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Protein

54S ribosomal protein bL35m

Gene

YNL122C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.2 Publications

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial translation Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-33143-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
54S ribosomal protein bL35m1 Publication
Alternative name(s):
Mitochondrial large ribosomal subunit protein bL35m1 Publication
Gene namesi
Ordered Locus Names:YNL122C
ORF Names:N1901
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL122C.
SGDiS000005066. YNL122C.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial large ribosomal subunit Source: SGD
  • mitochondrion Source: SGD

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000203430? – 11554S ribosomal protein bL35m
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PRIDEiP53921.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.1 Publication

Protein-protein interaction databases

BioGridi35705. 86 interactors.
DIPiDIP-2009N.
IntActiP53921. 1 interactor.
MINTiMINT-396727.
STRINGi4932.YNL122C.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Belectron microscopy3.20Z1-115[»]
5MRCelectron microscopy3.25Z54-115[»]
5MREelectron microscopy3.75Z54-115[»]
5MRFelectron microscopy4.97Z54-115[»]
ProteinModelPortaliP53921.
SMRiP53921.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000248549.
InParanoidiP53921.
OrthoDBiEOG092C5Q5V.

Family and domain databases

InterProiView protein in InterPro
IPR021137. Ribosomal_L35.
PfamiView protein in Pfam
PF01632. Ribosomal_L35p. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53921-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKISLHNKRQ RGDQNQNMSV FNVLKPLLKG SNSFKVKLNG FLFNNVSTIT
60 70 80 90 100
IRTLMKTHKG TAKRWRRTGN TFKRGIAGRK HGNIGWSHRS LKALTGRKIA
110
HPAYSKHLKR LLPYH
Length:115
Mass (Da):13,244
Last modified:October 1, 1996 - v1
Checksum:iB6C9DC84CE1EB016
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti11R → Q in strain: V1-09 and YJM339. 1 Publication1
Natural varianti31S → P in strain: YJM269, YJM270, YJM326 and YJM1129. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF125216 Genomic DNA. Translation: ABN58536.1.
EF125217 Genomic DNA. Translation: ABN58545.1.
EF125218 Genomic DNA. Translation: ABN58554.1.
EF125219 Genomic DNA. Translation: ABN58563.1.
EF125220 Genomic DNA. Translation: ABN58572.1.
EF125221 Genomic DNA. Translation: ABN58581.1.
EF125222 Genomic DNA. Translation: ABN58590.1.
EF125223 Genomic DNA. Translation: ABN58599.1.
EF125224 Genomic DNA. Translation: ABN58608.1.
EF125225 Genomic DNA. Translation: ABN58617.1.
EF125226 Genomic DNA. Translation: ABN58626.1.
EF125228 Genomic DNA. Translation: ABN58644.1.
Z69382 Genomic DNA. Translation: CAA93385.1.
Z71398 Genomic DNA. Translation: CAA96003.1.
AY692589 Genomic DNA. Translation: AAT92608.1.
BK006947 Genomic DNA. Translation: DAA10427.1.
PIRiS63063.
RefSeqiNP_014277.1. NM_001182960.1.

Genome annotation databases

EnsemblFungiiYNL122C; YNL122C; YNL122C.
GeneIDi855601.
KEGGisce:YNL122C.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiYNM2_YEAST
AccessioniPrimary (citable) accession number: P53921
Secondary accession number(s): B0KZR4
, B0KZU1, B0KZY6, D6W161
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 5, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names