UniProtKB - P53875 (RM19_YEAST)
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Protein
54S ribosomal protein L19, mitochondrial
Gene
MRPL19
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.2 Publications
Miscellaneous
Present with 3200 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- rRNA binding Source: GO_Central
- structural constituent of ribosome Source: SGD
GO - Biological processi
- mitochondrial translation Source: SGD
- ribosomal large subunit assembly Source: GO_Central
- translation Source: GO_Central
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
BioCyci | YEAST:G3O-33196-MONOMER. |
Names & Taxonomyi
Protein namesi | Recommended name: 54S ribosomal protein L19, mitochondrialAlternative name(s): Mitochondrial large ribosomal subunit protein uL11m1 Publication YmL19 |
Gene namesi | Name:MRPL19 Ordered Locus Names:YNL185C ORF Names:N1623 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YNL185C. |
SGDi | S000005129. MRPL19. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 73 | Mitochondrion1 PublicationAdd BLAST | 73 | |
ChainiPRO_0000030447 | 74 – 158 | 54S ribosomal protein L19, mitochondrialAdd BLAST | 85 |
Proteomic databases
MaxQBi | P53875. |
PaxDbi | P53875. |
PRIDEi | P53875. |
Interactioni
Subunit structurei
Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:9151978). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins (PubMed:24675956).1 Publication1 Publication
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
MRPL37 | P36532 | 2 | EBI-15532,EBI-15586 |
Protein-protein interaction databases
BioGridi | 35648. 158 interactors. |
DIPi | DIP-6781N. |
IntActi | P53875. 11 interactors. |
MINTi | P53875. |
STRINGi | 4932.YNL185C. |
Family & Domainsi
Sequence similaritiesi
Belongs to the universal ribosomal protein uL11 family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
GeneTreei | ENSGT00390000003153. |
HOGENOMi | HOG000082123. |
InParanoidi | P53875. |
KOi | K02867. |
OMAi | CKQFNAK. |
OrthoDBi | EOG092C5GX4. |
Family and domain databases
CDDi | cd00349. Ribosomal_L11. 1 hit. |
Gene3Di | 1.10.10.250. 1 hit. 3.30.1550.10. 1 hit. |
HAMAPi | MF_00736. Ribosomal_L11. 1 hit. |
InterProi | View protein in InterPro IPR000911. Ribosomal_L11/L12. IPR036796. Ribosomal_L11/L12_N_sf. IPR006519. Ribosomal_L11_bac-typ. IPR020783. Ribosomal_L11_C. IPR036769. Ribosomal_L11_C_sf. IPR020784. Ribosomal_L11_N. |
PANTHERi | PTHR11661. PTHR11661. 1 hit. |
Pfami | View protein in Pfam PF00298. Ribosomal_L11. 1 hit. PF03946. Ribosomal_L11_N. 1 hit. |
SMARTi | View protein in SMART SM00649. RL11. 1 hit. |
SUPFAMi | SSF46906. SSF46906. 1 hit. SSF54747. SSF54747. 1 hit. |
TIGRFAMsi | TIGR01632. L11_bact. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P53875-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQAAKNVIV KLIVGAGQAA PSPPVGPALG SKGIKAIDFC KEFNARSANY
60 70 80 90 100
QPGVPVPVLI TIKPDRTFTF EMKSPPTGYL LLKALKMDKG HGQPNVGTML
110 120 130 140 150
GSAPAKGPTR ALGELSLKHV YEIAKIKKSD ERHSLLEMEG IVKSIVGVAK
SMGIKVVP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z71461 Genomic DNA. Translation: CAA96078.1. BK006947 Genomic DNA. Translation: DAA10368.1. |
PIRi | S63140. |
RefSeqi | NP_014214.1. NM_001183023.1. |
Genome annotation databases
EnsemblFungii | YNL185C; YNL185C; YNL185C. |
GeneIDi | 855536. |
KEGGi | sce:YNL185C. |
Similar proteinsi
Entry informationi
Entry namei | RM19_YEAST | |
Accessioni | P53875Primary (citable) accession number: P53875 Secondary accession number(s): D6W102 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | March 28, 2018 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |