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P53938

- EOS1_YEAST

UniProt

P53938 - EOS1_YEAST

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Protein

N-glycosylation protein EOS1

Gene

EOS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in oxidative stress resistance and N-glycosylation.1 Publication

GO - Biological processi

  1. cellular response to oxidative stress Source: SGD
  2. protein N-linked glycosylation Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-33109-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
N-glycosylation protein EOS1
Alternative name(s):
ER-localized and oxidants sensitive protein 1
Gene namesi
Name:EOS1
Ordered Locus Names:YNL080C
ORF Names:N2327
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL080c.
SGDiS000005024. EOS1.

Subcellular locationi

Endoplasmic reticulum membrane 2 Publications; Multi-pass membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 136136LumenalSequence AnalysisAdd
BLAST
Transmembranei137 – 15721HelicalSequence AnalysisAdd
BLAST
Topological domaini158 – 16710CytoplasmicSequence Analysis
Transmembranei168 – 18821HelicalSequence AnalysisAdd
BLAST
Topological domaini189 – 1957LumenalSequence Analysis
Transmembranei196 – 21621HelicalSequence AnalysisAdd
BLAST
Topological domaini217 – 321105CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei322 – 34221HelicalSequence AnalysisAdd
BLAST
Topological domaini343 – 36624LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: SGD
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366N-glycosylation protein EOS1PRO_0000203446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP53938.
PaxDbiP53938.

Expressioni

Gene expression databases

GenevestigatoriP53938.

Interactioni

Protein-protein interaction databases

BioGridi35743. 187 interactions.
IntActiP53938. 1 interaction.
STRINGi4932.YNL080C.

Structurei

3D structure databases

ProteinModelPortaliP53938.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EOS1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46394.
HOGENOMiHOG000248035.
InParanoidiP53938.
OMAiHTWILIS.
OrthoDBiEOG7DFXP8.

Family and domain databases

InterProiIPR021100. N-glycosylation_EOS1.
[Graphical view]
PfamiPF12326. EOS1. 1 hit.
[Graphical view]
PRINTSiPR02070. NGLYCOSEOS1.

Sequencei

Sequence statusi: Complete.

P53938-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTWILSTGMG PHEDKYAKHE RATFKKTYSS MKTLSLNHLT AKQHMLMALC
60 70 80 90 100
RDISLLPPLT YIFTSLRKAW RVSMRTSITL YEPQSLRDAF TYFWQKLNSA
110 120 130 140 150
YDNNSSFEGA SQKAVNGDGK DSLLLSALTT ARASEYLLCS LWCLVSLYLS
160 170 180 190 200
YAILDSLMVR WIVKYSTVAA ILRMFSMSLI IVTLELLLLS SLSPELDYFL
210 220 230 240 250
HTWILISCVL TAVYIWQSYL TSDLRYIRNQ EGEVQEDTNV PEETEDYEDG
260 270 280 290 300
EDDADEDSHV VVADESTVDV PSNDSLSDNS DGGLFPVNRP SVSHSQSPKR
310 320 330 340 350
PKKYPKKAFN FTTKRTIDLY KITVLCVVPV GLASFITMLG LLRNLFIQRL
360
DVEQLERILH EMHPPA
Length:366
Mass (Da):41,674
Last modified:October 1, 1996 - v1
Checksum:iCFE1BA51A638DF5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ115393 Genomic DNA. Translation: AAZ22528.1.
X86470 Genomic DNA. Translation: CAA60178.1.
Z71356 Genomic DNA. Translation: CAA95954.1.
BK006947 Genomic DNA. Translation: DAA10465.1.
PIRiS53898.
RefSeqiNP_014319.1. NM_001182918.1.

Genome annotation databases

EnsemblFungiiYNL080C; YNL080C; YNL080C.
GeneIDi855644.
KEGGisce:YNL080C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ115393 Genomic DNA. Translation: AAZ22528.1 .
X86470 Genomic DNA. Translation: CAA60178.1 .
Z71356 Genomic DNA. Translation: CAA95954.1 .
BK006947 Genomic DNA. Translation: DAA10465.1 .
PIRi S53898.
RefSeqi NP_014319.1. NM_001182918.1.

3D structure databases

ProteinModelPortali P53938.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35743. 187 interactions.
IntActi P53938. 1 interaction.
STRINGi 4932.YNL080C.

Proteomic databases

MaxQBi P53938.
PaxDbi P53938.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL080C ; YNL080C ; YNL080C .
GeneIDi 855644.
KEGGi sce:YNL080C.

Organism-specific databases

CYGDi YNL080c.
SGDi S000005024. EOS1.

Phylogenomic databases

eggNOGi NOG46394.
HOGENOMi HOG000248035.
InParanoidi P53938.
OMAi HTWILIS.
OrthoDBi EOG7DFXP8.

Enzyme and pathway databases

BioCyci YEAST:G3O-33109-MONOMER.

Miscellaneous databases

NextBioi 979878.

Gene expression databases

Genevestigatori P53938.

Family and domain databases

InterProi IPR021100. N-glycosylation_EOS1.
[Graphical view ]
Pfami PF12326. EOS1. 1 hit.
[Graphical view ]
PRINTSi PR02070. NGLYCOSEOS1.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Quantitative trait loci mapped to single-nucleotide resolution in yeast."
    Deutschbauer A.M., Davis R.W.
    Nat. Genet. 37:1333-1340(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SK1.
  2. "Sequencing a cosmid clone of Saccharomyces cerevisiae chromosome XIV reveals 12 new open reading frames (ORFs) and an ancient duplication of six ORFs."
    Poehlmann R., Philippsen P.
    Yeast 12:391-402(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Analysis of deletion phenotypes and GFP fusions of 21 novel Saccharomyces cerevisiae open reading frames."
    Brachat A., Liebundguth N., Rebischung C., Lemire S., Schaerer F., Hoepfner D., Demchyshyn V., Howald I., Duesterhoeft A., Moestl D., Poehlmann R., Koetter P., Hall M.N., Wach A., Philippsen P.
    Yeast 16:241-253(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  8. "EOS1, whose deletion confers sensitivity to oxidative stress, is involved in N-glycosylation in Saccharomyces cerevisiae."
    Nakamura T., Ando A., Takagi H., Shima J.
    Biochem. Biophys. Res. Commun. 353:293-298(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  9. "Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes."
    Kung L.A., Tao S.-C., Qian J., Smith M.G., Snyder M., Zhu H.
    Mol. Syst. Biol. 5:308-308(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiEOS1_YEAST
AccessioniPrimary (citable) accession number: P53938
Secondary accession number(s): D6W199, Q45TY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 937 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3