Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CDC48-associated ubiquitin-like/zinc finger protein 1

Gene

CUZ1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have a role in the ubiquitin-proteasome system (UPS) protecting cells from metalloid-induced proteotoxicity.2 Publications

Miscellaneous

Present with 4280 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 58AN1-typePROSITE-ProRule annotationAdd BLAST44

GO - Molecular functioni

  • proteasome binding Source: SGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cellular response to arsenic-containing substance Source: SGD
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: SGD

Keywordsi

Biological processStress response
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-33171-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
CDC48-associated ubiquitin-like/zinc finger protein 11 Publication
Short name:
CDC48-associated UBL/Zn-finger protein 11 Publication
Gene namesi
Name:CUZ11 Publication
Ordered Locus Names:YNL155WImported
ORF Names:N1751
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL155W
SGDiS000005099 CUZ1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002034181 – 274CDC48-associated ubiquitin-like/zinc finger protein 1Add BLAST274

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei273PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53899
PaxDbiP53899
PRIDEiP53899

PTM databases

iPTMnetiP53899

Expressioni

Inductioni

By transcriptional activator RPN4.1 Publication

Interactioni

Subunit structurei

Interacts (via its ubiquitin-like domain) with CDC48 (via N-terminus). Associates with the 26S proteasome. Specifically interacts with the regulatory particle (RP) subunit RPN2. Exposure to arsenite, a known inducer of protein misfolding resulting in accumulation of polyubiquitinated conjugates, enhances the association with the proteoasome. Binds to ubiquitinated proteins conjugated to a 4 or more molecule ubiquitin chain. Binding to ubiquitinated proteins is zinc-dependent.2 Publications

Protein-protein interaction databases

BioGridi35674, 99 interactors
DIPiDIP-1796N
IntActiP53899, 6 interactors
MINTiP53899
STRINGi4932.YNL155W

Structurei

Secondary structure

1274
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi19 – 21Combined sources3
Beta strandi24 – 27Combined sources4
Turni32 – 34Combined sources3
Helixi40 – 42Combined sources3
Helixi46 – 48Combined sources3
Helixi51 – 55Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IJ4NMR-A11-59[»]
ProteinModelPortaliP53899
SMRiP53899
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni170 – 266Ubiquitin-like1 PublicationAdd BLAST97

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 58AN1-typePROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00730000111180
HOGENOMiHOG000248569
InParanoidiP53899
KOiK07059
OMAiGQHCQVE
OrthoDBiEOG092C5BYK

Family and domain databases

Gene3Di4.10.1110.10, 1 hit
InterProiView protein in InterPro
IPR035896 AN1-like_Znf
IPR000058 Znf_AN1
PfamiView protein in Pfam
PF01428 zf-AN1, 1 hit
SMARTiView protein in SMART
SM00154 ZnF_AN1, 1 hit
SUPFAMiSSF118310 SSF118310, 1 hit
PROSITEiView protein in PROSITE
PS51039 ZF_AN1, 1 hit

Sequencei

Sequence statusi: Complete.

P53899-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAIEKETG MLDVGKHCAY CRQLDFLPFH CSFCNEDFCS NHRLKEDHHC
60 70 80 90 100
RWLLEHEEVH KTEKSPSKSR DGSSSNDEAY FKSLLPERAS VRIQRVSETR
110 120 130 140 150
EPLRGSNTAK VSSTLNSKTL DKIFKFFQRN EKRKSNNKSK KNFGSSSNKI
160 170 180 190 200
IQLANLKKIA KGDPKIPMQN RIYIWCYLVD GDETDIAKED TRMPLYINKM
210 220 230 240 250
WPVGRAMDYL SIQLNVKSST LTNSSSNDKF QLCKLKEGKQ VSFYNIGASL
260 270
RVTNEIKDLD TLYLVHNNAD EKSN
Length:274
Mass (Da):31,517
Last modified:October 1, 1996 - v1
Checksum:i1BC3E0D932AC1365
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92517 Genomic DNA Translation: CAA63284.1
Z71431 Genomic DNA Translation: CAA96042.1
AY692693 Genomic DNA Translation: AAT92712.1
BK006947 Genomic DNA Translation: DAA10394.1
PIRiS60972
RefSeqiNP_014244.1, NM_001182993.1

Genome annotation databases

EnsemblFungiiYNL155W; YNL155W; YNL155W
GeneIDi855567
KEGGisce:YNL155W

Similar proteinsi

Entry informationi

Entry nameiCUZ1_YEAST
AccessioniPrimary (citable) accession number: P53899
Secondary accession number(s): D6W128
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health