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P53873

- SWT21_YEAST

UniProt

P53873 - SWT21_YEAST

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Protein

Protein SWT21

Gene

SWT21

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in mRNA splicing. Helps to stabilize the U1 snRNP-5' splice site interaction.1 Publication

GO - Biological processi

  1. mRNA splicing, via spliceosome Source: SGD
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciYEAST:G3O-33198-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SWT21
Alternative name(s):
Synthetic With TGS1 protein 21
Gene namesi
Name:SWT21
Ordered Locus Names:YNL187W
ORF Names:N1615
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL187w.
SGDiS000005131. SWT21.

Subcellular locationi

Nucleus 2 Publications

GO - Cellular componenti

  1. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Protein SWT21PRO_0000203403Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP53873.

Interactioni

Subunit structurei

Associates with snRNPs.

Binary interactionsi

WithEntry#Exp.IntActNotes
LSM1P470171EBI-29071,EBI-174

Protein-protein interaction databases

BioGridi35646. 16 interactions.
DIPiDIP-971N.
IntActiP53873. 2 interactions.
MINTiMINT-483287.
STRINGi4932.YNL187W.

Structurei

3D structure databases

ProteinModelPortaliP53873.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SWT21 family.Curated

Phylogenomic databases

eggNOGiNOG42241.
InParanoidiP53873.
OMAiFGIRQYL.
OrthoDBiEOG7MKWJ5.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.140.10.10. 1 hit.
InterProiIPR027295. Quinonprotein_ADH-like_fam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.

Sequencei

Sequence statusi: Complete.

P53873-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKKVICQDI FWSCDGTSFV SVHNDFGIRQ YLVPEESNTD KLNRNLLLPF
60 70 80 90 100
TRFFRNQSIV SCAIDPFYTL YNENSDRLAG DRIVVGGKNF PLQLYSLMDG
110 120 130 140 150
QCILSYDTMN KINGEYETVY SVKIDVESRV YTGSCRNKVA IYDKSRRDAV
160 170 180 190 200
WMNQSTKKAS KGRQSIISCF EEQPMGGQAL SRGSLLCGSY ANEMFQVDCR
210 220 230 240 250
HQRLERLNYT RTVAGGIVQI LTSDNGRYVY VVRRNSDAIS IYDRRNLQHE
260 270 280 290 300
LNVLRLPFRI HHNSAKLKAY IDTAYGLSMG TPQGTILNWG RDLVEFGGVP
310 320 330 340 350
SHNSVEDPLI TSIPPESEWR TNLDSTIPAT VVKNCPGDPE LFALSHGGTI

SLCRFGG
Length:357
Mass (Da):40,308
Last modified:October 1, 1996 - v1
Checksum:iED52B00C4902453A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71463 Genomic DNA. Translation: CAA96081.1.
BK006947 Genomic DNA. Translation: DAA10366.1.
PIRiS63142.
RefSeqiNP_014212.1. NM_001183025.1.

Genome annotation databases

EnsemblFungiiYNL187W; YNL187W; YNL187W.
GeneIDi855534.
KEGGisce:YNL187W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71463 Genomic DNA. Translation: CAA96081.1 .
BK006947 Genomic DNA. Translation: DAA10366.1 .
PIRi S63142.
RefSeqi NP_014212.1. NM_001183025.1.

3D structure databases

ProteinModelPortali P53873.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35646. 16 interactions.
DIPi DIP-971N.
IntActi P53873. 2 interactions.
MINTi MINT-483287.
STRINGi 4932.YNL187W.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL187W ; YNL187W ; YNL187W .
GeneIDi 855534.
KEGGi sce:YNL187W.

Organism-specific databases

CYGDi YNL187w.
SGDi S000005131. SWT21.

Phylogenomic databases

eggNOGi NOG42241.
InParanoidi P53873.
OMAi FGIRQYL.
OrthoDBi EOG7MKWJ5.

Enzyme and pathway databases

BioCyci YEAST:G3O-33198-MONOMER.

Miscellaneous databases

NextBioi 979589.

Gene expression databases

Genevestigatori P53873.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
2.140.10.10. 1 hit.
InterProi IPR027295. Quinonprotein_ADH-like_fam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "The yeast splicing factor Prp40p contains functional leucine-rich nuclear export signals that are essential for splicing."
    Murphy M.W., Olson B.L., Siliciano P.G.
    Genetics 166:53-65(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  4. "A targeted bypass screen identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for stable U1 snRNP/Pre-mRNA interaction."
    Hage R., Tung L., Du H., Stands L., Rosbash M., Chang T.H.
    Mol. Cell. Biol. 29:3941-3952(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, ASSOCIATION WITH SNRNPS.

Entry informationi

Entry nameiSWT21_YEAST
AccessioniPrimary (citable) accession number: P53873
Secondary accession number(s): D6W100
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3