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Protein

54S ribosomal protein L22, mitochondrial

Gene

MRPL22

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-33189-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
54S ribosomal protein L22, mitochondrial
Gene namesi
Name:MRPL22
Ordered Locus Names:YNL177C
ORF Names:N1657
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL177C.
SGDiS000005121. MRPL22.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2525MitochondrionSequence analysisAdd
BLAST
Chaini26 – 30928454S ribosomal protein L22, mitochondrialPRO_0000030487Add
BLAST

Proteomic databases

MaxQBiP53881.
PeptideAtlasiP53881.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S).1 Publication

Protein-protein interaction databases

BioGridi35654. 29 interactions.
DIPiDIP-7695N.
IntActiP53881. 39 interactions.
MINTiMINT-2787576.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J6Belectron microscopy3.20O1-309[»]
ProteinModelPortaliP53881.
SMRiP53881. Positions 159-270.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L22P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000248157.
InParanoidiP53881.
OMAiKKMSTEL.
OrthoDBiEOG78M0C6.

Family and domain databases

Gene3Di3.90.470.10. 1 hit.
InterProiIPR001063. Ribosomal_L22.
IPR005727. Ribosomal_L22_bac/chlpt-type.
[Graphical view]
PANTHERiPTHR13501. PTHR13501. 1 hit.
PfamiPF00237. Ribosomal_L22. 1 hit.
[Graphical view]
SUPFAMiSSF54843. SSF54843. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53881-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFHTARISQ VGVISRALLS SVSRRWIHVT PISLNNSGGS LFGSITENKP
60 70 80 90 100
KEGKNRGDED AGSFSNRLAI ASDSSGEAPE VNRDSITIEN DKLLQQHIIS
110 120 130 140 150
LQQPEQLASQ SLLSPLKREI YEANCKINGG FYKKDTIVKL PNSSERYKLK
160 170 180 190 200
LTKREIEVLE PSVYAQSYRI KSSMKKATLL LRLLGGLDVM KAISQCHFSN
210 220 230 240 250
KKIAREVAEL LQKGVKDGQK LGLKPEDLYI SQIWTGSDGF WRKRVEFKAR
260 270 280 290 300
TRIGIISHPY IHVRCILRTK SVTKRRLAYE AHLKEQKRAP WVQLGDKPIR

GVTGGVYKW
Length:309
Mass (Da):34,897
Last modified:September 21, 2011 - v2
Checksum:i84A670D7828FF123
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1511L → F in CAA96069 (PubMed:9169873).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71453 Genomic DNA. Translation: CAA96069.1.
BK006947 Genomic DNA. Translation: DAA10374.2.
PIRiS63132.
RefSeqiNP_014222.2. NM_001183015.2.

Genome annotation databases

EnsemblFungiiYNL177C; YNL177C; YNL177C.
GeneIDi855544.
KEGGisce:YNL177C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71453 Genomic DNA. Translation: CAA96069.1.
BK006947 Genomic DNA. Translation: DAA10374.2.
PIRiS63132.
RefSeqiNP_014222.2. NM_001183015.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J6Belectron microscopy3.20O1-309[»]
ProteinModelPortaliP53881.
SMRiP53881. Positions 159-270.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35654. 29 interactions.
DIPiDIP-7695N.
IntActiP53881. 39 interactions.
MINTiMINT-2787576.

Proteomic databases

MaxQBiP53881.
PeptideAtlasiP53881.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL177C; YNL177C; YNL177C.
GeneIDi855544.
KEGGisce:YNL177C.

Organism-specific databases

EuPathDBiFungiDB:YNL177C.
SGDiS000005121. MRPL22.

Phylogenomic databases

HOGENOMiHOG000248157.
InParanoidiP53881.
OMAiKKMSTEL.
OrthoDBiEOG78M0C6.

Enzyme and pathway databases

BioCyciYEAST:G3O-33189-MONOMER.

Miscellaneous databases

NextBioi979613.
PROiP53881.

Family and domain databases

Gene3Di3.90.470.10. 1 hit.
InterProiIPR001063. Ribosomal_L22.
IPR005727. Ribosomal_L22_bac/chlpt-type.
[Graphical view]
PANTHERiPTHR13501. PTHR13501. 1 hit.
PfamiPF00237. Ribosomal_L22. 1 hit.
[Graphical view]
SUPFAMiSSF54843. SSF54843. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 151.
    Strain: ATCC 204508 / S288c.
  3. "Tag-mediated isolation of yeast mitochondrial ribosome and mass spectrometric identification of its new components."
    Gan X., Kitakawa M., Yoshino K., Oshiro N., Yonezawa K., Isono K.
    Eur. J. Biochem. 269:5203-5214(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE MITOCHONDRIAL RIBOSOMAL LARGE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.

Entry informationi

Entry nameiRM22_YEAST
AccessioniPrimary (citable) accession number: P53881
Secondary accession number(s): D6W108
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 21, 2011
Last modified: May 11, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1800 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.