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Protein

Pre-rRNA-processing protein IPI3

Gene

IPI3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.2 Publications

GO - Molecular functioni

  • chromatin binding Source: SGD

GO - Biological processi

  • pre-replicative complex assembly involved in nuclear cell cycle DNA replication Source: SGD
  • regulation of DNA-dependent DNA replication initiation Source: SGD
  • ribosomal large subunit assembly Source: SGD
  • rRNA processing Source: SGD

Keywordsi

Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-33193-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-rRNA-processing protein IPI3
Alternative name(s):
Involved in processing IST2 protein 3
Gene namesi
Name:IPI3
Ordered Locus Names:YNL182C
ORF Names:N1636
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL182C
SGDiS000005126 IPI3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000514841 – 555Pre-rRNA-processing protein IPI3Add BLAST555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei388PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53877
PaxDbiP53877
PRIDEiP53877

PTM databases

iPTMnetiP53877

Interactioni

Subunit structurei

Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35650, 102 interactors
DIPiDIP-4297N
IntActiP53877, 41 interactors
MINTiP53877
STRINGi4932.YNL182C

Structurei

3D structure databases

ProteinModelPortaliP53877
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati29 – 68WD 1Sequence analysisAdd BLAST40
Repeati90 – 133WD 2Sequence analysisAdd BLAST44
Repeati137 – 176WD 3Sequence analysisAdd BLAST40
Repeati187 – 234WD 4Sequence analysisAdd BLAST48
Repeati255 – 296WD 5Sequence analysisAdd BLAST42
Repeati342 – 383WD 6Sequence analysisAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni460 – 504Interaction with RIX11 PublicationAdd BLAST45

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili513 – 554Sequence analysisAdd BLAST42

Domaini

The coiled-coil motif forms a homodimeric contact and facilitates RIX1 complex oligomerization.1 Publication

Sequence similaritiesi

Belongs to the WD repeat IPI3/WDR18 family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000113091
InParanoidiP53877
KOiK14829
OMAiMDEQVIF
OrthoDBiEOG092C3983

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

P53877-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEQVIFTTN TSGTIASVHS FEQINLRQCS TQSRNSCVQV GNKYLFIAQA
60 70 80 90 100
QKALINVYNL SGSFKRESVE QRLPLPEILK CLEVVENDGV QYDRIQGVNH
110 120 130 140 150
NLPDFNLPYL LLGSTESGKL YIWELNSGIL LNVKPMAHYQ SITKIKSILN
160 170 180 190 200
GKYIITSGND SRVIIWQTVD LVSASNDDPK PLCILHDHTL PVTDFQVSSS
210 220 230 240 250
QGKFLSCTDT KLFTVSQDAT IRCYDLSLIG SKKKQKANEN DVSIGKTPVL
260 270 280 290 300
LATFTTPYSI KSIVLDPADR ACYIGTAEGC FSLNLFYKLK GNAIVNLLQS
310 320 330 340 350
AGVNTVQKGR VFSLVQRNSL TGGENEDLDA LYAMGQLVCE NVLNSNVSCL
360 370 380 390 400
EISMDGTLLL IGDTEGKVSI AEIYSKQIIR TIQTLTTSQD SVGEVTNLLT
410 420 430 440 450
NPYRLERGNL LFEGESKGKQ PSNNNGHNFM KIPNLQRVIF DGKNKGHLHD
460 470 480 490 500
IWYQIGEPEA ETDPNLALPL NDFNAYLEQV KTQESIFSHI GKVSSNVKVI
510 520 530 540 550
DNKIDATSSL DSNAAKDEEI TELKTNIEAL THAYKELRDM HEKLYEEHQQ

MLDKQ
Length:555
Mass (Da):61,773
Last modified:October 1, 1996 - v1
Checksum:i8EED6854DF9405A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71458 Genomic DNA Translation: CAA96075.1
BK006947 Genomic DNA Translation: DAA10370.1
PIRiS63137
RefSeqiNP_014217.1, NM_001183020.1

Genome annotation databases

EnsemblFungiiYNL182C; YNL182C; YNL182C
GeneIDi855539
KEGGisce:YNL182C

Similar proteinsi

Entry informationi

Entry nameiIPI3_YEAST
AccessioniPrimary (citable) accession number: P53877
Secondary accession number(s): D6W104
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health