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P53900

- PFD4_YEAST

UniProt

P53900 - PFD4_YEAST

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Protein

Prefoldin subunit 4

Gene

GIM3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

GO - Molecular functioni

  1. tubulin binding Source: SGD

GO - Biological processi

  1. positive regulation of transcription elongation from RNA polymerase II promoter Source: SGD
  2. protein folding Source: InterPro
  3. tubulin complex assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-33170-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 4
Alternative name(s):
Genes involved in microtubule biogenesis protein 3
Gim complex subunit 3
Short name:
GimC subunit 3
Gene namesi
Name:GIM3
Synonyms:PFD4
Ordered Locus Names:YNL153C
ORF Names:N1761
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL153c.
SGDiS000005097. GIM3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. prefoldin complex Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 129129Prefoldin subunit 4PRO_0000124848Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP53900.
PaxDbiP53900.

Expressioni

Gene expression databases

GenevestigatoriP53900.

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PAC10P483634EBI-13246,EBI-13239

Protein-protein interaction databases

BioGridi35676. 411 interactions.
DIPiDIP-3000N.
IntActiP53900. 11 interactions.
MINTiMINT-434964.
STRINGi4932.YNL153C.

Structurei

3D structure databases

ProteinModelPortaliP53900.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

eggNOGiCOG1382.
GeneTreeiENSGT00390000006696.
HOGENOMiHOG000204477.
InParanoidiP53900.
KOiK09550.
OMAiYAKFGDN.
OrthoDBiEOG735492.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR002777. PFD_beta-like.
IPR016661. PFDN4.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR21100. PTHR21100. 1 hit.
PfamiPF01920. Prefoldin_2. 1 hit.
[Graphical view]
PIRSFiPIRSF016477. Prefoldin_subunit_4. 1 hit.
SUPFAMiSSF46579. SSF46579. 1 hit.

Sequencei

Sequence statusi: Complete.

P53900-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELLPQGQRN NTQVTFEDQQ KINEFSKLIM RKDAIAQELS LQREEKEYLD
60 70 80 90 100
DVSLEIELID EDEPVQYKVG DLFIFMKQSK VTAQLEKDAE RLDNKIETLE
110 120
DKQRDIDSRL DALKAILYAK FGDNINLER
Length:129
Mass (Da):15,180
Last modified:October 1, 1996 - v1
Checksum:i4738F9EA813E04A9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92517 Genomic DNA. Translation: CAA63286.1.
Z71429 Genomic DNA. Translation: CAA96040.1.
AY692812 Genomic DNA. Translation: AAT92831.1.
BK006947 Genomic DNA. Translation: DAA10396.1.
PIRiS60974.
RefSeqiNP_014246.1. NM_001182991.1.

Genome annotation databases

EnsemblFungiiYNL153C; YNL153C; YNL153C.
GeneIDi855569.
KEGGisce:YNL153C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92517 Genomic DNA. Translation: CAA63286.1 .
Z71429 Genomic DNA. Translation: CAA96040.1 .
AY692812 Genomic DNA. Translation: AAT92831.1 .
BK006947 Genomic DNA. Translation: DAA10396.1 .
PIRi S60974.
RefSeqi NP_014246.1. NM_001182991.1.

3D structure databases

ProteinModelPortali P53900.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35676. 411 interactions.
DIPi DIP-3000N.
IntActi P53900. 11 interactions.
MINTi MINT-434964.
STRINGi 4932.YNL153C.

Proteomic databases

MaxQBi P53900.
PaxDbi P53900.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL153C ; YNL153C ; YNL153C .
GeneIDi 855569.
KEGGi sce:YNL153C.

Organism-specific databases

CYGDi YNL153c.
SGDi S000005097. GIM3.

Phylogenomic databases

eggNOGi COG1382.
GeneTreei ENSGT00390000006696.
HOGENOMi HOG000204477.
InParanoidi P53900.
KOi K09550.
OMAi YAKFGDN.
OrthoDBi EOG735492.

Enzyme and pathway databases

BioCyci YEAST:G3O-33170-MONOMER.

Miscellaneous databases

NextBioi 979679.
PROi P53900.

Gene expression databases

Genevestigatori P53900.

Family and domain databases

Gene3Di 1.10.287.370. 1 hit.
InterProi IPR002777. PFD_beta-like.
IPR016661. PFDN4.
IPR009053. Prefoldin.
[Graphical view ]
PANTHERi PTHR21100. PTHR21100. 1 hit.
Pfami PF01920. Prefoldin_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF016477. Prefoldin_subunit_4. 1 hit.
SUPFAMi SSF46579. SSF46579. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of 36.8 kb from the left arm of chromosome XIV reveals 24 complete open reading frames: 18 correspond to new genes, one of which encodes a protein similar to the human myotonic dystrophy kinase."
    Nasr F., Becam A.-M., Herbert C.J.
    Yeast 12:169-175(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "A novel protein complex promoting formation of functional alpha- and gamma-tubulin."
    Geissler S., Siegers K., Schiebel E.
    EMBO J. 17:952-966(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  6. "Compartmentation of protein folding in vivo: sequestration of non-native polypeptide by the chaperonin-GimC system."
    Siegers K., Waldmann T., Leroux M.R., Grein K., Shevchenko A., Schiebel E., Hartl F.U.
    EMBO J. 18:75-84(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE PREFOLDIN COMPLEX.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPFD4_YEAST
AccessioniPrimary (citable) accession number: P53900
Secondary accession number(s): D6W130
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7470 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3