Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

U3 small nucleolar ribonucleoprotein protein IMP4

Gene

IMP4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing.2 Publications

GO - Molecular functioni

  • rRNA primary transcript binding Source: SGD
  • single-stranded telomeric DNA binding Source: SGD
  • snoRNA binding Source: SGD

GO - Biological processi

  • ribosomal small subunit biogenesis Source: SGD
  • rRNA methylation Source: Reactome
  • rRNA processing Source: SGD

Keywordsi

Molecular functionRibonucleoprotein
Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-33104-MONOMER
ReactomeiR-SCE-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar ribonucleoprotein protein IMP4
Short name:
U3 snoRNP protein IMP4
Alternative name(s):
Interacting with MPP10 protein 4
Gene namesi
Name:IMP4
Ordered Locus Names:YNL075W
ORF Names:N2353
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL075W
SGDiS000005019 IMP4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi119R → A: No effect on RNA binding. 1 Publication1
Mutagenesisi201R → A: No effect on RNA binding. 1 Publication1
Mutagenesisi220R → A: Loss of RNA binding. 1 Publication1
Mutagenesisi253R → A: Loss of RNA binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001202451 – 290U3 small nucleolar ribonucleoprotein protein IMP4Add BLAST290

Proteomic databases

MaxQBiP53941
PaxDbiP53941
PRIDEiP53941

Interactioni

Subunit structurei

Component of a heterotrimeric complex containing IMP3, IMP4 and MPP10. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35748, 61 interactors
DIPiDIP-4362N
IntActiP53941, 26 interactors
MINTiP53941
STRINGi4932.YNL075W

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WLCelectron microscopy3.80SM1-290[»]
5WYJelectron microscopy8.70MB1-290[»]
5WYKelectron microscopy4.50MB1-290[»]
ProteinModelPortaliP53941
SMRiP53941
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 267BrixPROSITE-ProRule annotationAdd BLAST182

Phylogenomic databases

GeneTreeiENSGT00550000074987
HOGENOMiHOG000172063
InParanoidiP53941
KOiK14561
OMAiFFNISDV
OrthoDBiEOG092C3ODK

Family and domain databases

InterProiView protein in InterPro
IPR007109 Brix
PfamiView protein in Pfam
PF04427 Brix, 1 hit
SMARTiView protein in SMART
SM00879 Brix, 1 hit
PROSITEiView protein in PROSITE
PS50833 BRIX, 1 hit

Sequencei

Sequence statusi: Complete.

P53941-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRQARERR EYLYRKAQEL QDSQLQQKRQ IIKQALAQGK PLPKELAEDE
60 70 80 90 100
SLQKDFRYDQ SLKESEEADD LQVDDEYAAT SGIMDPRIIV TTSRDPSTRL
110 120 130 140 150
SQFAKEIKLL FPNAVRLNRG NYVMPNLVDA CKKSGTTDLV VLHEHRGVPT
160 170 180 190 200
SLTISHFPHG PTAQFSLHNV VMRHDIINAG NQSEVNPHLI FDNFTTALGK
210 220 230 240 250
RVVCILKHLF NAGPKKDSER VITFANRGDF ISVRQHVYVR TREGVEIAEV
260 270 280 290
GPRFEMRLFE LRLGTLENKD ADVEWQLRRF IRTANKKDYL
Length:290
Mass (Da):33,482
Last modified:October 1, 1996 - v1
Checksum:iDF9F863364848B63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86470 Genomic DNA Translation: CAA60184.1
Z71351 Genomic DNA Translation: CAA95949.1
BK006947 Genomic DNA Translation: DAA10470.1
PIRiS53904
RefSeqiNP_014324.3, NM_001182913.3

Genome annotation databases

EnsemblFungiiYNL075W; YNL075W; YNL075W
GeneIDi855649
KEGGisce:YNL075W

Similar proteinsi

Entry informationi

Entry nameiIMP4_YEAST
AccessioniPrimary (citable) accession number: P53941
Secondary accession number(s): D6W1A4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Protein nomenclature information
    List of publications dealing with protein nomenclature and links to specialized websites
  2. Forthcoming format changes (XML)
    Announcements of forthcoming format changes in the XML format

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health