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P53917

- FAR11_YEAST

UniProt

P53917 - FAR11_YEAST

Protein

Factor arrest protein 11

Gene

FAR11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Participates in the control of the reentry into the cell cycle following pheromone treatment.2 Publications

    GO - Biological processi

    1. intra-S DNA damage checkpoint Source: SGD
    2. positive regulation of macroautophagy Source: SGD
    3. re-entry into mitotic cell cycle after pheromone arrest Source: SGD

    Keywords - Biological processi

    Cell cycle

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33148-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Factor arrest protein 11
    Gene namesi
    Name:FAR11
    Ordered Locus Names:YNL127W
    ORF Names:N1221, N1875
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNL127w.
    SGDiS000005071. FAR11.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: SGD
    2. Golgi trans cisterna Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 953953Factor arrest protein 11PRO_0000087190Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei18 – 181Phosphoserine1 Publication
    Modified residuei81 – 811Phosphoserine3 Publications
    Modified residuei524 – 5241Phosphoserine1 Publication
    Modified residuei527 – 5271Phosphoserine1 Publication
    Modified residuei528 – 5281Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP53917.
    PaxDbiP53917.
    PRIDEiP53917.

    Expressioni

    Gene expression databases

    GenevestigatoriP53917.

    Interactioni

    Subunit structurei

    Component of a complex at least composed of FAR3, FAR7, FAR8, FAR10, FAR11 and VPS64.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TPD3P313832EBI-28900,EBI-1936

    Protein-protein interaction databases

    BioGridi35700. 86 interactions.
    DIPiDIP-1830N.
    IntActiP53917. 21 interactions.
    MINTiMINT-390151.
    STRINGi4932.YNL127W.

    Structurei

    3D structure databases

    ProteinModelPortaliP53917.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FAR11 family.Curated

    Phylogenomic databases

    eggNOGiNOG247682.
    GeneTreeiENSGT00400000022095.
    HOGENOMiHOG000112500.
    OMAiLLQFYNM.
    OrthoDBiEOG7RV9QF.

    Family and domain databases

    InterProiIPR021819. DUF3402.
    IPR012486. N1221.
    [Graphical view]
    PfamiPF11882. DUF3402. 1 hit.
    PF07923. N1221. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53917-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNASGRSHSK GPIIRSVSLE DLKRNSSFKG NLKYKDEVTS HKEPQVGTLS    50
    NEELLKDLDN MLRGKLNMGR NSFHADKRNK SDGNISALTF KARSGLEGDI 100
    RTIDIQQDSS DENDNFKFSD DGVNKDRNNE KDNNTDNAVE FQDDAEEAEE 150
    ENEDESFANV DELDGFDLNK VSDGKHVPIN EKGEVDYNMP VDKEFQKSLD 200
    QCAASLEERS SAPYALQRAV DWELKMFYSL EDELSEWFCS SDYMHFGQTQ 250
    TLFKQKITQP QLFFDDENYA ASVVECLIED IPNSLASNLL ALSYISMGCF 300
    AFTNSKSEHT KIIRRNNLML VPHIQEIVHA FKKIAISCRD DNRNLKKQTI 350
    LLFHSSTILY FICSICIEGR GENPEAVNVV IDAFEKTDLL EFLTKYIENW 400
    RWNSRLAMRI RNMISLLFKL IVLQFGDSSV YKQTKSSIYN LHGLTYPSKH 450
    PEKLSISPLH YQAFREDITS RFPDYNMPSS GLPKDVDKSE SLSQFLEIPR 500
    PKSKNPLNMA LIVPEKHIAT PAPSPPSSPQ LMHLGEGPRP RKSFQTNMAY 550
    PCLYPSDNEG SEDDTLEDRI DLNIERKPDN DIVIPFSTEE AARILSESLE 600
    IKLSTKQLWY ERDLFMITER GWKQQLENEP YDYAALNHDA NSSKEEKSAI 650
    CIMQRIDKYY KSCLSSFNSL VFVLLQTMES SLTNNFHRKS EVSDKNLLNM 700
    LTPQLEIVRA KELSLKSAAG ILHALLKWFK LSHILKFEHL AVVIHDSRYI 750
    NTCASILSKY SEVYPERVFN KYVQTPNSFW KECSLSNESY RESYSVDDSG 800
    EVDTEIMPSF AYLLRILRKV TGNKTQRLKE LPLSIGILFK RYYRLFNLDM 850
    YHPILKITRE LTPFKNKRWK SEHMELISGV YLYEKLELTD NWVTGKDISG 900
    ELSDACGQEI ALRALLQFYN FQHYEISMED LGYGHRNSSS QDLLNKESEY 950
    LNI 953
    Length:953
    Mass (Da):109,793
    Last modified:October 1, 1996 - v1
    Checksum:i0FA7B36B181D97A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46843 Genomic DNA. Translation: CAA86898.1.
    Z71402 Genomic DNA. Translation: CAA96008.1.
    Z71403 Genomic DNA. Translation: CAA96009.1.
    Z69382 Genomic DNA. Translation: CAA93376.1.
    BK006947 Genomic DNA. Translation: DAA10422.1.
    PIRiS55156.
    RefSeqiNP_014272.3. NM_001182965.3.

    Genome annotation databases

    EnsemblFungiiYNL127W; YNL127W; YNL127W.
    GeneIDi855596.
    KEGGisce:YNL127W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46843 Genomic DNA. Translation: CAA86898.1 .
    Z71402 Genomic DNA. Translation: CAA96008.1 .
    Z71403 Genomic DNA. Translation: CAA96009.1 .
    Z69382 Genomic DNA. Translation: CAA93376.1 .
    BK006947 Genomic DNA. Translation: DAA10422.1 .
    PIRi S55156.
    RefSeqi NP_014272.3. NM_001182965.3.

    3D structure databases

    ProteinModelPortali P53917.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35700. 86 interactions.
    DIPi DIP-1830N.
    IntActi P53917. 21 interactions.
    MINTi MINT-390151.
    STRINGi 4932.YNL127W.

    Proteomic databases

    MaxQBi P53917.
    PaxDbi P53917.
    PRIDEi P53917.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNL127W ; YNL127W ; YNL127W .
    GeneIDi 855596.
    KEGGi sce:YNL127W.

    Organism-specific databases

    CYGDi YNL127w.
    SGDi S000005071. FAR11.

    Phylogenomic databases

    eggNOGi NOG247682.
    GeneTreei ENSGT00400000022095.
    HOGENOMi HOG000112500.
    OMAi LLQFYNM.
    OrthoDBi EOG7RV9QF.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33148-MONOMER.

    Miscellaneous databases

    NextBioi 979750.

    Gene expression databases

    Genevestigatori P53917.

    Family and domain databases

    InterProi IPR021819. DUF3402.
    IPR012486. N1221.
    [Graphical view ]
    Pfami PF11882. DUF3402. 1 hit.
    PF07923. N1221. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A 43.5 kb segment of yeast chromosome XIV, which contains MFA2, MEP2, CAP/SRV2, NAM9, FKB1/FPR1/RBP1, MOM22 and CPT1, predicts an adenosine deaminase gene and 14 new open reading frames."
      Mallet L., Bussereau F., Jacquet M.
      Yeast 11:1195-1209(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "The DNA sequence of cosmid 14-13b from chromosome XIV of Saccharomyces cerevisiae reveals an unusually high number of overlapping open reading frames."
      de Antoni A., D'Angelo M., Dal Pero F., Sartorello F., Pandolfo D., Pallavicini A., Lanfranchi G., Valle G.
      Yeast 13:261-266(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-953.
    5. "Identification and characterization of FAR3, a gene required for pheromone-mediated G1 arrest in Saccharomyces cerevisiae."
      Horecka J., Sprague G.F. Jr.
      Genetics 144:905-921(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae."
      Kemp H.A., Sprague G.F. Jr.
      Mol. Cell. Biol. 23:1750-1763(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH FAR3; FAR7; FAR8; FAR10 AND VPS64.
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
      Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
      Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: YAL6B.
    9. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81 AND SER-524, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    10. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81; SER-527 AND SER-528, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFAR11_YEAST
    AccessioniPrimary (citable) accession number: P53917
    Secondary accession number(s): D6W156
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1080 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3