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P53911

- EAF7_YEAST

UniProt

P53911 - EAF7_YEAST

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Protein

Chromatin modification-related protein EAF7

Gene
EAF7, YNL136W, N1212, N1843
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.

GO - Biological processi

  1. DNA repair Source: SGD
  2. histone acetylation Source: SGD
  3. regulation of transcription from RNA polymerase II promoter Source: SGD
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-33155-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin modification-related protein EAF7
Alternative name(s):
ESA1-associated factor 7
Gene namesi
Name:EAF7
Ordered Locus Names:YNL136W
ORF Names:N1212, N1843
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL136w.
SGDiS000005080. EAF7.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. histone acetyltransferase complex Source: SGD
  2. NuA4 histone acetyltransferase complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Chromatin modification-related protein EAF7PRO_0000215882Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei200 – 2001Phosphoserine1 Publication
Modified residuei225 – 2251Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53911.
PaxDbiP53911.

Expressioni

Gene expression databases

GenevestigatoriP53911.

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex composed of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ECM4P361561EBI-28927,EBI-2042717

Protein-protein interaction databases

BioGridi35690. 351 interactions.
IntActiP53911. 13 interactions.
MINTiMINT-2492018.
STRINGi4932.YNL136W.

Structurei

3D structure databases

ProteinModelPortaliP53911.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili209 – 310102 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the EAF7 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG279588.
KOiK11399.
OMAiIDEMENT.
OrthoDBiEOG76QFWQ.

Family and domain databases

InterProiIPR012423. Eaf7/MRGBP.
[Graphical view]
PANTHERiPTHR13581. PTHR13581. 1 hit.
PfamiPF07904. Eaf7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53911-1 [UniParc]FASTAAdd to Basket

« Hide

MVVHWTIVDE IRLLRWASEF KPAGIHKHFH MFCIVERMNS PDKYPVTLLQ    50
KETMKLGKVF TAKDIWDKLS QSYNLEKIDE MENTYSLEAT TESSRNGNGN 100
GDDAEIHEET LLELNNRIRV RKQDFTLPWE EYGELILENA RKSPNSNEEY 150
PRVEDMNEKD STIPKESPST DLKNDNNKQE KNATIKVKEL PEYHTEENDS 200
PIDVQKEPIK EVQSDEKELQ REHMSEEEQK MKSTNKTAAP VRKSQRLKRS 250
KEVKFEDEEK EEIEEDNTKD EEQKEKKEEI QEPKITHNEE VDKEKNENEE 300
GDDEREKSTS YENTNGSESE GVDEGVDEEL GYESEREAEG KGKQIESEGG 350
NLKKKTENKK GDDQQDDTKK DSKDKNEPLA KRTRHSSSTG NTSNETSPKR 400
KRRKAGSRKN SPPATRVSSR LRNKK 425
Length:425
Mass (Da):49,391
Last modified:October 1, 1996 - v1
Checksum:i4C99805F529B4CF1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46843 Genomic DNA. Translation: CAA86889.1.
Z71412 Genomic DNA. Translation: CAA96018.1.
BK006947 Genomic DNA. Translation: DAA10412.1.
PIRiS55147.
RefSeqiNP_014263.1. NM_001182974.1.

Genome annotation databases

EnsemblFungiiYNL136W; YNL136W; YNL136W.
GeneIDi855586.
KEGGisce:YNL136W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46843 Genomic DNA. Translation: CAA86889.1 .
Z71412 Genomic DNA. Translation: CAA96018.1 .
BK006947 Genomic DNA. Translation: DAA10412.1 .
PIRi S55147.
RefSeqi NP_014263.1. NM_001182974.1.

3D structure databases

ProteinModelPortali P53911.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35690. 351 interactions.
IntActi P53911. 13 interactions.
MINTi MINT-2492018.
STRINGi 4932.YNL136W.

Proteomic databases

MaxQBi P53911.
PaxDbi P53911.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL136W ; YNL136W ; YNL136W .
GeneIDi 855586.
KEGGi sce:YNL136W.

Organism-specific databases

CYGDi YNL136w.
SGDi S000005080. EAF7.

Phylogenomic databases

eggNOGi NOG279588.
KOi K11399.
OMAi IDEMENT.
OrthoDBi EOG76QFWQ.

Enzyme and pathway databases

BioCyci YEAST:G3O-33155-MONOMER.

Miscellaneous databases

NextBioi 979721.

Gene expression databases

Genevestigatori P53911.

Family and domain databases

InterProi IPR012423. Eaf7/MRGBP.
[Graphical view ]
PANTHERi PTHR13581. PTHR13581. 1 hit.
Pfami PF07904. Eaf7. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A 43.5 kb segment of yeast chromosome XIV, which contains MFA2, MEP2, CAP/SRV2, NAM9, FKB1/FPR1/RBP1, MOM22 and CPT1, predicts an adenosine deaminase gene and 14 new open reading frames."
    Mallet L., Bussereau F., Jacquet M.
    Yeast 11:1195-1209(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4."
    Krogan N.J., Baetz K., Keogh M.-C., Datta N., Sawa C., Kwok T.C.Y., Thompson N.J., Davey M.G., Pootoolal J., Hughes T.R., Emili A., Buratowski S., Hieter P., Greenblatt J.F.
    Proc. Natl. Acad. Sci. U.S.A. 101:13513-13518(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NUA4 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  7. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiEAF7_YEAST
AccessioniPrimary (citable) accession number: P53911
Secondary accession number(s): D6W146
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 300 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

Similar proteinsi