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Protein

Pro-apoptotic serine protease NMA111

Gene

NMA111

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nuclear serine protease which mediates apoptosis through proteolysis of the apoptotic inhibitor BIR1.3 Publications

Miscellaneous

Present with 3150 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei121Charge relay systemSequence analysis1
Active sitei152Charge relay systemSequence analysis1
Active sitei235Charge relay systemSequence analysis1

GO - Molecular functioni

  • serine-type endopeptidase activity Source: InterPro
  • serine-type peptidase activity Source: SGD

GO - Biological processi

  • apoptotic process Source: SGD
  • cellular lipid metabolic process Source: SGD
  • cellular response to heat Source: SGD
  • protein catabolic process Source: SGD

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processApoptosis

Enzyme and pathway databases

BioCyciYEAST:G3O-33144-MONOMER

Protein family/group databases

MEROPSiS01.434

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-apoptotic serine protease NMA111 (EC:3.4.21.-)
Alternative name(s):
111 kDa nuclear mediator of apoptosis
Gene namesi
Name:NMA111
Synonyms:YNM3
Ordered Locus Names:YNL123W
ORF Names:N1897
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL123W
SGDiS000005067 NMA111

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi235S → C: Impairs BIR1 degradation and death-promoting activity. 2 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002034291 – 997Pro-apoptotic serine protease NMA111Add BLAST997

Proteomic databases

MaxQBiP53920
PaxDbiP53920
PRIDEiP53920

PTM databases

iPTMnetiP53920

Interactioni

Subunit structurei

Interacts with BIR1.1 Publication

Protein-protein interaction databases

BioGridi35704, 78 interactors
IntActiP53920, 7 interactors
STRINGi4932.YNL123W

Structurei

3D structure databases

ProteinModelPortaliP53920
SMRiP53920
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini300 – 378PDZ 1Add BLAST79
Domaini779 – 854PDZ 2Add BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni83 – 273Serine proteaseAdd BLAST191

Sequence similaritiesi

Belongs to the peptidase S1C family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiP53920
OMAiVPYDLCD
OrthoDBiEOG092C0BB0

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR025926 PDZ-like_dom
IPR036034 PDZ_sf
IPR009003 Peptidase_S1_PA
IPR001940 Peptidase_S1C
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF12812 PDZ_1, 2 hits
PRINTSiPR00834 PROTEASES2C
SMARTiView protein in SMART
SM00228 PDZ, 2 hits
SUPFAMiSSF50156 SSF50156, 3 hits
SSF50494 SSF50494, 2 hits

Sequencei

Sequence statusi: Complete.

P53920-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTISLSNIKK RDHSKISDGT SGESSLVKRK QLESATGDQE EEYTDHEIII
60 70 80 90 100
EPLHFANNNN TVLTDSENYL RWQNTISNVV KSVVSIHFSQ VAPFDCDSAL
110 120 130 140 150
VSEATGFVVD AKLGIILTNR HVVGPGPFVG YVVFDNHEEC DVIPIYRDPV
160 170 180 190 200
HDFGFLKFDP KNIKYSKIKA LTLKPSLAKV GSEIRVVGND AGEKLSILAG
210 220 230 240 250
FISRIDRNAP EYGELTYNDF NTEYIQAAAS ASGGSSGSPV VNIDGYAVAL
260 270 280 290 300
QAGGSTEAST DFFLPLDRIL RALICIQTNK PITRGTIQVQ WLLKPYDECR
310 320 330 340 350
RLGLTSERES EARAKFPENI GLLVAETVLR EGPGYDKIKE GDTLISINGE
360 370 380 390 400
TISSFMQVDK IQDENVGKEI QLVIQRGGVE CTVTCTVGDL HAITPHRYVE
410 420 430 440 450
VCGATFHELS YQMARFYALP VRGVFLSSAS GSFNFDSKER VGWIVDSIDN
460 470 480 490 500
KETPDLDTFI EIMKTIPDRK RVTVRYHHLT DQHSPLVTSI YIDRHWCNEF
510 520 530 540 550
RVYTRNDTTG IWDYKNVADP LPADALKPRS AKIIPIPVNN EKVAKLSSSL
560 570 580 590 600
CTVATMAAVP LDSLSADILK TSGLIIDAEK GYVLVSRRVV PHDCLDTFVT
610 620 630 640 650
IADSLVVPAT VEFLHPTHNF AIVKYDPELV KAPLITPKLS TTRMKRGDKL
660 670 680 690 700
QFIGFTQNDR IVTSETTVTD ISSVSIPSNL IPRYRATNLE AISIDCNVST
710 720 730 740 750
RCNSGILTDN DGTVRGLWLP FLGERLENKE KVYLMGLDIM DCREVIDILK
760 770 780 790 800
NGGKPRVSIV DAGFGSISVL QARIRGVPEE WIMRMEHESN NRLQFITVSR
810 820 830 840 850
VSYTEDKIHL ETGDVILSVN GKLVTEMNDL NGVVSSADGI LPSAMLDFKV
860 870 880 890 900
VRDGNIVDLK IKTVEVQETD RFVIFAGSIL QKPHHAVLQA MVDVPKGVYC
910 920 930 940 950
TFRGESSPAL QYGISATNFI THVNEIETPD LDTFLKVVKT IPDNSYCKMR
960 970 980 990
LMTFDNVPFA ISLKTNYHYF PTAELKRDNI THKWIEKEFT GNSQSEK
Length:997
Mass (Da):110,881
Last modified:October 1, 1996 - v1
Checksum:iA26005C1DDDB932C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti162N → S in strain: YJM269, YJM270 and YJM1129. 1 Publication1
Natural varianti241V → L in strain: YJM269 and YJM270. 1 Publication1
Natural varianti331E → G in strain: YJM326. 1 Publication1
Natural varianti343T → S in strain: YJM269 and YJM270. 1 Publication1
Natural varianti386T → I in strain: YJM269, YJM270 and YJM1129. 1 Publication1
Natural varianti457D → G in strain: YJM269 and YJM270. 1 Publication1
Natural varianti530S → P in strain: YJM627. 1 Publication1
Natural varianti580K → N in strain: YJM627. 1 Publication1
Natural varianti621A → T in strain: YJM269 and YJM270. 1 Publication1
Natural varianti942P → F in strain: YJM627. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF125216 Genomic DNA Translation: ABN58534.1
EF125217 Genomic DNA Translation: ABN58544.1
EF125218 Genomic DNA Translation: ABN58553.1
EF125219 Genomic DNA Translation: ABN58562.1
EF125220 Genomic DNA Translation: ABN58571.1
EF125221 Genomic DNA Translation: ABN58580.1
EF125222 Genomic DNA Translation: ABN58589.1
EF125223 Genomic DNA Translation: ABN58598.1
EF125224 Genomic DNA Translation: ABN58607.1
EF125225 Genomic DNA Translation: ABN58616.1
EF125226 Genomic DNA Translation: ABN58625.1
EF125228 Genomic DNA Translation: ABN58643.1
Z69382 Genomic DNA Translation: CAA93384.1
Z71399 Genomic DNA Translation: CAA96004.1
BK006947 Genomic DNA Translation: DAA10426.1
PIRiS63064
RefSeqiNP_014276.1, NM_001182961.1

Genome annotation databases

EnsemblFungiiYNL123W; YNL123W; YNL123W
GeneIDi855600
KEGGisce:YNL123W

Similar proteinsi

Entry informationi

Entry nameiNM111_YEAST
AccessioniPrimary (citable) accession number: P53920
Secondary accession number(s): B0KZR3
, B0KZU0, B0KZX6, B0L003, B0L021, D6W160
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health