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Protein

Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1

Gene

TEP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May act as a phosphoinositide 3-phosphatase by regulating PtdIns(3,4,5)P3 levels.1 Publication

Catalytic activityi

Phosphatidylinositol 3,4,5-trisphosphate + H2O = phosphatidylinositol 4,5-bisphosphate + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei193 – 1931Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • ascospore wall assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciYEAST:G3O-33149-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1 (EC:3.1.3.67)
Gene namesi
Name:TEP1
Ordered Locus Names:YNL128W
ORF Names:N1220, N1872
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL128W.
SGDiS000005072. TEP1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1PRO_0000215906Add
BLAST

Proteomic databases

PeptideAtlasiP53916.

PTM databases

iPTMnetiP53916.

Interactioni

Protein-protein interaction databases

BioGridi35699. 46 interactions.
DIPiDIP-4928N.
IntActiP53916. 1 interaction.
MINTiMINT-571710.

Structurei

3D structure databases

ProteinModelPortaliP53916.
SMRiP53916. Positions 39-252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 255223Phosphatase tensin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 phosphatase tensin-type domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000141711.
InParanoidiP53916.
OMAiPKLLYRN.
OrthoDBiEOG76X682.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR029023. Tensin_lipid_phosphatase_dom.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS51181. PPASE_TENSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53916-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREEGSELEM EKGFLKWKPV NLMKKILSLP MKKTKNDIGL RLDISYILVN
60 70 80 90 100
LIVCSYPVNT YPKLLYRNSL DDLILFLTVY HGKGNFRIFN FRGEKEDSDY
110 120 130 140 150
KDNDLIGIAA KFESKDFEIQ ELRSTLINDG KIPISPIDLE TRTLVEEETN
160 170 180 190 200
NVICERIGWL DHFPPPFELL EEIVDGIENY LSVSKNRVAV LHCRMGKGRS
210 220 230 240 250
GMITVAYLMK YLQCPLGEAR LIFMQARFKY GMTNGVTIPS QLRYLRYHEF
260 270 280 290 300
FITHEKAAQE GISNEAVKFK FKFRLAKMTF LRPSSLITSE SAIVTTKIQH
310 320 330 340 350
YNDDRNALLT RKVVYSDIMA HECGGNMTFI FGRDYLTLEN DCRIEFTLGT
360 370 380 390 400
SKSKAASSII SWTSCASCWL NIYLETLMHI IKDDSSPDYF QVERLKRDEM
410 420 430
LGTTISWQEL DGFGELSTHG LKLFQALKLE WEII
Length:434
Mass (Da):50,152
Last modified:October 1, 1996 - v1
Checksum:iE56739475D1FA898
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46843 Genomic DNA. Translation: CAA86897.1.
Z71404 Genomic DNA. Translation: CAA96010.1.
BK006947 Genomic DNA. Translation: DAA10421.1.
PIRiS55155.
RefSeqiNP_014271.3. NM_001182966.4.

Genome annotation databases

EnsemblFungiiYNL128W; YNL128W; YNL128W.
GeneIDi855595.
KEGGisce:YNL128W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46843 Genomic DNA. Translation: CAA86897.1.
Z71404 Genomic DNA. Translation: CAA96010.1.
BK006947 Genomic DNA. Translation: DAA10421.1.
PIRiS55155.
RefSeqiNP_014271.3. NM_001182966.4.

3D structure databases

ProteinModelPortaliP53916.
SMRiP53916. Positions 39-252.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35699. 46 interactions.
DIPiDIP-4928N.
IntActiP53916. 1 interaction.
MINTiMINT-571710.

PTM databases

iPTMnetiP53916.

Proteomic databases

PeptideAtlasiP53916.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL128W; YNL128W; YNL128W.
GeneIDi855595.
KEGGisce:YNL128W.

Organism-specific databases

EuPathDBiFungiDB:YNL128W.
SGDiS000005072. TEP1.

Phylogenomic databases

HOGENOMiHOG000141711.
InParanoidiP53916.
OMAiPKLLYRN.
OrthoDBiEOG76X682.

Enzyme and pathway databases

BioCyciYEAST:G3O-33149-MONOMER.

Miscellaneous databases

PROiP53916.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR029023. Tensin_lipid_phosphatase_dom.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS51181. PPASE_TENSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A 43.5 kb segment of yeast chromosome XIV, which contains MFA2, MEP2, CAP/SRV2, NAM9, FKB1/FPR1/RBP1, MOM22 and CPT1, predicts an adenosine deaminase gene and 14 new open reading frames."
    Mallet L., Bussereau F., Jacquet M.
    Yeast 11:1195-1209(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation."
    Heymont J., Berenfeld L., Collins J., Kaganovich A., Maynes B., Moulin A., Ratskovskaya I., Poon P.P., Johnston G.C., Kamenetsky M., DeSilva J., Sun H., Petsko G.A., Engebrecht J.
    Proc. Natl. Acad. Sci. U.S.A. 97:12672-12677(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiTEP1_YEAST
AccessioniPrimary (citable) accession number: P53916
Secondary accession number(s): D6W155
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.