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Protein

Chromatin modification-related protein EAF7

Gene

EAF7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.

GO - Biological processi

  • DNA repair Source: SGD
  • histone acetylation Source: SGD
  • regulation of transcription from RNA polymerase II promoter Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-33155-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin modification-related protein EAF7
Alternative name(s):
ESA1-associated factor 7
Gene namesi
Name:EAF7
Ordered Locus Names:YNL136W
ORF Names:N1212, N1843
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL136W.
SGDiS000005080. EAF7.

Subcellular locationi

GO - Cellular componenti

  • histone acetyltransferase complex Source: SGD
  • NuA4 histone acetyltransferase complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002158821 – 425Chromatin modification-related protein EAF7Add BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei200PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53911.
PRIDEiP53911.

PTM databases

iPTMnetiP53911.

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex composed of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2.1 Publication

Protein-protein interaction databases

BioGridi35690. 352 interactors.
IntActiP53911. 15 interactors.
MINTiMINT-2492018.

Structurei

3D structure databases

ProteinModelPortaliP53911.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili209 – 310Sequence analysisAdd BLAST102

Sequence similaritiesi

Belongs to the EAF7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiP53911.
KOiK11399.
OMAiIDEMENT.
OrthoDBiEOG092C5HFX.

Family and domain databases

InterProiIPR012423. Eaf7/MRGBP.
[Graphical view]
PANTHERiPTHR13581:SF5. PTHR13581:SF5. 2 hits.
PfamiPF07904. Eaf7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53911-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVHWTIVDE IRLLRWASEF KPAGIHKHFH MFCIVERMNS PDKYPVTLLQ
60 70 80 90 100
KETMKLGKVF TAKDIWDKLS QSYNLEKIDE MENTYSLEAT TESSRNGNGN
110 120 130 140 150
GDDAEIHEET LLELNNRIRV RKQDFTLPWE EYGELILENA RKSPNSNEEY
160 170 180 190 200
PRVEDMNEKD STIPKESPST DLKNDNNKQE KNATIKVKEL PEYHTEENDS
210 220 230 240 250
PIDVQKEPIK EVQSDEKELQ REHMSEEEQK MKSTNKTAAP VRKSQRLKRS
260 270 280 290 300
KEVKFEDEEK EEIEEDNTKD EEQKEKKEEI QEPKITHNEE VDKEKNENEE
310 320 330 340 350
GDDEREKSTS YENTNGSESE GVDEGVDEEL GYESEREAEG KGKQIESEGG
360 370 380 390 400
NLKKKTENKK GDDQQDDTKK DSKDKNEPLA KRTRHSSSTG NTSNETSPKR
410 420
KRRKAGSRKN SPPATRVSSR LRNKK
Length:425
Mass (Da):49,391
Last modified:October 1, 1996 - v1
Checksum:i4C99805F529B4CF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46843 Genomic DNA. Translation: CAA86889.1.
Z71412 Genomic DNA. Translation: CAA96018.1.
BK006947 Genomic DNA. Translation: DAA10412.1.
PIRiS55147.
RefSeqiNP_014263.1. NM_001182974.1.

Genome annotation databases

EnsemblFungiiYNL136W; YNL136W; YNL136W.
GeneIDi855586.
KEGGisce:YNL136W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46843 Genomic DNA. Translation: CAA86889.1.
Z71412 Genomic DNA. Translation: CAA96018.1.
BK006947 Genomic DNA. Translation: DAA10412.1.
PIRiS55147.
RefSeqiNP_014263.1. NM_001182974.1.

3D structure databases

ProteinModelPortaliP53911.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35690. 352 interactors.
IntActiP53911. 15 interactors.
MINTiMINT-2492018.

PTM databases

iPTMnetiP53911.

Proteomic databases

MaxQBiP53911.
PRIDEiP53911.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL136W; YNL136W; YNL136W.
GeneIDi855586.
KEGGisce:YNL136W.

Organism-specific databases

EuPathDBiFungiDB:YNL136W.
SGDiS000005080. EAF7.

Phylogenomic databases

InParanoidiP53911.
KOiK11399.
OMAiIDEMENT.
OrthoDBiEOG092C5HFX.

Enzyme and pathway databases

BioCyciYEAST:G3O-33155-MONOMER.

Miscellaneous databases

PROiP53911.

Family and domain databases

InterProiIPR012423. Eaf7/MRGBP.
[Graphical view]
PANTHERiPTHR13581:SF5. PTHR13581:SF5. 2 hits.
PfamiPF07904. Eaf7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEAF7_YEAST
AccessioniPrimary (citable) accession number: P53911
Secondary accession number(s): D6W146
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 300 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.