Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P53889

- FMP41_YEAST

UniProt

P53889 - FMP41_YEAST

Protein

Uncharacterized mitochondrial hydrolase FMP41

Gene

FMP41

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi87 – 871Divalent metal cationBy similarity
    Metal bindingi89 – 891Divalent metal cationBy similarity
    Metal bindingi121 – 1211Divalent metal cationBy similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. response to stress Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    Metal-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33184-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized mitochondrial hydrolase FMP41 (EC:3.-.-.-)
    Gene namesi
    Name:FMP41
    Ordered Locus Names:YNL168C
    ORF Names:N1696
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNL168c.
    SGDiS000005112. FMP41.

    Subcellular locationi

    Mitochondrion 2 Publications

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 259259Uncharacterized mitochondrial hydrolase FMP41PRO_0000156843Add
    BLAST

    Proteomic databases

    MaxQBiP53889.
    PaxDbiP53889.
    PeptideAtlasiP53889.

    Expressioni

    Inductioni

    In high salinity conditions.1 Publication

    Gene expression databases

    GenevestigatoriP53889.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    YHR080CP388001EBI-29005,EBI-24597

    Protein-protein interaction databases

    BioGridi35660. 7 interactions.
    IntActiP53889. 10 interactions.
    MINTiMINT-2493962.
    STRINGi4932.YNL168C.

    Structurei

    Secondary structure

    1
    259
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 85
    Beta strandi12 – 154
    Helixi23 – 275
    Beta strandi36 – 394
    Helixi41 – 433
    Beta strandi44 – 463
    Beta strandi76 – 783
    Beta strandi84 – 863
    Beta strandi88 – 947
    Helixi106 – 1083
    Helixi110 – 1123
    Beta strandi113 – 1208
    Helixi125 – 13410
    Helixi139 – 1435
    Beta strandi148 – 1503
    Helixi156 – 1627
    Turni167 – 1693
    Beta strandi170 – 1767
    Beta strandi179 – 1857
    Helixi186 – 1883
    Beta strandi189 – 1913
    Helixi193 – 2019
    Beta strandi211 – 2133
    Beta strandi221 – 2233
    Beta strandi228 – 2358
    Beta strandi238 – 24912

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1NKQX-ray2.20A/B/C/D/E/F1-259[»]
    ProteinModelPortaliP53889.
    SMRiP53889. Positions 2-258.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP53889.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FAH family.Curated

    Phylogenomic databases

    eggNOGiCOG0179.
    GeneTreeiENSGT00530000063832.
    HOGENOMiHOG000063753.
    OMAiELYCKIN.
    OrthoDBiEOG741ZD8.

    Family and domain databases

    Gene3Di3.90.850.10. 1 hit.
    InterProiIPR002529. Fumarylacetoacetase_C.
    IPR011234. Fumarylacetoacetase_C-rel.
    [Graphical view]
    PfamiPF01557. FAA_hydrolase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56529. SSF56529. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P53889-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYNYLKAAR KIICIGRNYA AHIKELNNST PKQPFFFLKP TSSIVTPLSS    50
    SLVKTTRPAN STFNGLNEDG TNPGPIFIPR GVKVHHEIEL ALIVSKHLSN 100
    VTKMKPEEVY DSISGVALAL DLTARNVQDE AKKKGLPWTI SKGFDTFMPI 150
    SAIVSREKFS SYKSNLQDIF RVKCSVNGQL RQDGGTNLML HPLHKILQHI 200
    STMISLEPGD IILTGTPAGV GELKPGDRVH CELLQNNDNI VDMNFECENR 250
    PGPYEFRET 259
    Length:259
    Mass (Da):28,792
    Last modified:October 1, 1996 - v1
    Checksum:i6984B5BAB297CECC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92517 Genomic DNA. Translation: CAA63271.1.
    Z71444 Genomic DNA. Translation: CAA96055.1.
    BK006947 Genomic DNA. Translation: DAA10380.1.
    PIRiS60959.
    RefSeqiNP_014231.1. NM_001183006.1.

    Genome annotation databases

    EnsemblFungiiYNL168C; YNL168C; YNL168C.
    GeneIDi855553.
    KEGGisce:YNL168C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92517 Genomic DNA. Translation: CAA63271.1 .
    Z71444 Genomic DNA. Translation: CAA96055.1 .
    BK006947 Genomic DNA. Translation: DAA10380.1 .
    PIRi S60959.
    RefSeqi NP_014231.1. NM_001183006.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1NKQ X-ray 2.20 A/B/C/D/E/F 1-259 [» ]
    ProteinModelPortali P53889.
    SMRi P53889. Positions 2-258.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35660. 7 interactions.
    IntActi P53889. 10 interactions.
    MINTi MINT-2493962.
    STRINGi 4932.YNL168C.

    Proteomic databases

    MaxQBi P53889.
    PaxDbi P53889.
    PeptideAtlasi P53889.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNL168C ; YNL168C ; YNL168C .
    GeneIDi 855553.
    KEGGi sce:YNL168C.

    Organism-specific databases

    CYGDi YNL168c.
    SGDi S000005112. FMP41.

    Phylogenomic databases

    eggNOGi COG0179.
    GeneTreei ENSGT00530000063832.
    HOGENOMi HOG000063753.
    OMAi ELYCKIN.
    OrthoDBi EOG741ZD8.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33184-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P53889.
    NextBioi 979631.
    PROi P53889.

    Gene expression databases

    Genevestigatori P53889.

    Family and domain databases

    Gene3Di 3.90.850.10. 1 hit.
    InterProi IPR002529. Fumarylacetoacetase_C.
    IPR011234. Fumarylacetoacetase_C-rel.
    [Graphical view ]
    Pfami PF01557. FAA_hydrolase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56529. SSF56529. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of 36.8 kb from the left arm of chromosome XIV reveals 24 complete open reading frames: 18 correspond to new genes, one of which encodes a protein similar to the human myotonic dystrophy kinase."
      Nasr F., Becam A.-M., Herbert C.J.
      Yeast 12:169-175(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Strain: ATCC 76625 / YPH499.
    7. "Yeast translational response to high salinity: global analysis reveals regulation at multiple levels."
      Melamed D., Pnueli L., Arava Y.
      RNA 14:1337-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Crystal structure of yeast hypothetical protein ynq8_yeast."
      New York structural genomix research consortium (NYSGXRC)
      Submitted (JAN-2005) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).

    Entry informationi

    Entry nameiFMP41_YEAST
    AccessioniPrimary (citable) accession number: P53889
    Secondary accession number(s): D6W114
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2550 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3