P53873 (SWT21_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein SWT21

Alternative name(s):
Synthetic With TGS1 protein 21

Gene names

Name:	SWT21
Ordered Locus Names:	YNL187W
ORF Names:	N1615

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in mRNA splicing. Helps to stabilize the U1 snRNP-5' splice site interaction. Ref.4
Subunit structure	Associates with snRNPs.
Subcellular location	Nucleus Ref.3 Ref.4.
Sequence similarities	Belongs to the SWT21 family.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mRNA splicing, via spliceosome Inferred from mutant phenotype Ref.4. Source: SGD
Cellular_component	nucleus Inferred from direct assay Ref.4. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LSM1	P47017	1	EBI-29071,EBI-174

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	Protein SWT21		PRO_0000203403

Sequences

	Sequence		Length	Mass (Da)
	P53873 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: ED52B00C4902453A	FASTA	357	40,308
	10 20 30 40 50 60 MEKKVICQDI FWSCDGTSFV SVHNDFGIRQ YLVPEESNTD KLNRNLLLPF TRFFRNQSIV 70 80 90 100 110 120 SCAIDPFYTL YNENSDRLAG DRIVVGGKNF PLQLYSLMDG QCILSYDTMN KINGEYETVY 130 140 150 160 170 180 SVKIDVESRV YTGSCRNKVA IYDKSRRDAV WMNQSTKKAS KGRQSIISCF EEQPMGGQAL 190 200 210 220 230 240 SRGSLLCGSY ANEMFQVDCR HQRLERLNYT RTVAGGIVQI LTSDNGRYVY VVRRNSDAIS 250 260 270 280 290 300 IYDRRNLQHE LNVLRLPFRI HHNSAKLKAY IDTAYGLSMG TPQGTILNWG RDLVEFGGVP 310 320 330 340 350 SHNSVEDPLI TSIPPESEWR TNLDSTIPAT VVKNCPGDPE LFALSHGGTI SLCRFGG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J. Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"The yeast splicing factor Prp40p contains functional leucine-rich nuclear export signals that are essential for splicing." Murphy M.W., Olson B.L., Siliciano P.G. Genetics 166:53-65(2004) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[4]	"A targeted bypass screen identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for stable U1 snRNP/Pre-mRNA interaction." Hage R., Tung L., Du H., Stands L., Rosbash M., Chang T.H. Mol. Cell. Biol. 29:3941-3952(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, ASSOCIATION WITH SNRNPS.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z71463 Genomic DNA. Translation: CAA96081.1. BK006947 Genomic DNA. Translation: DAA10366.1.
PIR	S63142.
RefSeq	NP_014212.1. NM_001183025.1.
3D structure databases
ProteinModelPortal	P53873.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-971N.
IntAct	P53873. 2 interactions.
MINT	MINT-483287.
STRING	4932.YNL187W.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YNL187W; YNL187W; YNL187W.
GeneID	855534.
KEGG	sce:YNL187W.
Organism-specific databases
CYGD	YNL187w.
SGD	S000005131. SWT21.
Phylogenomic databases
eggNOG	NOG42241.
OMA	FGIRQYL.
OrthoDB	EOG44QX9D.
Enzyme and pathway databases
BioCyc	YEAST:G3O-33198-MONOMER.
Gene expression databases
Genevestigator	P53873.
GermOnline	YNL187W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	2.130.10.10. 1 hit. 2.140.10.10. 1 hit.
InterPro	IPR027295. Quinonprotein_ADH-like_fam. IPR015943. WD40/YVTN_repeat-like_dom. IPR017986. WD40_repeat_dom. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
ProtoNet	Search...
Other
NextBio	979589.

Entry information

Entry name

SWT21_YEAST

Accession

Primary (citable) accession number: P53873
Secondary accession number(s): D6W100

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 29, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program