NRK1

Functionⁱ

Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN).By similarity1 Publication

Miscellaneous

Present with 1460 molecules/cell in log phase SD medium.1 Publication

Catalytic activityⁱ

ATP + 1-(beta-D-ribofuranosyl)-nicotinamide = ADP + beta-nicotinamide D-ribonucleotide.By similarity

ATP + beta-D-ribosylnicotinate = ADP + nicotinate beta-D-ribonucleotide.By similarity

Pathwayⁱ: NAD(+) biosynthesis

This protein is involved in the pathway NAD(+) biosynthesis, which is part of Cofactor biosynthesis.By similarity
View all proteins of this organism that are known to be involved in the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	20	MagnesiumBy similarity	1
Active siteⁱ	39	Proton acceptorBy similarity	1
Metal bindingⁱ	39	MagnesiumBy similarity	1
Binding siteⁱ	158	ATPBy similarity	1
Binding siteⁱ	159	SubstrateBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	13 – 21	ATPBy similarity	9
Nucleotide bindingⁱ	162 – 164	ATPBy similarity	3
Nucleotide bindingⁱ	208 – 210	ATPBy similarity	3

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
ribosylnicotinamide kinase activity
Source: SGD
Inferred from direct assayⁱ
- 15137942

Complete GO annotation...

GO - Biological processⁱ

Complete GO annotation...

Keywordsⁱ

Molecular function	Kinase, Transferase
Biological process	Pyridine nucleotide biosynthesis
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:MONOMER3O-4139. YEAST:MONOMER3O-4139.
BRENDAⁱ	2.7.1.22. 984.
UniPathwayⁱ	UPA00253.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nicotinamide riboside kinase (EC:2.7.1.22By similarity) Short name: NRK Short name: NmR-K Alternative name(s): Nicotinic acid riboside kinase (EC:2.7.1.173By similarity) Ribosylnicotinamide kinase Short name: RNK Ribosylnicotinic acid kinase
Gene namesⁱ	Name:NRK1 Ordered Locus Names:YNL129W ORF Names:N1219, N1870
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome XIV

Organism-specific databases

EuPathDBⁱ	FungiDB:YNL129W.
Saccharomyces Genome Database More...SGDⁱ	S000005073. NRK1.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000215898	1 – 240	Nicotinamide riboside kinaseAdd BLAST		240

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P53915.
PRIDEⁱ	P53915.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	35698. 84 interactors.
Database of interacting proteins More...DIPⁱ	DIP-8168N.
Molecular INTeraction database More...MINTⁱ	MINT-4499900.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P53915.
SMRⁱ	P53915.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	39 – 42	Substrate bindingBy similarity	4
Regionⁱ	59 – 60	Substrate bindingBy similarity	2
Regionⁱ	164 – 165	Substrate bindingBy similarity	2

Sequence similaritiesⁱ

Belongs to the uridine kinase family. NRK subfamily.Curated

Phylogenomic databases

HOGENOMⁱ	HOG000248838.
InParanoidⁱ	P53915.
KEGG Orthology (KO) More...KOⁱ	K10524.
OMAⁱ	PQKFARA.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C4HBE.

Family and domain databases

InterProⁱ	View protein in InterPro IPR026681. NRK. IPR027417. P-loop_NTPase.
PANTHERⁱ	PTHR42666:SF5. PTHR42666:SF5. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 2 hits.

Sequenceⁱ

Sequence statusⁱ: Complete.

P53915-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTSKKVILVA LSGCSSSGKT TIAKLTASLF TKATLIHEDD FYKHDNEVPV 
        60         70         80         90        100
DAKYNIQNWD SPEALDFKLF GKELDVIKQT GKIATKLIHN NNVDDPFTKF 
       110        120        130        140        150
HIDRQVWDEL KAKYDSINDD KYEVVIVDGF MIFNNTGISK KFDLKILVRA 
       160        170        180        190        200
PYEVLKKRRA SRKGYQTLDS FWVDPPYYFD EFVYESYRAN HAQLFVNGDV 
       210        220        230        240
EGLLDPRKSK NIKEFINDDD TPIAKPLSWV CQEILKLCKD

Length:240

Mass (Da):27,690

Last modified:October 1, 1996 - v1

Checksum:ⁱF04E99885774CF53

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY611479 Genomic DNA. Translation: AAT11927.1. Z46843 Genomic DNA. Translation: CAA86896.1. Z71405 Genomic DNA. Translation: CAA96011.1. AY558011 Genomic DNA. Translation: AAS56337.1. BK006947 Genomic DNA. Translation: DAA10420.1.
PIRⁱ	S55154.
NCBI Reference Sequences More...RefSeqⁱ	NP_014270.1. NM_001182967.1.

Genome annotation databases

EnsemblFungiⁱ	YNL129W; YNL129W; YNL129W.
GeneIDⁱ	855594.
KEGGⁱ	sce:YNL129W.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY611479 Genomic DNA. Translation: AAT11927.1. Z46843 Genomic DNA. Translation: CAA86896.1. Z71405 Genomic DNA. Translation: CAA96011.1. AY558011 Genomic DNA. Translation: AAS56337.1. BK006947 Genomic DNA. Translation: DAA10420.1.
PIRⁱ	S55154.
NCBI Reference Sequences More...RefSeqⁱ	NP_014270.1. NM_001182967.1.

3D structure databases

ProteinModelPortalⁱ	P53915.
SMRⁱ	P53915.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	35698. 84 interactors.
Database of interacting proteins More...DIPⁱ	DIP-8168N.
Molecular INTeraction database More...MINTⁱ	MINT-4499900.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P53915.
PRIDEⁱ	P53915.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YNL129W; YNL129W; YNL129W.
GeneIDⁱ	855594.
KEGGⁱ	sce:YNL129W.

Organism-specific databases

EuPathDBⁱ	FungiDB:YNL129W.
Saccharomyces Genome Database More...SGDⁱ	S000005073. NRK1.

Phylogenomic databases

HOGENOMⁱ	HOG000248838.
InParanoidⁱ	P53915.
KEGG Orthology (KO) More...KOⁱ	K10524.
OMAⁱ	PQKFARA.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C4HBE.

Enzyme and pathway databases

UniPathwayⁱ	UPA00253.
BioCycⁱ	MetaCyc:MONOMER3O-4139. YEAST:MONOMER3O-4139.
BRENDAⁱ	2.7.1.22. 984.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P53915.

PROⁱ

PR:P53915.

Family and domain databases

InterProⁱ	View protein in InterPro IPR026681. NRK. IPR027417. P-loop_NTPase.
PANTHERⁱ	PTHR42666:SF5. PTHR42666:SF5. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 2 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NRK1_YEAST
Accessionⁱ	P53915Primary (citable) accession number: P53915 Secondary accession number(s): D6W154
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	June 7, 2017
	This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

PATHWAY comments
Index of metabolic and biosynthesis pathways
SIMILARITY comments
Index of protein domains and families
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome XIV
Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P53915 (NRK1_YEAST)

Your basket is currently empty.

Nicotinamide riboside kinase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: NAD(+) biosynthesis

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: NAD(+) biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ