ID   YNJ5_YEAST              Reviewed;         642 AA.
AC   P53932; D6W185;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   27-MAR-2024, entry version 140.
DE   RecName: Full=Uncharacterized transporter YNL095C;
GN   OrderedLocusNames=YNL095C; ORFNames=N2215;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 96604 / S288c / FY1679;
RX   PubMed=8771715;
RX   DOI=10.1002/(sici)1097-0061(199605)12:6<599::aid-yea938>3.0.co;2-9;
RA   Garcia-Cantalejo J.M., Boskovic J., Jimenez A.;
RT   "Sequence analysis of a 14.2 kb fragment of Saccharomyces cerevisiae
RT   chromosome XIV that includes the ypt53, tRNALeu and gsr m2 genes and four
RT   new open reading frames.";
RL   Yeast 12:599-608(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169873;
RA   Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
RA   Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
RA   Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
RA   Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
RA   Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F.,
RA   Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C.,
RA   Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A.,
RA   Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H.,
RA   Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L.,
RA   Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R.,
RA   Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D.,
RA   Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A.,
RA   Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C.,
RA   Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F.,
RA   Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G.,
RA   Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M.,
RA   Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its
RT   evolutionary implications.";
RL   Nature 387:93-98(1997).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   TOPOLOGY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 208353 / W303-1A;
RX   PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA   Kim H., Melen K., Oesterberg M., von Heijne G.;
RT   "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the auxin efflux carrier (TC 2.A.69) family.
CC       {ECO:0000305}.
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DR   EMBL; X85811; CAA59822.1; -; Genomic_DNA.
DR   EMBL; Z71371; CAA95971.1; -; Genomic_DNA.
DR   EMBL; BK006947; DAA10451.1; -; Genomic_DNA.
DR   PIR; S52730; S52730.
DR   RefSeq; NP_014304.1; NM_001182933.1.
DR   AlphaFoldDB; P53932; -.
DR   BioGRID; 35729; 53.
DR   DIP; DIP-4349N; -.
DR   STRING; 4932.YNL095C; -.
DR   iPTMnet; P53932; -.
DR   MaxQB; P53932; -.
DR   PaxDb; 4932-YNL095C; -.
DR   PeptideAtlas; P53932; -.
DR   EnsemblFungi; YNL095C_mRNA; YNL095C; YNL095C.
DR   GeneID; 855629; -.
DR   KEGG; sce:YNL095C; -.
DR   AGR; SGD:S000005039; -.
DR   SGD; S000005039; YNL095C.
DR   VEuPathDB; FungiDB:YNL095C; -.
DR   eggNOG; ENOG502QU6H; Eukaryota.
DR   GeneTree; ENSGT00940000176363; -.
DR   HOGENOM; CLU_021924_0_0_1; -.
DR   InParanoid; P53932; -.
DR   OrthoDB; 1424768at2759; -.
DR   BioCyc; YEAST:G3O-33123-MONOMER; -.
DR   BioGRID-ORCS; 855629; 0 hits in 10 CRISPR screens.
DR   PRO; PR:P53932; -.
DR   Proteomes; UP000002311; Chromosome XIV.
DR   RNAct; P53932; Protein.
DR   GO; GO:0005783; C:endoplasmic reticulum; HDA:SGD.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR040254; Ecm3-like.
DR   InterPro; IPR004776; Mem_transp_PIN-like.
DR   PANTHER; PTHR31274; PROTEIN ECM3; 1.
DR   PANTHER; PTHR31274:SF1; PROTEIN ECM3; 1.
DR   Pfam; PF03547; Mem_trans; 1.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..642
FT                   /note="Uncharacterized transporter YNL095C"
FT                   /id="PRO_0000123807"
FT   TOPO_DOM        1..15
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        37..42
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        64..73
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        95..104
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        126..142
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        164..460
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        461..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        482..499
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        500..520
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        521..538
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        539..559
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        560..574
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        575..595
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        596..614
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        615..635
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        636..642
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          183..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          227..324
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        237..324
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   642 AA;  71196 MW;  E4E3253D929FF4E2 CRC64;
     MVHITLGQAI WVSVKPIIKI YLIIGVGFLM AKMGILTVEA TRIISDIVLT VLLPSLSFNK
     IVANIEDKDI KSVGIICLSA LLIFGSGFFF AYVVRLFLPV PKQWYGGILA GGMFPNISDL
     PIAYLQSMDQ GLVFSEEEGN KGVANVIIFL TMFLICIFNL GGFRLIESDF EYNDDESAVR
     VSETTKTQPA VSANTTNTDT SERFFSNEQQ LFNNKYTARD SLTEAIGTKG ENADVPPISR
     RSTNSIAPLS LPDTSSNSKI TKPVQVKARN TIACTQSEES QATRGSNPLD SQSSASTIHS
     YNTSESYESS IDTMRARRTA SQPRAYNTTT LLEENCLDEK CPKNMSMAAL EPIRSIDMRA
     LPSQNIHHLI REYSNVDQYG HQRRNSSLRG ADMNDVHSIS SNSTLQTIKT ANLTRILTSD
     ATVSKKDIET SGESLPQWMR KFSLTPLLVF FLKNCLRPCS MAVIIALTVA FIPWVKALFV
     TTANTPHISQ APDNAPPLSF FMDFTGYVGA ACVPFGLILL GATLGRLKIG NLYPGFWKAA
     VTLVILRQCV MPIFGVLWCD RLVKAGWVNW QDDRMLLFVI AISWNLPTMT TLIYFTASFT
     PPETTAPIQM ECVSFFLMLQ YPLMVVSLPF LVSYFLKVQM NL
//