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Protein

Probable glutamine amidotransferase DUG3

Gene

DUG3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond.1 Publication

Miscellaneous

Present with 7300 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2For GATase activityBy similarity1

GO - Molecular functioni

  • amidophosphoribosyltransferase activity Source: SGD
  • omega peptidase activity Source: SGD
  • peptidase activity Source: SGD

GO - Biological processi

  • glutamine metabolic process Source: UniProtKB-KW
  • glutathione catabolic process Source: SGD

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BioCyciMetaCyc:G3O-33202-MONOMER.
YEAST:G3O-33202-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutamine amidotransferase DUG3
Alternative name(s):
Deficient in utilization of glutathione protein 3
GSH degradosomal complex subunit DUG3
Gene namesi
Name:DUG3
Ordered Locus Names:YNL191W
ORF Names:N1410
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL191W.
SGDiS000005135. DUG3.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002034012 – 357Probable glutamine amidotransferase DUG3Add BLAST356

Proteomic databases

MaxQBiP53871.
PRIDEiP53871.

Interactioni

Subunit structurei

Component of the GSH degradosomal complex composed of at least DUG1, DUG2 and DUG3.1 Publication

Protein-protein interaction databases

BioGridi35642. 19 interactors.
DIPiDIP-3956N.
IntActiP53871. 5 interactors.
MINTiMINT-501795.
STRINGi4932.YNL191W.

Structurei

3D structure databases

ProteinModelPortaliP53871.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 260Glutamine amidotransferase type-2PROSITE-ProRule annotationAdd BLAST259

Sequence similaritiesi

Belongs to the DUG3 family.Curated

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

HOGENOMiHOG000256686.
InParanoidiP53871.
KOiK18802.
OMAiPFRHGRW.
OrthoDBiEOG092C32TU.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR017932. GATase_2_dom.
IPR029055. Ntn_hydrolases_N.
IPR026869. Put_GATase_2.
PfamiView protein in Pfam
PF13230. GATase_4. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS51278. GATASE_TYPE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCRFLIFKGK QPIRLSHLLT RPAHSIINQS FDSRLRLDRR RPMNGDGFGV
60 70 80 90 100
AYYPLDTELS EDGPCLFKAI TPAWNNQNLS TLAEKTKSDL VFAHVRASTY
110 120 130 140 150
GVLSETNCHP FTYHSLCFMH NGGISNFKGI KRKLLNHIKD EYLNFIQGST
160 170 180 190 200
DSECAFALFL DTLDKLGYDP KKQDGDFGNV ALRKAMLRTI DYIRDWTKEA
210 220 230 240 250
NKDEAHVEPS LLNFAVTDGS TVVVSRYITS KTDEAASLHF SCGSSFVETS
260 270 280 290 300
PGEYRVERLD RNQDVIMVAS EPLTFERGDW TAVPTNSILT IKKQTILLHP
310 320 330 340 350
IIDEYYQEDP LYLRSSTLAE SKGLMGSIPL AKAVEKNVPP LEREGRTRPP

TAVAHIA
Length:357
Mass (Da):40,181
Last modified:October 1, 1996 - v1
Checksum:iAFAAEFE7152CFE1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71467 Genomic DNA. Translation: CAA96085.1.
AY692717 Genomic DNA. Translation: AAT92736.1.
BK006947 Genomic DNA. Translation: DAA10362.1.
PIRiS63146.
RefSeqiNP_014208.1. NM_001183029.1.

Genome annotation databases

EnsemblFungiiYNL191W; YNL191W; YNL191W.
GeneIDi855530.
KEGGisce:YNL191W.

Similar proteinsi

Entry informationi

Entry nameiDUG3_YEAST
AccessioniPrimary (citable) accession number: P53871
Secondary accession number(s): D6W0Z6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 27, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names