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P53873

- SWT21_YEAST

UniProt

P53873 - SWT21_YEAST

Protein

Protein SWT21

Gene

SWT21

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Involved in mRNA splicing. Helps to stabilize the U1 snRNP-5' splice site interaction.1 Publication

    GO - Biological processi

    1. mRNA splicing, via spliceosome Source: SGD

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33198-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein SWT21
    Alternative name(s):
    Synthetic With TGS1 protein 21
    Gene namesi
    Name:SWT21
    Ordered Locus Names:YNL187W
    ORF Names:N1615
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNL187w.
    SGDiS000005131. SWT21.

    Subcellular locationi

    Nucleus 2 Publications

    GO - Cellular componenti

    1. nucleus Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 357357Protein SWT21PRO_0000203403Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP53873.

    Interactioni

    Subunit structurei

    Associates with snRNPs.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LSM1P470171EBI-29071,EBI-174

    Protein-protein interaction databases

    BioGridi35646. 16 interactions.
    DIPiDIP-971N.
    IntActiP53873. 2 interactions.
    MINTiMINT-483287.
    STRINGi4932.YNL187W.

    Structurei

    3D structure databases

    ProteinModelPortaliP53873.
    SMRiP53873. Positions 8-35.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SWT21 family.Curated

    Phylogenomic databases

    eggNOGiNOG42241.
    OMAiFGIRQYL.
    OrthoDBiEOG7MKWJ5.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    2.140.10.10. 1 hit.
    InterProiIPR027295. Quinonprotein_ADH-like_fam.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P53873-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKKVICQDI FWSCDGTSFV SVHNDFGIRQ YLVPEESNTD KLNRNLLLPF    50
    TRFFRNQSIV SCAIDPFYTL YNENSDRLAG DRIVVGGKNF PLQLYSLMDG 100
    QCILSYDTMN KINGEYETVY SVKIDVESRV YTGSCRNKVA IYDKSRRDAV 150
    WMNQSTKKAS KGRQSIISCF EEQPMGGQAL SRGSLLCGSY ANEMFQVDCR 200
    HQRLERLNYT RTVAGGIVQI LTSDNGRYVY VVRRNSDAIS IYDRRNLQHE 250
    LNVLRLPFRI HHNSAKLKAY IDTAYGLSMG TPQGTILNWG RDLVEFGGVP 300
    SHNSVEDPLI TSIPPESEWR TNLDSTIPAT VVKNCPGDPE LFALSHGGTI 350
    SLCRFGG 357
    Length:357
    Mass (Da):40,308
    Last modified:October 1, 1996 - v1
    Checksum:iED52B00C4902453A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71463 Genomic DNA. Translation: CAA96081.1.
    BK006947 Genomic DNA. Translation: DAA10366.1.
    PIRiS63142.
    RefSeqiNP_014212.1. NM_001183025.1.

    Genome annotation databases

    EnsemblFungiiYNL187W; YNL187W; YNL187W.
    GeneIDi855534.
    KEGGisce:YNL187W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71463 Genomic DNA. Translation: CAA96081.1 .
    BK006947 Genomic DNA. Translation: DAA10366.1 .
    PIRi S63142.
    RefSeqi NP_014212.1. NM_001183025.1.

    3D structure databases

    ProteinModelPortali P53873.
    SMRi P53873. Positions 8-35.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35646. 16 interactions.
    DIPi DIP-971N.
    IntActi P53873. 2 interactions.
    MINTi MINT-483287.
    STRINGi 4932.YNL187W.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNL187W ; YNL187W ; YNL187W .
    GeneIDi 855534.
    KEGGi sce:YNL187W.

    Organism-specific databases

    CYGDi YNL187w.
    SGDi S000005131. SWT21.

    Phylogenomic databases

    eggNOGi NOG42241.
    OMAi FGIRQYL.
    OrthoDBi EOG7MKWJ5.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33198-MONOMER.

    Miscellaneous databases

    NextBioi 979589.

    Gene expression databases

    Genevestigatori P53873.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    2.140.10.10. 1 hit.
    InterProi IPR027295. Quinonprotein_ADH-like_fam.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "The yeast splicing factor Prp40p contains functional leucine-rich nuclear export signals that are essential for splicing."
      Murphy M.W., Olson B.L., Siliciano P.G.
      Genetics 166:53-65(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    4. "A targeted bypass screen identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for stable U1 snRNP/Pre-mRNA interaction."
      Hage R., Tung L., Du H., Stands L., Rosbash M., Chang T.H.
      Mol. Cell. Biol. 29:3941-3952(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, ASSOCIATION WITH SNRNPS.

    Entry informationi

    Entry nameiSWT21_YEAST
    AccessioniPrimary (citable) accession number: P53873
    Secondary accession number(s): D6W100
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3