MRPL19

Functionⁱ

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.2 Publications

Miscellaneous

Present with 3200 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functionⁱ

rRNA binding Source: GO_Central
structural constituent of ribosome
Source: SGD
Inferred from direct assayⁱ
- 9151978

Complete GO annotation...

GO - Biological processⁱ

mitochondrial translation
Source: SGD
Inferred by curatorⁱ
- 9151978
ribosomal large subunit assembly Source: GO_Central
translation Source: GO_Central

Complete GO annotation...

Keywordsⁱ

Molecular function	Ribonucleoprotein, Ribosomal protein

Molecular function

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-33196-MONOMER.

BioCycⁱ

YEAST:G3O-33196-MONOMER.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 54S ribosomal protein L19, mitochondrial Alternative name(s): Mitochondrial large ribosomal subunit protein uL11m1 Publication YmL19
Gene namesⁱ	Name:MRPL19 Ordered Locus Names:YNL185C ORF Names:N1623
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome XIV

Organism-specific databases

EuPathDBⁱ	FungiDB:YNL185C.
Saccharomyces Genome Database More...SGDⁱ	S000005129. MRPL19.

Subcellular locationⁱ

Mitochondrion
2 Publications
Manual assertion based on experiment inⁱ
- Ref.4
  "Global analysis of protein localization in budding yeast."
  Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
  Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
- Ref.6
  "The proteome of Saccharomyces cerevisiae mitochondria."
  Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E., Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P., Pfanner N., Meisinger C.
  Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Note:

Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.1 Publication

GO - Cellular componentⁱ

mitochondrial large ribosomal subunit
Source: SGD
Inferred from direct assayⁱ
- 9151978

Complete GO annotation...

Keywords - Cellular componentⁱ

Mitochondrion

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 73	Mitochondrion1 PublicationAdd BLAST		73
ChainⁱPRO_0000030447	74 – 158	54S ribosomal protein L19, mitochondrialAdd BLAST		85

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P53875.
PRIDEⁱ	P53875.

Interactionⁱ

Subunit structureⁱ

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:9151978). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins (PubMed:24675956).1 Publication1 Publication

Protein-protein interaction databases

BioGridⁱ	35648. 156 interactors.
Database of interacting proteins More...DIPⁱ	DIP-6781N.
IntActⁱ	P53875. 10 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-613200.
STRINGⁱ	4932.YNL185C.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P53875.
SMRⁱ	P53875.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the universal ribosomal protein uL11 family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003153.
HOGENOMⁱ	HOG000082123.
InParanoidⁱ	P53875.
KEGG Orthology (KO) More...KOⁱ	K02867.
OMAⁱ	CKQFNAK.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C5GX4.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00349. Ribosomal_L11. 1 hit.
Gene3Dⁱ	1.10.10.250. 1 hit. 3.30.1550.10. 1 hit.
HAMAPⁱ	MF_00736. Ribosomal_L11. 1 hit.
InterProⁱ	View protein in InterPro IPR000911. Ribosomal_L11/L12. IPR006519. Ribosomal_L11_bac-typ. IPR020783. Ribosomal_L11_C. IPR020784. Ribosomal_L11_N.
PANTHERⁱ	PTHR11661. PTHR11661. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00298. Ribosomal_L11. 1 hit. PF03946. Ribosomal_L11_N. 1 hit.
SMARTⁱ	View protein in SMART SM00649. RL11. 1 hit.
SUPFAMⁱ	SSF46906. SSF46906. 1 hit. SSF54747. SSF54747. 1 hit.
TIGRFAMsⁱ	TIGR01632. L11_bact. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P53875-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSQAAKNVIV KLIVGAGQAA PSPPVGPALG SKGIKAIDFC KEFNARSANY 
        60         70         80         90        100
QPGVPVPVLI TIKPDRTFTF EMKSPPTGYL LLKALKMDKG HGQPNVGTML 
       110        120        130        140        150
GSAPAKGPTR ALGELSLKHV YEIAKIKKSD ERHSLLEMEG IVKSIVGVAK 

SMGIKVVP

Length:158

Mass (Da):16,670

Last modified:October 1, 1996 - v1

Checksum:ⁱA47715F1FC547685

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z71461 Genomic DNA. Translation: CAA96078.1. BK006947 Genomic DNA. Translation: DAA10368.1.
PIRⁱ	S63140.
NCBI Reference Sequences More...RefSeqⁱ	NP_014214.1. NM_001183023.1.

Genome annotation databases

EnsemblFungiⁱ	YNL185C; YNL185C; YNL185C.
GeneIDⁱ	855536.
KEGGⁱ	sce:YNL185C.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z71461 Genomic DNA. Translation: CAA96078.1. BK006947 Genomic DNA. Translation: DAA10368.1.
PIRⁱ	S63140.
NCBI Reference Sequences More...RefSeqⁱ	NP_014214.1. NM_001183023.1.

3D structure databases

ProteinModelPortalⁱ	P53875.
SMRⁱ	P53875.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	35648. 156 interactors.
Database of interacting proteins More...DIPⁱ	DIP-6781N.
IntActⁱ	P53875. 10 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-613200.
STRINGⁱ	4932.YNL185C.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P53875.
PRIDEⁱ	P53875.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YNL185C; YNL185C; YNL185C.
GeneIDⁱ	855536.
KEGGⁱ	sce:YNL185C.

Organism-specific databases

EuPathDBⁱ	FungiDB:YNL185C.
Saccharomyces Genome Database More...SGDⁱ	S000005129. MRPL19.

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003153.
HOGENOMⁱ	HOG000082123.
InParanoidⁱ	P53875.
KEGG Orthology (KO) More...KOⁱ	K02867.
OMAⁱ	CKQFNAK.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C5GX4.

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-33196-MONOMER.

BioCycⁱ

YEAST:G3O-33196-MONOMER.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P53875.

PROⁱ

PR:P53875.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00349. Ribosomal_L11. 1 hit.
Gene3Dⁱ	1.10.10.250. 1 hit. 3.30.1550.10. 1 hit.
HAMAPⁱ	MF_00736. Ribosomal_L11. 1 hit.
InterProⁱ	View protein in InterPro IPR000911. Ribosomal_L11/L12. IPR006519. Ribosomal_L11_bac-typ. IPR020783. Ribosomal_L11_C. IPR020784. Ribosomal_L11_N.
PANTHERⁱ	PTHR11661. PTHR11661. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00298. Ribosomal_L11. 1 hit. PF03946. Ribosomal_L11_N. 1 hit.
SMARTⁱ	View protein in SMART SM00649. RL11. 1 hit.
SUPFAMⁱ	SSF46906. SSF46906. 1 hit. SSF54747. SSF54747. 1 hit.
TIGRFAMsⁱ	TIGR01632. L11_bact. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RM19_YEAST
Accessionⁱ	P53875Primary (citable) accession number: P53875 Secondary accession number(s): D6W102
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	July 5, 2017
	This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Ribosomal proteins
Ribosomal proteins families and list of entries
SIMILARITY comments
Index of protein domains and families
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome XIV
Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P53875 (RM19_YEAST)

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54S ribosomal protein L19, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ