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Protein

Protein NIS1

Gene

NIS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in a mitotic signaling network. Binds sumoylated proteins and may stabilize SUMO chains.1 Publication

GO - Biological processi

  • regulation of mitotic nuclear division Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-33107-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NIS1
Alternative name(s):
Jumonji domain-interacting protein 1
Neck protein interacting with septins protein 1
Gene namesi
Name:NIS1
Synonyms:JIP1
Ordered Locus Names:YNL078W
ORF Names:N2337
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL078W.
SGDiS000005022. NIS1.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: UniProtKB-SubCell
  • cellular bud neck Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Protein NIS1PRO_0000203447Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei260 – 2601PhosphoserineCombined sources
Modified residuei264 – 2641PhosphoserineCombined sources
Modified residuei300 – 3001PhosphoserineCombined sources
Modified residuei302 – 3021PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53939.

PTM databases

iPTMnetiP53939.

Expressioni

Inductioni

Expression is regulated by the ACE2 and SWI5 transcription factors.1 Publication

Interactioni

Subunit structurei

Interacts with CBF2, GIS1, NAP1, PRM8, REI1, SHS1 and SMT3.7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AIM44Q992994EBI-28760,EBI-29423
NAP1P252937EBI-28760,EBI-11850
NBA1Q082293EBI-28760,EBI-36841

Protein-protein interaction databases

BioGridi35745. 46 interactions.
DIPiDIP-1980N.
IntActiP53939. 16 interactions.
MINTiMINT-397951.

Structurei

3D structure databases

ProteinModelPortaliP53939.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi391 – 3988SUMO-binding

Phylogenomic databases

InParanoidiP53939.
OMAiDDSHITH.
OrthoDBiEOG092C3OCO.

Sequencei

Sequence statusi: Complete.

P53939-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METYETSIGT QSYPPTLFPP PLGTGGFTTS GYIHALVDST SNSNSNSNTN
60 70 80 90 100
SNTNSNTNSN SDTKIPIVQI SDDSHITHDS FKPYMEYHDA SHLRNRNISK
110 120 130 140 150
ADQVESTEVM EQFTQWSNYK MRSRSPTINA KPIRHTSQRR TDFTSKNELS
160 170 180 190 200
KFSKNHNFIF HKGFLKRQHS IRREDRQAKV RSRFRSKKEL TSVLNYIELE
210 220 230 240 250
QMDIANVLAS QPVNLHAIRN LTSRDPAVTP IPFLRSQMYA TSSRPPYLRN
260 270 280 290 300
RSISRKLPKS QPGSLPTTMP ATATKTIKQN STTPTTRSVY NKNVGRSNTS
310 320 330 340 350
PSVLYHPKRR GKLNTKSHAR KEQLLLELWR EYLMLVITQR TQLRLTLLCS
360 370 380 390 400
PGSASNESSV CSSNASDLDM SLLSTPSSLF QMAGETKSNP IIIPDSQDDS

ILSSDPF
Length:407
Mass (Da):45,908
Last modified:October 1, 1996 - v1
Checksum:i925C7B6063BCE4F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86470 Genomic DNA. Translation: CAA60180.1.
Z71354 Genomic DNA. Translation: CAA95952.1.
BK006947 Genomic DNA. Translation: DAA10467.1.
PIRiS53900.
RefSeqiNP_014321.3. NM_001182916.3.

Genome annotation databases

EnsemblFungiiYNL078W; YNL078W; YNL078W.
GeneIDi855646.
KEGGisce:YNL078W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86470 Genomic DNA. Translation: CAA60180.1.
Z71354 Genomic DNA. Translation: CAA95952.1.
BK006947 Genomic DNA. Translation: DAA10467.1.
PIRiS53900.
RefSeqiNP_014321.3. NM_001182916.3.

3D structure databases

ProteinModelPortaliP53939.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35745. 46 interactions.
DIPiDIP-1980N.
IntActiP53939. 16 interactions.
MINTiMINT-397951.

PTM databases

iPTMnetiP53939.

Proteomic databases

MaxQBiP53939.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL078W; YNL078W; YNL078W.
GeneIDi855646.
KEGGisce:YNL078W.

Organism-specific databases

EuPathDBiFungiDB:YNL078W.
SGDiS000005022. NIS1.

Phylogenomic databases

InParanoidiP53939.
OMAiDDSHITH.
OrthoDBiEOG092C3OCO.

Enzyme and pathway databases

BioCyciYEAST:G3O-33107-MONOMER.

Miscellaneous databases

PROiP53939.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiNIS1_YEAST
AccessioniPrimary (citable) accession number: P53939
Secondary accession number(s): D6W1A1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 504 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.