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Protein

Prefoldin subunit 4

Gene

GIM3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

GO - Molecular functioni

  • chaperone binding Source: GO_Central
  • tubulin binding Source: SGD

GO - Biological processi

  • cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process Source: SGD
  • positive regulation of transcription elongation from RNA polymerase II promoter Source: SGD
  • protein folding Source: GO_Central
  • tubulin complex assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-33170-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 4
Alternative name(s):
Genes involved in microtubule biogenesis protein 3
Gim complex subunit 3
Short name:
GimC subunit 3
Gene namesi
Name:GIM3
Synonyms:PFD4
Ordered Locus Names:YNL153C
ORF Names:N1761
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL153C.
SGDiS000005097. GIM3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • prefoldin complex Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001248481 – 129Prefoldin subunit 4Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP53900.
PRIDEiP53900.

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PAC10P483634EBI-13246,EBI-13239

GO - Molecular functioni

  • chaperone binding Source: GO_Central
  • tubulin binding Source: SGD

Protein-protein interaction databases

BioGridi35676. 411 interactors.
DIPiDIP-3000N.
IntActiP53900. 11 interactors.
MINTiMINT-434964.

Structurei

3D structure databases

ProteinModelPortaliP53900.
SMRiP53900.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000006696.
HOGENOMiHOG000204477.
InParanoidiP53900.
KOiK09550.
OMAiFSKLIMR.
OrthoDBiEOG092C5KAA.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR002777. PFD_beta-like.
IPR016661. PFDN4.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR21100:SF9. PTHR21100:SF9. 1 hit.
PfamiPF01920. Prefoldin_2. 1 hit.
[Graphical view]
PIRSFiPIRSF016477. Prefoldin_subunit_4. 1 hit.
SUPFAMiSSF46579. SSF46579. 1 hit.

Sequencei

Sequence statusi: Complete.

P53900-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLPQGQRN NTQVTFEDQQ KINEFSKLIM RKDAIAQELS LQREEKEYLD
60 70 80 90 100
DVSLEIELID EDEPVQYKVG DLFIFMKQSK VTAQLEKDAE RLDNKIETLE
110 120
DKQRDIDSRL DALKAILYAK FGDNINLER
Length:129
Mass (Da):15,180
Last modified:October 1, 1996 - v1
Checksum:i4738F9EA813E04A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92517 Genomic DNA. Translation: CAA63286.1.
Z71429 Genomic DNA. Translation: CAA96040.1.
AY692812 Genomic DNA. Translation: AAT92831.1.
BK006947 Genomic DNA. Translation: DAA10396.1.
PIRiS60974.
RefSeqiNP_014246.1. NM_001182991.1.

Genome annotation databases

EnsemblFungiiYNL153C; YNL153C; YNL153C.
GeneIDi855569.
KEGGisce:YNL153C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92517 Genomic DNA. Translation: CAA63286.1.
Z71429 Genomic DNA. Translation: CAA96040.1.
AY692812 Genomic DNA. Translation: AAT92831.1.
BK006947 Genomic DNA. Translation: DAA10396.1.
PIRiS60974.
RefSeqiNP_014246.1. NM_001182991.1.

3D structure databases

ProteinModelPortaliP53900.
SMRiP53900.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35676. 411 interactors.
DIPiDIP-3000N.
IntActiP53900. 11 interactors.
MINTiMINT-434964.

Proteomic databases

MaxQBiP53900.
PRIDEiP53900.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL153C; YNL153C; YNL153C.
GeneIDi855569.
KEGGisce:YNL153C.

Organism-specific databases

EuPathDBiFungiDB:YNL153C.
SGDiS000005097. GIM3.

Phylogenomic databases

GeneTreeiENSGT00390000006696.
HOGENOMiHOG000204477.
InParanoidiP53900.
KOiK09550.
OMAiFSKLIMR.
OrthoDBiEOG092C5KAA.

Enzyme and pathway databases

BioCyciYEAST:G3O-33170-MONOMER.

Miscellaneous databases

PROiP53900.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR002777. PFD_beta-like.
IPR016661. PFDN4.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR21100:SF9. PTHR21100:SF9. 1 hit.
PfamiPF01920. Prefoldin_2. 1 hit.
[Graphical view]
PIRSFiPIRSF016477. Prefoldin_subunit_4. 1 hit.
SUPFAMiSSF46579. SSF46579. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPFD4_YEAST
AccessioniPrimary (citable) accession number: P53900
Secondary accession number(s): D6W130
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7470 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.