P53889 (FMP41_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized mitochondrial hydrolase FMP41
EC=3.-.-.-

Gene names

Name:	FMP41
Ordered Locus Names:	YNL168C
ORF Names:	N1696

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Mitochondrion Ref.4 Ref.6.
Induction	In high salinity conditions. Ref.7
Miscellaneous	Present with 2550 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the FAH family.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Mitochondrion
Ligand	Metal-binding
Molecular function	Hydrolase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrion Inferred from direct assay Ref.4Ref.6PubMed 16823961. Source: SGD
Molecular_function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
YHR080C	P38800	1	EBI-29005,EBI-24597

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 259

259

Uncharacterized mitochondrial hydrolase FMP41

PRO_0000156843

Sites

Metal binding

87

1

Divalent metal cation By similarity

Metal binding

89

1

Divalent metal cation By similarity

Metal binding

121

1

Divalent metal cation By similarity

Secondary structure

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259

Helix Strand Turn

Details...

Helix

4 – 8

5

Beta strand

12 – 15

4

Helix

23 – 27

5

Beta strand

36 – 39

4

Helix

41 – 43

3

Beta strand

44 – 46

3

Beta strand

76 – 78

3

Beta strand

84 – 86

3

Beta strand

88 – 94

7

Helix

106 – 108

3

Helix

110 – 112

3

Beta strand

113 – 120

8

Helix

125 – 134

10

Helix

139 – 143

5

Beta strand

148 – 150

3

Helix

156 – 162

7

Turn

167 – 169

3

Beta strand

170 – 176

7

Beta strand

179 – 185

7

Helix

186 – 188

3

Beta strand

189 – 191

3

Helix

193 – 201

9

Beta strand

211 – 213

3

Beta strand

221 – 223

3

Beta strand

228 – 235

8

Beta strand

238 – 249

12

Sequences

	Sequence		Length	Mass (Da)
	P53889 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 6984B5BAB297CECC	FASTA	259	28,792
	10 20 30 40 50 60 MSYNYLKAAR KIICIGRNYA AHIKELNNST PKQPFFFLKP TSSIVTPLSS SLVKTTRPAN 70 80 90 100 110 120 STFNGLNEDG TNPGPIFIPR GVKVHHEIEL ALIVSKHLSN VTKMKPEEVY DSISGVALAL 130 140 150 160 170 180 DLTARNVQDE AKKKGLPWTI SKGFDTFMPI SAIVSREKFS SYKSNLQDIF RVKCSVNGQL 190 200 210 220 230 240 RQDGGTNLML HPLHKILQHI STMISLEPGD IILTGTPAGV GELKPGDRVH CELLQNNDNI 250 VDMNFECENR PGPYEFRET

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The sequence of 36.8 kb from the left arm of chromosome XIV reveals 24 complete open reading frames: 18 correspond to new genes, one of which encodes a protein similar to the human myotonic dystrophy kinase." Nasr F., Becam A.-M., Herbert C.J. Yeast 12:169-175(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J. Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]	"The proteome of Saccharomyces cerevisiae mitochondria." Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E., Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P., Pfanner N., Meisinger C. Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Strain: ATCC 76625 / YPH499.
[7]	"Yeast translational response to high salinity: global analysis reveals regulation at multiple levels." Melamed D., Pnueli L., Arava Y. RNA 14:1337-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[8]	"Crystal structure of yeast hypothetical protein ynq8_yeast." New York structural genomix research consortium (NYSGXRC) Submitted (JAN-2005) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X92517 Genomic DNA. Translation: CAA63271.1.
Z71444 Genomic DNA. Translation: CAA96055.1.
BK006947 Genomic DNA. Translation: DAA10380.1.

PIR

S60959.

RefSeq

NP_014231.1. NM_001183006.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1NKQ	X-ray	2.20	A/B/C/D/E/F	1-259	[»]

ProteinModelPortal

P53889.

SMR

P53889. Positions 2-258.

ModBase

Search...

Protein-protein interaction databases

IntAct

P53889. 10 interactions.

MINT

MINT-2493962.

STRING

4932.YNL168C.

Proteomic databases

PaxDb

P53889.

PeptideAtlas

P53889.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblFungi

YNL168C; YNL168C; YNL168C.

GeneID

855553.

KEGG

sce:YNL168C.

Organism-specific databases

CYGD

YNL168c.

SGD

S000005112. FMP41.

Phylogenomic databases

eggNOG

COG0179.

GeneTree

ENSGT00530000063832.

HOGENOM

HOG000063753.

OMA

KDHALEL.

OrthoDB

EOG48H0CC.

Gene expression databases

Genevestigator

P53889.

GermOnline

YNL168C. Saccharomyces cerevisiae.

Family and domain databases

Gene3D

3.90.850.10. 1 hit.

InterPro

IPR002529. Fumarylacetoacetase_C.
IPR011234. Fumarylacetoacetase_C-rel.
[Graphical view]

Pfam

PF01557. FAA_hydrolase. 1 hit.
[Graphical view]

SUPFAM

SSF56529. Fumarylacetoacetase_C-rel. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

P53889.

NextBio

979631.

Entry information

Entry name

FMP41_YEAST

Accession

Primary (citable) accession number: P53889
Secondary accession number(s): D6W114

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program