UniProtKB - P53901 (INN1_YEAST)
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Protein
Ingression protein 1
Gene
INN1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Required for the ingression of the plasma membrane into the bud neck at the end of cytokinesis, leading to the separation of the mother and daughter cells. Stimulates the synthesis of the primary septum (PS) by CHS2.3 Publications
GO - Molecular functioni
- enzyme regulator activity Source: SGD
GO - Biological processi
- anchoring of the mitotic actomyosin contractile ring to the plasma membrane Source: InterPro
- chromosome organization Source: SGD
- division septum assembly Source: SGD
- mitotic cytokinesis Source: SGD
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis |
Enzyme and pathway databases
BioCyci | YEAST:G3O-33169-MONOMER. |
Names & Taxonomyi
Protein namesi | Recommended name: Ingression protein 1 |
Gene namesi | Name:INN1 Ordered Locus Names:YNL152W ORF Names:N1765 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YNL152W. |
SGDi | S000005096. INN1. |
Subcellular locationi
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 28 | K → A: Impairs plasma membrane ingression; when associated with A-31. 1 Publication | 1 | |
Mutagenesisi | 31 | K → A: Impairs plasma membrane ingression; when associated with A-28. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000203419 | 1 – 409 | Ingression protein 1Add BLAST | 409 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 392 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P53901. |
PaxDbi | P53901. |
PRIDEi | P53901. |
TopDownProteomicsi | P53901. |
PTM databases
iPTMneti | P53901. |
Interactioni
Subunit structurei
Interacts with CYK2, CYK3 and IQG1.3 Publications
Binary interactionsi
Protein-protein interaction databases
BioGridi | 35677. 196 interactors. |
DIPi | DIP-4339N. |
IntActi | P53901. 15 interactors. |
MINTi | P53901. |
STRINGi | 4932.YNL152W. |
Structurei
3D structure databases
ProteinModelPortali | P53901. |
SMRi | P53901. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 134 | C2Add BLAST | 134 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 303 – 310 | Poly-Asp | 8 |
Domaini
The C2 domain is essential for membrane ingression during cytokinesis, but not for recruitment to the actomyosin ring.1 Publication
Sequence similaritiesi
Belongs to the INN1/fic1 family.Curated
Phylogenomic databases
HOGENOMi | HOG000142049. |
InParanoidi | P53901. |
OMAi | RIAHMTR. |
OrthoDBi | EOG092C26AJ. |
Family and domain databases
CDDi | cd08681. C2_fungal_Inn1p-like. 1 hit. |
Gene3Di | 2.60.40.150. 1 hit. |
InterProi | View protein in InterPro IPR000008. C2_dom. IPR035892. C2_domain_sf. IPR037791. C2_fungal_Inn1. |
Pfami | View protein in Pfam PF00168. C2. 1 hit. |
SMARTi | View protein in SMART SM00239. C2. 1 hit. |
i Sequence
Sequence statusi: Complete.
P53901-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEEVWNGNQ GILSVYVSKA RDLPNLNKLD KQNVMLRLRI AHMTRASNTL
60 70 80 90 100
HRAGQNPVFH YLEKFDITPE IKPLMYVEVY CDRRKKSPLP IGRCEIDLLN
110 120 130 140 150
AIRADPKEGY CTWYELKRSG DEFAGTIFIE LTFTPKVPRL NRDDLNKEMD
160 170 180 190 200
RLDSSMAMRP IPPLPTESEY DYVHGSTMRQ ITPQCVSTSH EDKDEGQPYR
210 220 230 240 250
NGNVFSMSSK SDTAVLANSN DPIILPPTFS ASMGTTSTLE TNDTAISNTS
260 270 280 290 300
NTKFHFANLR KLKEKINIFK NPDSSTNNCQ NESNKVDIEA LQKAIGVTSL
310 320 330 340 350
SYDEDDDDDD ENDAFYSSSH RVSHNYNQPP LPPIPTRDDM SNYSSSRNTP
360 370 380 390 400
LVRRDRPSRL DSSSPNSHPH PSGLNSPKLP PLPTTSNSNF NSRKNSMSPT
RKRPPPRLS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 221 | D → G in AAS56352 (PubMed:9169873).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X92517 Genomic DNA. Translation: CAA63287.1. Z71428 Genomic DNA. Translation: CAA96039.1. AY558026 Genomic DNA. Translation: AAS56352.1. BK006947 Genomic DNA. Translation: DAA10397.1. |
PIRi | S60975. |
RefSeqi | NP_014247.1. NM_001182990.1. |
Genome annotation databases
EnsemblFungii | YNL152W; YNL152W; YNL152W. |
GeneIDi | 855570. |
KEGGi | sce:YNL152W. |
Similar proteinsi
Entry informationi
Entry namei | INN1_YEAST | |
Accessioni | P53901Primary (citable) accession number: P53901 Secondary accession number(s): D6W131, Q6Q5J6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | March 28, 2018 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |