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Protein

Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1

Gene

TEP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

May act as a phosphoinositide 3-phosphatase by regulating PtdIns(3,4,5)P3 levels.1 Publication

Catalytic activityi

Phosphatidylinositol 3,4,5-trisphosphate + H2O = phosphatidylinositol 4,5-bisphosphate + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei193Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • ascospore wall assembly Source: SGD

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciYEAST:G3O-33149-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1 (EC:3.1.3.67)
Gene namesi
Name:TEP1
Ordered Locus Names:YNL128W
ORF Names:N1220, N1872
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:YNL128W
SGDiS000005072 TEP1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002159061 – 434Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1Add BLAST434

Proteomic databases

PaxDbiP53916
PRIDEiP53916

PTM databases

iPTMnetiP53916

Interactioni

Protein-protein interaction databases

BioGridi35699, 116 interactors
DIPiDIP-4928N
IntActiP53916, 12 interactors
MINTiP53916
STRINGi4932.YNL128W

Structurei

3D structure databases

ProteinModelPortaliP53916
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 255Phosphatase tensin-typePROSITE-ProRule annotationAdd BLAST223

Phylogenomic databases

HOGENOMiHOG000141711
InParanoidiP53916
OMAiWLNLYWE
OrthoDBiEOG092C24CO

Family and domain databases

InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR029023 Tensin_phosphatase
IPR016130 Tyr_Pase_AS
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS51181 PPASE_TENSIN, 1 hit

Sequencei

Sequence statusi: Complete.

P53916-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREEGSELEM EKGFLKWKPV NLMKKILSLP MKKTKNDIGL RLDISYILVN
60 70 80 90 100
LIVCSYPVNT YPKLLYRNSL DDLILFLTVY HGKGNFRIFN FRGEKEDSDY
110 120 130 140 150
KDNDLIGIAA KFESKDFEIQ ELRSTLINDG KIPISPIDLE TRTLVEEETN
160 170 180 190 200
NVICERIGWL DHFPPPFELL EEIVDGIENY LSVSKNRVAV LHCRMGKGRS
210 220 230 240 250
GMITVAYLMK YLQCPLGEAR LIFMQARFKY GMTNGVTIPS QLRYLRYHEF
260 270 280 290 300
FITHEKAAQE GISNEAVKFK FKFRLAKMTF LRPSSLITSE SAIVTTKIQH
310 320 330 340 350
YNDDRNALLT RKVVYSDIMA HECGGNMTFI FGRDYLTLEN DCRIEFTLGT
360 370 380 390 400
SKSKAASSII SWTSCASCWL NIYLETLMHI IKDDSSPDYF QVERLKRDEM
410 420 430
LGTTISWQEL DGFGELSTHG LKLFQALKLE WEII
Length:434
Mass (Da):50,152
Last modified:October 1, 1996 - v1
Checksum:iE56739475D1FA898
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46843 Genomic DNA Translation: CAA86897.1
Z71404 Genomic DNA Translation: CAA96010.1
BK006947 Genomic DNA Translation: DAA10421.1
PIRiS55155
RefSeqiNP_014271.3, NM_001182966.4

Genome annotation databases

EnsemblFungiiYNL128W; YNL128W; YNL128W
GeneIDi855595
KEGGisce:YNL128W

Similar proteinsi

Entry informationi

Entry nameiTEP1_YEAST
AccessioniPrimary (citable) accession number: P53916
Secondary accession number(s): D6W155
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

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