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Protein

54S ribosomal protein L19, mitochondrial

Gene

MRPL19

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.2 Publications

Miscellaneous

Present with 3200 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • rRNA binding Source: GO_Central
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial translation Source: SGD
  • ribosomal large subunit assembly Source: GO_Central
  • translation Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-33196-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
54S ribosomal protein L19, mitochondrial
Alternative name(s):
Mitochondrial large ribosomal subunit protein uL11m1 Publication
YmL19
Gene namesi
Name:MRPL19
Ordered Locus Names:YNL185C
ORF Names:N1623
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL185C.
SGDiS000005129. MRPL19.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 73Mitochondrion1 PublicationAdd BLAST73
ChainiPRO_000003044774 – 15854S ribosomal protein L19, mitochondrialAdd BLAST85

Proteomic databases

MaxQBiP53875.
PRIDEiP53875.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:9151978). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins (PubMed:24675956).1 Publication1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MRPL37P365322EBI-15532,EBI-15586

Protein-protein interaction databases

BioGridi35648. 156 interactors.
DIPiDIP-6781N.
IntActiP53875. 11 interactors.
MINTiMINT-613200.
STRINGi4932.YNL185C.

Structurei

3D structure databases

ProteinModelPortaliP53875.
SMRiP53875.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000003153.
HOGENOMiHOG000082123.
InParanoidiP53875.
KOiK02867.
OMAiCKQFNAK.
OrthoDBiEOG092C5GX4.

Family and domain databases

CDDicd00349. Ribosomal_L11. 1 hit.
Gene3Di1.10.10.250. 1 hit.
3.30.1550.10. 1 hit.
HAMAPiMF_00736. Ribosomal_L11. 1 hit.
InterProiView protein in InterPro
IPR000911. Ribosomal_L11/L12.
IPR006519. Ribosomal_L11_bac-typ.
IPR020783. Ribosomal_L11_C.
IPR020784. Ribosomal_L11_N.
PANTHERiPTHR11661. PTHR11661. 1 hit.
PfamiView protein in Pfam
PF00298. Ribosomal_L11. 1 hit.
PF03946. Ribosomal_L11_N. 1 hit.
SMARTiView protein in SMART
SM00649. RL11. 1 hit.
SUPFAMiSSF46906. SSF46906. 1 hit.
SSF54747. SSF54747. 1 hit.
TIGRFAMsiTIGR01632. L11_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53875-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQAAKNVIV KLIVGAGQAA PSPPVGPALG SKGIKAIDFC KEFNARSANY
60 70 80 90 100
QPGVPVPVLI TIKPDRTFTF EMKSPPTGYL LLKALKMDKG HGQPNVGTML
110 120 130 140 150
GSAPAKGPTR ALGELSLKHV YEIAKIKKSD ERHSLLEMEG IVKSIVGVAK

SMGIKVVP
Length:158
Mass (Da):16,670
Last modified:October 1, 1996 - v1
Checksum:iA47715F1FC547685
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71461 Genomic DNA. Translation: CAA96078.1.
BK006947 Genomic DNA. Translation: DAA10368.1.
PIRiS63140.
RefSeqiNP_014214.1. NM_001183023.1.

Genome annotation databases

EnsemblFungiiYNL185C; YNL185C; YNL185C.
GeneIDi855536.
KEGGisce:YNL185C.

Similar proteinsi

Entry informationi

Entry nameiRM19_YEAST
AccessioniPrimary (citable) accession number: P53875
Secondary accession number(s): D6W102
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 27, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names