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P53911

- EAF7_YEAST

UniProt

P53911 - EAF7_YEAST

Protein

Chromatin modification-related protein EAF7

Gene

EAF7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.

    GO - Biological processi

    1. DNA repair Source: SGD
    2. histone acetylation Source: SGD
    3. regulation of transcription from RNA polymerase II promoter Source: SGD
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator

    Keywords - Biological processi

    DNA damage, DNA repair, Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33155-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chromatin modification-related protein EAF7
    Alternative name(s):
    ESA1-associated factor 7
    Gene namesi
    Name:EAF7
    Ordered Locus Names:YNL136W
    ORF Names:N1212, N1843
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNL136w.
    SGDiS000005080. EAF7.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. histone acetyltransferase complex Source: SGD
    2. NuA4 histone acetyltransferase complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425Chromatin modification-related protein EAF7PRO_0000215882Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei200 – 2001Phosphoserine1 Publication
    Modified residuei225 – 2251Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP53911.
    PaxDbiP53911.

    Expressioni

    Gene expression databases

    GenevestigatoriP53911.

    Interactioni

    Subunit structurei

    Component of the NuA4 histone acetyltransferase complex composed of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ECM4P361561EBI-28927,EBI-2042717

    Protein-protein interaction databases

    BioGridi35690. 351 interactions.
    IntActiP53911. 13 interactions.
    MINTiMINT-2492018.
    STRINGi4932.YNL136W.

    Structurei

    3D structure databases

    ProteinModelPortaliP53911.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili209 – 310102Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the EAF7 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG279588.
    KOiK11399.
    OMAiIDEMENT.
    OrthoDBiEOG76QFWQ.

    Family and domain databases

    InterProiIPR012423. Eaf7/MRGBP.
    [Graphical view]
    PANTHERiPTHR13581. PTHR13581. 1 hit.
    PfamiPF07904. Eaf7. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53911-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVHWTIVDE IRLLRWASEF KPAGIHKHFH MFCIVERMNS PDKYPVTLLQ    50
    KETMKLGKVF TAKDIWDKLS QSYNLEKIDE MENTYSLEAT TESSRNGNGN 100
    GDDAEIHEET LLELNNRIRV RKQDFTLPWE EYGELILENA RKSPNSNEEY 150
    PRVEDMNEKD STIPKESPST DLKNDNNKQE KNATIKVKEL PEYHTEENDS 200
    PIDVQKEPIK EVQSDEKELQ REHMSEEEQK MKSTNKTAAP VRKSQRLKRS 250
    KEVKFEDEEK EEIEEDNTKD EEQKEKKEEI QEPKITHNEE VDKEKNENEE 300
    GDDEREKSTS YENTNGSESE GVDEGVDEEL GYESEREAEG KGKQIESEGG 350
    NLKKKTENKK GDDQQDDTKK DSKDKNEPLA KRTRHSSSTG NTSNETSPKR 400
    KRRKAGSRKN SPPATRVSSR LRNKK 425
    Length:425
    Mass (Da):49,391
    Last modified:October 1, 1996 - v1
    Checksum:i4C99805F529B4CF1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46843 Genomic DNA. Translation: CAA86889.1.
    Z71412 Genomic DNA. Translation: CAA96018.1.
    BK006947 Genomic DNA. Translation: DAA10412.1.
    PIRiS55147.
    RefSeqiNP_014263.1. NM_001182974.1.

    Genome annotation databases

    EnsemblFungiiYNL136W; YNL136W; YNL136W.
    GeneIDi855586.
    KEGGisce:YNL136W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46843 Genomic DNA. Translation: CAA86889.1 .
    Z71412 Genomic DNA. Translation: CAA96018.1 .
    BK006947 Genomic DNA. Translation: DAA10412.1 .
    PIRi S55147.
    RefSeqi NP_014263.1. NM_001182974.1.

    3D structure databases

    ProteinModelPortali P53911.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35690. 351 interactions.
    IntActi P53911. 13 interactions.
    MINTi MINT-2492018.
    STRINGi 4932.YNL136W.

    Proteomic databases

    MaxQBi P53911.
    PaxDbi P53911.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNL136W ; YNL136W ; YNL136W .
    GeneIDi 855586.
    KEGGi sce:YNL136W.

    Organism-specific databases

    CYGDi YNL136w.
    SGDi S000005080. EAF7.

    Phylogenomic databases

    eggNOGi NOG279588.
    KOi K11399.
    OMAi IDEMENT.
    OrthoDBi EOG76QFWQ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33155-MONOMER.

    Miscellaneous databases

    NextBioi 979721.

    Gene expression databases

    Genevestigatori P53911.

    Family and domain databases

    InterProi IPR012423. Eaf7/MRGBP.
    [Graphical view ]
    PANTHERi PTHR13581. PTHR13581. 1 hit.
    Pfami PF07904. Eaf7. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A 43.5 kb segment of yeast chromosome XIV, which contains MFA2, MEP2, CAP/SRV2, NAM9, FKB1/FPR1/RBP1, MOM22 and CPT1, predicts an adenosine deaminase gene and 14 new open reading frames."
      Mallet L., Bussereau F., Jacquet M.
      Yeast 11:1195-1209(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4."
      Krogan N.J., Baetz K., Keogh M.-C., Datta N., Sawa C., Kwok T.C.Y., Thompson N.J., Davey M.G., Pootoolal J., Hughes T.R., Emili A., Buratowski S., Hieter P., Greenblatt J.F.
      Proc. Natl. Acad. Sci. U.S.A. 101:13513-13518(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE NUA4 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    7. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
      Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
      Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiEAF7_YEAST
    AccessioniPrimary (citable) accession number: P53911
    Secondary accession number(s): D6W146
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 300 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3