Add
BLAST
Transmembranei226 – 24621Helical; Reviewed prediction
Add
BLAST
Topological domaini247 – 2559Cytoplasmic Reviewed prediction
Transmembranei256 – 27621Helical; Reviewed prediction
Add
BLAST
Topological domaini277 – 33458Extracellular Reviewed prediction
Add
BLAST
Transmembranei335 – 35521Helical; Reviewed prediction
Add
BLAST
Topological domaini356 – 37419Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei375 – 39521Helical; Reviewed prediction
Add
BLAST
Topological domaini396 – 43338Extracellular Reviewed prediction
Add
BLAST
Transmembranei434 – 45421Helical; Reviewed prediction
Add
BLAST
Topological domaini455 – 4595Cytoplasmic Reviewed prediction
Transmembranei460 – 48021Helical; Reviewed prediction
Add
BLAST
Topological domaini481 – 52343Extracellular Reviewed prediction
Add
BLAST
Transmembranei524 – 54421Helical; Reviewed prediction
Add
BLAST
Topological domaini545 – 58642Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 586586Probable transporter AQR1
PRO_0000173443Add
BLAST

Proteomic databases

MaxQBiP53943.
PaxDbiP53943.

Expressioni

Gene expression databases

GenevestigatoriP53943.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TAF2P232551EBI-28741,EBI-18862

Protein-protein interaction databases

BioGridi35758. 17 interactions.
IntActiP53943. 2 interactions.
MINTiMINT-2735094.
STRINGi4932.YNL065W.

Structurei

3D structure databases

ProteinModelPortaliP53943.
SMRiP53943. Positions 115-280.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00620000088227.
HOGENOMiHOG000248839.
OMAiGATACTN.
OrthoDBiEOG75F4PT.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53943-1 [UniParc]FASTAAdd to Basket

« Hide

MSRSNSIYTE DIEMYPTHNE QHLTREYTKP DGQTKSEKLN FEGAYINSHG    50
TLSKTTTREI EGDLDSETSS HSSDDKVDPT QQITAETKAP YTLLSYGQKW 100
GMVAILTMCG FWSSLGSPIY YPALRQLEKQ FNVDENMVNV TVVVYLLFQG 150
ISPTVSGGLA DCFGRRPIIL AGMLIYVIAS IGLACAPSYG VIIFLRCIQS 200
IGISPTIAIS SGVVGDFTLK HERGTFVGAT SGFVLLGQCF GSLIGAVLTA 250
RWDWRAIFWF LTIGCGSCFL IAFLILPETK RTIAGNLSIK PKRFINRAPI 300
FLLGPVRRRF KYDNPDYETL DPTIPKLDLS SAGKILVLPE IILSLFPSGL 350
LFAMWTLMLS SISSGLSVAP YNYHLVIIGV CYLPGGIGGL MGSFFTGRII 400
DMYFKRKIKK FEQDKANGLI PQDAEINMFK VRLVCLLPQN FLAVVAYLLF 450
GWSIDKGWRI ESILITSFVC SYCAMSTLST STTLLVDLYP TKSSTASSCF 500
NFVRCSLSTI FMGCFAKMKA AMTVGGTFTF LCALVFFFNF LMFIPMKYGM 550
KWREDRLLKQ QRQSWLNTLA VKAKKGTKRD QNDNHN 586
Length:586
Mass (Da):65,296
Last modified:October 1, 1996 - v1
Checksum:iEC9AE745F2E2C79D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti174 – 1741L → P in AAT93141. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12141 Genomic DNA. Translation: AAA99646.1.
Z71341 Genomic DNA. Translation: CAA95938.1.
AY693122 Genomic DNA. Translation: AAT93141.1.
X86470 Genomic DNA. Translation: CAA60197.1.
BK006947 Genomic DNA. Translation: DAA10481.1.
PIRiS58713.
RefSeqiNP_014334.3. NM_001182903.3.

Genome annotation databases

EnsemblFungiiYNL065W; YNL065W; YNL065W.
GeneIDi855660.
KEGGisce:YNL065W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12141 Genomic DNA. Translation: AAA99646.1 .
Z71341 Genomic DNA. Translation: CAA95938.1 .
AY693122 Genomic DNA. Translation: AAT93141.1 .
X86470 Genomic DNA. Translation: CAA60197.1 .
BK006947 Genomic DNA. Translation: DAA10481.1 .
PIRi S58713.
RefSeqi NP_014334.3. NM_001182903.3.

3D structure databases

ProteinModelPortali P53943.
SMRi P53943. Positions 115-280.
ModBasei Search...

Protein-protein interaction databases

BioGridi 35758. 17 interactions.
IntActi P53943. 2 interactions.
MINTi MINT-2735094.
STRINGi 4932.YNL065W.

Protein family/group databases

TCDBi 2.A.1.2.36. the major facilitator superfamily (mfs).

Proteomic databases

MaxQBi P53943.
PaxDbi P53943.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL065W ; YNL065W ; YNL065W .
GeneIDi 855660.
KEGGi sce:YNL065W.

Organism-specific databases

CYGDi YNL065w.
SGDi S000005009. AQR1.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00620000088227.
HOGENOMi HOG000248839.
OMAi GATACTN.
OrthoDBi EOG75F4PT.

Enzyme and pathway databases

BioCyci YEAST:G3O-33095-MONOMER.

Miscellaneous databases

NextBioi 979923.

Gene expression databases

Genevestigatori P53943.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 2 hits.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of a 44 420 bp fragment located on the left arm of chromosome XIV from Saccharomyces cerevisiae."
    Bergez P., Doignon F., Crouzet M.
    Yeast 11:967-974(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S288c / FY1676.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Sequencing a cosmid clone of Saccharomyces cerevisiae chromosome XIV reveals 12 new open reading frames (ORFs) and an ancient duplication of six ORFs."
    Poehlmann R., Philippsen P.
    Yeast 12:391-402(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-335.
    Strain: ATCC 96604 / S288c / FY1679.
  6. "AQR1 gene (ORF YNL065w) encodes a plasma membrane transporter of the major facilitator superfamily that confers resistance to short-chain monocarboxylic acids and quinidine in Saccharomyces cerevisiae."
    Tenreiro S., Nunes P.A., Viegas C.A., Neves M.S., Teixeira M.C., Cabral M.G., Sa-Correia I.
    Biochem. Biophys. Res. Commun. 292:741-748(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  7. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiAQR1_YEAST
AccessioniPrimary (citable) accession number: P53943
Secondary accession number(s): D6W1B5, Q6B1F8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

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