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Protein

Pro-apoptotic serine protease NMA111

Gene

NMA111

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nuclear serine protease which mediates apoptosis through proteolysis of the apoptotic inhibitor BIR1.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei121Charge relay systemSequence analysis1
Active sitei152Charge relay systemSequence analysis1
Active sitei235Charge relay systemSequence analysis1

GO - Molecular functioni

  • serine-type endopeptidase activity Source: InterPro
  • serine-type peptidase activity Source: SGD

GO - Biological processi

  • apoptotic process Source: SGD
  • cellular lipid metabolic process Source: SGD
  • cellular response to heat Source: SGD
  • protein catabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciYEAST:G3O-33144-MONOMER.

Protein family/group databases

MEROPSiS01.434.

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-apoptotic serine protease NMA111 (EC:3.4.21.-)
Alternative name(s):
111 kDa nuclear mediator of apoptosis
Gene namesi
Name:NMA111
Synonyms:YNM3
Ordered Locus Names:YNL123W
ORF Names:N1897
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL123W.
SGDiS000005067. NMA111.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi235S → C: Impairs BIR1 degradation and death-promoting activity. 2 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002034291 – 997Pro-apoptotic serine protease NMA111Add BLAST997

Proteomic databases

MaxQBiP53920.
PRIDEiP53920.

PTM databases

iPTMnetiP53920.

Interactioni

Subunit structurei

Interacts with BIR1.1 Publication

Protein-protein interaction databases

BioGridi35704. 16 interactors.
MINTiMINT-4499860.

Structurei

3D structure databases

ProteinModelPortaliP53920.
SMRiP53920.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini300 – 378PDZ 1Add BLAST79
Domaini779 – 854PDZ 2Add BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni83 – 273Serine proteaseAdd BLAST191

Sequence similaritiesi

Belongs to the peptidase S1C family.Curated
Contains 2 PDZ (DHR) domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiP53920.
OMAiDPKAIKY.
OrthoDBiEOG092C0BB0.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR001478. PDZ.
IPR025926. PDZ-like_dom.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
PF12812. PDZ_1. 2 hits.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 3 hits.
SSF50494. SSF50494. 2 hits.

Sequencei

Sequence statusi: Complete.

P53920-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTISLSNIKK RDHSKISDGT SGESSLVKRK QLESATGDQE EEYTDHEIII
60 70 80 90 100
EPLHFANNNN TVLTDSENYL RWQNTISNVV KSVVSIHFSQ VAPFDCDSAL
110 120 130 140 150
VSEATGFVVD AKLGIILTNR HVVGPGPFVG YVVFDNHEEC DVIPIYRDPV
160 170 180 190 200
HDFGFLKFDP KNIKYSKIKA LTLKPSLAKV GSEIRVVGND AGEKLSILAG
210 220 230 240 250
FISRIDRNAP EYGELTYNDF NTEYIQAAAS ASGGSSGSPV VNIDGYAVAL
260 270 280 290 300
QAGGSTEAST DFFLPLDRIL RALICIQTNK PITRGTIQVQ WLLKPYDECR
310 320 330 340 350
RLGLTSERES EARAKFPENI GLLVAETVLR EGPGYDKIKE GDTLISINGE
360 370 380 390 400
TISSFMQVDK IQDENVGKEI QLVIQRGGVE CTVTCTVGDL HAITPHRYVE
410 420 430 440 450
VCGATFHELS YQMARFYALP VRGVFLSSAS GSFNFDSKER VGWIVDSIDN
460 470 480 490 500
KETPDLDTFI EIMKTIPDRK RVTVRYHHLT DQHSPLVTSI YIDRHWCNEF
510 520 530 540 550
RVYTRNDTTG IWDYKNVADP LPADALKPRS AKIIPIPVNN EKVAKLSSSL
560 570 580 590 600
CTVATMAAVP LDSLSADILK TSGLIIDAEK GYVLVSRRVV PHDCLDTFVT
610 620 630 640 650
IADSLVVPAT VEFLHPTHNF AIVKYDPELV KAPLITPKLS TTRMKRGDKL
660 670 680 690 700
QFIGFTQNDR IVTSETTVTD ISSVSIPSNL IPRYRATNLE AISIDCNVST
710 720 730 740 750
RCNSGILTDN DGTVRGLWLP FLGERLENKE KVYLMGLDIM DCREVIDILK
760 770 780 790 800
NGGKPRVSIV DAGFGSISVL QARIRGVPEE WIMRMEHESN NRLQFITVSR
810 820 830 840 850
VSYTEDKIHL ETGDVILSVN GKLVTEMNDL NGVVSSADGI LPSAMLDFKV
860 870 880 890 900
VRDGNIVDLK IKTVEVQETD RFVIFAGSIL QKPHHAVLQA MVDVPKGVYC
910 920 930 940 950
TFRGESSPAL QYGISATNFI THVNEIETPD LDTFLKVVKT IPDNSYCKMR
960 970 980 990
LMTFDNVPFA ISLKTNYHYF PTAELKRDNI THKWIEKEFT GNSQSEK
Length:997
Mass (Da):110,881
Last modified:October 1, 1996 - v1
Checksum:iA26005C1DDDB932C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti162N → S in strain: YJM269, YJM270 and YJM1129. 1 Publication1
Natural varianti241V → L in strain: YJM269 and YJM270. 1 Publication1
Natural varianti331E → G in strain: YJM326. 1 Publication1
Natural varianti343T → S in strain: YJM269 and YJM270. 1 Publication1
Natural varianti386T → I in strain: YJM269, YJM270 and YJM1129. 1 Publication1
Natural varianti457D → G in strain: YJM269 and YJM270. 1 Publication1
Natural varianti530S → P in strain: YJM627. 1 Publication1
Natural varianti580K → N in strain: YJM627. 1 Publication1
Natural varianti621A → T in strain: YJM269 and YJM270. 1 Publication1
Natural varianti942P → F in strain: YJM627. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF125216 Genomic DNA. Translation: ABN58534.1.
EF125217 Genomic DNA. Translation: ABN58544.1.
EF125218 Genomic DNA. Translation: ABN58553.1.
EF125219 Genomic DNA. Translation: ABN58562.1.
EF125220 Genomic DNA. Translation: ABN58571.1.
EF125221 Genomic DNA. Translation: ABN58580.1.
EF125222 Genomic DNA. Translation: ABN58589.1.
EF125223 Genomic DNA. Translation: ABN58598.1.
EF125224 Genomic DNA. Translation: ABN58607.1.
EF125225 Genomic DNA. Translation: ABN58616.1.
EF125226 Genomic DNA. Translation: ABN58625.1.
EF125228 Genomic DNA. Translation: ABN58643.1.
Z69382 Genomic DNA. Translation: CAA93384.1.
Z71399 Genomic DNA. Translation: CAA96004.1.
BK006947 Genomic DNA. Translation: DAA10426.1.
PIRiS63064.
RefSeqiNP_014276.1. NM_001182961.1.

Genome annotation databases

EnsemblFungiiYNL123W; YNL123W; YNL123W.
GeneIDi855600.
KEGGisce:YNL123W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF125216 Genomic DNA. Translation: ABN58534.1.
EF125217 Genomic DNA. Translation: ABN58544.1.
EF125218 Genomic DNA. Translation: ABN58553.1.
EF125219 Genomic DNA. Translation: ABN58562.1.
EF125220 Genomic DNA. Translation: ABN58571.1.
EF125221 Genomic DNA. Translation: ABN58580.1.
EF125222 Genomic DNA. Translation: ABN58589.1.
EF125223 Genomic DNA. Translation: ABN58598.1.
EF125224 Genomic DNA. Translation: ABN58607.1.
EF125225 Genomic DNA. Translation: ABN58616.1.
EF125226 Genomic DNA. Translation: ABN58625.1.
EF125228 Genomic DNA. Translation: ABN58643.1.
Z69382 Genomic DNA. Translation: CAA93384.1.
Z71399 Genomic DNA. Translation: CAA96004.1.
BK006947 Genomic DNA. Translation: DAA10426.1.
PIRiS63064.
RefSeqiNP_014276.1. NM_001182961.1.

3D structure databases

ProteinModelPortaliP53920.
SMRiP53920.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35704. 16 interactors.
MINTiMINT-4499860.

Protein family/group databases

MEROPSiS01.434.

PTM databases

iPTMnetiP53920.

Proteomic databases

MaxQBiP53920.
PRIDEiP53920.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL123W; YNL123W; YNL123W.
GeneIDi855600.
KEGGisce:YNL123W.

Organism-specific databases

EuPathDBiFungiDB:YNL123W.
SGDiS000005067. NMA111.

Phylogenomic databases

InParanoidiP53920.
OMAiDPKAIKY.
OrthoDBiEOG092C0BB0.

Enzyme and pathway databases

BioCyciYEAST:G3O-33144-MONOMER.

Miscellaneous databases

PROiP53920.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR001478. PDZ.
IPR025926. PDZ-like_dom.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
PF12812. PDZ_1. 2 hits.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 3 hits.
SSF50494. SSF50494. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiNM111_YEAST
AccessioniPrimary (citable) accession number: P53920
Secondary accession number(s): B0KZR3
, B0KZU0, B0KZX6, B0L003, B0L021, D6W160
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3150 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.