Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

54S ribosomal protein L19, mitochondrial

Gene

MRPL19

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.2 Publications

Miscellaneous

Present with 3200 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • rRNA binding Source: GO_Central
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial translation Source: SGD
  • ribosomal large subunit assembly Source: GO_Central
  • translation Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-33196-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
54S ribosomal protein L19, mitochondrial
Alternative name(s):
Mitochondrial large ribosomal subunit protein uL11m1 Publication
YmL19
Gene namesi
Name:MRPL19
Ordered Locus Names:YNL185C
ORF Names:N1623
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL185C
SGDiS000005129 MRPL19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 73Mitochondrion1 PublicationAdd BLAST73
ChainiPRO_000003044774 – 15854S ribosomal protein L19, mitochondrialAdd BLAST85

Proteomic databases

MaxQBiP53875
PaxDbiP53875
PRIDEiP53875

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:9151978). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins (PubMed:24675956).1 Publication1 Publication

Protein-protein interaction databases

BioGridi35648, 158 interactors
ComplexPortaliCPX-1602 54S mitochondrial large ribosomal subunit
DIPiDIP-6781N
IntActiP53875, 10 interactors
MINTiP53875
STRINGi4932.YNL185C

Structurei

3D structure databases

ProteinModelPortaliP53875
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000003153
HOGENOMiHOG000082123
InParanoidiP53875
KOiK02867
OMAiCKQFNAK
OrthoDBiEOG092C5GX4

Family and domain databases

CDDicd00349 Ribosomal_L11, 1 hit
Gene3Di1.10.10.250, 1 hit
3.30.1550.10, 1 hit
HAMAPiMF_00736 Ribosomal_L11, 1 hit
InterProiView protein in InterPro
IPR000911 Ribosomal_L11/L12
IPR036796 Ribosomal_L11/L12_N_sf
IPR006519 Ribosomal_L11_bac-typ
IPR020783 Ribosomal_L11_C
IPR036769 Ribosomal_L11_C_sf
IPR020784 Ribosomal_L11_N
PANTHERiPTHR11661 PTHR11661, 1 hit
PfamiView protein in Pfam
PF00298 Ribosomal_L11, 1 hit
PF03946 Ribosomal_L11_N, 1 hit
SMARTiView protein in SMART
SM00649 RL11, 1 hit
SUPFAMiSSF46906 SSF46906, 1 hit
SSF54747 SSF54747, 1 hit
TIGRFAMsiTIGR01632 L11_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53875-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQAAKNVIV KLIVGAGQAA PSPPVGPALG SKGIKAIDFC KEFNARSANY
60 70 80 90 100
QPGVPVPVLI TIKPDRTFTF EMKSPPTGYL LLKALKMDKG HGQPNVGTML
110 120 130 140 150
GSAPAKGPTR ALGELSLKHV YEIAKIKKSD ERHSLLEMEG IVKSIVGVAK

SMGIKVVP
Length:158
Mass (Da):16,670
Last modified:October 1, 1996 - v1
Checksum:iA47715F1FC547685
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71461 Genomic DNA Translation: CAA96078.1
BK006947 Genomic DNA Translation: DAA10368.1
PIRiS63140
RefSeqiNP_014214.1, NM_001183023.1

Genome annotation databases

EnsemblFungiiYNL185C; YNL185C; YNL185C
GeneIDi855536
KEGGisce:YNL185C

Similar proteinsi

Entry informationi

Entry nameiRM19_YEAST
AccessioniPrimary (citable) accession number: P53875
Secondary accession number(s): D6W102
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health