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Protein

Ingression protein 1

Gene

INN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the ingression of the plasma membrane into the bud neck at the end of cytokinesis, leading to the separation of the mother and daughter cells. Stimulates the synthesis of the primary septum (PS) by CHS2.3 Publications

GO - Molecular functioni

  • enzyme regulator activity Source: SGD

GO - Biological processi

  • anchoring of the mitotic actomyosin contractile ring to the plasma membrane Source: InterPro
  • chromosome organization Source: SGD
  • division septum assembly Source: SGD
  • mitotic cytokinesis Source: SGD

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-33169-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ingression protein 1
Gene namesi
Name:INN1
Ordered Locus Names:YNL152W
ORF Names:N1765
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL152W
SGDiS000005096 INN1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi28K → A: Impairs plasma membrane ingression; when associated with A-31. 1 Publication1
Mutagenesisi31K → A: Impairs plasma membrane ingression; when associated with A-28. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002034191 – 409Ingression protein 1Add BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei392PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53901
PaxDbiP53901
PRIDEiP53901
TopDownProteomicsiP53901

PTM databases

iPTMnetiP53901

Interactioni

Subunit structurei

Interacts with CYK2, CYK3 and IQG1.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35677, 196 interactors
DIPiDIP-4339N
IntActiP53901, 12 interactors
MINTiP53901
STRINGi4932.YNL152W

Structurei

3D structure databases

ProteinModelPortaliP53901
SMRiP53901
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 134C2Add BLAST134

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi303 – 310Poly-Asp8

Domaini

The C2 domain is essential for membrane ingression during cytokinesis, but not for recruitment to the actomyosin ring.1 Publication

Sequence similaritiesi

Belongs to the INN1/fic1 family.Curated

Phylogenomic databases

HOGENOMiHOG000142049
InParanoidiP53901
OMAiRIAHMTR
OrthoDBiEOG092C26AJ

Family and domain databases

CDDicd08681 C2_fungal_Inn1p-like, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037791 C2_fungal_Inn1
PfamiView protein in Pfam
PF00168 C2, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit

Sequencei

Sequence statusi: Complete.

P53901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEEVWNGNQ GILSVYVSKA RDLPNLNKLD KQNVMLRLRI AHMTRASNTL
60 70 80 90 100
HRAGQNPVFH YLEKFDITPE IKPLMYVEVY CDRRKKSPLP IGRCEIDLLN
110 120 130 140 150
AIRADPKEGY CTWYELKRSG DEFAGTIFIE LTFTPKVPRL NRDDLNKEMD
160 170 180 190 200
RLDSSMAMRP IPPLPTESEY DYVHGSTMRQ ITPQCVSTSH EDKDEGQPYR
210 220 230 240 250
NGNVFSMSSK SDTAVLANSN DPIILPPTFS ASMGTTSTLE TNDTAISNTS
260 270 280 290 300
NTKFHFANLR KLKEKINIFK NPDSSTNNCQ NESNKVDIEA LQKAIGVTSL
310 320 330 340 350
SYDEDDDDDD ENDAFYSSSH RVSHNYNQPP LPPIPTRDDM SNYSSSRNTP
360 370 380 390 400
LVRRDRPSRL DSSSPNSHPH PSGLNSPKLP PLPTTSNSNF NSRKNSMSPT

RKRPPPRLS
Length:409
Mass (Da):46,226
Last modified:October 1, 1996 - v1
Checksum:i66C2B81D21CE5520
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti221D → G in AAS56352 (PubMed:9169873).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92517 Genomic DNA Translation: CAA63287.1
Z71428 Genomic DNA Translation: CAA96039.1
AY558026 Genomic DNA Translation: AAS56352.1
BK006947 Genomic DNA Translation: DAA10397.1
PIRiS60975
RefSeqiNP_014247.1, NM_001182990.1

Genome annotation databases

EnsemblFungiiYNL152W; YNL152W; YNL152W
GeneIDi855570
KEGGisce:YNL152W

Similar proteinsi

Entry informationi

Entry nameiINN1_YEAST
AccessioniPrimary (citable) accession number: P53901
Secondary accession number(s): D6W131, Q6Q5J6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

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