Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chromatin modification-related protein EAF7

Gene

EAF7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.

Miscellaneous

Present with 300 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • DNA repair Source: SGD
  • histone acetylation Source: SGD
  • regulation of transcription by RNA polymerase II Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator
Biological processDNA damage, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-33155-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin modification-related protein EAF7
Alternative name(s):
ESA1-associated factor 7
Gene namesi
Name:EAF7
Ordered Locus Names:YNL136W
ORF Names:N1212, N1843
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL136W
SGDiS000005080 EAF7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002158821 – 425Chromatin modification-related protein EAF7Add BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei200PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53911
PaxDbiP53911
PRIDEiP53911

PTM databases

iPTMnetiP53911

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex composed of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35690, 612 interactors
IntActiP53911, 35 interactors
MINTiP53911
STRINGi4932.YNL136W

Structurei

3D structure databases

ProteinModelPortaliP53911
SMRiP53911
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili209 – 310Sequence analysisAdd BLAST102

Sequence similaritiesi

Belongs to the EAF7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiP53911
KOiK11399
OMAiMNGHKPV
OrthoDBiEOG092C5HFX

Family and domain databases

InterProiView protein in InterPro
IPR012423 Eaf7/MRGBP
PANTHERiPTHR13581 PTHR13581, 1 hit
PfamiView protein in Pfam
PF07904 Eaf7, 1 hit

Sequencei

Sequence statusi: Complete.

P53911-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVHWTIVDE IRLLRWASEF KPAGIHKHFH MFCIVERMNS PDKYPVTLLQ
60 70 80 90 100
KETMKLGKVF TAKDIWDKLS QSYNLEKIDE MENTYSLEAT TESSRNGNGN
110 120 130 140 150
GDDAEIHEET LLELNNRIRV RKQDFTLPWE EYGELILENA RKSPNSNEEY
160 170 180 190 200
PRVEDMNEKD STIPKESPST DLKNDNNKQE KNATIKVKEL PEYHTEENDS
210 220 230 240 250
PIDVQKEPIK EVQSDEKELQ REHMSEEEQK MKSTNKTAAP VRKSQRLKRS
260 270 280 290 300
KEVKFEDEEK EEIEEDNTKD EEQKEKKEEI QEPKITHNEE VDKEKNENEE
310 320 330 340 350
GDDEREKSTS YENTNGSESE GVDEGVDEEL GYESEREAEG KGKQIESEGG
360 370 380 390 400
NLKKKTENKK GDDQQDDTKK DSKDKNEPLA KRTRHSSSTG NTSNETSPKR
410 420
KRRKAGSRKN SPPATRVSSR LRNKK
Length:425
Mass (Da):49,391
Last modified:October 1, 1996 - v1
Checksum:i4C99805F529B4CF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46843 Genomic DNA Translation: CAA86889.1
Z71412 Genomic DNA Translation: CAA96018.1
BK006947 Genomic DNA Translation: DAA10412.1
PIRiS55147
RefSeqiNP_014263.1, NM_001182974.1

Genome annotation databases

EnsemblFungiiYNL136W; YNL136W; YNL136W
GeneIDi855586
KEGGisce:YNL136W

Similar proteinsi

Entry informationi

Entry nameiEAF7_YEAST
AccessioniPrimary (citable) accession number: P53911
Secondary accession number(s): D6W146
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health