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P53917

- FAR11_YEAST

UniProt

P53917 - FAR11_YEAST

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Protein

Factor arrest protein 11

Gene

FAR11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Participates in the control of the reentry into the cell cycle following pheromone treatment.2 Publications

GO - Biological processi

  1. intra-S DNA damage checkpoint Source: SGD
  2. positive regulation of macroautophagy Source: SGD
  3. re-entry into mitotic cell cycle after pheromone arrest Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

BioCyciYEAST:G3O-33148-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Factor arrest protein 11
Gene namesi
Name:FAR11
Ordered Locus Names:YNL127W
ORF Names:N1221, N1875
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL127w.
SGDiS000005071. FAR11.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: SGD
  2. Golgi trans cisterna Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 953953Factor arrest protein 11PRO_0000087190Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181Phosphoserine1 Publication
Modified residuei81 – 811Phosphoserine3 Publications
Modified residuei524 – 5241Phosphoserine1 Publication
Modified residuei527 – 5271Phosphoserine1 Publication
Modified residuei528 – 5281Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53917.
PaxDbiP53917.
PRIDEiP53917.

Expressioni

Gene expression databases

GenevestigatoriP53917.

Interactioni

Subunit structurei

Component of a complex at least composed of FAR3, FAR7, FAR8, FAR10, FAR11 and VPS64.

Binary interactionsi

WithEntry#Exp.IntActNotes
TPD3P313832EBI-28900,EBI-1936

Protein-protein interaction databases

BioGridi35700. 86 interactions.
DIPiDIP-1830N.
IntActiP53917. 21 interactions.
MINTiMINT-390151.
STRINGi4932.YNL127W.

Structurei

3D structure databases

ProteinModelPortaliP53917.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAR11 family.Curated

Phylogenomic databases

eggNOGiNOG247682.
GeneTreeiENSGT00400000022095.
HOGENOMiHOG000112500.
InParanoidiP53917.
OMAiLLQFYNM.
OrthoDBiEOG7RV9QF.

Family and domain databases

InterProiIPR021819. DUF3402.
IPR012486. N1221.
[Graphical view]
PfamiPF11882. DUF3402. 1 hit.
PF07923. N1221. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53917 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNASGRSHSK GPIIRSVSLE DLKRNSSFKG NLKYKDEVTS HKEPQVGTLS
60 70 80 90 100
NEELLKDLDN MLRGKLNMGR NSFHADKRNK SDGNISALTF KARSGLEGDI
110 120 130 140 150
RTIDIQQDSS DENDNFKFSD DGVNKDRNNE KDNNTDNAVE FQDDAEEAEE
160 170 180 190 200
ENEDESFANV DELDGFDLNK VSDGKHVPIN EKGEVDYNMP VDKEFQKSLD
210 220 230 240 250
QCAASLEERS SAPYALQRAV DWELKMFYSL EDELSEWFCS SDYMHFGQTQ
260 270 280 290 300
TLFKQKITQP QLFFDDENYA ASVVECLIED IPNSLASNLL ALSYISMGCF
310 320 330 340 350
AFTNSKSEHT KIIRRNNLML VPHIQEIVHA FKKIAISCRD DNRNLKKQTI
360 370 380 390 400
LLFHSSTILY FICSICIEGR GENPEAVNVV IDAFEKTDLL EFLTKYIENW
410 420 430 440 450
RWNSRLAMRI RNMISLLFKL IVLQFGDSSV YKQTKSSIYN LHGLTYPSKH
460 470 480 490 500
PEKLSISPLH YQAFREDITS RFPDYNMPSS GLPKDVDKSE SLSQFLEIPR
510 520 530 540 550
PKSKNPLNMA LIVPEKHIAT PAPSPPSSPQ LMHLGEGPRP RKSFQTNMAY
560 570 580 590 600
PCLYPSDNEG SEDDTLEDRI DLNIERKPDN DIVIPFSTEE AARILSESLE
610 620 630 640 650
IKLSTKQLWY ERDLFMITER GWKQQLENEP YDYAALNHDA NSSKEEKSAI
660 670 680 690 700
CIMQRIDKYY KSCLSSFNSL VFVLLQTMES SLTNNFHRKS EVSDKNLLNM
710 720 730 740 750
LTPQLEIVRA KELSLKSAAG ILHALLKWFK LSHILKFEHL AVVIHDSRYI
760 770 780 790 800
NTCASILSKY SEVYPERVFN KYVQTPNSFW KECSLSNESY RESYSVDDSG
810 820 830 840 850
EVDTEIMPSF AYLLRILRKV TGNKTQRLKE LPLSIGILFK RYYRLFNLDM
860 870 880 890 900
YHPILKITRE LTPFKNKRWK SEHMELISGV YLYEKLELTD NWVTGKDISG
910 920 930 940 950
ELSDACGQEI ALRALLQFYN FQHYEISMED LGYGHRNSSS QDLLNKESEY

LNI
Length:953
Mass (Da):109,793
Last modified:October 1, 1996 - v1
Checksum:i0FA7B36B181D97A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46843 Genomic DNA. Translation: CAA86898.1.
Z71402 Genomic DNA. Translation: CAA96008.1.
Z71403 Genomic DNA. Translation: CAA96009.1.
Z69382 Genomic DNA. Translation: CAA93376.1.
BK006947 Genomic DNA. Translation: DAA10422.1.
PIRiS55156.
RefSeqiNP_014272.3. NM_001182965.3.

Genome annotation databases

EnsemblFungiiYNL127W; YNL127W; YNL127W.
GeneIDi855596.
KEGGisce:YNL127W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46843 Genomic DNA. Translation: CAA86898.1 .
Z71402 Genomic DNA. Translation: CAA96008.1 .
Z71403 Genomic DNA. Translation: CAA96009.1 .
Z69382 Genomic DNA. Translation: CAA93376.1 .
BK006947 Genomic DNA. Translation: DAA10422.1 .
PIRi S55156.
RefSeqi NP_014272.3. NM_001182965.3.

3D structure databases

ProteinModelPortali P53917.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35700. 86 interactions.
DIPi DIP-1830N.
IntActi P53917. 21 interactions.
MINTi MINT-390151.
STRINGi 4932.YNL127W.

Proteomic databases

MaxQBi P53917.
PaxDbi P53917.
PRIDEi P53917.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL127W ; YNL127W ; YNL127W .
GeneIDi 855596.
KEGGi sce:YNL127W.

Organism-specific databases

CYGDi YNL127w.
SGDi S000005071. FAR11.

Phylogenomic databases

eggNOGi NOG247682.
GeneTreei ENSGT00400000022095.
HOGENOMi HOG000112500.
InParanoidi P53917.
OMAi LLQFYNM.
OrthoDBi EOG7RV9QF.

Enzyme and pathway databases

BioCyci YEAST:G3O-33148-MONOMER.

Miscellaneous databases

NextBioi 979750.

Gene expression databases

Genevestigatori P53917.

Family and domain databases

InterProi IPR021819. DUF3402.
IPR012486. N1221.
[Graphical view ]
Pfami PF11882. DUF3402. 1 hit.
PF07923. N1221. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A 43.5 kb segment of yeast chromosome XIV, which contains MFA2, MEP2, CAP/SRV2, NAM9, FKB1/FPR1/RBP1, MOM22 and CPT1, predicts an adenosine deaminase gene and 14 new open reading frames."
    Mallet L., Bussereau F., Jacquet M.
    Yeast 11:1195-1209(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "The DNA sequence of cosmid 14-13b from chromosome XIV of Saccharomyces cerevisiae reveals an unusually high number of overlapping open reading frames."
    de Antoni A., D'Angelo M., Dal Pero F., Sartorello F., Pandolfo D., Pallavicini A., Lanfranchi G., Valle G.
    Yeast 13:261-266(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-953.
  5. "Identification and characterization of FAR3, a gene required for pheromone-mediated G1 arrest in Saccharomyces cerevisiae."
    Horecka J., Sprague G.F. Jr.
    Genetics 144:905-921(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae."
    Kemp H.A., Sprague G.F. Jr.
    Mol. Cell. Biol. 23:1750-1763(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH FAR3; FAR7; FAR8; FAR10 AND VPS64.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
    Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
    Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: YAL6B.
  9. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81 AND SER-524, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  10. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81; SER-527 AND SER-528, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFAR11_YEAST
AccessioniPrimary (citable) accession number: P53917
Secondary accession number(s): D6W156
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1080 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3