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P53877

- IPI3_YEAST

UniProt

P53877 - IPI3_YEAST

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Protein

Pre-rRNA-processing protein IPI3

Gene

IPI3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.2 Publications

GO - Molecular functioni

  1. chromatin binding Source: SGD

GO - Biological processi

  1. pre-replicative complex assembly involved in nuclear cell cycle DNA replication Source: SGD
  2. regulation of DNA-dependent DNA replication initiation Source: SGD
  3. ribosomal large subunit assembly Source: SGD
  4. rRNA processing Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-33193-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-rRNA-processing protein IPI3
Alternative name(s):
Involved in processing IST2 protein 3
Gene namesi
Name:IPI3
Ordered Locus Names:YNL182C
ORF Names:N1636
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL182c.
SGDiS000005126. IPI3.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nuclear pre-replicative complex Source: SGD
  2. nucleoplasm Source: SGD
  3. Rix1 complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Pre-rRNA-processing protein IPI3PRO_0000051484Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei388 – 3881Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53877.
PaxDbiP53877.
PeptideAtlasiP53877.

Expressioni

Gene expression databases

GenevestigatoriP53877.

Interactioni

Subunit structurei

Component of the RIX1 complex, composed of at least IPI1, IPI3 and RIX1. The complex interacts with MDN1 and the pre-60S ribosome particles.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RIX1P388837EBI-29063,EBI-24899

Protein-protein interaction databases

BioGridi35650. 57 interactions.
DIPiDIP-4297N.
IntActiP53877. 20 interactions.
MINTiMINT-529654.
STRINGi4932.YNL182C.

Structurei

3D structure databases

ProteinModelPortaliP53877.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati90 – 13344WD 1Add
BLAST
Repeati137 – 17640WD 2Add
BLAST
Repeati187 – 23448WD 3Add
BLAST
Repeati342 – 38342WD 4Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat IPI3 family.Curated
Contains 4 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
HOGENOMiHOG000113091.
InParanoidiP53877.
KOiK14829.
OMAiDEQVIFT.
OrthoDBiEOG7SFJ5S.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53877-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDEQVIFTTN TSGTIASVHS FEQINLRQCS TQSRNSCVQV GNKYLFIAQA
60 70 80 90 100
QKALINVYNL SGSFKRESVE QRLPLPEILK CLEVVENDGV QYDRIQGVNH
110 120 130 140 150
NLPDFNLPYL LLGSTESGKL YIWELNSGIL LNVKPMAHYQ SITKIKSILN
160 170 180 190 200
GKYIITSGND SRVIIWQTVD LVSASNDDPK PLCILHDHTL PVTDFQVSSS
210 220 230 240 250
QGKFLSCTDT KLFTVSQDAT IRCYDLSLIG SKKKQKANEN DVSIGKTPVL
260 270 280 290 300
LATFTTPYSI KSIVLDPADR ACYIGTAEGC FSLNLFYKLK GNAIVNLLQS
310 320 330 340 350
AGVNTVQKGR VFSLVQRNSL TGGENEDLDA LYAMGQLVCE NVLNSNVSCL
360 370 380 390 400
EISMDGTLLL IGDTEGKVSI AEIYSKQIIR TIQTLTTSQD SVGEVTNLLT
410 420 430 440 450
NPYRLERGNL LFEGESKGKQ PSNNNGHNFM KIPNLQRVIF DGKNKGHLHD
460 470 480 490 500
IWYQIGEPEA ETDPNLALPL NDFNAYLEQV KTQESIFSHI GKVSSNVKVI
510 520 530 540 550
DNKIDATSSL DSNAAKDEEI TELKTNIEAL THAYKELRDM HEKLYEEHQQ

MLDKQ
Length:555
Mass (Da):61,773
Last modified:October 1, 1996 - v1
Checksum:i8EED6854DF9405A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71458 Genomic DNA. Translation: CAA96075.1.
BK006947 Genomic DNA. Translation: DAA10370.1.
PIRiS63137.
RefSeqiNP_014217.1. NM_001183020.1.

Genome annotation databases

EnsemblFungiiYNL182C; YNL182C; YNL182C.
GeneIDi855539.
KEGGisce:YNL182C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71458 Genomic DNA. Translation: CAA96075.1 .
BK006947 Genomic DNA. Translation: DAA10370.1 .
PIRi S63137.
RefSeqi NP_014217.1. NM_001183020.1.

3D structure databases

ProteinModelPortali P53877.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35650. 57 interactions.
DIPi DIP-4297N.
IntActi P53877. 20 interactions.
MINTi MINT-529654.
STRINGi 4932.YNL182C.

Proteomic databases

MaxQBi P53877.
PaxDbi P53877.
PeptideAtlasi P53877.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL182C ; YNL182C ; YNL182C .
GeneIDi 855539.
KEGGi sce:YNL182C.

Organism-specific databases

CYGDi YNL182c.
SGDi S000005126. IPI3.

Phylogenomic databases

eggNOGi COG2319.
HOGENOMi HOG000113091.
InParanoidi P53877.
KOi K14829.
OMAi DEQVIFT.
OrthoDBi EOG7SFJ5S.

Enzyme and pathway databases

BioCyci YEAST:G3O-33193-MONOMER.

Miscellaneous databases

NextBioi 979601.

Gene expression databases

Genevestigatori P53877.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 2 hits.
[Graphical view ]
SMARTi SM00320. WD40. 3 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 2 hits.
PROSITEi PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: IDENTIFICATION IN THE RIX1 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  4. "Rea1, a dynein-related nuclear AAA-ATPase, is involved in late rRNA processing and nuclear export of 60 S subunits."
    Galani K., Nissan T.A., Petfalski E., Tollervey D., Hurt E.
    J. Biol. Chem. 279:55411-55418(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RIX1 COMPLEX, SUBCELLULAR LOCATION, FUNCTION OF THE RIX1 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  5. Cited for: IDENTIFICATION IN THE RIX1 COMPLEX, FUNCTION OF THE RIX1 COMPLEX.
  6. "A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits."
    Nissan T.A., Galani K., Maco B., Tollervey D., Aebi U., Hurt E.
    Mol. Cell 15:295-301(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RIX1 COMPLEX, INTERACTION WITH MDN1 AND PRE-60S RIBOSOMAL PARTICLES, IDENTIFICATION BY MASS SPECTROMETRY.
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-388, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiIPI3_YEAST
AccessioniPrimary (citable) accession number: P53877
Secondary accession number(s): D6W104
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3