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Protein

Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1

Gene

TEP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

May act as a phosphoinositide 3-phosphatase by regulating PtdIns(3,4,5)P3 levels.1 Publication

Catalytic activityi

Phosphatidylinositol 3,4,5-trisphosphate + H2O = phosphatidylinositol 4,5-bisphosphate + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei193Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • ascospore wall assembly Source: SGD

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciYEAST:G3O-33149-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1 (EC:3.1.3.67)
Gene namesi
Name:TEP1
Ordered Locus Names:YNL128W
ORF Names:N1220, N1872
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL128W.
SGDiS000005072. TEP1.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002159061 – 434Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1Add BLAST434

Proteomic databases

PRIDEiP53916.

PTM databases

iPTMnetiP53916.

Interactioni

Protein-protein interaction databases

BioGridi35699. 110 interactors.
DIPiDIP-4928N.
IntActiP53916. 12 interactors.
MINTiMINT-571710.
STRINGi4932.YNL128W.

Structurei

3D structure databases

ProteinModelPortaliP53916.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 255Phosphatase tensin-typePROSITE-ProRule annotationAdd BLAST223

Phylogenomic databases

HOGENOMiHOG000141711.
InParanoidiP53916.
OMAiWLNLYWE.
OrthoDBiEOG092C24CO.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR029023. Tensin_phosphatase.
IPR016130. Tyr_Pase_AS.
PfamiView protein in Pfam
PF00782. DSPc. 1 hit.
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiView protein in PROSITE
PS51181. PPASE_TENSIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P53916-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREEGSELEM EKGFLKWKPV NLMKKILSLP MKKTKNDIGL RLDISYILVN
60 70 80 90 100
LIVCSYPVNT YPKLLYRNSL DDLILFLTVY HGKGNFRIFN FRGEKEDSDY
110 120 130 140 150
KDNDLIGIAA KFESKDFEIQ ELRSTLINDG KIPISPIDLE TRTLVEEETN
160 170 180 190 200
NVICERIGWL DHFPPPFELL EEIVDGIENY LSVSKNRVAV LHCRMGKGRS
210 220 230 240 250
GMITVAYLMK YLQCPLGEAR LIFMQARFKY GMTNGVTIPS QLRYLRYHEF
260 270 280 290 300
FITHEKAAQE GISNEAVKFK FKFRLAKMTF LRPSSLITSE SAIVTTKIQH
310 320 330 340 350
YNDDRNALLT RKVVYSDIMA HECGGNMTFI FGRDYLTLEN DCRIEFTLGT
360 370 380 390 400
SKSKAASSII SWTSCASCWL NIYLETLMHI IKDDSSPDYF QVERLKRDEM
410 420 430
LGTTISWQEL DGFGELSTHG LKLFQALKLE WEII
Length:434
Mass (Da):50,152
Last modified:October 1, 1996 - v1
Checksum:iE56739475D1FA898
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46843 Genomic DNA. Translation: CAA86897.1.
Z71404 Genomic DNA. Translation: CAA96010.1.
BK006947 Genomic DNA. Translation: DAA10421.1.
PIRiS55155.
RefSeqiNP_014271.3. NM_001182966.4.

Genome annotation databases

EnsemblFungiiYNL128W; YNL128W; YNL128W.
GeneIDi855595.
KEGGisce:YNL128W.

Similar proteinsi

Entry informationi

Entry nameiTEP1_YEAST
AccessioniPrimary (citable) accession number: P53916
Secondary accession number(s): D6W155
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 22, 2017
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names