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P53889

- FMP41_YEAST

UniProt

P53889 - FMP41_YEAST

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Protein

Uncharacterized mitochondrial hydrolase FMP41

Gene

FMP41

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi87 – 871Divalent metal cationBy similarity
Metal bindingi89 – 891Divalent metal cationBy similarity
Metal bindingi121 – 1211Divalent metal cationBy similarity

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Stress response

Keywords - Ligandi

Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33184-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized mitochondrial hydrolase FMP41 (EC:3.-.-.-)
Gene namesi
Name:FMP41
Ordered Locus Names:YNL168C
ORF Names:N1696
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL168c.
SGDiS000005112. FMP41.

Subcellular locationi

Mitochondrion 2 Publications

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Uncharacterized mitochondrial hydrolase FMP41PRO_0000156843Add
BLAST

Proteomic databases

MaxQBiP53889.
PaxDbiP53889.
PeptideAtlasiP53889.

Expressioni

Inductioni

In high salinity conditions.1 Publication

Gene expression databases

GenevestigatoriP53889.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
YHR080CP388001EBI-29005,EBI-24597

Protein-protein interaction databases

BioGridi35660. 8 interactions.
IntActiP53889. 10 interactions.
MINTiMINT-2493962.
STRINGi4932.YNL168C.

Structurei

Secondary structure

1
259
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 85Combined sources
Beta strandi12 – 154Combined sources
Helixi23 – 275Combined sources
Beta strandi36 – 394Combined sources
Helixi41 – 433Combined sources
Beta strandi44 – 463Combined sources
Beta strandi76 – 783Combined sources
Beta strandi84 – 863Combined sources
Beta strandi88 – 947Combined sources
Helixi106 – 1083Combined sources
Helixi110 – 1123Combined sources
Beta strandi113 – 1208Combined sources
Helixi125 – 13410Combined sources
Helixi139 – 1435Combined sources
Beta strandi148 – 1503Combined sources
Helixi156 – 1627Combined sources
Turni167 – 1693Combined sources
Beta strandi170 – 1767Combined sources
Beta strandi179 – 1857Combined sources
Helixi186 – 1883Combined sources
Beta strandi189 – 1913Combined sources
Helixi193 – 2019Combined sources
Beta strandi211 – 2133Combined sources
Beta strandi221 – 2233Combined sources
Beta strandi228 – 2358Combined sources
Beta strandi238 – 24912Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NKQX-ray2.20A/B/C/D/E/F1-259[»]
ProteinModelPortaliP53889.
SMRiP53889. Positions 2-258.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP53889.

Family & Domainsi

Sequence similaritiesi

Belongs to the FAH family.Curated

Phylogenomic databases

eggNOGiCOG0179.
GeneTreeiENSGT00530000063832.
HOGENOMiHOG000063753.
InParanoidiP53889.
OMAiELYCKIN.
OrthoDBiEOG741ZD8.

Family and domain databases

Gene3Di3.90.850.10. 1 hit.
InterProiIPR002529. Fumarylacetoacetase_C.
IPR011234. Fumarylacetoacetase_C-rel.
[Graphical view]
PfamiPF01557. FAA_hydrolase. 1 hit.
[Graphical view]
SUPFAMiSSF56529. SSF56529. 1 hit.

Sequencei

Sequence statusi: Complete.

P53889-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSYNYLKAAR KIICIGRNYA AHIKELNNST PKQPFFFLKP TSSIVTPLSS
60 70 80 90 100
SLVKTTRPAN STFNGLNEDG TNPGPIFIPR GVKVHHEIEL ALIVSKHLSN
110 120 130 140 150
VTKMKPEEVY DSISGVALAL DLTARNVQDE AKKKGLPWTI SKGFDTFMPI
160 170 180 190 200
SAIVSREKFS SYKSNLQDIF RVKCSVNGQL RQDGGTNLML HPLHKILQHI
210 220 230 240 250
STMISLEPGD IILTGTPAGV GELKPGDRVH CELLQNNDNI VDMNFECENR

PGPYEFRET
Length:259
Mass (Da):28,792
Last modified:October 1, 1996 - v1
Checksum:i6984B5BAB297CECC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92517 Genomic DNA. Translation: CAA63271.1.
Z71444 Genomic DNA. Translation: CAA96055.1.
BK006947 Genomic DNA. Translation: DAA10380.1.
PIRiS60959.
RefSeqiNP_014231.1. NM_001183006.1.

Genome annotation databases

EnsemblFungiiYNL168C; YNL168C; YNL168C.
GeneIDi855553.
KEGGisce:YNL168C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92517 Genomic DNA. Translation: CAA63271.1 .
Z71444 Genomic DNA. Translation: CAA96055.1 .
BK006947 Genomic DNA. Translation: DAA10380.1 .
PIRi S60959.
RefSeqi NP_014231.1. NM_001183006.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1NKQ X-ray 2.20 A/B/C/D/E/F 1-259 [» ]
ProteinModelPortali P53889.
SMRi P53889. Positions 2-258.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35660. 8 interactions.
IntActi P53889. 10 interactions.
MINTi MINT-2493962.
STRINGi 4932.YNL168C.

Proteomic databases

MaxQBi P53889.
PaxDbi P53889.
PeptideAtlasi P53889.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL168C ; YNL168C ; YNL168C .
GeneIDi 855553.
KEGGi sce:YNL168C.

Organism-specific databases

CYGDi YNL168c.
SGDi S000005112. FMP41.

Phylogenomic databases

eggNOGi COG0179.
GeneTreei ENSGT00530000063832.
HOGENOMi HOG000063753.
InParanoidi P53889.
OMAi ELYCKIN.
OrthoDBi EOG741ZD8.

Enzyme and pathway databases

BioCyci YEAST:G3O-33184-MONOMER.

Miscellaneous databases

EvolutionaryTracei P53889.
NextBioi 979631.
PROi P53889.

Gene expression databases

Genevestigatori P53889.

Family and domain databases

Gene3Di 3.90.850.10. 1 hit.
InterProi IPR002529. Fumarylacetoacetase_C.
IPR011234. Fumarylacetoacetase_C-rel.
[Graphical view ]
Pfami PF01557. FAA_hydrolase. 1 hit.
[Graphical view ]
SUPFAMi SSF56529. SSF56529. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of 36.8 kb from the left arm of chromosome XIV reveals 24 complete open reading frames: 18 correspond to new genes, one of which encodes a protein similar to the human myotonic dystrophy kinase."
    Nasr F., Becam A.-M., Herbert C.J.
    Yeast 12:169-175(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.
  7. "Yeast translational response to high salinity: global analysis reveals regulation at multiple levels."
    Melamed D., Pnueli L., Arava Y.
    RNA 14:1337-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Crystal structure of yeast hypothetical protein ynq8_yeast."
    New York structural genomix research consortium (NYSGXRC)
    Submitted (JAN-2005) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).

Entry informationi

Entry nameiFMP41_YEAST
AccessioniPrimary (citable) accession number: P53889
Secondary accession number(s): D6W114
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2550 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3