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P53917 (FAR11_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Factor arrest protein 11
Gene names
Name:FAR11
Ordered Locus Names:YNL127W
ORF Names:N1221, N1875
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length953 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Participates in the control of the reentry into the cell cycle following pheromone treatment. Ref.5 Ref.6

Subunit structure

Component of a complex at least composed of FAR3, FAR7, FAR8, FAR10, FAR11 and VPS64.

Miscellaneous

Present with 1080 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the FAR11 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TPD3P313832EBI-28900,EBI-1936

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 953953Factor arrest protein 11
PRO_0000087190

Amino acid modifications

Modified residue181Phosphoserine Ref.8
Modified residue811Phosphoserine Ref.9 Ref.10 Ref.11
Modified residue5241Phosphoserine Ref.9
Modified residue5271Phosphoserine Ref.11
Modified residue5281Phosphoserine Ref.11

Sequences

Sequence LengthMass (Da)Tools
P53917 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 0FA7B36B181D97A3

FASTA953109,793
        10         20         30         40         50         60 
MNASGRSHSK GPIIRSVSLE DLKRNSSFKG NLKYKDEVTS HKEPQVGTLS NEELLKDLDN 

        70         80         90        100        110        120 
MLRGKLNMGR NSFHADKRNK SDGNISALTF KARSGLEGDI RTIDIQQDSS DENDNFKFSD 

       130        140        150        160        170        180 
DGVNKDRNNE KDNNTDNAVE FQDDAEEAEE ENEDESFANV DELDGFDLNK VSDGKHVPIN 

       190        200        210        220        230        240 
EKGEVDYNMP VDKEFQKSLD QCAASLEERS SAPYALQRAV DWELKMFYSL EDELSEWFCS 

       250        260        270        280        290        300 
SDYMHFGQTQ TLFKQKITQP QLFFDDENYA ASVVECLIED IPNSLASNLL ALSYISMGCF 

       310        320        330        340        350        360 
AFTNSKSEHT KIIRRNNLML VPHIQEIVHA FKKIAISCRD DNRNLKKQTI LLFHSSTILY 

       370        380        390        400        410        420 
FICSICIEGR GENPEAVNVV IDAFEKTDLL EFLTKYIENW RWNSRLAMRI RNMISLLFKL 

       430        440        450        460        470        480 
IVLQFGDSSV YKQTKSSIYN LHGLTYPSKH PEKLSISPLH YQAFREDITS RFPDYNMPSS 

       490        500        510        520        530        540 
GLPKDVDKSE SLSQFLEIPR PKSKNPLNMA LIVPEKHIAT PAPSPPSSPQ LMHLGEGPRP 

       550        560        570        580        590        600 
RKSFQTNMAY PCLYPSDNEG SEDDTLEDRI DLNIERKPDN DIVIPFSTEE AARILSESLE 

       610        620        630        640        650        660 
IKLSTKQLWY ERDLFMITER GWKQQLENEP YDYAALNHDA NSSKEEKSAI CIMQRIDKYY 

       670        680        690        700        710        720 
KSCLSSFNSL VFVLLQTMES SLTNNFHRKS EVSDKNLLNM LTPQLEIVRA KELSLKSAAG 

       730        740        750        760        770        780 
ILHALLKWFK LSHILKFEHL AVVIHDSRYI NTCASILSKY SEVYPERVFN KYVQTPNSFW 

       790        800        810        820        830        840 
KECSLSNESY RESYSVDDSG EVDTEIMPSF AYLLRILRKV TGNKTQRLKE LPLSIGILFK 

       850        860        870        880        890        900 
RYYRLFNLDM YHPILKITRE LTPFKNKRWK SEHMELISGV YLYEKLELTD NWVTGKDISG 

       910        920        930        940        950 
ELSDACGQEI ALRALLQFYN FQHYEISMED LGYGHRNSSS QDLLNKESEY LNI 

« Hide

References

« Hide 'large scale' references
[1]"A 43.5 kb segment of yeast chromosome XIV, which contains MFA2, MEP2, CAP/SRV2, NAM9, FKB1/FPR1/RBP1, MOM22 and CPT1, predicts an adenosine deaminase gene and 14 new open reading frames."
Mallet L., Bussereau F., Jacquet M.
Yeast 11:1195-1209(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"The DNA sequence of cosmid 14-13b from chromosome XIV of Saccharomyces cerevisiae reveals an unusually high number of overlapping open reading frames."
de Antoni A., D'Angelo M., Dal Pero F., Sartorello F., Pandolfo D., Pallavicini A., Lanfranchi G., Valle G.
Yeast 13:261-266(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-953.
[5]"Identification and characterization of FAR3, a gene required for pheromone-mediated G1 arrest in Saccharomyces cerevisiae."
Horecka J., Sprague G.F. Jr.
Genetics 144:905-921(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae."
Kemp H.A., Sprague G.F. Jr.
Mol. Cell. Biol. 23:1750-1763(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH FAR3; FAR7; FAR8; FAR10 AND VPS64.
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]"Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: YAL6B.
[9]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81 AND SER-524, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[10]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81; SER-527 AND SER-528, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z46843 Genomic DNA. Translation: CAA86898.1.
Z71402 Genomic DNA. Translation: CAA96008.1.
Z71403 Genomic DNA. Translation: CAA96009.1.
Z69382 Genomic DNA. Translation: CAA93376.1.
BK006947 Genomic DNA. Translation: DAA10422.1.
PIRS55156.
RefSeqNP_014272.3. NM_001182965.3.

3D structure databases

ProteinModelPortalP53917.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35700. 86 interactions.
DIPDIP-1830N.
IntActP53917. 21 interactions.
MINTMINT-390151.
STRING4932.YNL127W.

Proteomic databases

PaxDbP53917.
PRIDEP53917.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYNL127W; YNL127W; YNL127W.
GeneID855596.
KEGGsce:YNL127W.

Organism-specific databases

CYGDYNL127w.
SGDS000005071. FAR11.

Phylogenomic databases

eggNOGNOG247682.
GeneTreeENSGT00400000022095.
HOGENOMHOG000112500.
OMALLQFYNM.
OrthoDBEOG7RV9QF.

Enzyme and pathway databases

BioCycYEAST:G3O-33148-MONOMER.

Gene expression databases

GenevestigatorP53917.

Family and domain databases

InterProIPR021819. DUF3402.
IPR012486. N1221.
[Graphical view]
PfamPF11882. DUF3402. 1 hit.
PF07923. N1221. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio979750.

Entry information

Entry nameFAR11_YEAST
AccessionPrimary (citable) accession number: P53917
Secondary accession number(s): D6W156
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 19, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families