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Protein

U3 small nucleolar ribonucleoprotein protein IMP4

Gene

IMP4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing.2 Publications

GO - Molecular functioni

  • rRNA primary transcript binding Source: SGD
  • single-stranded telomeric DNA binding Source: SGD
  • snoRNA binding Source: SGD

GO - Biological processi

  • ribosomal small subunit biogenesis Source: SGD
  • rRNA methylation Source: Reactome
  • rRNA processing Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-33104-MONOMER.
ReactomeiR-SCE-6790901. rRNA modification in the nucleus.
R-SCE-6791226. Major pathway of rRNA processing in the nucleolus.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar ribonucleoprotein protein IMP4
Short name:
U3 snoRNP protein IMP4
Alternative name(s):
Interacting with MPP10 protein 4
Gene namesi
Name:IMP4
Ordered Locus Names:YNL075W
ORF Names:N2353
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL075W.
SGDiS000005019. IMP4.

Subcellular locationi

  • Nucleusnucleolus 1 Publication

GO - Cellular componenti

  • Mpp10 complex Source: SGD
  • nucleoplasm Source: Reactome
  • small-subunit processome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi119 – 1191R → A: No effect on RNA binding. 1 Publication
Mutagenesisi201 – 2011R → A: No effect on RNA binding. 1 Publication
Mutagenesisi220 – 2201R → A: Loss of RNA binding. 1 Publication
Mutagenesisi253 – 2531R → A: Loss of RNA binding. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290U3 small nucleolar ribonucleoprotein protein IMP4PRO_0000120245Add
BLAST

Proteomic databases

MaxQBiP53941.

Interactioni

Subunit structurei

Component of a heterotrimeric complex containing IMP3, IMP4 and MPP10. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MPP10P470834EBI-9243,EBI-11168

Protein-protein interaction databases

BioGridi35748. 52 interactions.
DIPiDIP-4362N.
IntActiP53941. 22 interactions.
MINTiMINT-8285419.

Structurei

3D structure databases

ProteinModelPortaliP53941.
SMRiP53941. Positions 87-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 267182BrixPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Brix domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000074987.
HOGENOMiHOG000172063.
InParanoidiP53941.
KOiK14561.
OMAiRFEMKPY.
OrthoDBiEOG092C3ODK.

Family and domain databases

Gene3Di3.40.50.10480. 1 hit.
InterProiIPR004154. Anticodon-bd.
IPR007109. Brix.
[Graphical view]
PfamiPF04427. Brix. 1 hit.
[Graphical view]
SMARTiSM00879. Brix. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
PROSITEiPS50833. BRIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53941-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRQARERR EYLYRKAQEL QDSQLQQKRQ IIKQALAQGK PLPKELAEDE
60 70 80 90 100
SLQKDFRYDQ SLKESEEADD LQVDDEYAAT SGIMDPRIIV TTSRDPSTRL
110 120 130 140 150
SQFAKEIKLL FPNAVRLNRG NYVMPNLVDA CKKSGTTDLV VLHEHRGVPT
160 170 180 190 200
SLTISHFPHG PTAQFSLHNV VMRHDIINAG NQSEVNPHLI FDNFTTALGK
210 220 230 240 250
RVVCILKHLF NAGPKKDSER VITFANRGDF ISVRQHVYVR TREGVEIAEV
260 270 280 290
GPRFEMRLFE LRLGTLENKD ADVEWQLRRF IRTANKKDYL
Length:290
Mass (Da):33,482
Last modified:October 1, 1996 - v1
Checksum:iDF9F863364848B63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86470 Genomic DNA. Translation: CAA60184.1.
Z71351 Genomic DNA. Translation: CAA95949.1.
BK006947 Genomic DNA. Translation: DAA10470.1.
PIRiS53904.
RefSeqiNP_014324.3. NM_001182913.3.

Genome annotation databases

EnsemblFungiiYNL075W; YNL075W; YNL075W.
GeneIDi855649.
KEGGisce:YNL075W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86470 Genomic DNA. Translation: CAA60184.1.
Z71351 Genomic DNA. Translation: CAA95949.1.
BK006947 Genomic DNA. Translation: DAA10470.1.
PIRiS53904.
RefSeqiNP_014324.3. NM_001182913.3.

3D structure databases

ProteinModelPortaliP53941.
SMRiP53941. Positions 87-149.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35748. 52 interactions.
DIPiDIP-4362N.
IntActiP53941. 22 interactions.
MINTiMINT-8285419.

Proteomic databases

MaxQBiP53941.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL075W; YNL075W; YNL075W.
GeneIDi855649.
KEGGisce:YNL075W.

Organism-specific databases

EuPathDBiFungiDB:YNL075W.
SGDiS000005019. IMP4.

Phylogenomic databases

GeneTreeiENSGT00550000074987.
HOGENOMiHOG000172063.
InParanoidiP53941.
KOiK14561.
OMAiRFEMKPY.
OrthoDBiEOG092C3ODK.

Enzyme and pathway databases

BioCyciYEAST:G3O-33104-MONOMER.
ReactomeiR-SCE-6790901. rRNA modification in the nucleus.
R-SCE-6791226. Major pathway of rRNA processing in the nucleolus.

Miscellaneous databases

PROiP53941.

Family and domain databases

Gene3Di3.40.50.10480. 1 hit.
InterProiIPR004154. Anticodon-bd.
IPR007109. Brix.
[Graphical view]
PfamiPF04427. Brix. 1 hit.
[Graphical view]
SMARTiSM00879. Brix. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
PROSITEiPS50833. BRIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIMP4_YEAST
AccessioniPrimary (citable) accession number: P53941
Secondary accession number(s): D6W1A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.