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P53938 (EOS1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-glycosylation protein EOS1
Alternative name(s):
ER-localized and oxidants sensitive protein 1
Gene names
Name:EOS1
Ordered Locus Names:YNL080C
ORF Names:N2327
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in oxidative stress resistance and N-glycosylation. Ref.8

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.5 Ref.8.

Post-translational modification

N-glycosylated.

Miscellaneous

Present with 937 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the EOS1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 366366N-glycosylation protein EOS1
PRO_0000203446

Regions

Topological domain1 – 136136Lumenal Potential
Transmembrane137 – 15721Helical; Potential
Topological domain158 – 16710Cytoplasmic Potential
Transmembrane168 – 18821Helical; Potential
Topological domain189 – 1957Lumenal Potential
Transmembrane196 – 21621Helical; Potential
Topological domain217 – 321105Cytoplasmic Potential
Transmembrane322 – 34221Helical; Potential
Topological domain343 – 36624Lumenal Potential

Amino acid modifications

Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation1041N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P53938 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: CFE1BA51A638DF5A

FASTA36641,674
        10         20         30         40         50         60 
MTWILSTGMG PHEDKYAKHE RATFKKTYSS MKTLSLNHLT AKQHMLMALC RDISLLPPLT 

        70         80         90        100        110        120 
YIFTSLRKAW RVSMRTSITL YEPQSLRDAF TYFWQKLNSA YDNNSSFEGA SQKAVNGDGK 

       130        140        150        160        170        180 
DSLLLSALTT ARASEYLLCS LWCLVSLYLS YAILDSLMVR WIVKYSTVAA ILRMFSMSLI 

       190        200        210        220        230        240 
IVTLELLLLS SLSPELDYFL HTWILISCVL TAVYIWQSYL TSDLRYIRNQ EGEVQEDTNV 

       250        260        270        280        290        300 
PEETEDYEDG EDDADEDSHV VVADESTVDV PSNDSLSDNS DGGLFPVNRP SVSHSQSPKR 

       310        320        330        340        350        360 
PKKYPKKAFN FTTKRTIDLY KITVLCVVPV GLASFITMLG LLRNLFIQRL DVEQLERILH 


EMHPPA 

« Hide

References

« Hide 'large scale' references
[1]"Quantitative trait loci mapped to single-nucleotide resolution in yeast."
Deutschbauer A.M., Davis R.W.
Nat. Genet. 37:1333-1340(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: SK1.
[2]"Sequencing a cosmid clone of Saccharomyces cerevisiae chromosome XIV reveals 12 new open reading frames (ORFs) and an ancient duplication of six ORFs."
Poehlmann R., Philippsen P.
Yeast 12:391-402(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Analysis of deletion phenotypes and GFP fusions of 21 novel Saccharomyces cerevisiae open reading frames."
Brachat A., Liebundguth N., Rebischung C., Lemire S., Schaerer F., Hoepfner D., Demchyshyn V., Howald I., Duesterhoeft A., Moestl D., Poehlmann R., Koetter P., Hall M.N., Wach A., Philippsen P.
Yeast 16:241-253(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[8]"EOS1, whose deletion confers sensitivity to oxidative stress, is involved in N-glycosylation in Saccharomyces cerevisiae."
Nakamura T., Ando A., Takagi H., Shima J.
Biochem. Biophys. Res. Commun. 353:293-298(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[9]"Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes."
Kung L.A., Tao S.-C., Qian J., Smith M.G., Snyder M., Zhu H.
Mol. Syst. Biol. 5:308-308(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ115393 Genomic DNA. Translation: AAZ22528.1.
X86470 Genomic DNA. Translation: CAA60178.1.
Z71356 Genomic DNA. Translation: CAA95954.1.
BK006947 Genomic DNA. Translation: DAA10465.1.
PIRS53898.
RefSeqNP_014319.1. NM_001182918.1.

3D structure databases

ProteinModelPortalP53938.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35743. 186 interactions.
IntActP53938. 1 interaction.
STRING4932.YNL080C.

Proteomic databases

PaxDbP53938.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYNL080C; YNL080C; YNL080C.
GeneID855644.
KEGGsce:YNL080C.

Organism-specific databases

CYGDYNL080c.
SGDS000005024. EOS1.

Phylogenomic databases

eggNOGNOG46394.
HOGENOMHOG000248035.
OMASLMVRWI.
OrthoDBEOG7DFXP8.

Enzyme and pathway databases

BioCycYEAST:G3O-33109-MONOMER.

Gene expression databases

GenevestigatorP53938.

Family and domain databases

InterProIPR021100. N-glycosylation_EOS1.
[Graphical view]
PfamPF12326. EOS1. 1 hit.
[Graphical view]
PRINTSPR02070. NGLYCOSEOS1.
ProtoNetSearch...

Other

NextBio979878.

Entry information

Entry nameEOS1_YEAST
AccessionPrimary (citable) accession number: P53938
Secondary accession number(s): D6W199, Q45TY2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families