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P53873 (SWT21_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein SWT21
Alternative name(s):
Synthetic With TGS1 protein 21
Gene names
Name:SWT21
Ordered Locus Names:YNL187W
ORF Names:N1615
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in mRNA splicing. Helps to stabilize the U1 snRNP-5' splice site interaction. Ref.4

Subunit structure

Associates with snRNPs.

Subcellular location

Nucleus Ref.3 Ref.4.

Sequence similarities

Belongs to the SWT21 family.

Ontologies

Keywords
   Biological processmRNA processing
mRNA splicing
   Cellular componentNucleus
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmRNA splicing, via spliceosome

Inferred from mutant phenotype Ref.4. Source: SGD

   Cellular_componentnucleus

Inferred from direct assay Ref.4. Source: SGD

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

LSM1P470171EBI-29071,EBI-174

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 357357Protein SWT21
PRO_0000203403

Sequences

Sequence LengthMass (Da)Tools
P53873 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: ED52B00C4902453A

FASTA35740,308
        10         20         30         40         50         60 
MEKKVICQDI FWSCDGTSFV SVHNDFGIRQ YLVPEESNTD KLNRNLLLPF TRFFRNQSIV 

        70         80         90        100        110        120 
SCAIDPFYTL YNENSDRLAG DRIVVGGKNF PLQLYSLMDG QCILSYDTMN KINGEYETVY 

       130        140        150        160        170        180 
SVKIDVESRV YTGSCRNKVA IYDKSRRDAV WMNQSTKKAS KGRQSIISCF EEQPMGGQAL 

       190        200        210        220        230        240 
SRGSLLCGSY ANEMFQVDCR HQRLERLNYT RTVAGGIVQI LTSDNGRYVY VVRRNSDAIS 

       250        260        270        280        290        300 
IYDRRNLQHE LNVLRLPFRI HHNSAKLKAY IDTAYGLSMG TPQGTILNWG RDLVEFGGVP 

       310        320        330        340        350 
SHNSVEDPLI TSIPPESEWR TNLDSTIPAT VVKNCPGDPE LFALSHGGTI SLCRFGG 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"The yeast splicing factor Prp40p contains functional leucine-rich nuclear export signals that are essential for splicing."
Murphy M.W., Olson B.L., Siliciano P.G.
Genetics 166:53-65(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[4]"A targeted bypass screen identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for stable U1 snRNP/Pre-mRNA interaction."
Hage R., Tung L., Du H., Stands L., Rosbash M., Chang T.H.
Mol. Cell. Biol. 29:3941-3952(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, ASSOCIATION WITH SNRNPS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z71463 Genomic DNA. Translation: CAA96081.1.
BK006947 Genomic DNA. Translation: DAA10366.1.
PIRS63142.
RefSeqNP_014212.1. NM_001183025.1.

3D structure databases

ProteinModelPortalP53873.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35646. 16 interactions.
DIPDIP-971N.
IntActP53873. 2 interactions.
MINTMINT-483287.
STRING4932.YNL187W.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYNL187W; YNL187W; YNL187W.
GeneID855534.
KEGGsce:YNL187W.

Organism-specific databases

CYGDYNL187w.
SGDS000005131. SWT21.

Phylogenomic databases

eggNOGNOG42241.
OMAFGIRQYL.
OrthoDBEOG7MKWJ5.

Enzyme and pathway databases

BioCycYEAST:G3O-33198-MONOMER.

Gene expression databases

GenevestigatorP53873.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
2.140.10.10. 1 hit.
InterProIPR027295. Quinonprotein_ADH-like_fam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
ProtoNetSearch...

Other

NextBio979589.

Entry information

Entry nameSWT21_YEAST
AccessionPrimary (citable) accession number: P53873
Secondary accession number(s): D6W100
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families